2. Apoptosis Autophagy
  3. Autophagy Apoptosis
  4. UCM-1336

UCM-1336 是有效的 ICMT 抑制剂，其 IC50 值为2 μM。UCM-1336诱导内源性Ras错位，降低Ras激活，通过自噬和凋亡诱导细胞死亡。

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UCM-1336 Chemical Structure

UCM-1336 Chemical Structure

CAS No. : 1621535-90-7

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3.  试用装只面向终端客户。

规格 价格 是否有货 数量
5 mg ￥500
In-stock
10 mg ￥850
In-stock
25 mg ￥1750
In-stock
50 mg ￥2800
In-stock
100 mg ￥4500
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

UCM-1336 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UCM-1336 is a potent ICMT inhibitor, with an IC50 of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decreases Ras activation and induces cell death by autophagy and apoptosis[1].

IC50 & Target

IC50: 2 μM (2 μM)[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HL-60 IC50
2 μM
Compound: 3; UCM-1336
Cytotoxicity against human HL60 cells harboring N-Ras Q61K mutant assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells harboring N-Ras Q61K mutant assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31181882]
MDA-MB-231 IC50
5 μM
Compound: 3; UCM-1336
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by XTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by XTT assay
[PMID: 31181882]
MIA PaCa-2 IC50
2 μM
Compound: 3; UCM-1336
Cytotoxicity against human MIAPaCa2 cells harboring K-Ras G12C mutant assessed as reduction in cell viability after 72 hrs by XTT assay
Cytotoxicity against human MIAPaCa2 cells harboring K-Ras G12C mutant assessed as reduction in cell viability after 72 hrs by XTT assay
[PMID: 31181882]
NIH3T3 IC50
> 50 μM
Compound: 3; UCM-1336
Cytotoxicity against mouse NIH/3T3 cells harboring N-Ras Q61K mutant assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against mouse NIH/3T3 cells harboring N-Ras Q61K mutant assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31181882]
PANC-1 IC50
7 μM
Compound: 3; UCM-1336
Cytotoxicity against human PANC1 cells harboring K-Ras G12D mutant assessed as reduction in cell viability after 72 hrs by XTT assay
Cytotoxicity against human PANC1 cells harboring K-Ras G12D mutant assessed as reduction in cell viability after 72 hrs by XTT assay
[PMID: 31181882]
Sf9 IC50
2 μM
Compound: 3; UCM-1336
Inhibition of recombinant human ICMT expressed in Sf9 insect cell membranes using biotin-farnesyl-L-cysteine as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by scintillation counting analysis
Inhibition of recombinant human ICMT expressed in Sf9 insect cell membranes using biotin-farnesyl-L-cysteine as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by scintillation counting analysis
[PMID: 31181882]
SW-620 IC50
3 μM
Compound: 3; UCM-1336
Cytotoxicity against human SW620 cells harboring K-Ras G12V mutant assessed as reduction in cell viability after 72 hrs by XTT assay
Cytotoxicity against human SW620 cells harboring K-Ras G12V mutant assessed as reduction in cell viability after 72 hrs by XTT assay
[PMID: 31181882]
分子量

423.59

Formula

C26H37N3O2
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (236.08 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3608 mL 11.8039 mL 23.6077 mL
5 mM 0.4722 mL 2.3608 mL 4.7215 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

扫码获得
动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
纯度 & 产品资料
参考文献

UCM-1336 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3608 mL 11.8039 mL 23.6077 mL 59.0193 mL
5 mM 0.4722 mL 2.3608 mL 4.7215 mL 11.8039 mL
10 mM 0.2361 mL 1.1804 mL 2.3608 mL 5.9019 mL
15 mM 0.1574 mL 0.7869 mL 1.5738 mL 3.9346 mL
20 mM 0.1180 mL 0.5902 mL 1.1804 mL 2.9510 mL
25 mM 0.0944 mL 0.4722 mL 0.9443 mL 2.3608 mL
30 mM 0.0787 mL 0.3935 mL 0.7869 mL 1.9673 mL
40 mM 0.0590 mL 0.2951 mL 0.5902 mL 1.4755 mL
50 mM 0.0472 mL 0.2361 mL 0.4722 mL 1.1804 mL
60 mM 0.0393 mL 0.1967 mL 0.3935 mL 0.9837 mL
80 mM 0.0295 mL 0.1475 mL 0.2951 mL 0.7377 mL
100 mM 0.0236 mL 0.1180 mL 0.2361 mL 0.5902 mL

Keywords:

UCM-13361621535-90-7UCM1336UCM 1336AutophagyApoptosisICMTRasapoptosisautophagyInhibitorinhibitorinhibit

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