2. Gene
  3. Jak3 - Janus kinase 3 Gene

Jak3 - Janus kinase 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：两面神激酶 3

种属: Rattus norvegicus

同用名: RATJAK3

基因 ID: 25326 | 基因类型: protein coding

关于 Jak3

Primary_assembly 16: 18,386,405-18,398,536 forward strand.mRatBN7.2:CM026989.1

This gene has 1 transcript (splice variant), 103 orthologues, 32 paralogues and is associated with 39 phenotypes. Biased expression in Spleen (RPKM 69.2), Thymus (RPKM 61.) and 8 other tissues.

功能概要

预测该基因编码的蛋白编码的蛋白可启动蛋白磷酸酶结合活性和蛋白酪氨酸激酶活性。参与多个过程，包括激活 T 细胞增殖的正调节；细胞溶质钙离子浓度的正向调节；一氧化氮合酶生物合成过程的正调控。位于细胞质中。舌鳞状细胞癌的生物标志物。与 T 细胞急性淋巴细胞白血病有关的该基因的人类直系同源物；急性巨核细胞白血病；成人 T 细胞白血病；和幼年型粒单核细胞白血病。与人 JAK3（Janus 激酶 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable protein Phosphatase binding activity and protein tyrosine kinase activity. Involved in several processes, including positive regulation of activated T cell proliferation; positive regulation of cytosolic calcium ion concentration; and positive regulation of nitric-oxide synthase biosynthetic process. Located in cytoplasm. Biomarker of tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; acute megakaryocytic leukemia; adult T-cell leukemia; and juvenile myelomonocytic leukemia. Orthologous to human JAK3 (Janus kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Jak3 基因产物(1)

mRNA Protein Name
NM_012855.2 NP_036987.2 tyrosine-protein kinase JAK3

Jak3 蛋白结构

FERM_F1

FERM_F1: cl39717 (40 - 113)

FERM_F2

FERM_F2: cl39028 (125 - 244)

FERM_C_JAK3

FERM_C_JAK3: cd13334 (249 - 358)

SH2

SH2: cl15255 (358 - 454)

PKc_like

PKc_like: cl21453 (516 - 773)

PKc_like

PKc_like: cl21453 (812 - 1094)

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  • 1100 a.a.
蛋白主名 其他名称

tyrosine-protein kinase JAK3

JAK-3

Janus kinase 3, protein-tyrosine kinase

相关产品

Approval
生物活性分子 (20)
目录号 产品名 作用方式
纯度 是否罕见病
HY-50856 Ruxolitinib Inhibitor 99.99% 是
HY-40354 Tofacitinib Inhibitor 99.99% 是
HY-19569 Upadacitinib Inhibitor 99.98% 是
HY-15315 Baricitinib Inhibitor 99.97% 是
HY-50858 Ruxolitinib phosphate Inhibitor 99.97% 是
HY-100754 Ritlecitinib Inhibitor 99.80% 是
HY-16379 Pacritinib Inhibitor 99.93% 是
HY-40354A Tofacitinib citrate Inhibitor 99.98% 是
HY-18300 Filgotinib Inhibitor 99.68% 是
HY-19568 Peficitinib Inhibitor 99.43% 是
HY-15315A Baricitinib phosphate Inhibitor 99.97% 是
HY-109053 Delgocitinib Inhibitor 99.87% 否
HY-13577A Oclacitinib monomaleate Inhibitor 99.63% 否
HY-13577 Oclacitinib Inhibitor 99.59% 否
HY-18300A Filgotinib maleate Inhibitor 99.88% 否
HY-50859 Ruxolitinib sulfate Inhibitor / 否
HY-19569A Upadacitinib tartrate tetrahydrate Inhibitor / 否
HY-19568A Peficitinib hydrobromide Inhibitor / 否
HY-16379A Pacritinib hydrochloride Inhibitor / 否
HY-19568B Peficitinib hydrochloride Inhibitor / 否
Clinical Phase
生物活性分子 (18)
目录号 产品名 作用方式
纯度 Phase
HY-10961 Momelotinib Inhibitor 99.37% Phase 3
HY-50514 AT9283 Inhibitor 99.67% Phase 3
HY-12469 Decernotinib Inhibitor 99.91% Phase 3
HY-15999 Cerdulatinib Inhibitor 99.06% Phase 3
HY-10962 Momelotinib sulfate Inhibitor 98.06% Phase 3
HY-112724 Ivarmacitinib Inhibitor 99.82% Phase 3
HY-15999A Cerdulatinib hydrochloride Inhibitor 99.89% Phase 3
HY-10963 Momelotinib mesylate Inhibitor / Phase 3
HY-13034 Gandotinib Inhibitor 99.82% Phase 2
HY-15270 BMS-911543 Inhibitor 98.53% Phase 2
HY-19631A Ilginatinib Inhibitor 99.94% Phase 2
HY-112708 Brepocitinib Inhibitor 99.97% Phase 2
HY-112708A Brepocitinib P-Tosylate Inhibitor 99.86% Phase 2
HY-19631B Ilginatinib hydrochloride Inhibitor 98.92% Phase 2
HY-19631 Ilginatinib maleate Inhibitor 99.87% Phase 2
HY-10058 AT9283 lactic acid Inhibitor / Phase 2
HY-13775 XL019 Inhibitor ≥98.0% Phase 1
HY-101024 PF-06263276 Inhibitor 99.38% Phase 1
Pre-clinical Phase
生物活性分子 (69)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-14435 Pyridone 6 Inhibitor 98.13% 否
HY-10410 TG101209 Inhibitor 99.22% 否
HY-15343 CEP-33779 Inhibitor 99.77% 否
HY-15508 JANEX-1 Inhibitor 99.84% 否
HY-14722 NVP-BSK805 Inhibitor 99.89% 否
HY-10411 AZ960 Inhibitor 97.08% 否
HY-131140 BD750 Inhibitor 99.10% 否
HY-100895 SAR-20347 Inhibitor 97.12% 否
HY-145696 SJ10542 Inhibitor 99.92% 否
HY-13895 WHI-P154 Inhibitor 99.39% 否
HY-130247 Flonoltinib Inhibitor 99.79% 否
HY-151262 JAK-IN-23 Inhibitor 98.90% 否
HY-108264 TCS 21311 Inhibitor 99.18% 否
HY-12589 ZM39923 hydrochloride Inhibitor 98.19% 否
HY-19544 JAK3-IN-1 Inhibitor 99.31% 否
HY-101976 JAK3-IN-6 Inhibitor 99.90% 否
HY-14722A NVP-BSK805 dihydrochloride Inhibitor 99.36% 否
HY-150023 BI-1622 Inhibitor 98.97% 否
HY-11067 WHI-P97 Inhibitor 99.70% 否
HY-120469 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Inhibitor 99.80% 否
HY-131906 JAK2-IN-7 Inhibitor 99.15% 否
HY-102046 FM-381 Inhibitor 99.58% 否
HY-111750 JAK-IN-3 Inhibitor 98.92% 否
HY-139423 JAK1-IN-8 Inhibitor ≥95.0% 否
HY-130247A Flonoltinib TFA Inhibitor 99.77% 否
HY-100754B (2R,5S)-Ritlecitinib Inhibitor 99.77% 否
HY-13961 GLPG0634 analog Inhibitor 98.07% 否
HY-152080 TUL01101 Inhibitor 99.71% 否
HY-150720 TYK2-IN-12 Inhibitor 98.43% 否
HY-143444 JAK-IN-20 Inhibitor / 否
HY-153440 JAK-IN-25 Inhibitor 98.44% 否
HY-13450 ZM 449829 Inhibitor 99.73% 否
HY-119935 JAK3 covalent inhibitor-1 Inhibitor / 否
HY-10652 JAK-2/3-IN-1 Inhibitor / 否
HY-138222 JANEX-1 hydrochloride Inhibitor / 否
HY-155951 JAK3-IN-14 Inhibitor 99.32% 否
HY-161618 MJ04 Inhibitor / 否
HY-147975 JAK3-IN-12 Inhibitor / 否
HY-151285 JAK-2/3-IN-3 Inhibitor / 否
HY-151258 TK4g Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-131014 FM-479 / 否
HY-147741 DPPY Inhibitor / 否
HY-18949 JI6 Inhibitor / 否
HY-149296 JAK1-IN-12 Inhibitor / 否
HY-143885 JAK1/TYK2-IN-3 Inhibitor / 否
HY-100849 JAK 3i Inhibitor / 否
HY-161354 JAK3 covalent inhibitor-2 Inhibitor / 否
HY-123099 MS-1020 Inhibitor / 否
HY-146727 JAK3-IN-11 Inhibitor / 否
HY-147754 JAK3/BTK-IN-6 Inhibitor / 否
HY-168269 Tyk2-IN-20 Inhibitor / 否
HY-154994 JAK-IN-30 Inhibitor / 否
HY-161967 JAK2/FLT3-IN-3 Inhibitor / 否
HY-157121 JAK-IN-34 Inhibitor / 否
HY-151256 JAK-2/3-IN-2 Inhibitor / 否
HY-133747 JAK3-IN-9 Inhibitor / 否
HY-108342 PF-00956980 Inhibitor / 否
HY-147742 Thi-DPPY Inhibitor / 否
HY-151259 TK4b Inhibitor / 否
HY-162862 JAK-IN-38 Inducer / 否
HY-161912 5TTU Inhibitor / 否
HY-122101 NSC114792 Inhibitor / 否
HY-123625 R-348 choline Inhibitor / 否
HY-162862 JAK-IN-38 Inhibitor / 否
HY-130247B Flonoltinib monomaleate Inhibitor / 否
HY-123187 AS2553627 Inhibitor / 否
HY-12589A ZM39923 Inhibitor / 否
HY-U00390 JAK3-IN-7 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Jak3 NCBI NCBI:3718
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