2. Gene
  3. Syk - spleen associated tyrosine kinase Gene

Syk - spleen associated tyrosine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：脾相关酪氨酸激酶

种属: Rattus norvegicus

同用名: p72syk

基因 ID: 25155 | 基因类型: protein coding

关于 Syk

Primary_assembly 17: 12,604,619-12,661,410 reverse strand.mRatBN7.2:CM026990.1

This gene has 2 transcripts (splice variants), 202 orthologues, 32 paralogues and is associated with 9 phenotypes. Biased expression in Spleen (RPKM 486.2), Thymus (RPKM 76.4) and 4 other tissues.

功能概要

该基因编码的蛋白可启动蛋白质域特异性结合活性；蛋白酪氨酸激酶活性；和泛素蛋白连接酶结合活性。参与肥大细胞脱颗粒和蛋白质自身磷酸化的正调节。预测位于早期吞噬体和细胞核。预测是B细胞受体复合物和T细胞受体复合物的一部分。预测为质膜细胞质侧的外在成分。用于研究抗基底膜肾小球肾炎。该基因的人类直系同源物与原发性免疫缺陷病有关。与人 SYK（脾相关酪氨酸激酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein domain specific binding activity; protein tyrosine kinase activity; and ubiquitin protein Ligase binding activity. Involved in positive regulation of mast cell degranulation and protein autophosphorylation. Predicted to be located in early phagosome and nucleus. Predicted to be part of B cell receptor complex and T cell receptor complex. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Used to study anti-basement membrane glomerulonephritis. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human Syk (spleen associated tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Syk 基因产物(1)

mRNA Protein Name
NM_012758.2 NP_036890.2 tyrosine-protein kinase SYK
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18579528 RGD
enables protein domain specific binding IDA
IDA: 通过直接分析推断
16861349 RGD
enables protein kinase activity IDA
IDA: 通过直接分析推断
16861349 RGD
enables protein tyrosine kinase activity EXP
EXP: 通过实验结果推断
10931839 RGD
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
8920860 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of mast cell degranulation IMP
IMP: 通过突变表型推断
16861349 RGD
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
16861349 RGD
involved in regulation of immune response IDA
IDA: 通过直接分析推断
12417718 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Syk 蛋白结构

SH2_N-SH2_Zap70_Syk_like

SH2_N-SH2_Zap70_Syk_like: cd09938 (11 - 114)

SH2_C-SH2_Syk_like

SH2_C-SH2_Syk_like: cd10401 (162 - 260)

PTKc_Syk

PTKc_Syk: cd05116 (369 - 624)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 629 a.a.
蛋白主名 其他名称

tyrosine-protein kinase SYK

spleen tyrosine kinase

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13038A Fostamatinib Inhibitor 99.50% 是
HY-13038 Fostamatinib Disodium Inhibitor 99.88% 是
HY-13038B Fostamatinib disodium hexahydrate Inhibitor 99.73% 是
Clinical Phase
生物活性分子 (16)
目录号 产品名 作用方式
纯度 Phase
HY-15968 Entospletinib Inhibitor 99.88% Phase 3
HY-15999 Cerdulatinib Inhibitor 99.06% Phase 3
HY-145598 Sovleplenib Inhibitor 99.94% Phase 3
HY-15999A Cerdulatinib hydrochloride Inhibitor 99.89% Phase 3
HY-15323 PRT062607 Hydrochloride Inhibitor 98.07% Phase 2
HY-109091 Lanraplenib Inhibitor 99.12% Phase 2
HY-103018 Gusacitinib Inhibitor 99.41% Phase 2
HY-100867A Mivavotinib monohydrochloride Inhibitor 99.91% Phase 2
HY-15322 PRT062607 Inhibitor 97.13% Phase 2
HY-109082 Cevidoplenib Inhibitor 99.58% Phase 2
HY-109091B Lanraplenib succinate Inhibitor 98.58% Phase 2
HY-100867 Mivavotinib Inhibitor / Phase 2
HY-109091A Lanraplenib monosuccinate Inhibitor / Phase 2
HY-103018A Gusacitinib hydrochloride Inhibitor / Phase 2
HY-13518 Piceatannol Inhibitor 98.90% Phase 1
HY-112809 GSK2646264 Inhibitor 98.39% Phase 1
Pre-clinical Phase
生物活性分子 (44)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12067 R406 Inhibitor 96.70% 否
HY-11108 R406 free base Inhibitor 99.80% 否
HY-14985 BAY 61-3606 dihydrochloride Inhibitor 99.91% 否
HY-12974 PRT-060318 Inhibitor 99.04% 否
HY-78263 MNS Inhibitor 99.55% 否
HY-112390A Syk Inhibitor II Inhibitor 98.15% 否
HY-16420 R112 Inhibitor 99.71% 否
HY-76474A BAY 61-3606 hydrochloride Inhibitor 98.98% 否
HY-16902 RO9021 Inhibitor 98.88% 否
HY-136198 SRX3207 Inhibitor 98.50% 否
HY-12736A GSK143 dihydrochloride Inhibitor 99.73% 否
HY-109082A Cevidoplenib dimesylate Inhibitor 98.96% 否
HY-138961 ER-27319 Inhibitor 98.66% 否
HY-138961 ER-27319 Inhibitor 98.66% 否
HY-138961 ER-27319 Inhibitor 98.66% 否
HY-138961 ER-27319 Inhibitor 98.66% 否
HY-131341 Syk-IN-4 Inhibitor ≥98.0% 否
HY-15324 PRT062607 acetate Inhibitor 99.83% 否
HY-15324 PRT062607 acetate Inhibitor 99.83% 否
HY-12657 Syk-IN-1 Inhibitor 99.18% 否
HY-108489 ER-27319 maleate Inhibitor ≥99.4% 否
HY-151634 Syk-IN-6 Inhibitor / 否
HY-10230S Midostaurin-d5 Inhibitor ≥98.0% 否
HY-112386 OXSI-2 Inhibitor / 否
HY-76474 BAY 61-3606 Inhibitor 98.21% 否
HY-130680 Syk-IN-3 Inhibitor / 否
HY-12736 GSK143 Inhibitor / 否
HY-155513 Syk-IN-8 Inhibitor / 否
HY-162427 NMS-0963 Inhibitor / 否
HY-120214 TAS05567 Inhibitor / 否
HY-149895 Syk-IN-7 Inhibitor / 否
HY-145029 SYK/JAK-IN-1 Inhibitor / 否
HY-P2504 Syk Kinase Peptide Substrate, Biotin labeled / 否
HY-112390C Syk Inhibitor II hydrochloride Inhibitor / 否
HY-112319 MK-8457 Inhibitor / 否
HY-112390 Syk Inhibitor II dihydrochloride Inhibitor / 否
HY-N3702 Dehydroabietinol Inhibitor / 否
HY-112390B Syk Inhibitor II dihydrochloride dihydrate Inhibitor / 否
HY-P2505 Syk Kinase Peptide Substrate / 否
HY-160930 TOP1288 Inhibitor / 否
HY-124146 BI1002494 Inhibitor / 否
HY-120533 Syk-IN-11 Inhibitor / 否
HY-N7314 Asebogenin Inhibitor / 否
HY-123625 R-348 choline Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Syk NCBI NCBI:6850
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