2. Gene
  3. CCNH - cyclin H Gene

CCNH - cyclin H Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白 H

种属: Homo sapiens

同用名: CAK; p34; p37; CycH

基因 ID: 902 | 基因类型: protein coding

关于 CCNH

Cytogenetic location: 5q14.3 Genomic coordinates (GRCh38): 5:87,311,471-87,412,930 (from NCBI)

This gene has 13 transcripts (splice variants), 216 orthologues and 6 paralogues. Ubiquitous expression in placenta (RPKM 15.0), testis (RPKM 11.2) and 25 other tissues.

功能概要

由该基因编码的蛋白质属于高度保守的细胞周期蛋白家族，其成员的特点是在整个细胞周期中蛋白质丰度具有显着的周期性。细胞周期蛋白作为 CDK 激酶的调节剂发挥作用。不同的细胞周期蛋白表现出不同的表达和降解模式，这有助于每个有丝分裂事件的时间协调。该细胞周期蛋白与 CDK7 激酶和无名指蛋白 MAT1 形成复合物。激酶复合物能够磷酸化 CDK2 和 CDC2 激酶，因此起到 CDK 激活激酶 (CAK) 的作用。该细胞周期蛋白及其激酶伙伴是 TFIIH 以及 RNA 聚合酶 II 蛋白复合物的成分。它们参与两种不同的转录调节过程，表明基础转录控制与细胞周期机制之间存在重要联系。在 4 号染色体上发现了该基因的假基因。交替剪接导致多个转录变体。[RefSeq 提供，2010 年 11 月]

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010]

CCNH 基因产物(5)

mRNA Protein Name
NM_001199189.2 NP_001186118.1 cyclin-H isoform 2
NM_001239.4 NP_001230.1 cyclin-H isoform 1
NM_001363539.2 NP_001350468.1 cyclin-H isoform 3
NM_001364075.2 NP_001351004.1 cyclin-H isoform 4
NM_001364076.2 NP_001351005.1 cyclin-H isoform 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to RNA polymerase II general transcription initiation factor activity IDA
IDA: 通过直接分析推断
7533895 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8521818 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein stabilization IMP
IMP: 通过突变表型推断
23393140 GOA
involved in regulation of G1/S transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
23622515 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9852112 GOA
involved in transcription initiation at RNA polymerase II promoter IDA
IDA: 通过直接分析推断
7533895 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CAK-ERCC2 complex IDA
IDA: 通过直接分析推断
8692841 GOA
part of cyclin-dependent protein kinase holoenzyme complex IDA
IDA: 通过直接分析推断
23622515 GOA
part of transcription factor TFIIH core complex IDA
IDA: 通过直接分析推断
8692841 GOA
part of transcription factor TFIIH holo complex IDA
IDA: 通过直接分析推断
9852112 GOA
part of transcription factor TFIIK complex IDA
IDA: 通过直接分析推断
8692841 GOA
part of transcription factor TFIIK complex IMP
IMP: 通过突变表型推断
23393140 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCNH 蛋白结构

Cyclin_N

Cyclin_N: Cyclin, N-terminal domain (74 - 158)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
蛋白主名 其他名称

cyclin-H

CAK complex subunit

CCNH 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CCNH P51946 MTMR7 Homo sapiens Q9Y216
Validated Y2H
32296183
种属内
CCNH P51946 TRIML2 Homo sapiens Q8N7C3
Validated Y2H
32296183
种属内
CCNH P51946 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
种属内
CCNH P51946 TCF12 Homo sapiens Q99081-3
Validated Y2H
32296183
种属内
CCNH P51946 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
种属内
CCNH P51946 RHOH Homo sapiens Q15669
Validated Y2H
32296183
种属内
CCNH P51946 RHOH Homo sapiens Q15669
Y2H Array
32296183
种属内
CCNH P51946 RHOH Homo sapiens Q15669
Y2H Prey Pooling
32296183
种属内
CCNH P51946 CDK3 Homo sapiens Q00526
Validated Y2H
32296183
种属内
CCNH P51946 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
种属内
CCNH P51946 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
种属内
CCNH P51946 KLC3 Homo sapiens Q6P597
Y2H Prey Pooling
25416956
种属内
CCNH P51946 SSX2IP Homo sapiens Q9Y2D8
Y2H Array
25416956
种属内
CCNH P51946 SSX2IP Homo sapiens Q9Y2D8
Validated Y2H
25416956
种属内
CCNH P51946 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
32296183
种属内
CCNH P51946 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
32296183
种属内
CCNH P51946 BLZF1 Homo sapiens Q9H2G9
Y2H Array
32296183
种属内
CCNH P51946 CCDC170 Homo sapiens Q8IYT3
Validated Y2H
25416956
种属内
CCNH P51946 CCDC170 Homo sapiens Q8IYT3
Y2H Array
25416956
种属内
CCNH P51946 CDK6 Homo sapiens Q00534
Validated Y2H
32296183
种属内
CCNH P51946 SNAPIN Homo sapiens O95295
Y2H Prey Pooling
32296183
种属内
CCNH P51946 SNAPIN Homo sapiens O95295
Y2H Array
32296183
种属内
CCNH P51946 MCRS1 Homo sapiens Q96EZ8
Y2H Array
32296183
种属内
CCNH P51946 MCRS1 Homo sapiens Q96EZ8
Y2H Prey Pooling
32296183
种属内
CCNH P51946 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
种属内
CCNH P51946 CCT4 Homo sapiens P50991
Y2H Prey Pooling
32296183
种属内
CCNH P51946 CCT4 Homo sapiens P50991
Y2H Array
32296183
种属内
CCNH P51946 PSMA1 Homo sapiens P25786
Validated Y2H
25416956
种属内
CCNH P51946 PSMA1 Homo sapiens P25786
Y2H Array
25416956
种属内
CCNH P51946 PSMA1 Homo sapiens P25786
Y2H Pooling
16189514
种属内
CCNH P51946 RARA Homo sapiens P10276
Pull Down
16769902
种属内
CCNH P51946 RARA Homo sapiens P10276
Anti Tag CoIP
16769902
种属内
CCNH P51946 SFN Homo sapiens P31947
Y2H Prey Pooling
25416956
种属内
CCNH P51946 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
种属内
CCNH P51946 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
种属内
CCNH P51946 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
种属内
CCNH P51946 GOLGA2 Homo sapiens Q08379
Y2H
21988832
种属内
CCNH P51946 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
种属内
CCNH P51946 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
种属内
CCNH P51946 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
种属内
CCNH P51946 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
种属内
CCNH P51946 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
种属内
CCNH P51946 DUSP12 Homo sapiens Q9UNI6
Y2H Array
32296183
种属内
CCNH P51946 DUSP12 Homo sapiens Q9UNI6
Validated Y2H
25416956
种属内
CCNH P51946 DUSP12 Homo sapiens Q9UNI6
Validated Y2H
32296183
种属内
CCNH P51946 DUSP12 Homo sapiens Q9UNI6
Y2H Prey Pooling
25416956
种属内
CCNH P51946 DUSP12 Homo sapiens Q9UNI6
Y2H Prey Pooling
32296183
种属内
CCNH P51946 GRIPAP1 Homo sapiens Q4V328
Validated Y2H
32296183
种属内
CCNH P51946 GRIPAP1 Homo sapiens Q4V328
Y2H Array
32296183
种属内
CCNH P51946 GRIPAP1 Homo sapiens Q4V328
Y2H Prey Pooling
32296183
种属内
CCNH P51946 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
种属内
CCNH P51946 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
25416956
种属内
CCNH P51946 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
种属内
CCNH P51946 SORBS3 Homo sapiens O60504
Y2H Array
32296183
种属内
CCNH P51946 ZNRD2 Homo sapiens O60232
Y2H Pooling
16189514
种属内
CCNH P51946 ZNRD2 Homo sapiens O60232
Y2H Prey Pooling
25416956
种属内
CCNH P51946 CTBP2 Homo sapiens P56545
Anti Tag CoIP
21988832
种属内
CCNH P51946 CTBP2 Homo sapiens P56545
Y2H
21988832
种属内
CCNH P51946 CTBP2 Homo sapiens P56545
Y2H Array
21988832
种属内
CCNH P51946 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
种属内
CCNH P51946 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
种属内
CCNH P51946 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
种属内
CCNH P51946 PPFIA1 Homo sapiens Q13136
Validated Y2H
25416956
种属内
CCNH P51946 PPFIA1 Homo sapiens Q13136
Y2H Array
25416956
种属内
CCNH P51946 PPFIA1 Homo sapiens Q13136
Y2H Array
29892012
种属内
CCNH P51946 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
种属内
CCNH P51946 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
种属内
CCNH P51946 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CCNH 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70041 Cyclin-H/CCNH Protein, Human (His) P51946 (M1-L323) ≥95%
HY-P75361 CDK7-CCNH-MNAT1 Protein, Human (sf9, His) P50613 (A2-F346)&P51946 (Y2-L323)&P51948 (D2-S309) ≥95%

CCNH 抗体

目录号 产品名 应用 反应物种
HY-P80636 Cyclin H Antibody (YA788) WB Human, Mouse
HY-P80637 Cyclin H Antibody WB Human

关联疾病

疾病名称 别名
Basal Cell Carcinoma, Multiple

Multiple Basal Cell Carcinoma
Angioosteohypertrophic Syndrome

Klippel-Trenaunay-Weber Syndrome

Haemangiectatic Hypertrophy
Capillary Malformation-Arteriovenous Malformation 1

Parkes Weber Syndrome

Capillary Malformation-Arteriovenous Malformation

Capillary Malformation-Arteriovenous Malformation Syndrome

CMAVM1

Cmavm

Cm-Avm Syndrome

Pkws

Cm-Avm

Parkes-Weber Syndrome

Capillary Malformation-Arteriovenous Malformation, Type 1
Basal Cell Carcinoma 1

Basal Cell Carcinoma, Susceptibility To, 1

Basal Cell Carcinoma

BCC1

BCC

Multiple Basal Cell Carcinoma

Non-Syndromic Basal Cell Carcinoma

Carcinoma, Basal Cell, Susceptibility To, Type 1

Experimental Organism Basal Cell Carcinoma

Basal Cell Carcinoma, Multiple
Telangiectasia, Hereditary Hemorrhagic, Type 1

Orw Disease

HHT1

Hht

Telangiectasia, Hereditary Hemorrhagic, Of Rendu, Osler, And Weber

Osler-Rendu-Weber Disease

Telangiectasia, Hereditary Hemorrhagic, 1

Hereditary Hemorrhagic Telangiectasia Of Rendu, Osler, And Weber

Orw1

Osler-Rendu-Weber Syndrome

Osler-Rendu-Weber Syndrome 1

Telangiectasia Hemorrhagic, Hereditary, Type 1

Hereditary Hemorrhagic Telangiectasia
Hemangioma, Capillary Infantile

HCI

Capillary Infantile Hemangioma

Hemangioma, Hereditary Capillary

Hemangioma, Capillary Infantile, Susceptibility To

Hemangioma, Capillary Infantile, Somatic

Hemangioma Hereditary Capillary
Hereditary Hemorrhagic Telangiectasia

Rendu-Osler-Weber Disease

Hht

Osler-Weber-Rendu Disease

Telangiectasia, Hereditary Hemorrhagic

Osler Hemorrhagic Telangiectasia Syndrome

Orw Disease

Osler Weber Rendu Syndrome

Osler-Rendu-Weber Disease

Osler-Weber-Rendu Syndrome

Rendu-Osler Disease

Telangiectasia Hereditary Hemorrhagic

Telangiectasia Hemorrhagic, Hereditary

Hht - [Hereditary Haemorrhagic Telangiectasia]

Osler Haemorrhagic Telangiectasia Syndrome
Klippel-Trenaunay-Weber Syndrome

Klippel-Trenaunay Syndrome

KTS

Ktw Syndrome

Angioosteohypertrophy Syndrome

Angio-Osteohypertrophy Syndrome

Klippel Trenaunay Syndrome

Klippel-Trénaunay-Weber Syndrome

Haemangiectatic Hypertrophy

Weber-Klippel-Trenaunay

Congenital Dysplastic Angiopathy

Klippel-Trenaunay Disease

Weber Klippel Trenaunay
Trichothiodystrophy

Ttd

Amish Brittle Hair Syndrome

Bids Syndrome

Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome

Ibids

Pibids

Trichothiodystrophy Syndromes
Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs
Xeroderma Pigmentosum, Complementation Group B

Xeroderma Pigmentosum Group B

Xeroderma Pigmentosum, Group B

XPB

Xpbc

Xp Group B

Xp, Group B

Xeroderma Pigmentosum Complementation Group B

XP-B

Xeroderma Pigmentosum Group B With Cockayne Syndrome

Xeroderma Pigmentosum Ii

Xp2

Xp-B/Cs
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Xeroderma Pigmentosum, Complementation Group D

Xeroderma Pigmentosum, Group D

Xpdc

Xeroderma Pigmentosum Iv

XPD

Xeroderma Pigmentosum Group D

Xeroderma Pigmentosum Viii

Xp Group D

Xp Group H

Xp4

Xp8

Xph

Xp, Group D

Xp4 Xeroderma Pigmentosum Viii, Formerly

Xp8, Formerly

Xp, Group H, Formerly

Xph, Formerly

Xeroderma Pigmentosum Complementation Group D

XP-D

Xp-D/Cs
Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum
Xeroderma Pigmentosum, Complementation Group G

Xeroderma Pigmentosum, Group G

Xeroderma Pigmentosum Vii

Xp7

XPG

Xeroderma Pigmentosum Group G

Xp Group G

Xp, Group G

Xpgc

Xeroderma Pigmentosum, Group G/Cockayne Syndrome

Xeroderma Pigmentosum, Type 7

Xeroderma Pigmentosum Complementation Group G

XP-G

Xp-G/Cs

Xeroderma Pigmentosum Group G/Cockayne Syndrome
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome

Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

Syndactyly With Renal And Anogenital Malformations

STAR

Syndactyly, Telecanthus, Anogenital And Renal Malformations

Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02132 CCNH Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CCNH VGNC VGNC:60561
Mus musculus CCNH MGD MGI:1913921
Canis familiaris CCNH VGNC VGNC:38902
Macaca mulatta CCNH VGNC VGNC:70732
Rattus norvegicus CCNH RGD RGD:69419
Bos taurus CCNH VGNC VGNC:97249
Others CCNH NCBI
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