2. Gene
  3. Cd4 - CD4 antigen Gene

Cd4 - CD4 antigen Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: L3T4; Ly-4

基因 ID: 12504 | 基因类型: protein coding

关于 Cd4

功能概要

Predicted to enable several functions, including interleukin-16 binding activity; interleukin-16 receptor activity; and protein homodimerization activity. Involved in helper T cell enhancement of adaptive immune response. Acts upstream of or within several processes, including defense response to Gram-negative bacterium; positive regulation of calcium-mediated signaling; and positive regulation of peptidyl-tyrosine phosphorylation. Located in endoplasmic reticulum; external side of plasma membrane; and membrane raft. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 79. Orthologous to human CD4 (CD4 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd4 基因产物(1)

mRNA Protein Name
NM_013488.3 NP_038516.1 T-cell surface glycoprotein CD4 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
7486703 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of T cell activation IDA
IDA: 通过直接分析推断
12421911 MGI
acts upstream of calcium-mediated signaling IDA
IDA: 通过直接分析推断
9208839 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: 通过直接分析推断
9208839 MGI
involved in cell surface receptor signaling pathway IDA
IDA: 通过直接分析推断
2784195 MGI
acts upstream of or within cytokine production IGI
IGI: 通过遗传相互作用推断
7930593 MGI
acts upstream of or within cytokine production IMP
IMP: 通过突变表型推断
7930593 MGI
acts upstream of or within defense response to Gram-negative bacterium IMP
IMP: 通过突变表型推断
14688352 MGI
involved in helper T cell enhancement of adaptive immune response IMP
IMP: 通过突变表型推断
1832488 MGI
acts upstream of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
9208839 MGI
acts upstream of or within positive regulation of T cell activation IDA
IDA: 通过直接分析推断
12421911 MGI
acts upstream of or within positive regulation of calcium-mediated signaling IDA
IDA: 通过直接分析推断
9208839 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
9208839 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
8612131 MGI
located in endoplasmic reticulum lumen IDA
IDA: 通过直接分析推断
16223484 MGI
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
16223484 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
7477352 MGI
located in membrane raft IDA
IDA: 通过直接分析推断
15128768 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
3262426 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

T-cell surface glycoprotein CD4

T-cell differentiation antigen L3T4

T-cell surface antigen T4/Leu-3

重组 Cd4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72904 CD4 Protein, Mouse (HEK293, His) NP_038516.1 (K27-T394) ≥95%
HY-P77517 CD4 Protein, Mouse (Biotinylated, HEK293, His-Avi) NP_038516.1 (K27-T394) ≥95%

相关产品

Approval
生物活性分子 (5)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0689A Indinavir sulfate 99.97% 是
HY-15440A Fostemsavir Inhibitor 99.52% 否
HY-15440B Fostemsavir Tris Inhibitor 99.94% 否
HY-B0689 Indinavir / 否
HY-B0689B Indinavir sulfate ethanolate / 否
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99222 Teplizumab ≥99.0% 否
HY-P99028 Ibalizumab Inhibitor 99.52% 否
Clinical Phase
生物活性分子 (6)
目录号 产品名 作用方式
纯度 Phase
HY-105037A Forigerimod TFA Inhibitor 98.89% Phase 3
HY-148808 Zelasudil Inhibitor 99.86% Phase 2
HY-P0272 Peptide T Inhibitor 98.86% Phase 2
HY-14135 BMS 488043 Inhibitor / Phase 2
HY-P0272A Peptide T TFA Inhibitor / Phase 2
HY-15440 Temsavir Inhibitor 98.06% Phase 1
抗体抑制剂 (4)
目录号 产品名 作用方式
纯度 Phase
HY-P9998 Semzuvolimab Inhibitor 95.00% Phase 3
HY-P99908 Efineptakin alfa Activator 99.70% Phase 2
HY-P99607 Clenoliximab Inhibitor / Phase 2
HY-P99433 Alvircept sudotox Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (71)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-150741 ODN 2216 / 否
HY-110382 Cyclic-di-GMP disodium Activator 99.23% 否
HY-150741C ODN 2216 sodium Activator 97.88% 否
HY-107780B Cyclic-di-GMP diammonium Activator 99.07% 否
HY-15898 Y-320 99.74% 否
HY-P2560 LCMV GP (61-80) 99.80% 否
HY-134809 Cyclotriazadisulfonamide Inhibitor 98.54% 否
HY-124750 NecroX-7 Inhibitor 99.69% 否
HY-P1066 Apelin-17(human, bovine) 98.29% 否
HY-155978A RDN2150 TFA 99.62% 否
HY-119347 Cirsilineol Inhibitor ≥98.0% 否
HY-P1064 Apelin-36(human) 98.05% 否
HY-139780 JNJ-61803534 Inhibitor 99.88% 否
HY-Y0788 Indoline 99.89% 否
HY-14134 BMS-378806 Inhibitor 98.94% 否
HY-107780 Cyclic-di-GMP Activator 98.18% 否
HY-157793 SMU-L11 99.64% 否
HY-P1997 Ferrichrome Iron-free ≥98.0% 否
HY-12465 Z-Ile-Leu-aldehyde 97.28% 否
HY-P1065 Apelin-36(rat, mouse) 99.12% 否
HY-W181026 KLF10-IN-1 99.84% 否
HY-164426 HEI3090 Activator 99.04% 否
HY-100039 YYA-021 Inhibitor 98.96% 否
HY-105037 Forigerimod Inhibitor / 否
HY-138115 7ß,27-Dihydroxycholesterol Activator ≥99.0% 否
HY-148432 FGF22-IN-1 Inhibitor 98.07% 否
HY-155978 RDN2150 / 否
HY-P1064A Apelin-36(human) TFA 98.11% 否
HY-P1409A ADWX 1 TFA Inhibitor / 否
HY-16106S Talazoparib-13C,d4 99.30% 否
HY-76648 NBD-556 Inhibitor 99.57% 否
HY-W102449S 4-Acetyl-N-methylaniline-13C,d3 97.05% 否
HY-135432 Etrasimod arginine Modulator / 否
HY-106055 Murabutide Inhibitor / 否
HY-107780A Cyclic-di-GMP sodium Activator / 否
HY-111366 CD12681 Agonist / 否
HY-119202 (S)-BMS-378806 / 否
HY-121820 DMJ-I-228 Inhibitor / 否
HY-123312 CK-548 Inhibitor / 否
HY-123902 Ophiobolin C Inhibitor / 否
HY-126037 (±)-ML 209 Antagonist 99.87% 否
HY-128790S 4-Methoxyestrone-13C,d3 / 否
HY-137618B Rp-dGTPαS / 否
HY-137640A Sp-8-Br-cAMPS sodium Agonist / 否
HY-144746 PD-1/PD-L1-IN-26 Inhibitor / 否
HY-145491 Resolvin D5 / 否
HY-15091 Anisperimus / 否
HY-159123 KHK-6 Inhibitor / 否
HY-161255 3,4-DAA Inhibitor / 否
HY-169335 HIV-1 inhibitor-77 Inhibitor / 否
HY-B0094S3 Artemisinin-13C,d4 / 否
HY-P10308 [(Cys(Bzl)84,Glu(OBzl)85)]CD4 (81-92) / 否
HY-P1065A Apelin-36(rat, mouse) TFA / 否
HY-P1066A Apelin-17(human, bovine) TFA / 否
HY-P2561 Influenza Matrix Protein (61-72) / 否
HY-P3554 Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl Inhibitor / 否
HY-P4902 Retrocyclin-1 Inhibitor / 否
HY-P5930 HOXB7 8–25 / 否
HY-RS02245 CD4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W005355S8 Sodium 2-oxobutanoate-13C,d4 / 否
HY-W006057AS14 Sodium 3-methyl-2-oxobutanoate-13C,d4 / 否
HY-W780197 Methanol-13C,d4 / 否
HY-Y0781S5 Pyruvic acid-13C,d4 / 否
HY-117160S2 4-trans-Hydroxy glibenclamide-13C,d4 / 否
HY-123756 NBD-10007 Inhibitor / 否
HY-12926 ST7612AA1 / 否
HY-134809A Cyclotriazadisulfonamide hydrochloride / 否
HY-13644 Gusperimus / 否
HY-154771S Clopidogrelat-13C,d4 / 否
HY-B0202S4 Irbesartan-13C,d4 / 否
HY-110216 5J-4 Inhibitor 95% 否
抗体抑制剂 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99999 Anti-Mouse CD4 Antibody (YTS 191) Inhibitor ≥95.0% 否
HY-P99680 Keliximab Inhibitor 98.23% 否
HY-P990969 Amtabafusp alfa Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cd4 NCBI NCBI:920
Canis familiaris Cd4 NCBI NCBI:403931
Macaca fascicularis Cd4 NCBI NCBI:101864991
Leporidae Cd4 NCBI
Rattus norvegicus Cd4 NCBI NCBI:24932
Macaca mulatta Cd4 NCBI NCBI:713807
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