2. Gene
  3. BLK - BLK proto-oncogene, Src family tyrosine kinase Gene

BLK - BLK proto-oncogene, Src family tyrosine kinase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：BLK 原癌基因，Src 家族酪氨酸激酶

种属: Homo sapiens

同用名: MODY11

基因 ID: 640 | 基因类型: protein coding

关于 BLK

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:11,494,387-11,564,599 (from NCBI)

This gene has 9 transcripts (splice variants), 196 orthologues, 32 paralogues and is associated with 3 phenotypes. Biased expression in lymph node (RPKM 18.9), spleen (RPKM 13.7) and 4 other tissues.

功能概要

该基因编码原癌基因 Src 家族的非受体酪氨酸激酶，通常参与细胞增殖和分化。该蛋白在 B 细胞受体信号传导和 B 细胞发育中发挥作用。该蛋白质还刺激胰岛素合成和分泌以响应葡萄糖，并增强几种胰腺 β 细胞转录因子的表达。[RefSeq 提供，2010 年 8 月]

This gene encodes a nonreceptor tyrosine-kinase of the Src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates Insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]

BLK 基因产物(2)

mRNA Protein Name
NM_001330465.2 NP_001317394.1 tyrosine-protein kinase Blk isoform 2
NM_001715.3 NP_001706.2 tyrosine-protein kinase Blk isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
876631 GOA
enables non-membrane spanning protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
23555801 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16273093 GOA
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
30356214 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in B cell receptor signaling pathway IDA
IDA: 通过直接分析推断
876631 GOA
involved in B cell receptor signaling pathway IMP
IMP: 通过突变表型推断
23555801 GOA
involved in peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
30356214 GOA
involved in positive regulation of insulin secretion IMP
IMP: 通过突变表型推断
19667185 GOA
involved in positive regulation of protein binding IMP
IMP: 通过突变表型推断
23555801 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BLK 蛋白结构

SH3_1

SH3_1: SH3 domain (64 - 110)

SH2

SH2: SH2 domain (124 - 205)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (241 - 489)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
蛋白主名 其他名称

tyrosine-protein kinase Blk

B lymphoid tyrosine kinase

BLK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BLK P51451 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
种属内
BLK P51451 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
种属内
BLK P51451 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
种属内
BLK P51451 ZBTB32 Homo sapiens A0A0C4DGF1
Y2H Prey Pooling
32296183
种属内
BLK P51451 ZBTB32 Homo sapiens A0A0C4DGF1
Y2H Array
32296183
种属内
BLK P51451 ZNF774 Homo sapiens Q6NX45
Y2H Array
32296183
种属内
BLK P51451 ZNF774 Homo sapiens Q6NX45
Validated Y2H
32296183
种属内
BLK P51451 ZNF774 Homo sapiens Q6NX45
Y2H Prey Pooling
32296183
种属内
BLK P51451 FXR1 Homo sapiens P51114-2
Y2H Prey Pooling
32296183
种属内
BLK P51451 EFS Homo sapiens O43281-2
Y2H Prey Pooling
32296183
种属内
BLK P51451 EFS Homo sapiens O43281-2
Y2H Array
32296183
种属内
BLK P51451 FLACC1 Homo sapiens Q96Q35-2
Validated Y2H
32296183
种属内
BLK P51451 FLACC1 Homo sapiens Q96Q35-2
Y2H Prey Pooling
32296183
种属内
BLK P51451 FLACC1 Homo sapiens Q96Q35-2
Y2H Array
32296183
种属内
BLK P51451 PXN Homo sapiens P49023-2
Y2H Prey Pooling
32296183
种属内
BLK P51451 PXN Homo sapiens P49023-2
Y2H Array
32296183
种属内
BLK P51451 ZBTB42 Homo sapiens B2RXF5
Y2H Prey Pooling
32296183
种属内
BLK P51451 ZBTB42 Homo sapiens B2RXF5
Y2H Array
32296183
种属内
BLK P51451 GRB10 Homo sapiens Q13322-4
Y2H Array
32296183
种属内
BLK P51451 GRB10 Homo sapiens Q13322-4
Validated Y2H
32296183
种属内
BLK P51451 GRB10 Homo sapiens Q13322-4
Y2H Prey Pooling
32296183
种属内
BLK P51451 KIT Homo sapiens P10721
FPS
24728074
种属内
BLK P51451 STAP2 Homo sapiens Q9UGK3
Validated Y2H
32296183
种属内
BLK P51451 STAP2 Homo sapiens Q9UGK3
Y2H Array
32296183
种属内
BLK P51451 STAP2 Homo sapiens Q9UGK3
Y2H Prey Pooling
32296183
种属内
BLK P51451 SLA Homo sapiens Q13239-3
Y2H Prey Pooling
32296183
种属内
BLK P51451 SLA Homo sapiens Q13239-3
Validated Y2H
32296183
种属内
BLK P51451 SLA Homo sapiens Q13239-3
Y2H Array
32296183
种属内
BLK P51451 JAKMIP1 Homo sapiens Q96N16
Validated Y2H
32296183
种属内
BLK P51451 JAKMIP1 Homo sapiens Q96N16
Y2H Array
32296183
种属内
BLK P51451 JAKMIP1 Homo sapiens Q96N16
Y2H Prey Pooling
32296183
种属内
BLK P51451 TDP2 Homo sapiens O95551
Y2H Prey Pooling
32296183
种属内
BLK P51451 TDP2 Homo sapiens O95551
Y2H Array
32296183
种属内
BLK P51451 SSBP3 Homo sapiens Q9BWW4
Validated Y2H
32296183
种属内
BLK P51451 SSBP3 Homo sapiens Q9BWW4
Y2H Array
32296183
种属内
BLK P51451 SSBP3 Homo sapiens Q9BWW4
Y2H Prey Pooling
32296183
种属内
BLK P51451 EGFR Homo sapiens P00533
Ub Reconstruction
24658140
种属内
BLK P51451 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
种属内
BLK P51451 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
31980649
种属内
BLK P51451 VIM Homo sapiens P08670
Anti Tag CoIP
31980649
种属内
BLK P51451 SH2D1B Homo sapiens O14796
Y2H Prey Pooling
32296183
种属内
BLK P51451 SH2D1B Homo sapiens O14796
Y2H Array
32296183
种属内
BLK P51451 BIRC2 Homo sapiens Q13490
Y2H Prey Pooling
32296183
种属内
BLK P51451 BIRC2 Homo sapiens Q13490
Validated Y2H
32296183
种属内
BLK P51451 BIRC2 Homo sapiens Q13490
Y2H Array
32296183
种属内
BLK P51451 GAB1 Homo sapiens Q13480
FPS
24728074
种属内
BLK P51451 STAT3 Homo sapiens P40763
Y2H Array
25416956
种属内
BLK P51451 STAT3 Homo sapiens P40763
Y2H Array
32296183
种属内
BLK P51451 STAT3 Homo sapiens P40763
Y2H Prey Pooling
25416956
种属内
BLK P51451 STAT3 Homo sapiens P40763
Y2H Prey Pooling
32296183
种属内
BLK P51451 STAT3 Homo sapiens P40763
Y2H Array
31515488
种属内
BLK P51451 AR Homo sapiens P10275
FPS
24728074
种属内
BLK P51451 HSF2BP Homo sapiens O75031
Y2H Array
32296183
种属内
BLK P51451 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
种属内
BLK P51451 EFS Homo sapiens O43281
Y2H Prey Pooling
25416956
种属内
BLK P51451 EFS Homo sapiens O43281
Y2H Array
31515488
种属内
BLK P51451 EFS Homo sapiens O43281
Validated Y2H
25416956
种属内
BLK P51451 FXR2 Homo sapiens P51116
Y2H Array
32296183
种属内
BLK P51451 FXR2 Homo sapiens P51116
Y2H Prey Pooling
32296183
种属内
BLK P51451 ZBTB8A Homo sapiens Q96BR9
Validated Y2H
32296183
种属内
BLK P51451 ZBTB8A Homo sapiens Q96BR9
Y2H Array
32296183
种属内
BLK P51451 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
32296183
种属内
BLK P51451 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
种属内
BLK P51451 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
种属内
BLK P51451 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
种属内
BLK P51451 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
种属内
BLK P51451 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
种属内
BLK P51451 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
种属内
BLK P51451 PIK3R3 Homo sapiens Q92569
Y2H Array
32296183
种属内
BLK P51451 PIK3R3 Homo sapiens Q92569
Y2H Prey Pooling
32296183
种属内
BLK P51451 PIK3R3 Homo sapiens Q92569
Validated Y2H
32296183
种属内
BLK P51451 PIK3R1 Homo sapiens P27986-2
Y2H Array
32296183
种属内
BLK P51451 PIK3R1 Homo sapiens P27986-2
Y2H Prey Pooling
32296183
种属内
BLK P51451 CRKL Homo sapiens P46109
Y2H Array
32296183
种属内
BLK P51451 CRKL Homo sapiens P46109
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 BLK 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70040 BLK Protein, Human (His) P51451 (G2-P505) ≥95%
HY-P72853 BLK Protein, Human (sf9, GST) P51451 (M1-P505) ≥95%

关联疾病

疾病名称 别名
Maturity-Onset Diabetes Of The Young, Type 11

Maturity-Onset Diabetes Of The Young Type 11

MODY11

Maturity-Onset Diabetes Of The Young 11

Mody-11

Mody Type 11

Diabetes Of The Young, Maturity-Onset, Type 11
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
Maturity-Onset Diabetes Of The Young, Type 7

Maturity-Onset Diabetes Of The Young Type 7

MODY7

Maturity-Onset Diabetes Of The Young, Type Vii

Maturity-Onset Diabetes Of The Young 7

Mody-7

Mody Type 7

Diabetes Of The Young, Maturity-Onset, Type 7
Maturity-Onset Diabetes Of The Young, Type 9

Maturity-Onset Diabetes Of The Young Type 9

MODY9

Maturity-Onset Diabetes Of The Young, Type Ix

Maturity-Onset Diabetes Of The Young 9

Mody-9

Mody Type 9

Diabetes Of The Young, Maturity-Onset, Type 9
Maturity-Onset Diabetes Of The Young, Type 13

Maturity-Onset Diabetes Of The Young Type 13

MODY13

Mody Type 13

Mody, Type 13

Maturity-Onset Diabetes Of The Young 13

Diabetes Of The Young, Maturity-Onset, Type 13
Maturity-Onset Diabetes Of The Young, Type 8, With Exocrine Dysfunction

Maturity-Onset Diabetes Of The Young Type 8

MODY8

Dped

Maturity-Onset Diabetes Of The Young, Type Viii

Mody Type 8

Diabetes And Pancreatic Exocrine Dysfunction

Diabetes-Pancreatic Exocrine Dysfunction Syndrome

Diabetes And Pancreatic Exocrine

Maturity-Onset Diabetes Of The Young Type 8 With Exocrine Dysfunction

Maturity-Onset Diabetes Of The Young 8 With Exocrine Dysfunction

Diabetes And Pancreatic Exocrine Dysfunction Syndrome

Mody-8

Diabetes Of The Young, Maturity-Onset, Type 8
Maturity-Onset Diabetes Of The Young, Type 14

Maturity-Onset Diabetes Of The Young Type 14

MODY14

Maturity-Onset Diabetes Of The Young 14

Diabetes Of The Young, Maturity-Onset, Type 14
Kawasaki Disease

Mucocutaneous Lymph Node Syndrome

Acute Febrile Mucocutaneous Lymph Node Syndrome

Kawasaki Syndrome

Kd

Infantile Polyarteritis

Kawasaki Disease, Susceptibility To

Acute Febrile Mcls

Kawasaki'S Disease

Mlns

KWD
Maturity-Onset Diabetes Of The Young, Type 10

Maturity-Onset Diabetes Of The Young Type 10

MODY10

Maturity-Onset Diabetes Of The Young 10

Mody-10

Mody Type 10

Diabetes Of The Young, Maturity-Onset, Type 10
Keratolytic Winter Erythema

KWE

Oudtshoorn Skin Disease

Erythrokeratolysis Hiemalis Ichthyosis

Erythrokeratolysis Hiemalis

Oudtshoorn Skin

Oudtshoorn Disease
Maturity-Onset Diabetes Of The Young, Type 6

MODY6

Maturity-Onset Diabetes Of The Young Type 6

Maturity-Onset Diabetes Of The Young 6

Mody Type 6

Mody, Type 6

Mody-6

Diabetes Of The Young, Maturity-Onset, Type 6
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Heart Aneurysm

Cardiac Aneurysm
Coronary Aneurysm

Aneurysm Of Coronary Vessels

Aneurysmal Lesion Of Coronary Artery

Arteriovenous Aneurysm Of Coronary Vessels
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Maturity-Onset Diabetes Of The Young, Type 4

Maturity-Onset Diabetes Of The Young Type 4

MODY4

Mody, Type Iv

Mody Type 4

Mody, Type 4

Maturity-Onset Diabetes Of The Young 4

Mody-4

Diabetes Of The Young, Maturity-Onset, Type 4

Maturity-Onset Diabetes Of The Young, Type Iv
Maturity-Onset Diabetes Of The Young, Type 1

Maturity-Onset Diabetes Of The Young Type 1

MODY1

Mild Juvenile Diabetes Mellitus

Mody, Type I

Diabetes Mellitus Type 2

Mody Type 1

Mody, Type 1

Maturity-Onset Diabetes Of The Young 1

Mody-1

Diabetes Of The Young, Maturity-Onset, Type 1
Maturity-Onset Diabetes Of The Young, Type 2

Maturity-Onset Diabetes Of The Young Type 2

MODY2

Mody Glucokinase-Related

Mody Type 2

Mody, Type 2

Mody, Glucokinase-Related

Mody, Type Ii

Maturity-Onset Diabetes Of The Young 2

Mody-2

Diabetes Of The Young, Maturity-Onset, Type 2

Diabetes Mellitus Autosomal Dominant Type Ii
Co-Trimoxazole Allergy

Bactrim Allergy

Cotrimoxazol Allergy

Tmp/Smx Allergy

Trimethoprim/Sulfamethoxazole Allergy
Maturity-Onset Diabetes Of The Young, Type 3

Maturity-Onset Diabetes Of The Young Type 3

MODY3

Mody, Type Iii

Mody Type 3

Mody, Type 3

Maturity-Onset Diabetes Of The Young 3

Mody-3

Diabetes Of The Young, Maturity-Onset, Type 3
Renal Cysts And Diabetes Syndrome

RCAD

Mody5

Congenital Anomalies Of The Kidney And Urinary Tract With Diabetes

Cakut With Diabetes

Maturity-Onset Diabetes Of The Young Type 5

Tubulointerstitial Kidney Disease, Autosomal Dominant, 3

Adtkd3

Atypical Familial Juvenile Hyperuricemic Nephropathy

Atypical Fjhn

Familial Hypoplastic Glomerulocystic Kidney

Maturity-Onset Diabetes Of The Young, Type 5

Hyperuricemic Nephropathy, Familial Juvenile, Atypical

Fjhn, Atypical

Glomerulocystic Kidney Disease, Hypoplastic Type

Glomerulocystic Kidney, Familial Hypoplastic

Hypoplastic Type Glomerulocystic Kidney Disease

Glomerulocystic Kidney Disease Hypoplastic Type

Renal-Diabetes Mody5 Syndrome
Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable
Lymph Node Disease

Abnormality Of The Lymph Nodes

Disorder Of Lymph Node
Permanent Neonatal Diabetes Mellitus

Pndm

Permanent Diabetes Mellitus Of Infancy

Pdmi

Neonatal Diabetes Mellitus, Permanent
Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome

Chromosome 11p11.2 Deletion Syndrome

Pss

11p11.2 Deletion

P11pds

Defect11 Syndrome

Deletion Of Chromosome 11p11.2

POSHS
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-118105 RK-20448 Inhibitor 99.38% 否
HY-120622 BMS-243117 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus BLK RGD RGD:1308859
Macaca mulatta BLK VGNC VGNC:70253
Canis familiaris BLK VGNC VGNC:38464
Bos taurus BLK VGNC VGNC:26504
Mus musculus BLK MGD MGI:88169
Felis catus BLK VGNC VGNC:60121
Others BLK NCBI
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