2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage Immunology/Inflammation
  3. Phosphodiesterase (PDE) CDK Interleukin Related
  4. Aristolochic acid D

Aristolochic acid D  (Synonyms: Aristolochic acid-IVa)

目录号: HY-N1465 纯度: 99.74%
COA 产品使用指南 技术支持

Aristolochic acid D (Aristolochic acid-IVa) 是一种具有口服活性的 PDE2 (IC50: 4.673 μM) 和 CDK2 (IC50: 25 μM) 抑制剂，可从 Aristolochia indica L. 中分离得到。Aristolochic acid D 具有抗炎活性，无致癌性和肾毒性。 Aristolochic acid D 可用于炎症和肿瘤相关疾病的研究。

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Aristolochic acid D

Aristolochic acid D Chemical Structure

CAS No. : 17413-38-6

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2508
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1 mg ￥927
In-stock
5 mg ￥2280
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Customer Review

Other Forms of Aristolochic acid D:

Aristolochic acid D 相关抗体

Top Publications Citing Use of Products

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aristolochic acid D (Aristolochic acid-IVa) is an orally active PDE2 (IC50: 4.673 μM) and CDK2 (IC50: 25 μM) inhibitor that can be isolated from Aristolochia indica L. Aristolochic acid D exhibits anti-inflammatory activity and is non-carcinogenic and non-nephrotoxic. Aristolochic acid D can be used in the research of inflammation and tumor-related diseases[1][2][3][4][5][6].

IC50 & Target[2][5][6]

IL-6

 

PDE2

4.673 μM (IC50)

CDK2

25 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Neutrophil IC50
5.78 μg/mL
Compound: 5
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation after 5 mins
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation after 5 mins
[PMID: 21353775]
Neutrophil IC50
8.49 μg/mL
Compound: 5
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release after 5 mins
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release after 5 mins
[PMID: 21353775]
体外研究
(In Vitro)

Aristolochic acid D (0-300 μM; 48 h) 对 LLC-PK1 细胞无显著细胞毒性，也无法诱导 caspase-3/7 激活[1]。
Aristolochic acid D (50-100 μM; 8 h) 在 LPS (HY-D1056A1) 处理的 RAW 264.7 细胞中显著降低 TNF-α 和 IL-6 产生[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aristolochic acid D 相关抗体:

ELISA Assay[2]

Cell Line: RAW 264.7 cells treated LPS (HY-D1056A1)
Concentration: 50 and 100 μM
Incubation Time: Pretreated with 2 h, then co-incubation for 6 h
Result: Reduced the production of TNF-α and IL-6.
体内研究
(In Vivo)

Aristolochic acid D (400-600 μg/耳; 局部涂抹; 单剂量) 在耳肿胀小鼠模型中具有改善作用[2]。
Aristolochic acid D (100 mg/kg; 灌胃; 单剂量) 在 LPS (HY-D1056A1) 处理的 TNF-IRES-Luc 小鼠中，显著降低 TNF-α 荧光素酶活性，对全身炎症表现出快速抑制作用但持续时间较短[2]。
Aristolochic acid D (3 -10 mg/kg; 灌胃; 每周五次; 从第 12 天至第 42 天) 在慢性关节炎小鼠模型中具有抗炎活性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice aged 6-8 weeks old treated phorbol 12-myristate 13-acetate (HY-18739) to induce ear edema[2]
Dosage: 400 and 600 μg/ear
Administration: Topical application; single dose
Result: Exhibitd topical anti-inflammatory activity.
Significantly reduced ear weight, inflammatory cell infiltration and edema.
Animal Model: Male BALB/cAnSmoc-Zap70em(W163C)Smoc (SKG) mice aged 6-8 weeks old treated Mannan (HY-W145667) (SKG model that spontaneously develops chronic arthritis closely resembling human Rheumatoid Arthritis)[3]
Dosage: 3 and 10 mg/kg
Administration: Oral gavage; five times a week; from day 12 to day 42
Result: Alleviated mannan-accelerated arthritis symptoms, reducing inflammatory infiltration, improving bone microstructure, decreasing levels of inflammatory factors, and regulating macrophage polarization as well as restoring the Th17/Treg balance.
分子量

357.27

Formula

C17H11NO8
CAS 号
性状

固体

颜色

Yellow to orange

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (69.98 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7990 mL 13.9950 mL 27.9900 mL
5 mM 0.5598 mL 2.7990 mL 5.5980 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.74%

COA (293 KB) LCMS (94 KB)

产品使用指南 (1538 KB)
参考文献

Aristolochic acid D 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7990 mL 13.9950 mL 27.9900 mL 69.9751 mL
5 mM 0.5598 mL 2.7990 mL 5.5980 mL 13.9950 mL
10 mM 0.2799 mL 1.3995 mL 2.7990 mL 6.9975 mL
15 mM 0.1866 mL 0.9330 mL 1.8660 mL 4.6650 mL
20 mM 0.1400 mL 0.6998 mL 1.3995 mL 3.4988 mL
25 mM 0.1120 mL 0.5598 mL 1.1196 mL 2.7990 mL
30 mM 0.0933 mL 0.4665 mL 0.9330 mL 2.3325 mL
40 mM 0.0700 mL 0.3499 mL 0.6998 mL 1.7494 mL
50 mM 0.0560 mL 0.2799 mL 0.5598 mL 1.3995 mL
60 mM 0.0467 mL 0.2333 mL 0.4665 mL 1.1663 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aristolochic acid D17413-38-6Aristolochic acid-IVaPhosphodiesterase (PDE)CDKInterleukin RelatedCyclin dependent kinaseILLLC-PK1 cellsRAW 264.7 cellsear edema modelarthritis modelInhibitorinhibitorinhibit

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