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  2. Hdac7 - histone deacetylase 7 Gene

Hdac7 - histone deacetylase 7 Gene

中文名称:组蛋白脱乙酰酶 7

种属: Mus musculus

同用名: HD7; HD7a; Hdac7a; mFLJ00062; 5830434K02Rik

基因 ID: 56233 | 基因类型: protein coding

关于 Hdac7

Chromosome 15: 97,690,545-97,742,383 reverse strand.GRCm39:CM001008.3

This gene has 13 transcripts (splice variants), 263 orthologues, 10 paralogues and is associated with 16 phenotypes. Broad expression in thymus adult (RPKM 141.4), lung adult (RPKM 54.7) and 16 other tissues.

功能概要

该基因编码的蛋白可启动染色质结合活性和转录辅阻遏物活性。作用于细胞-细胞连接组件的上游或内部; RNA 聚合酶 II 对转录的负调控;和血管生成。预测位于胞质溶胶和细胞核中。预计是组蛋白脱乙酰酶复合物的一部分。在肾上腺表达;胚胎;眼睛;内耳;和耳囊肿。与人类 HDAC7(组蛋白脱乙酰酶 7)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables chromatin binding activity and transcription corepressor activity. Acts upstream of or within cell-cell junction assembly; negative regulation of transcription by RNA polymerase II; and vasculogenesis. Predicted to be located in cytosol and nucleus. Predicted to be part of histone deacetylase complex. Is expressed in adrenal gland; embryo; eye; inner ear; and otocyst. Orthologous to human HDAC7 (histone deacetylase 7). [provided by Alliance of Genome Resources, Apr 2022]

Hdac7 基因产物(9)

mRNA Protein Name
NM_001204276.1 NP_001191205.1 histone deacetylase 7 isoform 2
NM_019572.3 NP_062518.2 histone deacetylase 7 isoform 4
NM_001378971.1 NP_001365900.1 histone deacetylase 7 isoform 9
NM_001204277.1 NP_001191206.1 histone deacetylase 7 isoform 3
NM_001204280.1 NP_001191209.1 histone deacetylase 7 isoform 7
NM_001204281.1 NP_001191210.1 histone deacetylase 7 isoform 8
NM_001204275.1 NP_001191204.1 histone deacetylase 7 isoform 1
NM_001204279.1 NP_001191208.1 histone deacetylase 7 isoform 6
NM_001204278.1 NP_001191207.1 histone deacetylase 7 isoform 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
16109736 MGI
enables histone deacetylase activity IDA
IDA: 通过直接分析推断
10640276 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10640276 MGI
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
10640276 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell-cell junction assembly IMP
IMP: 通过突变表型推断
16873063 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
16260608 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10640276 MGI
acts upstream of or within vasculogenesis IMP
IMP: 通过突变表型推断
16873063 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in nucleus IDA
IDA: 通过直接分析推断
10640276 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Hdac7 蛋白结构

PHA03247

PHA03247: cl33720 (121 - 524)

HDAC7

HDAC7: cd10008 (543 - 918)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 975 a.a.
蛋白主名 其他名称

histone deacetylase 7

histone deacetylase 7A

Hdac7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Hdac7 Q8C2B3 Ywhae Mus musculus P62259
Pull Down
16956611
种属内
Hdac7 Q8C2B3 Ywhae Mus musculus P62259
CoIP
11585834
种属内
Hdac7 Q8C2B3 Ywhae Mus musculus P62259
Pull Down
15166223
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hdac7 NCBI NCBI:51564