2. NF-κB Immunology/Inflammation Metabolic Enzyme/Protease Anti-infection Apoptosis
  3. Keap1-Nrf2 NF-κB Reactive Oxygen Species SARS-CoV Apoptosis
  4. Danshensu sodium

Danshensu sodium  (Synonyms: 丹参素钠盐; Dan shen suan A sodium; Salvianic acid A sodium)

目录号: HY-N1913A 纯度: 98.00%
COA 产品使用指南

摩尔计算器

Danshensu (Dan shen suan A) sodium 是一种具有口服活性的酚类化合物，可诱导 Nrf2/HO-1 激活并抑制 NF-κB 通路。Danshensu sodium 可减少活性氧 (ROS) 的产生，上调抗氧化防御机制并抑制内在的细胞凋亡途径。Danshensu sodium 对 SARS-CoV-2 显示出有效的抗病毒活性，EC50 为 0.97 μM。Danshensu sodium 具有抗氧化、抗凋亡、抗肺部炎症等作用，具有用于 COVID-19、心脑血管等疾病研究的潜力。

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Danshensu sodium Chemical Structure

Danshensu sodium Chemical Structure

CAS No. : 81075-52-7

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规格 价格 是否有货 数量
1 mg ￥783
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5 mg ￥1959
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Other Forms of Danshensu sodium:

Danshensu sodium 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research[1][2][3].

体外研究
(In Vitro)

Danshensu (Dan shen suan A) sodium 有效抑制 SARS-CoV-2 S 蛋白假型病毒 (SARS-CoV-2 S) 进入 ACE2 过表达的 HEK-293T 细胞 (IC50=0.31μM) 和 Vero-E6 细胞 (IC50=4.97μM)[1].
Danshensu (0-100 μM；24小时) sodium 在较高浓度 (50 和 100 μM) 会导致 FaDu 和 Ca9-22 细胞的迁移和侵袭显着减少[2].
Danshensu (0-100 μM；24小时) sodium 剂量依赖性降低 FaDu 细胞中 ERK 磷酸化和 p38 磷酸化[2].
Danshensu (0-100 μM；24、48、72 小时) sodium 对人口腔癌细胞没有任何细胞毒性作用[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Danshensu sodium 相关抗体:

Cell Migration Assay [2]

Cell Line: FaDu and Ca9-22 cells
Concentration: 25, 50, and 100 μM
Incubation Time: 24 h
Result: At higher concentrations (50 and 100 μM) caused significant reduction in migration and invasion of both FaDu and Ca9-22 cells.

Western Blot Analysis[2]

Cell Line: FaDu and Ca9-22 cells
Concentration: 25, 50, and 100 μM
Incubation Time: 24 h
Result: Phosphorylation of ERK reduced dose-dependently after 24 h in FaDu cell.
Caused significant reduction in p38 phosphorylation.
体内研究
(In Vivo)

Danshensu (Dan shen suan A; 25、50、100mg/kg；每天口服给药，连续 7 天或静脉注射一次) sodium 在 SARS-CoV-2 S 感染前给药后，可剂量依赖性地减轻 SARS-CoV-2 S 感染小鼠的病理改变[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult BALB/c mice (male, 6-8 weeks, 20±2 g)[1]
Dosage: 25, 50, 100 mg/kg
Administration: Oral administration (daily for 7 continuous days) or i.v. (once)
Result: Could prevent SARS-CoV-2 S protein-induced acute lung inflammation.
Ameliorated inflammatory cytokines in serum and lung tissue.
分子量

220.15

Formula

C9H9NaO5
CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

丹参素钠盐
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

纯度 & 产品资料

纯度: 98.00%

COA (285 KB)

产品使用指南 (1538 KB)
参考文献

Danshensu sodium 相关分类

  • 摩尔计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Danshensu81075-52-7Dan shen suan ASalvianic acid A丹参素钠盐Keap1-Nrf2NF-κBReactive Oxygen SpeciesSARS-CoVApoptosisNuclear factor-κBNuclear factor-kappaBSARS coronavirusOrallyHO-1antioxidant defense mechanismanti-oxidationanti-apoptosislung inflammatoryCOVID-19cardiovascularcerebrovascularInhibitorinhibitorinhibit

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