SRSF1 - serine and arginine rich splicing factor 1 Gene

中文名称：富丝氨酸和精氨酸的剪接因子 1

种属: Homo sapiens

同用名: ASF; SF2; SFRS1; SF2p33; SRp30a

基因 ID: 6426 | 基因类型: protein coding

关于 SRSF1

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:57,989,038-58,007,246 (from NCBI)

This gene has 9 transcripts (splice variants), 239 orthologues, 8 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 44.8), appendix (RPKM 40.8) and 25 other tissues.

功能概要

该基因编码富含精氨酸/丝氨酸的剪接因子蛋白家族的成员。编码的蛋白质可以激活或抑制剪接，具体取决于其磷酸化状态及其相互作用伙伴。已发现该基因的多个转录变体。该基因在 13 号染色体上有一个假基因。[RefSeq 提供，2014 年 6 月]

This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014]

SRSF1 基因产物(2)

mRNA	Protein	Name
NM_001078166.2	NP_001071634.1	serine/arginine-rich splicing factor 1 isoform 2
NM_006924.5	NP_008855.1	serine/arginine-rich splicing factor 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA topoisomerase binding	IPI IPI: 通过物理相互作用推断	9611241	GOA
enables RNA binding	IDA IDA: 通过直接分析推断	19561594	GOA
enables RNA binding	IPI IPI: 通过物理相互作用推断	20797886	GOA
enables mRNA binding	IDA IDA: 通过直接分析推断	21984414	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9237760	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in alternative mRNA splicing, via spliceosome	IDA IDA: 通过直接分析推断	8940107	GOA
involved in mRNA 5'-splice site recognition	IDA IDA: 通过直接分析推断	8940107	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of catalytic step 2 spliceosome	IDA IDA: 通过直接分析推断	11991638	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	24449914	GOA
part of exon-exon junction complex	IDA IDA: 通过直接分析推断	16314458	GOA
located in nuclear speck	IDA IDA: 通过直接分析推断	20797886	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	9885563	GOA
located in nucleus	IDA IDA: 通过直接分析推断	21984414	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SRSF1 蛋白结构

RRM_1

0
100
200
248 a.a.

蛋白主名

其他名称

serine/arginine-rich splicing factor 1

SR splicing factor 1

SRSF1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SRSF1	Q07955	SNRNP70	Homo sapiens	P08621	Anti Tag CoIP	33961781
种属内	SRSF1	Q07955	NXF1	Homo sapiens	Q9UBU9	Pull Down	15184380
种属内	SRSF1	Q07955	NXF1	Homo sapiens	Q9UBU9	Y2H	21988832
种属内	SRSF1	Q07955	NXF1	Homo sapiens	Q9UBU9	CoIP	15184380
种属内	SRSF1	Q07955	TRAF5	Homo sapiens	O00463	Anti Tag CoIP	21822258
种属内	SRSF1	Q07955	SRPK1	Homo sapiens	Q96SB4	Affinity Chrom	10196197
种属内	SRSF1	Q07955	SRPK1	Homo sapiens	Q96SB4	Protein Kinase Assay	23602568
种属内	SRSF1	Q07955	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	33961781
种属内	SRSF1	Q07955	SRPK2	Homo sapiens	P78362	Protein Kinase Assay	23602568
种属间	SRSF1	Q07955	Srpk1	Mus musculus	O70551	Far-WB	10196197
种属间	SRSF1	Q07955	Srpk1	Mus musculus	O70551	Anti Tag CoIP	10196197
种属内	SRSF1	Q07955	CIR1	Homo sapiens	Q86X95	Y2H	15652350
种属内	SRSF1	Q07955	CIR1	Homo sapiens	Q86X95	Anti Tag CoIP	15652350
种属内	SRSF1	Q07955	TRA2B	Homo sapiens	P62995	Y2H Array	32296183
种属内	SRSF1	Q07955	TRA2B	Homo sapiens	P62995	Y2H Prey Pooling	32296183
种属内	SRSF1	Q07955	U2AF2	Homo sapiens	P26368	Anti Tag CoIP	33961781
种属内	SRSF1	Q07955	U2AF2	Homo sapiens	P26368	Y2H Pooling	16189514

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SRSF1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P700524	SRSF1 Protein, Human (His-SUMO)	Q07955-1 (S2-T248)	≥95%

关联疾病

疾病名称

别名

Homocystinuria

Cystathionine Beta Synthase Deficiency	Homocysteinemia
Cbs Deficiency	Cystathionine Synthase Deficiency
Cystathionine Beta-Synthase Deficiency Disease

Retinal Melanoma

Malignant Retinal Melanoma

Malignant Melanoma Of Retina

Xeroderma Pigmentosum, Complementation Group D

Xeroderma Pigmentosum, Group D	Xpdc
Xeroderma Pigmentosum Iv	XPD
Xeroderma Pigmentosum Group D	Xeroderma Pigmentosum Viii
Xp Group D	Xp Group H
Xp4	Xp8
Xph	Xp, Group D
Xp4 Xeroderma Pigmentosum Viii, Formerly	Xp8, Formerly
Xp, Group H, Formerly	Xph, Formerly
Xeroderma Pigmentosum Complementation Group D	XP-D
Xp-D/Cs

Unilateral Focal Polymicrogyria

Deafness, Autosomal Recessive 110

DFNB110	Autosomal Recessive Nonsyndromic Deafness 110
Autosomal Recessive Deafness 110	Deafness, Autosomal Recessive, 110

Trichothiodystrophy

Ttd	Amish Brittle Hair Syndrome
Bids Syndrome	Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome
Ibids	Pibids
Trichothiodystrophy Syndromes

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-117661	SPHINX31	Inhibitor	99.13%	否
HY-RS13790	SRSF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	SRSF1	VGNC	VGNC:99464
Mus musculus	SRSF1	MGD	MGI:98283
Canis familiaris	SRSF1	VGNC	VGNC:46816
Rattus norvegicus	SRSF1	RGD	RGD:1587490
Bos taurus	SRSF1	VGNC	VGNC:35297
Others	SRSF1	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SRSF1 - serine and arginine rich splicing factor 1 Gene

关于 SRSF1

功能概要

SRSF1 基因产物(2)

SRSF1 蛋白结构

SRSF1 蛋白互作信息

重组 SRSF1 蛋白

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

SRSF1 - serine and arginine rich splicing factor 1 Gene

关于 SRSF1

功能概要

SRSF1 基因产物(2)

SRSF1 蛋白结构

SRSF1 蛋白互作信息

重组 SRSF1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z