alpha-Mangostin (Synonyms: α-倒捻子素; α-Mangostin)

目录号: HY-N0328 纯度: 99.64%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

alpha-Mangostin (α-Mangostin) 是具有广泛生物活性的膳食呫吨酮，如抗氧化剂，抗过敏，抗病毒，抗菌，抗炎和抗癌作用。它是IDH1突变体 (IDH1-R132H) 的抑制剂，K_i值为 2.85 μM。

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alpha-Mangostin Chemical Structure

CAS No. : 6147-11-1

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥550	In-stock
5 mg	￥312	In-stock
10 mg	￥500	In-stock
25 mg	￥1100	In-stock
50 mg	￥1800	In-stock
100 mg	￥2800	In-stock
200 mg		询价
500 mg		询价

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Customer Review

Other Forms of alpha-Mangostin:

MCE 顾客使用本产品发表的 4 篇科研文献

: alpha-Mangostin purchased from MCE. Usage Cited in: J Cell Mol Med. 2020 Jan;24(1):760-771. [Abstract]; MA (alpha-Mangostin) impedes proliferation and induces cell cycle arrest in gallbladder cancer cells. GBC-SD cells are treated with MA, and proliferation was assessed by the EdU assay.

: alpha-Mangostin purchased from MCE. Usage Cited in: J Cell Mol Med. 2020 Jan;24(1):760-771. [Abstract]; MA (alpha-Mangostin) impedes proliferation and induces cell cycle arrest in gallbladder cancer cells. NOZ cells are treated with MA, and proliferation was assessed by the EdU assay.

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生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a K_i of 2.85 μM.

IC₅₀ & Target

IC50: 2.85 μM (IDH1-R132H)^[1]

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A-375	IC₅₀	2.7 μM Compound: SST0673	Antiproliferative activity against human A375 cells assessed as reduction in cell viability incubated for 72 hrs by trypan blue or crystal violet staining based assay Antiproliferative activity against human A375 cells assessed as reduction in cell viability incubated for 72 hrs by trypan blue or crystal violet staining based assay	[PMID: 32435392]
A-431	IC₅₀	7.2 μM Compound: NSC27593	Antiproliferative activity against human A-431 cells overexpressing EGFR assessed as cell growth inhibition by MTT assay Antiproliferative activity against human A-431 cells overexpressing EGFR assessed as cell growth inhibition by MTT assay	[PMID: 34995690]
ASPC1	IC₅₀	4.02 μM Compound: 1	Cytotoxicity against human AsPC1 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against human AsPC1 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]
B16-F10	IC₅₀	3.23 μM Compound: 1	Cytotoxicity against mouse B16F10 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against mouse B16F10 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]
Daoy	IC₅₀	1.9 μM Compound: SST0673	Antiproliferative activity against human DaOY cells assessed as reduction in cell viability incubated for 72 hrs by trypan blue or crystal violet staining based assay Antiproliferative activity against human DaOY cells assessed as reduction in cell viability incubated for 72 hrs by trypan blue or crystal violet staining based assay	[PMID: 32435392]
DLD-1	IC₅₀	7.5 μM Compound: alpha-mangostin	Cytotoxicity against human DLD1 cells after 24 hrs by Trypan blue exclusion test Cytotoxicity against human DLD1 cells after 24 hrs by Trypan blue exclusion test	[PMID: 17553685]
HeLa	IC₅₀	> 10 μM Compound: 3	Inhibition of NFkappa p65 in nuclear extract of human HeLa cells assessed as blockade of NFkappa p65 binding to biotinylated-consesus sequence by ELISA Inhibition of NFkappa p65 in nuclear extract of human HeLa cells assessed as blockade of NFkappa p65 binding to biotinylated-consesus sequence by ELISA	[PMID: 21428375]
HeLa	IC₅₀	11.95 μM Compound: NSC27593	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition by MTT assay Antiproliferative activity against human HeLa cells assessed as cell growth inhibition by MTT assay	[PMID: 34995690]
HeLa S3	IC₅₀	> 10 μM Compound: 12	Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
HepG2	IC₅₀	> 10 μM Compound: 12	Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
HepG2	IC₅₀	8.55 μM Compound: alpha-Mangostin	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31343173]
HL-60	IC₅₀	6.8 μM Compound: 1	Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by Trypan blue exclusion test Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by Trypan blue exclusion test	[PMID: 12932141]
HT-29	IC₅₀	> 10 μM Compound: 12	Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
HT-29	IC₅₀	0.2 μM Compound: 3	Effect on mitochondrial membrane potential in human HT-29 cells after 2 hrs using JC-1 staining by fluorescence assay Effect on mitochondrial membrane potential in human HT-29 cells after 2 hrs using JC-1 staining by fluorescence assay	[PMID: 21428375]
HT-29	ED₅₀	4.1 μM Compound: 3	Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay	[PMID: 21428375]
KB	IC₅₀	> 10 μM Compound: 12	Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
KB	IC₅₀	14.14 μM Compound: alpha-mangostin	Cytotoxicity against human KB cells after 48 hrs by MTT assay Cytotoxicity against human KB cells after 48 hrs by MTT assay	[PMID: 30684866]
MCF7	IC₅₀	> 10 μM Compound: 12	Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
MCF7	IC₅₀	3.5 μg/mL Compound: 6	Cytotoxicity against human MCF7 cells assessed as [3H]hypoxanthin incorporation after 24 to 72 hrs Cytotoxicity against human MCF7 cells assessed as [3H]hypoxanthin incorporation after 24 to 72 hrs	[PMID: 19296616]
MCF7	IC₅₀	9.95 μM Compound: alpha-Mangostin	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31343173]
MDA-MB-231	IC₅₀	12.75 μM Compound: 105	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33619958]
MDA-MB-231	IC₅₀	3.04 μM Compound: 1	Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]
MRC5	CC₅₀	7.5 μM Compound: alpha-mangostin	Cytotoxicity against human MRC5 SV2 cells measured after 72 hrs by resazurin based fluorescence assay Cytotoxicity against human MRC5 SV2 cells measured after 72 hrs by resazurin based fluorescence assay	[PMID: 27517813]
NCI-H460	IC₅₀	3.23 μM Compound: 1	Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]
SW-620	IC₅₀	2.97 μM Compound: 1	Cytotoxicity against human SW620 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against human SW620 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]

体外研究
(In Vitro)

alpha-Mangostin (α-Mangostin) 对 IDH1-R132H 具有选择性抑制作用，但对 IDH1 没有抑制作用。alpha-Mangostin (α-Mangostin) 竞争性抑制 alpha-mangostin (α-KG) 与 IDH1-R132H 的结合。结构-关系研究表明，α-Mangostin (α-Mangostin) 具有最强的核心抑制剂结构。α-Mangostin (α-Mangostin) 选择性地促进 IDH1 (+/R132H) MCF10A 细胞中 5-甲基胞嘧啶 (5mC) 和组蛋白 H3 三甲基化赖氨酸残基的去甲基化^[1]。
在用 alpha-mangostin 处理的细胞中，细胞增殖以剂量依赖性方式显著降低。Alpha-mangostin 还增加 Bax (促凋亡)、裂解的 caspase-3、裂解的 caspase-9 和裂解的聚 (ADP-核糖) 聚合酶 (PARP) 的水平^[2]。
alpha-Mangostin (α-Mangostin) 显著抑制光诱导的光感受器退化和 200 μM H₂O₂ 诱导的 RPE 细胞凋亡。α-Mangostin (α-Mangostin) 抑制 200 μM H₂O₂ 诱导的活性氧 (ROS) 生成和光诱导的丙二醛 (MDA) 生成)^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

与 TAA_DMSO 处理相比，α-Mangostin (α-Mangostin) 通过降低 p53 表达来降低肝纤维化的风险。与单独使用 DMSO 相比，alpha-Mangostin 处理后肝酶 AST 和 ALT 的血清水平降低^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

410.46

Formula

C₂₄H₂₆O₆

CAS 号

6147-11-1

性状

固体

颜色

Light yellow to yellow

中文名称

α-倒捻子素

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

DMSO 中的溶解度 : 110 mg/mL (267.99 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H₂O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4363 mL	12.1815 mL	24.3629 mL
5 mM	0.4873 mL	2.4363 mL	4.8726 mL
10 mM	0.2436 mL	1.2181 mL	2.4363 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.75 mg/mL (6.70 mM); 澄清溶液

此方案可获得 ≥ 2.75 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 27.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.64%

选择批次：

Data Sheet (644 KB) SDS (479 KB)

COA (193 KB) LCMS (255 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Kim HJ, et al. Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5625-31. [Content Brief]

[2]. Lee HN, et al. Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.) in YD-15 tongue mucoepidermoid carcinoma cells. Int J Mol Med. 2016 Apr;37(4):939-48. [Content Brief]

Cell Assay ^[1]	IDH1^+/+ and IDH1 MCF10A cells are grown in DMEM/F-12 media, supplemented with 5% horse serum, 20 ng/mL EGF, 0.5 μg/mL hydrocortisone, 10 μg/mL insulin. IDH1^+/+ and IDH1 MCF10A cells are seeded in 6 well plates. After an exposure to 5 μM alpha-mangostin. cells are collected after indicated times and the viable cell number is calculated, using hemacytometer counting^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[4]	Rats: Male Wistar rats are divided into 3 groups and treated with intraperitoneal injections of TAA (200 mg/kg). One subgroup is left untreated whereas the other two are treated either with 100 mg/kg alpha-mangostin or vehicle alone (80% DMSO, 20% water), which are administered intraperitoneally 3 times per weekfor a total of4 weeks. The incidence offibrotic nodules on the liver and the serum levels of the liver enzymes aspartate transaminase (AST) and alanine transaminase (ALT) are measured^[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Kim HJ, et al. Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5625-31. [Content Brief] [2]. Lee HN, et al. Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.) in YD-15 tongue mucoepidermoid carcinoma cells. Int J Mol Med. 2016 Apr;37(4):939-48. [Content Brief]

alpha-Mangostin 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4363 mL	12.1815 mL	24.3629 mL	60.9073 mL
	5 mM	0.4873 mL	2.4363 mL	4.8726 mL	12.1815 mL
	10 mM	0.2436 mL	1.2181 mL	2.4363 mL	6.0907 mL
	15 mM	0.1624 mL	0.8121 mL	1.6242 mL	4.0605 mL
	20 mM	0.1218 mL	0.6091 mL	1.2181 mL	3.0454 mL
	25 mM	0.0975 mL	0.4873 mL	0.9745 mL	2.4363 mL
	30 mM	0.0812 mL	0.4060 mL	0.8121 mL	2.0302 mL
	40 mM	0.0609 mL	0.3045 mL	0.6091 mL	1.5227 mL
	50 mM	0.0487 mL	0.2436 mL	0.4873 mL	1.2181 mL
	60 mM	0.0406 mL	0.2030 mL	0.4060 mL	1.0151 mL
	80 mM	0.0305 mL	0.1523 mL	0.3045 mL	0.7613 mL
	100 mM	0.0244 mL	0.1218 mL	0.2436 mL	0.6091 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

alpha-Mangostin6147-11-1α-Mangostinα-倒捻子素Reactive Oxygen SpeciesApoptosisBacterialFungalVirus ProteaseInhibitorinhibitorinhibit

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alpha-Mangostin (Synonyms: α-倒捻子素; α-Mangostin)

Customer Review

Other Forms of alpha-Mangostin:

MCE 顾客使用本产品发表的 4 篇科研文献

alpha-Mangostin 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

生物活性

实验参考方法

纯度 & 产品资料

参考文献

摩尔计算器

稀释计算器

alpha-Mangostin 相关分类

完整储备液配制表

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alpha-Mangostin (Synonyms: α-倒捻子素; α-Mangostin)

Customer Review

Other Forms of alpha-Mangostin:

alpha-Mangostin 相关抗体

MCE 顾客使用本产品发表的 4 篇科研文献

alpha-Mangostin 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

生物活性

实验参考方法

纯度 & 产品资料

参考文献

alpha-Mangostin 相关抗体:

摩尔计算器

稀释计算器

alpha-Mangostin 相关分类

完整储备液配制表

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您最近查看的产品:

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