2. GPCR/G Protein Neuronal Signaling PI3K/Akt/mTOR
  3. Dopamine Receptor Akt
  4. Quinagolide hydrochloride

Quinagolide hydrochloride  (Synonyms: 盐酸喹高利特; CV205-502 hydrochloride)

目录号: HY-13736A
产品使用指南

摩尔计算器

Quinagolide hydrochloride (CV205-502 hydrochloride) 是选择性的、具有口服活性的多巴胺 D2 受体 激动剂。Quinagolide hydrochloride 是催乳素抑制剂。Quinagolide hydrochloride 下调 AKT 的水平及其磷酸化。Quinagolide hydrochloride 具有抗肿瘤活性，可用于癌症的研究。

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Quinagolide hydrochloride Chemical Structure

Quinagolide hydrochloride Chemical Structure

CAS No. : 94424-50-7

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1 mg ￥1250
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10 mg ￥4100
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Customer Review

Other Forms of Quinagolide hydrochloride:

Quinagolide hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Dopamine Receptor 亚型特异性产品:

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

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Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Quinagolide hydrochloride (CV205-502 hydrochloride) is a selective and orally active dopamine D2 receptor agonist. Quinagolide hydrochloride is an inhibitor of prolactin. Quinagolide hydrochloride down-regulates AKT levels and its phosphorylation. Quinagolide hydrochloride shows antitumor effects, it can be used for the research of cancer[1][2].

体外研究
(In Vitro)

Quinagolide hydrochloride (100 nM; 48 h) reduces non-ergot dopamine receptor 2 (DRD2) mRNA expression in ectopic lines[2].
Quinagolide hydrochloride (100 nM; 48 h) inhibits the invasive properties of endometrial mesenchymal stromal cells (E-MSCs)[2].
Quinagolide hydrochloride (100 nM; 24 h) significantly reduces the endothelial differentiation of E-MSCs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Quinagolide hydrochloride 相关抗体:

Western Blot Analysis[2]

Cell Line: Eutopic and ectopic E-MSCs
Concentration: 100 nM
Incubation Time: 24 h
Result: Reduced total AKT levels in ectopic E-MSCs and significantly decreased AKT phosphorylation in both eutopic and ectopic cell lines.
体内研究
(In Vivo)

Quinagolide hydrochloride (0.03-0.6 mg/kg; s.c. once daily for 2 month) effectively inhibits tumor growth in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Wistar-Furth rats bearing SMtTW tumors[1]
Dosage: 0.03-0.6 mg/kg
Administration: Subcutaneous injection; 0.03-0.6 mg/kg once daily for 2 month
Result: Induced normalization of plasma PRL levels in all animals, reduced the tumor size compared with the control group at a dose of 0.3 mg/kg. Showed maximal inhibitory effects on PRL secretion and tumor growth at a dose of 0.3 mg/kg.
Clinical Trial
分子量

432.02

Formula

C20H34ClN3O3S
CAS 号
性状

固体

颜色

White to off-white

中文名称

盐酸喹高利特
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 3.85 mg/mL (8.91 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3147 mL 11.5735 mL 23.1471 mL
5 mM 0.4629 mL 2.3147 mL 4.6294 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Quinagolide hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3147 mL 11.5735 mL 23.1471 mL 57.8677 mL
5 mM 0.4629 mL 2.3147 mL 4.6294 mL 11.5735 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinagolide94424-50-7CV205-502盐酸喹高利特Dopamine ReceptorAktPKBProtein kinase BdopaminephosphorylationcancerDRD2E-MSCendothelial differentiationSMtTWratInhibitorinhibitorinhibit

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目录号：
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