1. Gene
  2. HNRNPH1 - heterogeneous nuclear ribonucleoprotein H1 Gene

HNRNPH1 - heterogeneous nuclear ribonucleoprotein H1 Gene

中文名称:异质核核糖核蛋白 H1

种属: Homo sapiens

同用名: HNRPH; HNRPH1; NEDCDS; hnRNPH

基因 ID: 3187 | 基因类型: protein coding

关于 HNRNPH1

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:179,614,178-179,634,784 (from NCBI)

This gene has 50 transcripts (splice variants), 1 gene allele, 143 orthologues, 8 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 153.8), lymph node (RPKM 101.7) and 25 other tissues.

功能概要

该基因编码普遍表达的异质核核糖核蛋白 (hnRNP) 亚家族的成员。 hnRNPs 是与异质核 RNA 复合的 RNA 结合蛋白。这些蛋白质与细胞核中的前体 mRNA 相关,并且似乎影响前体 mRNA 加工以及 mRNA 代谢和运输的其他方面。虽然所有的 hnRNPs 都存在于细胞核中,但有些可能在细胞核和细胞质之间穿梭。 hnRNP 蛋白具有独特的核酸结合特性。该基因编码的蛋白质具有三个重复的与 RNA 结合的准 RRM 结构域,与家族成员 HNRPF 非常相似。该基因可能与 I 型遗传性淋巴水肿有关。已经描述了可变剪接的转录本变体[RefSeq 提供,2012 年 3 月]

This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and Other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]

HNRNPH1 基因产物(52)

mRNA Protein Name
NM_001257293.2 NP_001244222.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001363572.2 NP_001350501.1 heterogeneous nuclear ribonucleoprotein H isoform b
NM_001364225.2 NP_001351154.1 heterogeneous nuclear ribonucleoprotein H isoform c
NM_001364226.2 NP_001351155.1 heterogeneous nuclear ribonucleoprotein H isoform c
NM_001364227.2 NP_001351156.1 heterogeneous nuclear ribonucleoprotein H isoform c
NM_001364228.2 NP_001351157.1 heterogeneous nuclear ribonucleoprotein H isoform c
NM_001364229.2 NP_001351158.1 heterogeneous nuclear ribonucleoprotein H isoform c
NM_001364230.2 NP_001351159.1 heterogeneous nuclear ribonucleoprotein H isoform d
NM_001364231.2 NP_001351160.1 heterogeneous nuclear ribonucleoprotein H isoform l
NM_001364232.2 NP_001351161.1 heterogeneous nuclear ribonucleoprotein H isoform d
NM_001364233.2 NP_001351162.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364234.2 NP_001351163.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364235.2 NP_001351164.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364236.2 NP_001351165.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364237.2 NP_001351166.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364238.2 NP_001351167.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364239.2 NP_001351168.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364240.2 NP_001351169.1 heterogeneous nuclear ribonucleoprotein H isoform e
NM_001364241.2 NP_001351170.1 heterogeneous nuclear ribonucleoprotein H isoform f
NM_001364242.2 NP_001351171.1 heterogeneous nuclear ribonucleoprotein H isoform f
NM_001364243.2 NP_001351172.1 heterogeneous nuclear ribonucleoprotein H isoform f
NM_001364244.2 NP_001351173.1 heterogeneous nuclear ribonucleoprotein H isoform g
NM_001364245.2 NP_001351174.1 heterogeneous nuclear ribonucleoprotein H isoform b
NM_001364246.2 NP_001351175.1 heterogeneous nuclear ribonucleoprotein H isoform t
NM_001364247.2 NP_001351176.1 heterogeneous nuclear ribonucleoprotein H isoform t
NM_001364248.2 NP_001351177.1 heterogeneous nuclear ribonucleoprotein H isoform h
NM_001364250.2 NP_001351179.1 heterogeneous nuclear ribonucleoprotein H isoform i
NM_001364251.2 NP_001351180.1 heterogeneous nuclear ribonucleoprotein H isoform j
NM_001364252.2 NP_001351181.1 heterogeneous nuclear ribonucleoprotein H isoform j
NM_001364253.2 NP_001351182.1 heterogeneous nuclear ribonucleoprotein H isoform j
NM_001364254.2 NP_001351183.1 heterogeneous nuclear ribonucleoprotein H isoform k
NM_001364255.2 NP_001351184.1 heterogeneous nuclear ribonucleoprotein H isoform k
NM_001395176.1 NP_001382105.1 heterogeneous nuclear ribonucleoprotein H isoform l
NM_001395177.1 NP_001382106.1 heterogeneous nuclear ribonucleoprotein H isoform m
NM_001395178.1 NP_001382107.1 heterogeneous nuclear ribonucleoprotein H isoform n
NM_001395179.1 NP_001382108.1 heterogeneous nuclear ribonucleoprotein H isoform o
NM_001395180.1 NP_001382109.1 heterogeneous nuclear ribonucleoprotein H isoform o
NM_001395181.1 NP_001382110.1 heterogeneous nuclear ribonucleoprotein H isoform p
NM_001395182.1 NP_001382111.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001395183.1 NP_001382112.1 heterogeneous nuclear ribonucleoprotein H isoform q
NM_001395184.1 NP_001382113.1 heterogeneous nuclear ribonucleoprotein H isoform r
NM_001395186.1 NP_001382115.1 heterogeneous nuclear ribonucleoprotein H isoform f
NM_001395187.1 NP_001382116.1 heterogeneous nuclear ribonucleoprotein H isoform g
NM_001395188.1 NP_001382117.1 heterogeneous nuclear ribonucleoprotein H isoform s
NM_001395189.1 NP_001382118.1 heterogeneous nuclear ribonucleoprotein H isoform b
NM_001395190.1 NP_001382119.1 heterogeneous nuclear ribonucleoprotein H isoform u
NM_001395191.1 NP_001382120.1 heterogeneous nuclear ribonucleoprotein H isoform v
NM_001395192.1 NP_001382121.1 heterogeneous nuclear ribonucleoprotein H isoform w
NM_001395193.1 NP_001382122.1 heterogeneous nuclear ribonucleoprotein H isoform x
NM_001395194.1 NP_001382123.1 heterogeneous nuclear ribonucleoprotein H isoform k
NM_001395195.1 NP_001382124.1 heterogeneous nuclear ribonucleoprotein H isoform y
NM_005520.3 NP_005511.1 heterogeneous nuclear ribonucleoprotein H isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
16946708 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9111328 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of RNA splicing IDA
IDA: 通过直接分析推断
16946708 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
11991638 GOA
located in nucleus IDA
IDA: 通过直接分析推断
24910439 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HNRNPH1 蛋白结构

(14 - 84)

(113 - 182)

zf-RNPHF

zf-RNPHF: RNPHF zinc finger (255 - 290)

(291 - 358)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 449 a.a.
蛋白主名 其他名称

heterogeneous nuclear ribonucleoprotein H

epididymis secretory sperm binding protein

HNRNPH1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HNRNPH1 P31943 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
种属内
HNRNPH1 P31943 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
种属内
HNRNPH1 P31943 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
种属内
HNRNPH1 P31943 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
种属内
HNRNPH1 P31943 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
种属内
HNRNPH1 P31943 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
种属内
HNRNPH1 P31943 POLR1C Homo sapiens O15160
MAPPIT
32296183
种属内
HNRNPH1 P31943 ARHGEF16 Homo sapiens Q5VV41
Validated Y2H
32296183
种属内
HNRNPH1 P31943 PATZ1 Homo sapiens Q9HBE1-4
Y2H Prey Pooling
32296183
种属内
HNRNPH1 P31943 PATZ1 Homo sapiens Q9HBE1-4
Validated Y2H
32296183
种属内
HNRNPH1 P31943 PATZ1 Homo sapiens Q9HBE1-4
Y2H Array
32296183
种属内
HNRNPH1 P31943 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
种属内
HNRNPH1 P31943 KRTAP13-2 Homo sapiens Q52LG2
Validated Y2H
32296183
种属内
HNRNPH1 P31943 KRTAP13-2 Homo sapiens Q52LG2
Y2H Array
32296183
种属内
HNRNPH1 P31943 KRTAP13-2 Homo sapiens Q52LG2
Y2H Prey Pooling
32296183
种属内
HNRNPH1 P31943 RBFOX2 Homo sapiens O43251-10
Y2H Array
32296183
种属内
HNRNPH1 P31943 RBFOX2 Homo sapiens O43251-10
Y2H Prey Pooling
32296183
种属内
HNRNPH1 P31943 SAXO4 Homo sapiens Q7Z5V6-2
Validated Y2H
32296183
种属内
HNRNPH1 P31943 PEX5 Homo sapiens P50542-3
Y2H Prey Pooling
32296183
种属内
HNRNPH1 P31943 PEX5 Homo sapiens P50542-3
Validated Y2H
32296183
种属内
HNRNPH1 P31943 PEX5 Homo sapiens P50542-3
Y2H Array
32296183
种属内
HNRNPH1 P31943 OXER1 Homo sapiens Q8TDS5
Y2H Prey Pooling
32296183
种属内
HNRNPH1 P31943 OXER1 Homo sapiens Q8TDS5
Validated Y2H
32296183
种属内
HNRNPH1 P31943 OXER1 Homo sapiens Q8TDS5
Y2H Array
32296183
种属内
HNRNPH1 P31943 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
种属内
HNRNPH1 P31943 RNF4 Homo sapiens P78317
Validated Y2H
32296183
种属内
HNRNPH1 P31943 RNF4 Homo sapiens P78317
Y2H Array
32296183
种属内
HNRNPH1 P31943 MSI2 Homo sapiens Q96DH6
Anti Tag CoIP
35271311
种属内
HNRNPH1 P31943 MSI2 Homo sapiens Q96DH6
Y2H Prey Pooling
32296183
种属内
HNRNPH1 P31943 MSI2 Homo sapiens Q96DH6
Validated Y2H
32296183
种属内
HNRNPH1 P31943 MSI2 Homo sapiens Q96DH6
Y2H Array
32296183
种属内
HNRNPH1 P31943 MRPL53 Homo sapiens Q96EL3
Anti Tag CoIP
35271311
种属内
HNRNPH1 P31943 MRPL53 Homo sapiens Q96EL3
Validated Y2H
32296183
种属内
HNRNPH1 P31943 RBM38 Homo sapiens Q9H0Z9
Y2H Prey Pooling
32296183
种属内
HNRNPH1 P31943 RBM38 Homo sapiens Q9H0Z9
Y2H Array
32296183
种属内
HNRNPH1 P31943 RBM38 Homo sapiens Q9H0Z9
Validated Y2H
32296183
种属内
HNRNPH1 P31943 MYPOP Homo sapiens Q86VE0
Validated Y2H
32296183
种属内
HNRNPH1 P31943 NUDT16L1 Homo sapiens Q9BRJ7
Validated Y2H
32296183
种属内
HNRNPH1 P31943 NUDT16L1 Homo sapiens Q9BRJ7
Anti Tag CoIP
35271311
种属内
HNRNPH1 P31943 HNRNPF Homo sapiens P52597
Validated Y2H
32296183
种属内
HNRNPH1 P31943 HNRNPM Homo sapiens P52272
Y2H Prey Pooling
32296183
种属内
HNRNPH1 P31943 HNRNPM Homo sapiens P52272
Validated Y2H
32296183
种属内
HNRNPH1 P31943 HNRNPF Homo sapiens P52597
Anti Tag CoIP
35271311
种属内
HNRNPH1 P31943 TARDBP Homo sapiens Q13148
Y2H Array
32814053
种属内
HNRNPH1 P31943 TARDBP Homo sapiens Q13148
Anti Tag CoIP
29725819
种属内
HNRNPH1 P31943 HNRNPM Homo sapiens P52272
Y2H Array
32296183
种属内
HNRNPH1 P31943 HNRNPM Homo sapiens P52272
Anti Tag CoIP
35271311
种属内
HNRNPH1 P31943 TARDBP Homo sapiens Q13148
Y2H Pooling
32814053
种属内
HNRNPH1 P31943 HNRNPA1 Homo sapiens P09651
Anti Tag CoIP
35271311
种属内
HNRNPH1 P31943 TARDBP Homo sapiens Q13148
Validated Y2H
32814053
种属内
HNRNPH1 P31943 GPS2 Homo sapiens Q13227
Validated Y2H
32296183
种属内
HNRNPH1 P31943 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
种属内
HNRNPH1 P31943 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
种属内
HNRNPH1 P31943 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
种属内
HNRNPH1 P31943 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
种属内
HNRNPH1 P31943 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
种属内
HNRNPH1 P31943 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
种属内
HNRNPH1 P31943 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
种属内
HNRNPH1 P31943 RAMAC Homo sapiens Q9BTL3
Validated Y2H
32296183
种属内
HNRNPH1 P31943 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
种属内
HNRNPH1 P31943 CATSPER1 Homo sapiens Q8NEC5
Validated Y2H
32296183
种属内
HNRNPH1 P31943 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
种属内
HNRNPH1 P31943 DDX17 Homo sapiens Q92841
Y2H Prey Pooling
32296183
种属内
HNRNPH1 P31943 DDX17 Homo sapiens Q92841
Validated Y2H
32296183
种属内
HNRNPH1 P31943 DDX17 Homo sapiens Q92841
Y2H Array
32296183
种属内
HNRNPH1 P31943 TEKT4 Homo sapiens Q8WW24
Validated Y2H
32296183
种属内
HNRNPH1 P31943 TEKT3 Homo sapiens Q9BXF9
Validated Y2H
32296183
种属内
HNRNPH1 P31943 DZIP3 Homo sapiens Q86Y13
Validated Y2H
32296183
种属内
HNRNPH1 P31943 DZIP3 Homo sapiens Q86Y13
Y2H Prey Pooling
32296183
种属内
HNRNPH1 P31943 DZIP3 Homo sapiens Q86Y13
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 HNRNPH1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72233 HNRNPH1 Protein, Human (His-SUMO) P31943 (M2-A449) ≥95%

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Craniofacial Dysmorphism And Skeletal Defects

NEDCDS

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All

Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

Precursor T-Cell Acute Lymphocytic Leukemia

Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Adult T-Cell Lymphoma/Leukemia

Bain Type Of X-Linked Syndromic Intellectual Disability

Intellectual Disability, X-Linked, Syndromic, Bain Type

Hnrnph2 Deficiency

Intellectual Developmental Disorder, X-Linked, Syndromic, Bain Type

MRXSB

Mental Retardation, X-Linked, Syndromic, Bain Type

Intellectual Developmental Disorder, X-Linked Syndromic, Bain Type

Hereditary Lymphedema

Milroy Disease

Myotonic Disease

Myotonic Disorders

Myotonic Syndrome

Symptomatic Myotonia

Myotonic Dystrophy 2

Myotonic Dystrophy Type 2

Proximal Myotonic Myopathy

Promm

Ricker Syndrome

DM2

Dystrophia Myotonica 2

Myotonic Myopathy, Proximal

Myotonic Disorders

Dystrophia Myotonica Type 2

Proximal Myotonic Dystrophy

Ricker Disease

Myotonic Dystrophy, Type 2

Dystrophy, Myotonic, Type 2

Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma

Myotonic Dystrophy 1

Myotonic Dystrophy

Dystrophia Myotonica

Steinert Disease

Myotonic Dystrophy Type 1

Myotonia Atrophica

DM1

Congenital Myotonic Dystrophy

Myotonia Dystrophica

Steinert Myotonic Dystrophy

Dystrophia Myotonica 1

Dm

Steinert'S Disease

Steinert Myotonic Dystrophy Syndrome

Myotonic Dystrophy Of Steinert

Dystrophia Myotonica Type 1

Myotonic Dystrophy Congenital

Dystrophy, Myotonic, Type 1

Dm - [Dystrophia Myotonica]

Myotonic Muscular Dystrophy

Spinocerebellar Ataxia 8

Spinocerebellar Ataxia Type 8

SCA8

Ataxia, Spinocerebellar, Type 8

Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome

Fragile X Tremor/Ataxia Syndrome

Fxtas

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1

Frontotemporal Dementia And/Or Motor Neuron Disease

Ftdmnd

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia

Alsftd

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1

Frontotemporal Dementia With Motor Neuron Disease

Ftdals

Ftd-Als

Ftd-Mnd

Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1

Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1

Frontotemporal Lobar Degeneration

Grn-Related Frontotemporal Dementia

Congenital Myasthenic Syndrome

Congenital Myasthenia

Congenital Myasthenic Syndromes

Cms

Myasthenic Syndromes, Congenital

Myasthenic Syndromes Congenital

Myasthenic Syndrome, Congenital

Congenital Myasthenic Syndrome Ib

Congenital And Developmental Myasthenia

Developmental Myasthenia

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus HNRNPH1 RGD RGD:620840
Mus musculus HNRNPH1 MGD MGI:1891925
Canis familiaris HNRNPH1 VGNC VGNC:51723
Felis catus HNRNPH1 VGNC VGNC:67607
Bos taurus HNRNPH1 VGNC VGNC:52245
Macaca mulatta HNRNPH1 VGNC VGNC:84387
Others HNRNPH1 NCBI