2. Gene
  3. TRIB3 - tribbles pseudokinase 3 Gene

TRIB3 - tribbles pseudokinase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：tribbles 假激酶 3

种属: Homo sapiens

同用名: NIPK; SINK; TRB3; SKIP3; C20orf97

基因 ID: 57761 | 基因类型: protein coding

关于 TRIB3

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:380,760-397,559 (from NCBI)

This gene has 4 transcripts (splice variants), 192 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 19.9), liver (RPKM 5.0) and 16 other tissues.

功能概要

该基因编码的蛋白质是一种推定的蛋白激酶，由转录因子 NF-kappaB 诱导。编码的蛋白质是 NF-kappaB 的负调节因子，还可以使细胞对 TNF 和 TRAIL 诱导的细胞凋亡敏感。此外，该蛋白还可以负向调节细胞存活的丝氨酸-苏氨酸激酶 Akt1。不同的启动子使用和交替剪接导致多个转录变体。[RefSeq 提供，2014 年 7 月]

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced Apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase Akt1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]

TRIB3 基因产物(6)

mRNA Protein Name
NM_001301188.1 NP_001288117.1 tribbles homolog 3 isoform 1
NM_001301190.1 NP_001288119.1 tribbles homolog 3 isoform 1
NM_001301193.1 NP_001288122.1 tribbles homolog 3 isoform 1
NM_001301196.1 NP_001288125.1 tribbles homolog 3 isoform 1
NM_001301201.1 NP_001288130.1 tribbles homolog 3 isoform 2
NM_021158.5 NP_066981.2 tribbles homolog 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables kinase activity IDA
IDA: 通过直接分析推断
12743605 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12743605 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
12791994 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
15775988 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
15775988 GOA
involved in negative regulation of protein kinase activity IDA
IDA: 通过直接分析推断
12791994 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15775988 GOA
involved in regulation of MAP kinase activity IDA
IDA: 通过直接分析推断
15299019 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
15775988 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIB3 蛋白结构

Pkinase

Pkinase: Protein kinase domain (111 - 315)

  • 0
  • 100
  • 200
  • 300
  • 358 a.a.
蛋白主名 其他名称

tribbles homolog 3

TRB-3

重组 TRIB3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74491 TRIB3 Protein, Human (sf9, GST) Q96RU7 (M1-G358) ≥95%

关联疾病

疾病名称 别名
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Geotrichosis
Diabetes Mellitus

Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16261 Trib3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS15017 TRIB3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus TRIB3 VGNC VGNC:81253
Rattus norvegicus TRIB3 RGD RGD:708432
Canis familiaris TRIB3 VGNC VGNC:47802
Bos taurus TRIB3 VGNC VGNC:36310
Mus musculus TRIB3 MGD MGI:1345675
Macaca mulatta TRIB3 VGNC VGNC:79015
Others TRIB3 NCBI
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