2. Gene
  3. TOLLIP - toll interacting protein Gene

TOLLIP - toll interacting protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：toll 相互作用蛋白

种属: Homo sapiens

同用名: IL-1RAcPIP

基因 ID: 54472 | 基因类型: protein coding

关于 TOLLIP

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,274,371-1,309,632 (from NCBI)

This gene has 13 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in brain (RPKM 31.0), testis (RPKM 17.9) and 25 other tissues.

功能概要

该基因编码一种泛素结合蛋白，该蛋白与多种 Toll 样受体 (TLR) 信号级联组分相互作用。编码的蛋白质调节炎症信号，并参与白细胞介素 1 受体运输和 IL1R 相关激酶的转换。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2016 年 1 月]

This gene encodes a ubiquitin-binding protein that interacts with several Toll-like Receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

TOLLIP 基因产物(5)

mRNA Protein Name
NM_001318512.2 NP_001305441.1 toll-interacting protein isoform 2
NM_001318514.2 NP_001305443.1 toll-interacting protein isoform 3
NM_001318515.2 NP_001305444.1 toll-interacting protein isoform 5
NM_001318516.2 NP_001305445.1 toll-interacting protein isoform 4
NM_019009.4 NP_061882.2 toll-interacting protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Toll-like receptor binding IPI
IPI: 通过物理相互作用推断
11441107 GOA
enables kinase binding IPI
IPI: 通过物理相互作用推断
10854325 GOA
enables molecular adaptor activity IDA
IDA: 通过直接分析推断
10854325 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11397809 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in epithelial cell differentiation IEP
IEP: 通过表达模式推断
21492153 GOA
involved in interleukin-1-mediated signaling pathway IDA
IDA: 通过直接分析推断
10854325 GOA
involved in phosphorylation IDA
IDA: 通过直接分析推断
1085432 GOA
involved in protein localization to endosome IDA
IDA: 通过直接分析推断
16412388 GOA
involved in signal transduction IPI
IPI: 通过物理相互作用推断
11441107 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein-containing complex IDA
IDA: 通过直接分析推断
10854325 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TOLLIP 蛋白结构

C2

C2: C2 domain (55 - 132)

CUE

CUE: CUE domain (231 - 270)

  • 0
  • 100
  • 200
  • 274 a.a.
蛋白主名 其他名称

toll-interacting protein

adapter protein

重组 TOLLIP 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71373 TOLLIP Protein, Human (His) Q9H0E2-1 (A2-P274) ≥95%

关联疾病

疾病名称 别名
Tick Paralysis
Idiopathic Interstitial Pneumonia

Hamman-Rich Syndrome

Diffuse Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis

Ipf

Idiopathic Interstitial Pneumonias

Idiopathic Interstitial Pneumonia, Not Otherwise Specified

Pulmonary Fibrosis
Acute Vascular Insufficiency Of Intestine

Acute Gastrointestinal Tract Vascular Insuffic.

Acute Git Vascular Insuffic.

Acute Intestinal Ischemia

Acute Intestinal Vascular Insufficiency
Lymphoproliferative Syndrome, X-Linked, 1

Lymphomatoid Papulosis

Duncan Disease

Purtilo Syndrome

X-Linked Lymphoproliferative Syndrome

Xlp

X-Linked Lymphoproliferative Disease

XLP1

Lyp

Lymphoproliferative Disease, X-Linked

Xlpd

X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency

Ebv Infection, Severe, Susceptibility To

Ebvs

Immunodeficiency 5

Imd5

X-Linked Lymphoproliferative Syndrome 1

Epstein-Barr Virus Infection, Familial Fatal

Ebv Infection, Severe

Infectious Mononucleosis, Severe

Infectious Mononucleosis, Severe, Susceptibility To

Immunodeficiency, X-Linked Progressive Combined Variable

Epstein Barr Virus Infection, Familial Fatal

X-Linked Progressive Combined Variable Immunodeficiency 5

Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males

Familial Fatal Epstein-Barr Infection

Severe Susceptibility To Ebv Infection

Severe Susceptibility To Infectious Mononucleosis

Sap Deficiency

Sh2d1a/Slam-Associated Protein Deficiency

X-Linked Lymphoproliferative Syndrome Type 1

X-Linked Progressive Combined Variable Immunodeficiency

Lymphoproliferative Syndrome, X-Linked

Sap

X-Linked Lymphoproliferative Disorder
Nonspecific Interstitial Pneumonia

Nsip

Non-Specific Interstitial Pneumonia

Non-Specific Idiopathic Interstitial Pneumonia

Non-Specific Interstitial Pneumonia Nos
Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis

Ipf

Fibrocystic Pulmonary Dysplasia

Pulmonary Fibrosis, Idiopathic

Pulmonary Fibrosis, Idiopathic, Susceptibility To

Cryptogenic Fibrosing Alveolitis

ILD2

Idiopathic Pulmonary Fibrosis, Familial

Fibrosing Alveolitis, Cryptogenic

Uip

Fibrosing Alveolitis

Interstitial Pneumonitis, Usual

Familial Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis, Chronic Form

Usual Interstitial Pneumonia

Fibrosing Alveolitis Cryptogenic

Hamman-Rich Disease

Idiopathic Pulmonary Fibrosis Familial

Interstitial Pneumonitis Usual

Fibrosis Idiopathic Pulmonary

Fibrosis, Pulmonary, Idiopathic

Hamman-Rich Syndrome

Chronic Idiopathic Pulmonary Fibrosis

Acute Interstitial Pneumonia

Interstitial Pulmonary Fibrosis

Ipf - [Idiopathic Pulmonary Fibrosis]

Idiopathic Lung Fibrosis

Fibrosing Lung Disease

Pulmonary Fibrosis Nos

Fibrosing Pneumonitis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14875 TOLLIP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TOLLIP RGD RGD:1304676
Felis catus TOLLIP VGNC VGNC:66440
Bos taurus TOLLIP VGNC VGNC:36216
Macaca mulatta TOLLIP VGNC VGNC:79035
Canis familiaris TOLLIP VGNC VGNC:52056
Mus musculus TOLLIP MGD MGI:1891808
Others TOLLIP NCBI
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