TRIB3 - tribbles pseudokinase 3 Gene

中文名称：tribbles 假激酶 3

种属: Homo sapiens

同用名: NIPK; SINK; TRB3; SKIP3; C20orf97

基因 ID: 57761 | 基因类型: protein coding

关于 TRIB3

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:380,760-397,559 (from NCBI)

This gene has 4 transcripts (splice variants), 192 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 19.9), liver (RPKM 5.0) and 16 other tissues.

功能概要

该基因编码的蛋白质是一种推定的蛋白激酶，由转录因子 NF-kappaB 诱导。编码的蛋白质是 NF-kappaB 的负调节因子，还可以使细胞对 TNF 和 TRAIL 诱导的细胞凋亡敏感。此外，该蛋白还可以负向调节细胞存活的丝氨酸-苏氨酸激酶 Akt1。不同的启动子使用和交替剪接导致多个转录变体。[RefSeq 提供，2014 年 7 月]

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced Apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase Akt1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]

TRIB3 基因产物(6)

mRNA	Protein	Name
NM_001301188.1	NP_001288117.1	tribbles homolog 3 isoform 1
NM_001301190.1	NP_001288119.1	tribbles homolog 3 isoform 1
NM_001301193.1	NP_001288122.1	tribbles homolog 3 isoform 1
NM_001301196.1	NP_001288125.1	tribbles homolog 3 isoform 1
NM_001301201.1	NP_001288130.1	tribbles homolog 3 isoform 2
NM_021158.5	NP_066981.2	tribbles homolog 3 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
NOT enables kinase activity	IDA IDA: 通过直接分析推断	12743605	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12743605	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	12791994	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA IDA: 通过直接分析推断	15775988	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	15775988	GOA
involved in negative regulation of protein kinase activity	IDA IDA: 通过直接分析推断	12791994	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	15775988	GOA
involved in regulation of MAP kinase activity	IDA IDA: 通过直接分析推断	15299019	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: 通过直接分析推断	15775988	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIB3 蛋白结构

Pkinase

0
100
200
300
358 a.a.

蛋白主名

其他名称

tribbles homolog 3

TRB-3

TRIB3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TRIB3	Q96RU7	PADI4	Homo sapiens	Q9UM07	Validated Y2H	32296183
种属内	TRIB3	Q96RU7	APOBEC3C	Homo sapiens	Q9NRW3	Validated Y2H	32296183
种属内	TRIB3	Q96RU7	RPGRIP1	Homo sapiens	Q96KN7	Validated Y2H	25416956
种属内	TRIB3	Q96RU7	RPGRIP1	Homo sapiens	Q96KN7-4	Validated Y2H	25910212
种属内	TRIB3	Q96RU7	RPGRIP1	Homo sapiens	Q96KN7-4	Y2H Bait-Prey Pool	25910212
种属内	TRIB3	Q96RU7	RPGRIP1	Homo sapiens	Q96KN7-4	Y2H Array	25910212
种属内	TRIB3	Q96RU7	SHFL	Homo sapiens	Q9NUL5-4	Validated Y2H	32296183
种属内	TRIB3	Q96RU7	SPAG8	Homo sapiens	Q99932-2	Validated Y2H	32296183
种属内	TRIB3	Q96RU7	GPATCH2L	Homo sapiens	Q9NWQ4-1	Validated Y2H	32296183
种属内	TRIB3	Q96RU7	PITX2	Homo sapiens	Q99697-2	Validated Y2H	32296183
种属内	TRIB3	Q96RU7	PKNOX2	Homo sapiens	Q96KN3	Y2H Prey Pooling	32296183
种属内	TRIB3	Q96RU7	PKNOX2	Homo sapiens	Q96KN3	Y2H Array	32296183
种属内	TRIB3	Q96RU7	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	32296183
种属内	TRIB3	Q96RU7	PRMT5	Homo sapiens	O14744	Y2H	23455924
种属内	TRIB3	Q96RU7	PRMT5	Homo sapiens	O14744	Anti Tag CoIP	23455924
种属内	TRIB3	Q96RU7	AKAP8L	Homo sapiens	Q9ULX6	Validated Y2H	32296183
种属内	TRIB3	Q96RU7	AKAP8L	Homo sapiens	Q9ULX6	Y2H Prey Pooling	32296183
种属内	TRIB3	Q96RU7	AKAP8L	Homo sapiens	Q9ULX6	Y2H Array	32296183
种属内	TRIB3	Q96RU7	EXOSC5	Homo sapiens	Q9NQT4	Validated Y2H	32296183
种属内	TRIB3	Q96RU7	ATF4	Homo sapiens	P18848	Y2H Array	25416956
种属内	TRIB3	Q96RU7	ATF4	Homo sapiens	P18848	Y2H Array	32296183
种属内	TRIB3	Q96RU7	ATF4	Homo sapiens	P18848	Y2H Prey Pooling	25416956
种属内	TRIB3	Q96RU7	ATF4	Homo sapiens	P18848	Y2H Prey Pooling	32296183
种属内	TRIB3	Q96RU7	ATF4	Homo sapiens	P18848	Validated Y2H	25910212
种属内	TRIB3	Q96RU7	ATF4	Homo sapiens	P18848	Y2H	12743605
种属内	TRIB3	Q96RU7	ATF4	Homo sapiens	P18848	Y2H Bait-Prey Pool	25910212
种属内	TRIB3	Q96RU7	ATF4	Homo sapiens	P18848	Y2H Array	25910212
种属内	TRIB3	Q96RU7	ATF4	Homo sapiens	P18848	Validated Y2H	25416956
种属内	TRIB3	Q96RU7	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	TRIB3	Q96RU7	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	TRIB3	Q96RU7	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	TRIB3	Q96RU7	UTP23	Homo sapiens	Q9BRU9	Validated Y2H	32296183
种属内	TRIB3	Q96RU7	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
种属内	TRIB3	Q96RU7	CBX8	Homo sapiens	Q9HC52	Validated Y2H	32296183
种属内	TRIB3	Q96RU7	INO80B	Homo sapiens	Q9C086	Validated Y2H	32296183
种属内	TRIB3	Q96RU7	MDFI	Homo sapiens	Q99750	Y2H Bait-Prey Pool	25910212
种属内	TRIB3	Q96RU7	MDFI	Homo sapiens	Q99750	Validated Y2H	25910212
种属内	TRIB3	Q96RU7	MDFI	Homo sapiens	Q99750	Y2H Array	25910212
种属内	TRIB3	Q96RU7	TCF19	Homo sapiens	Q9Y242	Validated Y2H	32296183
种属内	TRIB3	Q96RU7	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
种属内	TRIB3	Q96RU7	ARMC7	Homo sapiens	Q9H6L4	Validated Y2H	32296183
种属内	TRIB3	Q96RU7	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
种属内	TRIB3	Q96RU7	TEKT3	Homo sapiens	Q9BXF9	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TRIB3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P74491	TRIB3 Protein, Human (sf9, GST)	Q96RU7 (M1-G358)	≥95%

TRIB3 抗体

目录号	产品名	应用	反应物种
HY-P82429	TRIB3 Antibody (YA2174)	WB	Human

关联疾病

疾病名称

别名

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Geotrichosis

Diabetes Mellitus

Diabetes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16261	Trib3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS15017	TRIB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	TRIB3	VGNC	VGNC:81253
Rattus norvegicus	TRIB3	RGD	RGD:708432
Canis familiaris	TRIB3	VGNC	VGNC:47802
Bos taurus	TRIB3	VGNC	VGNC:36310
Mus musculus	TRIB3	MGD	MGI:1345675
Macaca mulatta	TRIB3	VGNC	VGNC:79015
Others	TRIB3	NCBI

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