2. Metabolic Enzyme/Protease Anti-infection
  3. ATP Citrate Lyase Bacterial HIF/HIF Prolyl-Hydroxylase Endogenous Metabolite
  4. Lithium citrate tetrahydrate

Lithium citrate tetrahydrate  (Synonyms: 柠檬酸三锂盐四水合物; Litarex tetrahydrate)

目录号: HY-B1295 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Lithium citrate (Litarex) tetrahydrate 是藤黄果的主要活性成分。Lithium citrate tetrahydrate 可竞争性抑制柠檬酸裂解酶 (ATP citrate lyase) ，并具有减肥效果。Lithium citrate tetrahydrate 有效抑制结石形成并抑制 HIF，具有抗氧化，抗炎和抗肿瘤作用。

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Lithium citrate tetrahydrate Chemical Structure

Lithium citrate tetrahydrate Chemical Structure

CAS No. : 6080-58-6

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥110
In-stock
1 g ￥100
In-stock
5 g ￥180
In-stock
10 g   询价  
50 g   询价  

* Please select Quantity before adding items.

Lithium citrate tetrahydrate 相关抗体

Top Publications Citing Use of Products

查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

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HIF-1α HIF

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lithium citrate (Litarex) tetrahydrate is the major active ingredient of Garcinia cambogia. Lithium citrate tetrahydrate competitively inhibits ATP citrate lyase with weight loss benefits. Lithium citrate tetrahydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects[1][2][3][4].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Lithium citrate tetrahydrate shows an HIF inhibitory effect compared with the control group in ARPE19 cells and 661W cells. Lithium citrate tetrahydrate can downregulate Hif1a and the downstream genes in ARPE19 cells and 661W cells. Lithium citrate tetrahydrate suppresses HIF-1α protein expression increased by CoCl2 administration in ARPE19 cells and 661W cells[2].
In chicken hepatocytes, Lithium citrate tetrahydrate decreases the accumulation of lipid droplets and accelerated energy metabolism. Lithium citrate tetrahydrate protects the cells from ER stress by increasing the antioxidant status and mitochondrial functions[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lithium citrate tetrahydrate 相关抗体:
体内研究
(In Vivo)

Lithium citrate (100-200 mg/kg) tetrahydrate treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). There is significantly less calcium oxalate crystal deposition in mice (male C57BL/6J mice) treated with Lithium citrate tetrahydrate. Lithium citrate tetrahydrate attenuates the oxidative stress induced by calcium oxalate crystallization. Lithium citrate tetrahydrate has inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 β, and IL-6. In addition, Lithium citrate tetrahydrate alleviates tubular injury and apoptosis caused by calcium oxalate crystals[1].
The administration of Lithium citrate tetrahydrate can suppress body weight gain and fat accumulation in animals[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

281.98

Formula

C6H13Li3O11
CAS 号
性状

固体

颜色

White to off-white

中文名称

柠檬酸三锂盐四水合物
结构分类
初始来源

Aspergillus niger
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : ≥ 100 mg/mL (354.64 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5464 mL 17.7318 mL 35.4635 mL
5 mM 0.7093 mL 3.5464 mL 7.0927 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 50 mg/mL (177.32 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥98.0%

COA (294 KB) HNMR (247 KB)

产品使用指南 (1538 KB)
参考文献

Lithium citrate tetrahydrate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.5464 mL 17.7318 mL 35.4635 mL 88.6588 mL
5 mM 0.7093 mL 3.5464 mL 7.0927 mL 17.7318 mL
10 mM 0.3546 mL 1.7732 mL 3.5464 mL 8.8659 mL
15 mM 0.2364 mL 1.1821 mL 2.3642 mL 5.9106 mL
20 mM 0.1773 mL 0.8866 mL 1.7732 mL 4.4329 mL
25 mM 0.1419 mL 0.7093 mL 1.4185 mL 3.5464 mL
30 mM 0.1182 mL 0.5911 mL 1.1821 mL 2.9553 mL
40 mM 0.0887 mL 0.4433 mL 0.8866 mL 2.2165 mL
50 mM 0.0709 mL 0.3546 mL 0.7093 mL 1.7732 mL
60 mM 0.0591 mL 0.2955 mL 0.5911 mL 1.4776 mL
80 mM 0.0443 mL 0.2216 mL 0.4433 mL 1.1082 mL
100 mM 0.0355 mL 0.1773 mL 0.3546 mL 0.8866 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lithium citrate tetrahydrate6080-58-6Litarex tetrahydrate柠檬酸三锂盐四水合物ATP Citrate LyaseBacterialHIF/HIF Prolyl-HydroxylaseEndogenous MetaboliteACLYHypoxia-inducible factorsHIFsHIF-PHCitratecleavageextramitochondrialCaOxstonessafetyantioxidationanti-inflammationHIF-1αATPInhibitorinhibitorinhibit

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