2. Gene
  3. Mmp2 - matrix metallopeptidase 2 Gene

Mmp2 - matrix metallopeptidase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：基质金属肽酶 2

种属: Rattus norvegicus

基因 ID: 81686 | 基因类型: protein coding

关于 Mmp2

Primary_assembly 19: 14,154,657-14,182,870 reverse strand.mRatBN7.2:CM026992.1

This gene has 2 transcripts (splice variants), 210 orthologues, 23 paralogues and is associated with 166 phenotypes. Biased expression in Uterus (RPKM 651.), Lung (RPKM 536.) and 8 other tissues.

功能概要

该基因编码的蛋白可启动纤连蛋白结合活性和肽酶活性。参与多个过程，包括细胞对雌二醇刺激的反应；循环系统发育；和生殖结构发育。位于细胞质和细胞外空间。用于研究动脉疾病（多种）；结膜炎;和短暂性脑缺血。多种疾病的生物标志物，包括急性坏死性胰腺炎；动脉疾病（多发性）；胆管疾病（多发）；脑缺血（多发）；和肝硬化（多发）。该基因的人类直系同源物与动脉疾病有关（多个）；眼病（多发）；弹性假黄瘤;和颞动脉炎。与人 MMP2（基质金属肽酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables fibronectin binding activity and peptidase activity. Involved in several processes, including cellular response to estradiol stimulus; circulatory system development; and reproductive structure development. Located in cytoplasm and extracellular space. Used to study artery disease (multiple); conjunctivitis; and transient cerebral ischemia. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); bile duct disease (multiple); brain ischemia (multiple); and liver cirrhosis (multiple). Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]

Mmp2 基因产物(1)

mRNA Protein Name
NM_031054.2 NP_112316.2 72 kDa type IV collagenase precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables fibronectin binding IPI
IPI: 通过物理相互作用推断
18039280 RGD
enables peptidase activity IDA
IDA: 通过直接分析推断
8531210 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
28659595 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in angiogenesis IEP
IEP: 通过表达模式推断
12234794 RGD
involved in cell migration IMP
IMP: 通过突变表型推断
20371087 RGD
involved in cellular response to cytokine stimulus IEP
IEP: 通过表达模式推断
19909738 RGD
involved in cellular response to estradiol stimulus IMP
IMP: 通过突变表型推断
19861308 RGD
involved in cellular response to fluid shear stress IEP
IEP: 通过表达模式推断
21637818 RGD
involved in cellular response to interleukin-1 IEP
IEP: 通过表达模式推断
16046515 RGD
involved in collagen catabolic process IDA
IDA: 通过直接分析推断
22410640 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
15044600 RGD
involved in heart development IDA
IDA: 通过直接分析推断
12061388 RGD
involved in luteinization IEP
IEP: 通过表达模式推断
10537164 RGD
involved in macrophage chemotaxis IDA
IDA: 通过直接分析推断
20110414 RGD
involved in negative regulation of cell adhesion IDA
IDA: 通过直接分析推断
14645107 RGD
involved in negative regulation of vasoconstriction IDA
IDA: 通过直接分析推断
19482300 RGD
involved in ovarian follicle development IDA
IDA: 通过直接分析推断
15617683 RGD
involved in ovulation from ovarian follicle IEP
IEP: 通过表达模式推断
14668206 RGD
involved in parturition IEP
IEP: 通过表达模式推断
19923067 RGD
involved in peripheral nervous system axon regeneration IDA
IDA: 通过直接分析推断
15026117 RGD
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
16857167 RGD
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
21637818 RGD
involved in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
27614125 RGD
involved in prostate gland epithelium morphogenesis IMP
IMP: 通过突变表型推断
20108352 RGD
involved in protein catabolic process IDA
IDA: 通过直接分析推断
16899336 RGD
involved in proteolysis IDA
IDA: 通过直接分析推断
20110414 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
19685505 RGD
involved in response to cytokine IEP
IEP: 通过表达模式推断
17822627 RGD
involved in response to electrical stimulus IEP
IEP: 通过表达模式推断
19660200 RGD
involved in response to estrogen IDA
IDA: 通过直接分析推断
16765374 RGD
involved in response to hydrogen peroxide IDA
IDA: 通过直接分析推断
16934674 RGD
involved in response to hyperoxia IEP
IEP: 通过表达模式推断
19099751 RGD
involved in response to hypoxia IDA
IDA: 通过直接分析推断
16980344 RGD
involved in response to mechanical stimulus IDA
IDA: 通过直接分析推断
15350851 RGD
involved in response to nicotine IEP
IEP: 通过表达模式推断
19879865 RGD
involved in response to oxidative stress IDA
IDA: 通过直接分析推断
15642321 RGD
involved in response to retinoic acid IEP
IEP: 通过表达模式推断
19099751 RGD
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
16846501 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
19874802 RGD
involved in tissue remodeling IDA
IDA: 通过直接分析推断
16740171 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
23911909 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mmp2 蛋白结构

PG_binding_1

PG_binding_1: pfam01471 (69 - 96)

Peptidase_M10

Peptidase_M10: pfam00413 (117 - 445)

FN2

FN2: smart00059 (225 - 273)

FN2

FN2: smart00059 (283 - 331)

FN2

FN2: smart00059 (341 - 389)

HX

HX: cd00094 (467 - 661)

  • 0
  • 200
  • 400
  • 600
  • 662 a.a.
蛋白主名 其他名称

72 kDa type IV collagenase

72 kDa gelatinase

MMP-2

gelatinase A

matrix metalloproteinase-2

重组 Mmp2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700573 MMP-2 Protein, Rat (P. pastoris, His) P33436 (Y110-C662) ≥95%

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0689A Indinavir sulfate 99.97% 是
HY-B0493 Niflumic acid Inhibitor 99.88% 否
HY-B0689 Indinavir 99.96% 是
HY-B0689B Indinavir sulfate ethanolate / 否
Clinical Phase
生物活性分子 (8)
目录号 产品名 作用方式
纯度 Phase
HY-12169 Marimastat Inhibitor 99.81% Phase 3
HY-12170 Prinomastat 99.27% Phase 3
HY-12170A Prinomastat hydrochloride 98.18% Phase 3
HY-15768 Ilomastat Inhibitor 98.39% Phase 2
HY-10398 CTS-1027 Inhibitor 99.19% Phase 2
HY-106992 S 3304 Inhibitor 99.11% Phase 2
HY-19485 XL-784 Inhibitor 98.13% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (89)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0431 Astragaloside IV Inhibitor 99.93% 否
HY-122022 JR-AB2-011 Inhibitor 99.16% 否
HY-13564 Batimastat Inhibitor 98.92% 否
HY-12354 SB-3CT Inhibitor 99.59% 否
HY-122214 AC-73 Inducer 99.89% 否
HY-110397 KP-457 Inhibitor 99.18% 否
HY-N0069 Solamargine 99.97% 否
HY-103444 ARP-100 Inhibitor ≥99.0% 否
HY-W068119A N-(2-Aminoethyl)maleimide hydrochloride 99.97% 否
HY-N0532 Morroniside Inhibitor 99.88% 否
HY-107394 UK 356618 Inhibitor 98.91% 否
HY-N0084 Betulinaldehyde Inhibitor 98.72% 否
HY-107428 PD-166793 Inhibitor 99.45% 否
HY-P3513 β-Neo-Endorphin Activator 99.32% 否
HY-131498 MOCAc-PLGL(Dpa)AR 99.86% 否
HY-112546 MMP-2 Inhibitor I Inhibitor 99.23% 否
HY-120213 YH-306 98.34% 否
HY-124373 ND-336 Inhibitor 95.4% 否
HY-P0273A Histatin 5 TFA Inhibitor 99.98% 否
HY-107639 UK-370106 Inhibitor ≥99.0% 否
HY-101535 ARP101 Inhibitor 99.39% 否
HY-116399 MMP-2/MMP-9-IN-1 Inhibitor 99.25% 否
HY-146754 MMP2-IN-1 99.18% 否
HY-148571 TP0597850 Inhibitor 99.09% 否
HY-117970 MMPI-1154 Inhibitor 99.87% 否
HY-12168 Tanomastat Inhibitor 99.7% 否
HY-122506 Salviolone Inhibitor 99.61% 否
HY-147746 MMP2-IN-3 Inhibitor 99.64% 否
HY-W001925 7-Methoxy-1-tetralone 99.93% 否
HY-114911 Feprazone Inhibitor 99.88% 否
HY-147031 JAMM protein inhibitor 2 Inhibitor 98.20% 否
HY-147745 MMP2-IN-2 Inhibitor 98.80% 否
HY-P2213A GPLGIAGQ TFA Inducer 98.40% 否
HY-110116 SD-2590 hydrochloride Inhibitor 99.1% 否
HY-110397G KP-457 (GMP) Inhibitor / 否
HY-114785 BPHA Inhibitor / 否
HY-131417 cis-ACCP Inhibitor ≥97.0% 否
HY-14240 PG 116800 Inhibitor 99.81% 否
HY-N5136 25(R,S)-Ruscogenin Inhibitor 99.83% 否
HY-P1789A CTTHWGFTLC, CYCLIC TFA Inhibitor 98.91% 否
HY-RS08537 MMP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W011085 CP-471474 Inhibitor 99.2% 否
HY-111172 Inotilone Inhibitor / 否
HY-113621B Ageladine A dihydrochloride Inhibitor / 否
HY-119185 AZD-6605 / 否
HY-120349 LL-Z1640-4 Inhibitor / 否
HY-12168B (Rac)-Tanomastat Inhibitor / 否
HY-124373A (R)-ND-336 Inhibitor / 否
HY-130076 MMP-2 Inhibitor II Inhibitor / 否
HY-136699 Excisanin A / 否
HY-143407 FAK-IN-3 Inhibitor / 否
HY-147867 MMP-2/9-IN-1 Inhibitor / 否
HY-147936 TP0556351 Inhibitor / 否
HY-149378 MMP13-IN-5 Inhibitor / 否
HY-152030 Tubulin/MMP-IN-2 / 否
HY-154698 Homouridine / 否
HY-155201 YJ182 Inhibitor / 否
HY-155721 22-(4′-py)-JA Inhibitor / 否
HY-156247 IVMT-Rx-3 Inhibitor / 否
HY-157382 AChE-IN-51 Inhibitor / 否
HY-161707 MMP2-IN-4 Inhibitor / 否
HY-162038 RXP03 Inhibitor / 否
HY-162344 Ir-CA Inducer / 否
HY-164525 SD-7300 Inhibitor / 否
HY-168560 MMP Inhibitor 4 Inhibitor / 否
HY-168605 DH-18 / 否
HY-170604 MMP-2 Inhibitor-4 Inhibitor / 否
HY-77813S Benzyl isothiocyanate-d7 / 否
HY-N10176 D-Isofloridoside Inhibitor / 否
HY-N7385 Nudol / 否
HY-P1789 CTTHWGFTLC, CYCLIC Inhibitor / 否
HY-P2213 GPLGIAGQ Inducer / 否
HY-P3477 Mca-PLA-Nva-Dap(Dnp)-AR-NH2 / 否
HY-P3513A β-Neo-Endorphin acetate Activator / 否
HY-P4574 VPLSLYSG / 否
HY-P5380 TNO211 / 否
HY-RS08538 Mmp2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08539 Mmp2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W277900 2-Methoxy-2,4-diphenylfuran-3-one / 否
HY-119110 LY52 Inhibitor / 否
HY-123130 ABT-770 Inhibitor / 否
HY-124341 ND-378 Inhibitor / 否
HY-13564A Batimastat sodium salt Inhibitor / 否
HY-18694 CGS 27023A Inhibitor / 否
HY-35513 3-Aminobenzene-1,2-diol Inhibitor / 否
HY-N13208 Stevia Powder / 否
HY-114396 BR351 Inhibitor / 否
HY-P0273 Histatin 5 Inhibitor / 否
HY-43586 BR351 precursor Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mmp2 NCBI NCBI:4313
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z