TOLLIP - toll interacting protein Gene

中文名称：toll 相互作用蛋白

种属: Homo sapiens

同用名: IL-1RAcPIP

基因 ID: 54472 | 基因类型: protein coding

关于 TOLLIP

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,274,371-1,309,632 (from NCBI)

This gene has 13 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in brain (RPKM 31.0), testis (RPKM 17.9) and 25 other tissues.

功能概要

该基因编码一种泛素结合蛋白，该蛋白与多种 Toll 样受体 (TLR) 信号级联组分相互作用。编码的蛋白质调节炎症信号，并参与白细胞介素 1 受体运输和 IL1R 相关激酶的转换。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2016 年 1 月]

This gene encodes a ubiquitin-binding protein that interacts with several Toll-like Receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

TOLLIP 基因产物(5)

mRNA	Protein	Name
NM_001318512.2	NP_001305441.1	toll-interacting protein isoform 2
NM_001318514.2	NP_001305443.1	toll-interacting protein isoform 3
NM_001318515.2	NP_001305444.1	toll-interacting protein isoform 5
NM_001318516.2	NP_001305445.1	toll-interacting protein isoform 4
NM_019009.4	NP_061882.2	toll-interacting protein isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables Toll-like receptor binding	IPI IPI: 通过物理相互作用推断	11441107	GOA
enables kinase binding	IPI IPI: 通过物理相互作用推断	10854325	GOA
enables molecular adaptor activity	IDA IDA: 通过直接分析推断	10854325	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11397809	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in epithelial cell differentiation	IEP IEP: 通过表达模式推断	21492153	GOA
involved in interleukin-1-mediated signaling pathway	IDA IDA: 通过直接分析推断	10854325	GOA
involved in phosphorylation	IDA IDA: 通过直接分析推断	1085432	GOA
involved in protein localization to endosome	IDA IDA: 通过直接分析推断	16412388	GOA
involved in signal transduction	IPI IPI: 通过物理相互作用推断	11441107	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of protein-containing complex	IDA IDA: 通过直接分析推断	10854325	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TOLLIP 蛋白结构

CUE

0
100
200
274 a.a.

蛋白主名

其他名称

toll-interacting protein

adapter protein

TOLLIP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TOLLIP	Q9H0E2	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	DCDC2	Homo sapiens	Q9UHG0	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	DCDC2	Homo sapiens	Q9UHG0	Validated Y2H	32296183
种属内	TOLLIP	Q9H0E2	DCDC2	Homo sapiens	Q9UHG0	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	MEDAG	Homo sapiens	Q5VYS4	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	MEDAG	Homo sapiens	Q5VYS4	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	MSS51	Homo sapiens	Q4VC12	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	MSS51	Homo sapiens	Q4VC12	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	FAM168A	Homo sapiens	Q92567-2	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	FAM168A	Homo sapiens	Q92567-2	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	KRTAP15-1	Homo sapiens	Q3LI76	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	KRTAP15-1	Homo sapiens	Q3LI76	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	TOM1L1	Homo sapiens	O75674-2	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	TOM1L1	Homo sapiens	O75674-2	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	TOM1	Homo sapiens	O60784-2	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	TOM1	Homo sapiens	O60784-2	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	RBFOX1	Homo sapiens	Q9NWB1-5	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	RBFOX1	Homo sapiens	Q9NWB1-5	Validated Y2H	32296183
种属内	TOLLIP	Q9H0E2	RBFOX1	Homo sapiens	Q9NWB1-5	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	TOM1L2	Homo sapiens	Q6ZVM7-2	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	TOM1L2	Homo sapiens	Q6ZVM7-2	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	CIMIP2B	Homo sapiens	A8MTA8-2	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	CIMIP2B	Homo sapiens	A8MTA8-2	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	PRR20D	Homo sapiens	P86480	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	CSTF1	Homo sapiens	Q05048	Anti Tag CoIP	21903422
种属内	TOLLIP	Q9H0E2	CSTF1	Homo sapiens	Q05048	Anti Tag CoIP	33961781
种属内	TOLLIP	Q9H0E2	CSTF1	Homo sapiens	Q05048	BioID	34524948
种属内	TOLLIP	Q9H0E2	KRTAP7-1	Homo sapiens	Q8IUC3	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	KRTAP7-1	Homo sapiens	Q8IUC3	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	WRNIP1	Homo sapiens	Q96S55	Anti Tag CoIP	21903422
种属内	TOLLIP	Q9H0E2	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
种属内	TOLLIP	Q9H0E2	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
种属内	TOLLIP	Q9H0E2	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
种属内	TOLLIP	Q9H0E2	PRPF39	Homo sapiens	Q86UA1	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	PRPF39	Homo sapiens	Q86UA1	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	MVP	Homo sapiens	Q14764	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	MVP	Homo sapiens	Q14764	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	TTC9C	Homo sapiens	Q8N5M4	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	TTC9C	Homo sapiens	Q8N5M4	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	PEG10	Homo sapiens	Q86TG7	Anti Tag CoIP	21903422
种属内	TOLLIP	Q9H0E2	ARRDC3	Homo sapiens	Q96B67	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	ARRDC3	Homo sapiens	Q96B67	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	CDIP1	Homo sapiens	Q9H305	Validated Y2H	32296183
种属内	TOLLIP	Q9H0E2	CDIP1	Homo sapiens	Q9H305	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	CDIP1	Homo sapiens	Q9H305	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	TOM1L2	Homo sapiens	Q6ZVM7	Y2H Pooling	20936779
种属内	TOLLIP	Q9H0E2	TOM1L2	Homo sapiens	Q6ZVM7	Anti Tag CoIP	35271311
种属内	TOLLIP	Q9H0E2	RHOXF2	Homo sapiens	Q9BQY4	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	RHOXF2	Homo sapiens	Q9BQY4	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	RHOXF2	Homo sapiens	Q9BQY4	Y2H Pooling	16189514
种属内	TOLLIP	Q9H0E2	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
种属内	TOLLIP	Q9H0E2	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
种属内	TOLLIP	Q9H0E2	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
种属内	TOLLIP	Q9H0E2	IRAK2	Homo sapiens	O43187	Anti Tag CoIP	21903422
种属内	TOLLIP	Q9H0E2	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
种属内	TOLLIP	Q9H0E2	EIF2AK2	Homo sapiens	P19525	Anti Tag CoIP	21903422
种属内	TOLLIP	Q9H0E2	MSX2	Homo sapiens	P35548	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	MSX2	Homo sapiens	P35548	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	TOM1L1	Homo sapiens	O75674	Anti Tag CoIP	33961781
种属内	TOLLIP	Q9H0E2	TOM1L1	Homo sapiens	O75674	Anti Tag CoIP	21903422
种属内	TOLLIP	Q9H0E2	TOM1L1	Homo sapiens	O75674	Anti Tag CoIP	35271311
种属内	TOLLIP	Q9H0E2	TOM1L1	Homo sapiens	O75674	Y2H Pooling	20936779
种属内	TOLLIP	Q9H0E2	TOM1L1	Homo sapiens	O75674	Y2H Array	21988832
种属内	TOLLIP	Q9H0E2	MAP1LC3A	Homo sapiens	Q9H492	IF	25042851
种属内	TOLLIP	Q9H0E2	MAP1LC3A	Homo sapiens	Q9H492	Anti Tag CoIP	25042851
种属内	TOLLIP	Q9H0E2	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	25416956
种属内	TOLLIP	Q9H0E2	DAZAP2	Homo sapiens	Q15038	Validated Y2H	25416956
种属内	TOLLIP	Q9H0E2	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	RBPMS	Homo sapiens	Q93062	Validated Y2H	25416956
种属内	TOLLIP	Q9H0E2	NTAQ1	Homo sapiens	Q96HA8	Y2H Prey Pooling	25416956
种属内	TOLLIP	Q9H0E2	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	31515488
种属内	TOLLIP	Q9H0E2	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	25416956
种属内	TOLLIP	Q9H0E2	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	TOM1	Homo sapiens	O60784	Y2H Array	25416956
种属内	TOLLIP	Q9H0E2	TOM1	Homo sapiens	O60784	Anti Tag CoIP	35271311
种属内	TOLLIP	Q9H0E2	TOM1	Homo sapiens	O60784	Validated Y2H	25416956
种属内	TOLLIP	Q9H0E2	STN1	Homo sapiens	Q9H668	Validated Y2H	32296183
种属内	TOLLIP	Q9H0E2	STN1	Homo sapiens	Q9H668	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	STN1	Homo sapiens	Q9H668	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	DAB1	Homo sapiens	O75553	Validated Y2H	25416956
种属内	TOLLIP	Q9H0E2	DAB1	Homo sapiens	O75553	Y2H Array	25416956
种属内	TOLLIP	Q9H0E2	ATXN1	Homo sapiens	P54253	Y2H	16713569
种属内	TOLLIP	Q9H0E2	PHAF1	Homo sapiens	Q9BSU1	Y2H Prey Pooling	32296183
种属内	TOLLIP	Q9H0E2	PHAF1	Homo sapiens	Q9BSU1	Y2H Array	32296183
种属内	TOLLIP	Q9H0E2	DZIP3	Homo sapiens	Q86Y13	Anti Tag CoIP	21903422

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TOLLIP 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71373	TOLLIP Protein, Human (His)	Q9H0E2-1 (A2-P274)	≥95%

关联疾病

疾病名称

别名

Tick Paralysis

Idiopathic Interstitial Pneumonia

Hamman-Rich Syndrome	Diffuse Idiopathic Pulmonary Fibrosis
Idiopathic Fibrosing Alveolitis	Ipf
Idiopathic Interstitial Pneumonias	Idiopathic Interstitial Pneumonia, Not Otherwise Specified
Pulmonary Fibrosis

Acute Vascular Insufficiency Of Intestine

Acute Gastrointestinal Tract Vascular Insuffic.	Acute Git Vascular Insuffic.
Acute Intestinal Ischemia	Acute Intestinal Vascular Insufficiency

Lymphoproliferative Syndrome, X-Linked, 1

Lymphomatoid Papulosis	Duncan Disease
Purtilo Syndrome	X-Linked Lymphoproliferative Syndrome
Xlp	X-Linked Lymphoproliferative Disease
XLP1	Lyp
Lymphoproliferative Disease, X-Linked	Xlpd
X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency	Ebv Infection, Severe, Susceptibility To
Ebvs	Immunodeficiency 5
Imd5	X-Linked Lymphoproliferative Syndrome 1
Epstein-Barr Virus Infection, Familial Fatal	Ebv Infection, Severe
Infectious Mononucleosis, Severe	Infectious Mononucleosis, Severe, Susceptibility To
Immunodeficiency, X-Linked Progressive Combined Variable	Epstein Barr Virus Infection, Familial Fatal
X-Linked Progressive Combined Variable Immunodeficiency 5	Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males
Familial Fatal Epstein-Barr Infection	Severe Susceptibility To Ebv Infection
Severe Susceptibility To Infectious Mononucleosis	Sap Deficiency
Sh2d1a/Slam-Associated Protein Deficiency	X-Linked Lymphoproliferative Syndrome Type 1
X-Linked Progressive Combined Variable Immunodeficiency	Lymphoproliferative Syndrome, X-Linked
Sap	X-Linked Lymphoproliferative Disorder

Nonspecific Interstitial Pneumonia

Nsip	Non-Specific Interstitial Pneumonia
Non-Specific Idiopathic Interstitial Pneumonia	Non-Specific Interstitial Pneumonia Nos

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis	Ipf
Fibrocystic Pulmonary Dysplasia	Pulmonary Fibrosis, Idiopathic
Pulmonary Fibrosis, Idiopathic, Susceptibility To	Cryptogenic Fibrosing Alveolitis
ILD2	Idiopathic Pulmonary Fibrosis, Familial
Fibrosing Alveolitis, Cryptogenic	Uip
Fibrosing Alveolitis	Interstitial Pneumonitis, Usual
Familial Idiopathic Pulmonary Fibrosis	Idiopathic Fibrosing Alveolitis, Chronic Form
Usual Interstitial Pneumonia	Fibrosing Alveolitis Cryptogenic
Hamman-Rich Disease	Idiopathic Pulmonary Fibrosis Familial
Interstitial Pneumonitis Usual	Fibrosis Idiopathic Pulmonary
Fibrosis, Pulmonary, Idiopathic	Hamman-Rich Syndrome
Chronic Idiopathic Pulmonary Fibrosis	Acute Interstitial Pneumonia
Interstitial Pulmonary Fibrosis	Ipf - [Idiopathic Pulmonary Fibrosis]
Idiopathic Lung Fibrosis	Fibrosing Lung Disease
Pulmonary Fibrosis Nos	Fibrosing Pneumonitis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14875	TOLLIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	TOLLIP	RGD	RGD:1304676
Felis catus	TOLLIP	VGNC	VGNC:66440
Bos taurus	TOLLIP	VGNC	VGNC:36216
Macaca mulatta	TOLLIP	VGNC	VGNC:79035
Canis familiaris	TOLLIP	VGNC	VGNC:52056
Mus musculus	TOLLIP	MGD	MGI:1891808
Others	TOLLIP	NCBI

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