2. Anti-infection Cytoskeleton Cell Cycle/DNA Damage JAK/STAT Signaling Stem Cell/Wnt Apoptosis Autophagy
  3. Parasite Microtubule/Tubulin STAT MDM-2/p53 Apoptosis Autophagy
  4. Flubendazole

Flubendazole  (Synonyms: 氟苯咪唑)

目录号: HY-B0294 纯度: 99.33%
COA 产品使用指南

摩尔计算器

Flubendazole 是一种基于改变微管结构、抑制微管蛋白聚合和破坏微管功能的驱虫药。Flubendodium 通过阻断 STAT3 信号轴和自噬激活来诱导人结直肠癌 (CRC) 细胞凋亡。Flubendazole 诱导 P53 表达并减少 Cyclin B1 和 p-cdc2 表达。Flubendazole 是一种抗肿瘤剂。Flubendazole 可用于驱除蠕虫和肠道寄生虫。

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Flubendazole Chemical Structure

Flubendazole Chemical Structure

CAS No. : 31430-15-6

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥660
In-stock
100 mg ￥600
In-stock
500 mg ￥900
In-stock
1 g   询价  
5 g   询价  

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Customer Review

Other Forms of Flubendazole:

Flubendazole 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

查看所有亚型
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Flubendazole is an anthelmintic drug based on altering microtubule structure, inhibition of tubulin polymerization and disruption of microtubule function. Flubendazole induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. Flubendazole induces P53 expression and reduced Cyclin B1 and p-cdc2 expression. Flubendazole is an antitumor agent. Flubendazole can be used for worm and intestinal parasites[1][2].

IC50 & Target[1][2]

STAT3

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BT-549 IC50
0.125 μM
Compound: 28; 65
Anticancer activity against human BT-549 cells assessed as cell growth inhibition by MTS assay
Anticancer activity against human BT-549 cells assessed as cell growth inhibition by MTS assay
[PMID: 33650861]
Hs-578T IC50
0.125 μM
Compound: 28; 65
Anticancer activity against human Hs-578T cells assessed as cell growth inhibition by MTS assay
Anticancer activity against human Hs-578T cells assessed as cell growth inhibition by MTS assay
[PMID: 33650861]
MDA-MB-231 IC50
0.25 μM
Compound: 28; 65
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition by MTS assay
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition by MTS assay
[PMID: 33650861]
MDA-MB-231 IC50
0.5 μM
Compound: 28; 65
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
[PMID: 33650861]
PC-3M EC50
1.43 μM
Compound: Flubendazole
Cytotoxicity against human PC3M cells assessed as reduction in cell viability after 48 hrs by cyquant reagent based fluorescence spectrometric assay
Cytotoxicity against human PC3M cells assessed as reduction in cell viability after 48 hrs by cyquant reagent based fluorescence spectrometric assay
[PMID: 29288939]
体外研究
(In Vitro)

Flubendazole (0-400 μM；48小时) 抑制人结直肠癌 (CRC) 细胞增殖[1]。
Flubendazole (0.3-1.2 μM；48 小时) 可诱导 CRC 细胞凋亡[1]。
Flubendazole (0.3-1.2 μM；24小时) 通过灭活 mTOR 和 P62 并上调 CRC 细胞中的 LC3-I/II 来诱导自噬启动[1]。
Flubendazole (0.3-1.2 μM；24小时) 以剂量和时间依赖性方式强烈降低 P-STAT3 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Flubendazole 相关抗体:

Cell Viability Assay[1]

Cell Line: CRC cells (HCT116, RKO and SW480)
Concentration: 0-400 μM
Incubation Time: 48 h
Result: Effectively reduces the viability of CRC cells (HCT116, RKO and SW480) in a concentration-dependent manner, with an IC50 of 2-5 μM.

Apoptosis Analysis[1]

Cell Line: CRC cells (HCT116, RKO and SW480)
Concentration: 0.3, 0.6, 1.2 μM
Incubation Time: 48 h
Result: Increased the proportion of apoptotic cells in a dose-dependent manner.
Dose-dependently effectively increases caspase-3 activity.

Cell Autophagy Assay[1]

Cell Line: CRC cells (HCT116, RKO and SW480)
Concentration: 0.3, 0.6, 1.2 μM
Incubation Time: 24 h
Result: Induced autophagy initiation by inactivating mTOR and P62, and upregulating LC3-I/II, which are classical marker of autophagy.

Western Blot Analysis[1]

Cell Line: CRC cells (HCT116, RKO and SW480)
Concentration: 0.3, 0.6, 1.2 μM
Incubation Time: 24 h
Result: Strongly reduced the expression of phosphorylated STAT3 (P-STAT3) in a dose and time-dependent manner.
No obvious change in total STAT3 expression.
Decreased expression of MCL1 and survivin in a dose-dependent manner.
体内研究
(In Vivo)

Flubendazole (10、30mg/kg；腹腔注射；每隔一天；14 天) 可抑制结直肠癌 (CRC) 肿瘤异种移植物的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c athymic nude mice (6-8 weeks) with HCT116 cells[1]
Dosage: 10  or 30 mg/kg
Administration: Intraperitoneal injection; every other day; 14 days
Result: Markedly reduced the tumor volume.
Significantly reduces the protein level of P-STAT3, promotes autophagy and induces apoptosis in vivo.
分子量

313.28

Formula

C16H12FN3O3
CAS 号
性状

固体

颜色

White to off-white

中文名称

氟苯咪唑
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 4.17 mg/mL (13.31 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1920 mL 15.9602 mL 31.9203 mL
5 mM 0.6384 mL 3.1920 mL 6.3841 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： 50% PEG300    50% Saline

    Solubility: 5 mg/mL (15.96 mM); 悬浊液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.33%

COA (283 KB) HNMR (270 KB) LCMS (96 KB)

产品使用指南 (1538 KB)
参考文献

Flubendazole 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1920 mL 15.9602 mL 31.9203 mL 79.8008 mL
5 mM 0.6384 mL 3.1920 mL 6.3841 mL 15.9602 mL
10 mM 0.3192 mL 1.5960 mL 3.1920 mL 7.9801 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flubendazole31430-15-6氟苯咪唑ParasiteMicrotubule/TubulinSTATMDM-2/p53ApoptosisAutophagyAnthelminticmicrotubuletubulin polymerizationCRCCyclin B1p-cdc2wormintestinal parasitescolorectal cancerInhibitorinhibitorinhibit

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