Mosapride  (Synonyms: 莫沙必利; TAK-370; AS-4370)

Mosapride citrate is an orally active gastroenterokinetic compound. Mosapride citrate is a 5HT4agonist. Mosapride citrate is a CYP inducer. Mosapride citrate has a concentration-dependent inhibitory effect on Kv4.3, and its IC₅₀ value is 15.2 μM. Mosapride citrate can be used in the study of gastrointestinal diseases^{[1][2][3][4][5][6][7]}.

Mosapride citrate (1-100 nM) 显著增加了豚鼠结肠近端和远端收缩的平均幅度，缩短了结肠近端和远端转运时间^[3]。
Mosapride citrate (869 ng/mL, 48 h) 在人肝细胞 (HMC424, 478 和 493) 中增加Cytochrome P450 (CYP1A2、2B6和3A4) 的诱导能力^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mosapride citrate (0.3-3 mg/kg或30 mg/kg 口服) 促进大鼠胃排空，呈剂量依赖性。剂量为30 mg/kg时显著抑制大鼠胃排空^[5]。
Mosapride citrate (0.25, 0.5, 0.75 mg/kg 口服) 在大鼠中可通过激活5-HT4受体来减轻非甾体抗炎药诱导的溃疡^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

421.89

C₂₁H₂₅ClFN₃O₃

112885-41-3

莫沙必利

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tack J, et al. Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders. Aliment Pharmacol Ther. 2012 Apr;35(7):745-67.  [Content Brief]

  [2]. Curran MP, et al. Mosapride in gastrointestinal disorders. Drugs. 2008;68(7):981-91.  [Content Brief]

  [3]. Kim HS, et al. The effect of mosapride citrate on proximal and distal colonic motor function in the guinea-pig in vitro. Neurogastroenterol Motil. 2008 Feb;20(2):169-76.  [Content Brief]

  [4]. Kim YH, et al. Measurement of Human Cytochrome P450 Enzyme Induction Based on Mesalazine and Mosapride Citrate Treatments Using a Luminescent Assay. Biomol Ther (Seoul). 2015 Sep;23(5):486-92.  [Content Brief]

  [5]. Uchida M, et al. Dual role of mosapride citrate hydrate on the gastric emptying evaluated by the breath test in conscious rats. J Pharmacol Sci. 2013;121(4):282-7.  [Content Brief]

  [6]. Fujisawa M, et al. The 5-HT4 receptor agonist mosapride attenuates NSAID-induced gastric mucosal damage. J Gastroenterol. 2010 Feb;45(2):179-86.  [Content Brief]

  [7]. Sung KW, et al. Effect of mosapride on Kv4.3 potassium channels expressed in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 2013 Oct;386(10):905-16.  [Content Brief]