AGR2 - anterior gradient 2, protein disulphide isomerase family member Gene

中文名称：前梯度 2，蛋白质二硫化物异构酶家族成员

种属: Homo sapiens

同用名: AG2; AG-2; HPC8; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116

基因 ID: 10551 | 基因类型: protein coding

关于 AGR2

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:16,791,811-16,804,999 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 2 paralogues. Biased expression in stomach (RPKM 530.9), colon (RPKM 321.4) and 6 other tissues.

功能概要

该基因编码内质网 (ER) 蛋白二硫化物异构酶 (PDI) 家族的成员，该蛋白催化蛋白质折叠和硫醇-二硫化物交换反应。编码的蛋白质具有 N 端 ER 信号序列、催化活性硫氧还蛋白结构域和 C 端 ER 保留序列。这种蛋白质在细胞迁移、细胞转化和转移中发挥作用，是一种 p53 抑制剂。作为定位于 ER 的分子伴侣，它在富含半胱氨酸的跨膜受体和富含半胱氨酸的肠糖蛋白粘蛋白的折叠、运输和组装中发挥作用。该基因与炎症性肠病和癌症进展有关。[RefSeq 提供，2017 年 3 月]

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein Mucin. This gene has been implicated in inflammatory bowel disease and Cancer progression. [provided by RefSeq, Mar 2017]

AGR2 基因产物(1)

mRNA	Protein	Name
NM_006408.4	NP_006399.1	anterior gradient protein 2 homolog precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables dystroglycan binding	IDA IDA: 通过直接分析推断	12592373	GOA
enables epidermal growth factor receptor binding	IPI IPI: 通过物理相互作用推断	25666625	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	23220234	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12592373	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of IRE1-mediated unfolded protein response	IDA IDA: 通过直接分析推断	23220234	GOA
involved in positive regulation of PERK-mediated unfolded protein response	IDA IDA: 通过直接分析推断	23220234	GOA
involved in positive regulation of cell-substrate adhesion	IMP IMP: 通过突变表型推断	23274113	GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	25666625	GOA
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	22184114	GOA
involved in positive regulation of protein localization to plasma membrane	IMP IMP: 通过突变表型推断	25666625	GOA
NOT involved in response to endoplasmic reticulum stress	IMP IMP: 通过突变表型推断	25666625	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum	IMP IMP: 通过突变表型推断	22184114	GOA
located in extracellular region	IDA IDA: 通过直接分析推断	15834940	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	22184114	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AGR2 蛋白结构

Thioredoxin_7

0
100
175 a.a.

蛋白主名

其他名称

anterior gradient protein 2 homolog

anterior gradient homolog 2

AGR2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	AGR2	O95994	CDKN2AIPNL	Homo sapiens	Q96HQ2	Validated Y2H	32296183
种属内	AGR2	O95994	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
种属内	AGR2	O95994	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Prey Pooling	25416956
种属内	AGR2	O95994	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
种属内	AGR2	O95994	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
种属内	AGR2	O95994	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
种属内	AGR2	O95994	CRYGA	Homo sapiens	Q24JT5	Validated Y2H	32296183
种属内	AGR2	O95994	ZDHHC24	Homo sapiens	Q6UX98	Validated Y2H	32296183
种属内	AGR2	O95994	LGALS14	Homo sapiens	Q8TCE9	Validated Y2H	32296183
种属内	AGR2	O95994	NSD1	Homo sapiens	Q96L73-2	Validated Y2H	32296183
种属内	AGR2	O95994	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
种属内	AGR2	O95994	ZNF410	Homo sapiens	Q86VK4-3	Validated Y2H	32296183
种属内	AGR2	O95994	NRF1	Homo sapiens	Q16656-4	Validated Y2H	32296183
种属内	AGR2	O95994	TFAP2D	Homo sapiens	Q7Z6R9	Validated Y2H	32296183
种属内	AGR2	O95994	POM121	Homo sapiens	Q96HA1-2	Validated Y2H	32296183
种属内	AGR2	O95994	PSORS1C2	Homo sapiens	Q9UIG4	Validated Y2H	32296183
种属内	AGR2	O95994	VEZF1	Homo sapiens	Q14119	Validated Y2H	32296183
种属内	AGR2	O95994	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
种属内	AGR2	O95994	ASPH	Homo sapiens	Q12797-6	Validated Y2H	32296183
种属内	AGR2	O95994	ASPH	Homo sapiens	Q12797-6	Y2H Prey Pooling	32296183
种属内	AGR2	O95994	CYB5R2	Homo sapiens	Q6BCY4-2	Validated Y2H	32296183
种属内	AGR2	O95994	RBFOX1	Homo sapiens	Q9NWB1-5	Validated Y2H	32296183
种属内	AGR2	O95994	RBFOX1	Homo sapiens	Q9NWB1-5	Y2H Prey Pooling	32296183
种属内	AGR2	O95994	RBFOX1	Homo sapiens	Q9NWB1-5	Y2H Array	32296183
种属内	AGR2	O95994	WUGSC:H_DJ0726N20.gs.b	Homo sapiens	Q9Y6T4	Validated Y2H	32296183
种属内	AGR2	O95994	PHC3	Homo sapiens	Q8NDX5-7	Validated Y2H	32296183
种属内	AGR2	O95994	TYK2	Homo sapiens	P29597	Validated Y2H	32296183
种属内	AGR2	O95994	ANKRD11	Homo sapiens	X5D778	Validated Y2H	32296183
种属内	AGR2	O95994	CAMLG	Homo sapiens	P49069	Validated Y2H	32296183
种属内	AGR2	O95994	FAM110A	Homo sapiens	Q9BQ89	Validated Y2H	32296183
种属内	AGR2	O95994	APOBEC3B	Homo sapiens	Q9UH17-2	Validated Y2H	32296183
种属内	AGR2	O95994	PTTG2	Homo sapiens	Q9NZH5-2	Validated Y2H	32296183
种属内	AGR2	O95994	THOC1	Homo sapiens	Q96FV9	Validated Y2H	32296183
种属内	AGR2	O95994	RTL4	Homo sapiens	Q6ZR62	Y2H Prey Pooling	32296183
种属内	AGR2	O95994	RTL4	Homo sapiens	Q6ZR62	Validated Y2H	32296183
种属内	AGR2	O95994	RTL4	Homo sapiens	Q6ZR62	Y2H Array	32296183
种属内	AGR2	O95994	MUC2	Homo sapiens	Q02817	Anti Tag CoIP	34237462
种属内	AGR2	O95994	DCAF11	Homo sapiens	Q8TEB1	Validated Y2H	32296183
种属内	AGR2	O95994	PRPF18	Homo sapiens	Q99633	Validated Y2H	32296183
种属内	AGR2	O95994	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32296183
种属内	AGR2	O95994	CD68	Homo sapiens	P34810	Validated Y2H	32296183
种属内	AGR2	O95994	CD34	Homo sapiens	P28906	Validated Y2H	32296183
种属内	AGR2	O95994	MYL6	Homo sapiens	P60660	Validated Y2H	32296183
种属内	AGR2	O95994	LSM1	Homo sapiens	O15116	Y2H Prey Pooling	32296183
种属内	AGR2	O95994	LSM1	Homo sapiens	O15116	Y2H Array	32296183
种属内	AGR2	O95994	SGTA	Homo sapiens	O43765	Y2H Array	32296183
种属内	AGR2	O95994	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
种属内	AGR2	O95994	IMPDH2	Homo sapiens	P12268	Validated Y2H	32296183
种属内	AGR2	O95994	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
种属内	AGR2	O95994	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
种属内	AGR2	O95994	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
种属内	AGR2	O95994	PSMA1	Homo sapiens	P25786	Validated Y2H	32296183
种属内	AGR2	O95994	POLR2L	Homo sapiens	P62875	Validated Y2H	32296183
种属内	AGR2	O95994	PSMB1	Homo sapiens	P20618	Validated Y2H	32296183
种属内	AGR2	O95994	FAM117B	Homo sapiens	Q6P1L5	Validated Y2H	32296183
种属内	AGR2	O95994	FABP2	Homo sapiens	P12104	Y2H Array	25416956
种属内	AGR2	O95994	HSD3B7	Homo sapiens	Q9H2F3	Validated Y2H	32296183
种属内	AGR2	O95994	RBP5	Homo sapiens	P82980	Validated Y2H	32296183
种属内	AGR2	O95994	GRB2	Homo sapiens	P62993	Validated Y2H	32296183
种属内	AGR2	O95994	IL36RN	Homo sapiens	Q9UBH0	Validated Y2H	32296183
种属内	AGR2	O95994	GABPB1	Homo sapiens	Q06547	Validated Y2H	32296183
种属内	AGR2	O95994	GTF2H5	Homo sapiens	Q6ZYL4	Validated Y2H	32296183
种属内	AGR2	O95994	KLHL38	Homo sapiens	Q2WGJ6	Validated Y2H	32296183
种属内	AGR2	O95994	GUCA1A	Homo sapiens	P43080	Validated Y2H	32296183
种属内	AGR2	O95994	TCEA2	Homo sapiens	Q15560	Validated Y2H	32296183
种属内	AGR2	O95994	CREB1	Homo sapiens	P16220	Validated Y2H	32296183
种属内	AGR2	O95994	POM121	Homo sapiens	Q96HA1	Validated Y2H	25416956
种属内	AGR2	O95994	POM121	Homo sapiens	Q96HA1	Y2H Array	25416956
种属内	AGR2	O95994	POM121	Homo sapiens	Q96HA1	Y2H Prey Pooling	25416956
种属内	AGR2	O95994	GTPBP3	Homo sapiens	Q969Y2	Validated Y2H	32296183
种属内	AGR2	O95994	HMG20A	Homo sapiens	Q9NP66	Y2H Prey Pooling	32296183
种属内	AGR2	O95994	HMG20A	Homo sapiens	Q9NP66	Y2H Array	32296183
种属内	AGR2	O95994	HMG20A	Homo sapiens	Q9NP66	Validated Y2H	32296183
种属内	AGR2	O95994	CNNM3	Homo sapiens	Q8NE01	Validated Y2H	32296183
种属内	AGR2	O95994	NUP54	Homo sapiens	Q7Z3B4	Validated Y2H	32296183
种属内	AGR2	O95994	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
种属内	AGR2	O95994	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
种属内	AGR2	O95994	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
种属内	AGR2	O95994	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	25416956
种属内	AGR2	O95994	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
种属内	AGR2	O95994	BORCS8	Homo sapiens	Q96FH0	Validated Y2H	32296183
种属内	AGR2	O95994	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
种属内	AGR2	O95994	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
种属内	AGR2	O95994	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
种属内	AGR2	O95994	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	25416956
种属内	AGR2	O95994	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	32296183
种属内	AGR2	O95994	NUP62CL	Homo sapiens	Q9H1M0	Validated Y2H	32296183
种属内	AGR2	O95994	NUP62CL	Homo sapiens	Q9H1M0	Y2H Array	25416956
种属内	AGR2	O95994	NUP62CL	Homo sapiens	Q9H1M0	Y2H Prey Pooling	25416956
种属内	AGR2	O95994	NUP62CL	Homo sapiens	Q9H1M0	Validated Y2H	25416956
种属内	AGR2	O95994	TSTD2	Homo sapiens	Q5T7W7	Validated Y2H	32296183
种属内	AGR2	O95994	C3	Homo sapiens	P01024	Validated Y2H	32296183
种属内	AGR2	O95994	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
种属内	AGR2	O95994	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
种属内	AGR2	O95994	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
种属内	AGR2	O95994	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
种属内	AGR2	O95994	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
种属内	AGR2	O95994	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
种属内	AGR2	O95994	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
种属内	AGR2	O95994	HCK	Homo sapiens	P08631-2	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 AGR2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7465	AG-2 Protein, Human (HEK293, His, solution)	O95994 (R21-L175)	≥95%
HY-P7465A	AG-2 Protein, Human (HEK293, His)	O95994 (R21-L175)	≥95%

AGR2 抗体

目录号	产品名	应用	反应物种
HY-P82034	Anterior Gradient 2 Antibody (YA1779)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Rat

关联疾病

疾病名称

别名

Ileocolitis

Iieocolitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Non-Proliferative Fibrocystic Change Of The Breast

Non-Proliferative Fibrocystic Change

Breast Fibrocystic Change, Non-Proliferative Type

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma	Fhcc
Fibrolamellar Hepatocarcinoma	Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor	Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis	Fl-Hcc
Fibrolamellar Oncocytic Hepatoma	Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P5831	Biotin-H10	Inhibitor	98.04%	否
HY-RS00462	AGR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	AGR2	MGD	MGI:1344405
Bos taurus	AGR2	VGNC	VGNC:25740
Canis familiaris	AGR2	VGNC	VGNC:37715
Felis catus	AGR2	VGNC	VGNC:59690
Rattus norvegicus	AGR2	RGD	RGD:1304606
Macaca mulatta	AGR2	VGNC	VGNC:69748
Others	AGR2	NCBI

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