1. Cell Cycle/DNA Damage Cytoskeleton
  2. Microtubule/Tubulin
  3. Combretastatin A4

Combretastatin A4  (Synonyms: 康普瑞汀; CRC 87-09)

目录号: HY-N2146 纯度: 99.76%
COA 产品使用指南

Combretastatin A4 是一种 microtubule 抑制剂,能够与 β-tubulin 结合,Kd 值为 0.4 μM。

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Combretastatin A4 Chemical Structure

Combretastatin A4 Chemical Structure

CAS No. : 117048-59-6

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Customer Review

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.

IC50 & Target

Kd: 0.4 μM (β-tubulin)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
518A2 IC50
0.02 μM
Compound: CA4
Cytotoxicity against human 518A2 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Cytotoxicity against human 518A2 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 31958738]
518A2 IC50
1.8 nM
Compound: CA-4
Growth inhibition of human 518A2 cells after 72 hrs by MTT assay
Growth inhibition of human 518A2 cells after 72 hrs by MTT assay
[PMID: 27116710]
518A2 IC50
18 nM
Compound: CA4
Cytotoxicity against human 518A2 cells after 72 hrs by MTT assay
Cytotoxicity against human 518A2 cells after 72 hrs by MTT assay
[PMID: 20731355]
786-0 GI50
0.1 μM
Compound: CA4, NSC 613729
Growth inhibition of human 786-0 cells after 48 hrs by SRB assay
Growth inhibition of human 786-0 cells after 48 hrs by SRB assay
[PMID: 24387982]
786-0 GI50
0.1 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human 786-0 cells after 48 hrs by SRB assay
Growth inhibition of human 786-0 cells after 48 hrs by SRB assay
[PMID: 22982122]
786-0 GI50
0.1 μM
Compound: CA4; NSC 613729
Cytotoxicity against human 786-0 cells by SRB assay
Cytotoxicity against human 786-0 cells by SRB assay
[PMID: 26257861]
786-0 GI50
100 nM
Compound: CA4
Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
A10 EC50
< 0.025 μM
Compound: CA-4
Inhibition of tubulin in rat A10 cells assessed as induction of cellular microtubule disassembly after 18 hrs by indirect immunofluorescence technique
Inhibition of tubulin in rat A10 cells assessed as induction of cellular microtubule disassembly after 18 hrs by indirect immunofluorescence technique
[PMID: 20006519]
A10 EC50
0.007 μM
Compound: 1, CA-4
Antiproliferative activity against rat A10 cells assessed as microtubule depolymerization after 18 to 24 hrs by indirect immunofluorescence technique
Antiproliferative activity against rat A10 cells assessed as microtubule depolymerization after 18 to 24 hrs by indirect immunofluorescence technique
[PMID: 19894742]
A10 IC50
1 nM
Compound: 2, CSA4
Growth inhibition of rat A10 cells after 48 hrs by MTT assay
Growth inhibition of rat A10 cells after 48 hrs by MTT assay
[PMID: 22044164]
A10 EC50
13 nM
Compound: CA-4
Induction of interphase microtubule depolymerization in rat A10 cells after 18 to 24 hrs by indirect immunofluorescence assay
Induction of interphase microtubule depolymerization in rat A10 cells after 18 to 24 hrs by indirect immunofluorescence assay
[PMID: 23332369]
A10 EC50
7 nM
Compound: CA-4
Induction of microtubule depolymerization in rat A10 cells after 18 hrs by indirect immunofluorescence assay
Induction of microtubule depolymerization in rat A10 cells after 18 hrs by indirect immunofluorescence assay
[PMID: 23895532]
A10 EC50
9.8 nM
Compound: CA-4
Induction of microtubule depolymerization in rat A10 cells after 18 hrs by indirect immunofluorescence method
Induction of microtubule depolymerization in rat A10 cells after 18 hrs by indirect immunofluorescence method
[PMID: 30098869]
A10 EC50
9.8 nM
Compound: CA-4
Induction of microtubule depolymerization in rat A10 cells after 18 hrs by indirect immunofluorescence assay
Induction of microtubule depolymerization in rat A10 cells after 18 hrs by indirect immunofluorescence assay
[PMID: 25882519]
A2780 IC50
0.003 μM
Compound: CA-4
Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31185410]
A2780 IC50
0.004 μM
Compound: 1; CA-4
Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay
Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay
[PMID: 35065411]
A2780 IC50
0.004 μM
Compound: CA-4
Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 33581556]
A2780 IC50
0.005 μM
Compound: CA-4
Antiproliferative activity against human A2780 cells by MTT assay
Antiproliferative activity against human A2780 cells by MTT assay
[PMID: 29126741]
A2780 IC50
0.006 μM
Compound: 1; CA-4
Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay
Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay
[PMID: 29306206]
A2780 IC50
0.009 μM
Compound: CA-4
Cytotoxicity against human A2780 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human A2780 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 27149641]
A2780 IC50
0.012 μM
Compound: CA-4
Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34649064]
A2780 IC50
0.016 μM
Compound: CA-4
Antiproliferative activity against human A2780 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human A2780 cells measured after 48 hrs by MTT assay
[PMID: 27721152]
A2780 IC50
1.9 nM
Compound: 2, CA4
Antiproliferative activity against human A2780 cells after 5 days by MTT assay
Antiproliferative activity against human A2780 cells after 5 days by MTT assay
[PMID: 19837594]
A2780 IC50
12 nM
Compound: CA-4
Antiproliferative activity against human A2780 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human A2780 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 32339854]
A2780 IC50
12 nM
Compound: CA-4
Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay
Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay
[PMID: 28792756]
A2780 IC50
2.5 nM
Compound: CA-4
Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33618157]
A2780 IC50
2.84 μM
Compound: CA-4
Antiproliferative activity against human A2780 cells assessed as cell viability after 48 hrs by MTT assay
Antiproliferative activity against human A2780 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 26974371]
A2780 IC50
2.95 μM
Compound: CA-4
Antiproliferative activity against cisplatin resistant human A2780 cells assessed as cell viability after 48 hrs by MTT assay
Antiproliferative activity against cisplatin resistant human A2780 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 26974371]
A2780 IC50
72.753 μM
Compound: CA-4
Antiproliferative activity against paclitaxel-resistant human A2780 cells assessed as reduction in cell growth after 48 hrs by MTT assay
Antiproliferative activity against paclitaxel-resistant human A2780 cells assessed as reduction in cell growth after 48 hrs by MTT assay
[PMID: 33022479]
A-375 IC50
0.21 μM
Compound: Combretastatin A-4
Cytotoxicity against human A375 cells after 48 hrs by MTT assay
Cytotoxicity against human A375 cells after 48 hrs by MTT assay
[PMID: 30108703]
A-375 IC50
0.21 μM
Compound: Combretastatin-A4
Cytotoxicity against human A375 cells after 48 hrs by MTT assay
Cytotoxicity against human A375 cells after 48 hrs by MTT assay
[PMID: 27487568]
A-375 IC50
0.21 μM
Compound: 2a, CA-4
Cytotoxicity against human A375 cells after 48 hrs by MTT assay
Cytotoxicity against human A375 cells after 48 hrs by MTT assay
[PMID: 22543234]
A-375 IC50
2.1 nM
Compound: 4, CA4
Antiproliferative activity against human A375 after 48 hrs by spectrophotometry
Antiproliferative activity against human A375 after 48 hrs by spectrophotometry
[PMID: 21774499]
A-431 EC50
0.0035 μM
Compound: CA4
Cell cycle arrest in A431 cells by accumulation at G2/M phase
Cell cycle arrest in A431 cells by accumulation at G2/M phase
[PMID: 16377187]
A-431 EC50
0.0035 μM
Compound: CA4
Cell cycle arrest in A431 cells by accumulation at G2/M phase cell
Cell cycle arrest in A431 cells by accumulation at G2/M phase cell
[PMID: 16198562]
A-431 IC50
0.25 μM
Compound: 1a; CA-4
Cytotoxicity against human A431 cells after 48 hrs by MTT assay
Cytotoxicity against human A431 cells after 48 hrs by MTT assay
[PMID: 29291446]
A-431 IC50
188 nM
Compound: 4, CA4
Antiproliferative activity against human A431 after 48 hrs by spectrophotometry
Antiproliferative activity against human A431 after 48 hrs by spectrophotometry
[PMID: 21774499]
A498 GI50
0.006 μM
Compound: CA4, NSC 613729
Growth inhibition of human A498 cells after 48 hrs by SRB assay
Growth inhibition of human A498 cells after 48 hrs by SRB assay
[PMID: 24387982]
A498 GI50
0.006 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human A498 cells after 48 hrs by SRB assay
Growth inhibition of human A498 cells after 48 hrs by SRB assay
[PMID: 22982122]
A498 GI50
0.006 μM
Compound: CA4; NSC 613729
Cytotoxicity against human A498 cells by SRB assay
Cytotoxicity against human A498 cells by SRB assay
[PMID: 26257861]
A498 GI50
0.006 μM
Compound: CA-4
Growth inhibition of human A498 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human A498 cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
A498 GI50
50.1 nM
Compound: 1, CA-4
Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay
[PMID: 21920767]
A498 GI50
6.11 nM
Compound: CA4
Growth inhibition of human A498 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human A498 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
A549 IC50
> 10 μM
Compound: 2, CSA4
Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 22044164]
A549 IC50
> 10000 nM
Compound: 2
Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23214452]
A549 IC50
> 20 μM
Compound: 1a; CA-4
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 29291446]
A549 IC50
0.003 μM
Compound: CA-4
Antiproliferative activity against human A549 cells after 72 hrs by XTT assay
Antiproliferative activity against human A549 cells after 72 hrs by XTT assay
[PMID: 30216850]
A549 IC50
0.003 μM
Compound: II, CA-4
Cytotoxicity against human A549 cells after 72 hrs by XTT assay
Cytotoxicity against human A549 cells after 72 hrs by XTT assay
[PMID: 19939521]
A549 IC50
0.003 μM
Compound: CA4
Cytotoxicity against human A549 cells after 72 hrs by XTT assay
Cytotoxicity against human A549 cells after 72 hrs by XTT assay
[PMID: 19647439]
A549 IC50
0.003 μM
Compound: CA-4
Cytotoxicity against human A549 cells after 72 hrs by XTT assay
Cytotoxicity against human A549 cells after 72 hrs by XTT assay
[PMID: 18790642]
A549 IC50
0.003 μM
Compound: CA4
Cytotoxicity against human A549 cells after 72 hrs by XTT method
Cytotoxicity against human A549 cells after 72 hrs by XTT method
[PMID: 18502133]
A549 IC50
0.003 μM
Compound: CA4
Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by resazurin reduction assay
Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by resazurin reduction assay
[PMID: 26599530]
A549 IC50
0.0038 μM
Compound: CA-4
Cytotoxicity against human A549 cells after 72 hrs by resazurin based fluorescence assay
Cytotoxicity against human A549 cells after 72 hrs by resazurin based fluorescence assay
[PMID: 24669888]
A549 IC50
0.004 μM
Compound: CA-4
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 33581556]
A549 IC50
0.004 μM
Compound: CA-4
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31185410]
A549 IC50
0.004 μM
Compound: CA4
Growth inhibition of human A549 cells after 48 hrs by MTT assay
Growth inhibition of human A549 cells after 48 hrs by MTT assay
[PMID: 29509413]
A549 GI50
0.0047 μM
Compound: 42; CA4
Cytotoxicity against human A549 cells incubated for 52 hrs in oxic condition by sulforhodamine B assay
Cytotoxicity against human A549 cells incubated for 52 hrs in oxic condition by sulforhodamine B assay
[PMID: 32196334]
A549 IC50
0.005 μM
Compound: CA-4
Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 27149641]
A549 IC50
0.005 μM
Compound: 8; CA-4
Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 72 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 72 hrs by SRB assay
[PMID: 34454126]
A549 IC50
0.006 μM
Compound: 1; CA-4
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 35065411]
A549 GI50
0.0061 μM
Compound: 42; CA4
Cytotoxicity against human A549 cells incubated for 4 hrs in anoxic condition followed by oxic exposure for 48 hrs by sulforhodamine B assay
Cytotoxicity against human A549 cells incubated for 4 hrs in anoxic condition followed by oxic exposure for 48 hrs by sulforhodamine B assay
[PMID: 32196334]
A549 IC50
0.0075 μM
Compound: CA-4
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 35635956]
A549 IC50
0.008 μM
Compound: CA-4
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34649064]
A549 IC50
0.008 μM
Compound: CA4
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 25462279]
A549 IC50
0.009 μM
Compound: 1; CA-4
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 27994764]
A549 IC50
0.009 μM
Compound: 1; CA-4
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 30530194]
A549 IC50
0.01 μM
Compound: CA-4
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
[PMID: 27721152]
A549 IC50
0.01 μM
Compound: CA4
Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 28174064]
A549 IC50
0.012 μM
Compound: 2; CA-4
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
10.1039/C5MD00150A
A549 IC50
0.012 μM
Compound: CA-4
Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
[PMID: 31787361]
A549 IC50
0.014 μM
Compound: CA-4
Cytotoxicity against human A549/CDDP cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human A549/CDDP cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 27149641]
A549 IC50
0.015 μM
Compound: CA-4
Antiproliferative activity against human A549 assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human A549 assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 34175541]
A549 GI50
0.015 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human A549 cells after 48 hrs by SRB assay
Growth inhibition of human A549 cells after 48 hrs by SRB assay
[PMID: 22982122]
A549 IC50
0.016 μM
Compound: 2; CA-4
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 30245397]
A549 GI50
0.016 μM
Compound: CA4, NSC 613729
Growth inhibition of human A549 cells after 48 hrs by SRB assay
Growth inhibition of human A549 cells after 48 hrs by SRB assay
[PMID: 24387982]
A549 GI50
0.016 μM
Compound: CA4; NSC 613729
Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
[PMID: 26257861]
A549 GI50
0.016 μM
Compound: CA-4
Growth inhibition of human A549/ATCC cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human A549/ATCC cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
A549 GI50
0.018 μM
Compound: CA-4
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
10.1039/C5MD00139K
A549 IC50
0.021 μM
Compound: CA-4
Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 33895499]
A549 IC50
0.021 μM
Compound: CA-4
Antiproliferative activity against human A549 cells assessed as reduction in cell growth after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell growth after 48 hrs by MTT assay
[PMID: 33022479]
A549 IC50
0.021 μM
Compound: CA-4
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
[PMID: 32717486]
A549 IC50
0.027 μM
Compound: 2; CA-4
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36334455]
A549 IC50
0.035 μM
Compound: CA4
Cytotoxicity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
[PMID: 35964428]
A549 IC50
0.037 μM
Compound: CA-4; 2
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 30176537]
A549 IC50
0.04 μM
Compound: CA4
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
[PMID: 35551039]
A549 IC50
0.046 μM
Compound: CA-4
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 35447432]
A549 IC50
0.05 μM
Compound: CA-4
Cytotoxicity against human A549 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability by MTT assay
[PMID: 33010448]
A549 IC50
0.051 μM
Compound: 1; CA-4
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 26970659]
A549 IC50
0.052 μM
Compound: CA-4
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 25192811]
A549 GI50
0.056 μM
Compound: Combretastatin
Antiproliferative activity against human A549 cells after 48 hrs by SRB cell proliferation assay
Antiproliferative activity against human A549 cells after 48 hrs by SRB cell proliferation assay
[PMID: 29089233]
A549 IC50
0.058 μM
Compound: 2A; CA-4
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 28034647]
A549 IC50
0.058 μM
Compound: 1; CA-4
Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
[PMID: 33421913]
A549 GI50
0.06 μM
Compound: 2; CA4
Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay
[PMID: 27515320]
A549 GI50
0.0841 μM
Compound: CA-4
Antiproliferative activity against human A549 cells assessed as cell growth inhibition by SRB assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition by SRB assay
[PMID: 26242242]
A549 IC50
0.09 μg/mL
Compound: 1, CA-4
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 21440448]
A549 IC50
0.09 μM
Compound: CA-4
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 22512906]
A549 IC50
0.1 μM
Compound: CA-4
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 24909678]
A549 IC50
0.11 μM
Compound: Combretastatin A-4
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 30108703]
A549 IC50
0.11 μM
Compound: Combretastatin-A4
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 27487568]
A549 IC50
0.11 μM
Compound: 2a, CA-4
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 22543234]
A549 IC50
0.13 μM
Compound: CA-4
Antiproliferative activity against human A549 cells by MTT assay
Antiproliferative activity against human A549 cells by MTT assay
[PMID: 30502686]
A549 IC50
0.14 μM
Compound: CA-4
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 25828827]
A549 IC50
0.16 μM
Compound: CA-4
Antiproliferative activity against human A549 cells after 24 hrs by MTT assay
Antiproliferative activity against human A549 cells after 24 hrs by MTT assay
[PMID: 30606674]
A549 GI50
0.167 μM
Compound: CA-4
Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 31865012]
A549 IC50
0.18 μM
Compound: CA-4;1a
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 33550186]
A549 IC50
0.18 μM
Compound: CA-4
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 30633509]
A549 IC50
0.23 μM
Compound: CA-4
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
[PMID: 32035399]
A549 IC50
0.28 μM
Compound: 2
Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23809851]
A549 GI50
0.31 μM
Compound: CA-4
Growth inhibition of human A549 cells after 48 hrs by MTT assay
Growth inhibition of human A549 cells after 48 hrs by MTT assay
[PMID: 30041136]
A549 IC50
0.39 μM
Compound: CA-4
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 36252396]
A549 IC50
0.42 μM
Compound: CA-4
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 19665898]
A549 IC50
0.43 μM
Compound: CA-4
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 28622907]
A549 IC50
0.45 μM
Compound: CA-4
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 29407949]
A549 IC50
0.46 μg/mL
Compound: 2, CA-4
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 24916028]
A549 IC50
0.46 μM
Compound: CA-4
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 25703297]
A549 IC50
0.47 μM
Compound: CA-4
Anticancer activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Anticancer activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 31954880]
A549 IC50
0.53 μg/mL
Compound: CA-4
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 22503741]
A549 IC50
0.55 μg/mL
Compound: CA-4
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 22261027]
A549 IC50
0.55 μM
Compound: 1, CA-4
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
10.1039/C2MD20085F
A549 IC50
0.57 μM
Compound: CA-4
Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
[PMID: 31830637]
A549 IC50
0.6 μM
Compound: CA-4
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 34311158]
A549 GI50
0.82 μM
Compound: CA-4
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
[PMID: 32832031]
A549 IC50
1.15 μM
Compound: 1; CA-4
Antiproliferative activity against human A549 cells after 24 hrs by SRB assay
Antiproliferative activity against human A549 cells after 24 hrs by SRB assay
[PMID: 29268127]
A549 IC50
12.52 μM
Compound: CA-4
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
10.1039/C3MD00372H
A549 GI50
1200 nM
Compound: 1, CA-4
Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay
[PMID: 21920767]
A549 IC50
130 nM
Compound: CA-4
Antiproliferative activity against human A549 cells after 2 days by MTT assay
Antiproliferative activity against human A549 cells after 2 days by MTT assay
[PMID: 29432949]
A549 IC50
130.384 μM
Compound: CA-4
Antiproliferative activity against cisplatin resistant human A549 cells assessed as reduction in cell growth after 48 hrs by MTT assay
Antiproliferative activity against cisplatin resistant human A549 cells assessed as reduction in cell growth after 48 hrs by MTT assay
[PMID: 33022479]
A549 GI50
16.11 nM
Compound: CA4
Growth inhibition of human A549/ATCC cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human A549/ATCC cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
A549 IC50
180 nM
Compound: 1a, CA-4
Growth inhibition of human A549 cells after 72 hrs by MTT assay
Growth inhibition of human A549 cells after 72 hrs by MTT assay
[PMID: 25025853]
A549 IC50
180 nM
Compound: 1, CA-4
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 23445496]
A549 IC50
180 nM
Compound: CA-4, 1a, 1
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 23117171]
A549 IC50
180 nM
Compound: 1, CA-4
Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 22578111]
A549 IC50
180 nM
Compound: 1
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 22136312]
A549 IC50
180 nM
Compound: 1, CA-4
Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 21663319]
A549 IC50
180 nM
Compound: CA-4
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 20420439]
A549 IC50
180 nM
Compound: CA-4
Antiproliferative activity against human A549 cells after 72 hrs by resazurin-based fluorescence assay
Antiproliferative activity against human A549 cells after 72 hrs by resazurin-based fluorescence assay
[PMID: 29202409]
A549 IC50
180 nM
Compound: 1a, CA-4
Antiproliferative activity against human A549 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test
Antiproliferative activity against human A549 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test
[PMID: 25785605]
A549 IC50
2.78 μM
Compound: Combretastatin A-4
Antiproliferative activity against human A549 cells incubated for 24 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 24 hrs by MTT assay
[PMID: 32992133]
A549 IC50
2.79 μM
Compound: CA-4
Antiproliferative activity against human A549 cells after 24 to 48 hrs by CKK8 assay
Antiproliferative activity against human A549 cells after 24 to 48 hrs by CKK8 assay
[PMID: 25105922]
A549 GI50
2.8 μM
Compound: CA-4
Growth inhibition of human A549 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay
Growth inhibition of human A549 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay
[PMID: 26070164]
A549 IC50
2.83 μM
Compound: CA-4
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
[PMID: 36150341]
A549 IC50
200 nM
Compound: CA4
Antiproliferative activity against human A549 cells after 72 hrs by CellTiter Glo assay
Antiproliferative activity against human A549 cells after 72 hrs by CellTiter Glo assay
[PMID: 35797900]
A549 IC50
200 nM
Compound: 1; CA-4
Antiproliferative activity against human A549 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay
Antiproliferative activity against human A549 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay
[PMID: 33038796]
A549 IC50
200 nM
Compound: CA-4
Antiproliferative activity against human A549 cells after 72 hrs by MTS assay
Antiproliferative activity against human A549 cells after 72 hrs by MTS assay
[PMID: 30525602]
A549 IC50
200 nM
Compound: 7; CA-4
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 31401010]
A549 IC50
3.01 μM
Compound: CA-4
Antiproliferative activity against CA-4-resistant human A549 cells measured after 72 hrs by MTT assay
Antiproliferative activity against CA-4-resistant human A549 cells measured after 72 hrs by MTT assay
[PMID: 27187864]
A549 IC50
3.64 nM
Compound: 1, CA-4
Cytotoxicity against human A549 cells after 72 hrs by CCK-8 assay
Cytotoxicity against human A549 cells after 72 hrs by CCK-8 assay
[PMID: 23360369]
A549 IC50
4 nM
Compound: CA-4
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 28792756]
A549 IC50
4.422 nM
Compound: CA-4
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTS assay
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTS assay
[PMID: 31541870]
A549 GI50
4.8 nM
Compound: CA-4
Antiproliferation activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferation activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 33201714]
A549 IC50
49.05 μM
Compound: 3; CA-4
Growth inhibition of human A549 cells incubated for 48 hrs by MTT assay
Growth inhibition of human A549 cells incubated for 48 hrs by MTT assay
[PMID: 27172319]
A549 IC50
5.3 nM
Compound: 2, CA-4
Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay
Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay
[PMID: 22727370]
A549 IC50
5.3 μM
Compound: CA 4
Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay
[PMID: 28684120]
A549 GI50
5.5 nM
Compound: CA-4
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
[PMID: 34917259]
A549 GI50
5.5 nM
Compound: CA-4
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
[PMID: 31938468]
A549 IC50
5.6 nM
Compound: CA-4
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 23356786]
A549 IC50
5.99 μM
Compound: CA-4
Antiproliferative activity against human A549 cells after 72 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells after 72 hrs by CCK-8 assay
[PMID: 30108925]
A549 IC50
6.45 μM
Compound: Combretastatin
Antiproliferative activity in human A549 cells assessed as reduction in cell number incubated for 48 hrs by SRB assay
Antiproliferative activity in human A549 cells assessed as reduction in cell number incubated for 48 hrs by SRB assay
[PMID: 30108756]
A549 IC50
7 nM
Compound: CA-4
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 31610375]
A549 IC50
7.8 nM
Compound: 2, CA4
Antiproliferative activity against human A549 cells after 5 days by MTT assay
Antiproliferative activity against human A549 cells after 5 days by MTT assay
[PMID: 19837594]
A549 IC50
7.9 nM
Compound: 1, CA-4
Growth inhibition of human A549 cells after 48 hrs by SRB assay
Growth inhibition of human A549 cells after 48 hrs by SRB assay
[PMID: 24900453]
A549 IC50
9.29 μM
Compound: CA-4; B
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 28774575]
A549 IC50
94.3 nM
Compound: CA-4
Antiproliferative activity against human A549 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human A549 cells after 72 hrs by CCK8 assay
[PMID: 30006162]
A549/CDDP IC50
0.017 μM
Compound: CA4
Growth inhibition of human A549/CDDP cells after 48 hrs by MTT assay
Growth inhibition of human A549/CDDP cells after 48 hrs by MTT assay
[PMID: 29509413]
A549/TR IC50
0.175 μM
Compound: 1; CA-4
Antiproliferative activity against human taxol-resistant A549/TR cells after 72 hrs by MTT assay
Antiproliferative activity against human taxol-resistant A549/TR cells after 72 hrs by MTT assay
[PMID: 30530194]
ACHN IC50
0.005 μM
Compound: CA-4
Cytotoxicity against human ACHN cells after 48 hrs by MTT assay
Cytotoxicity against human ACHN cells after 48 hrs by MTT assay
[PMID: 25192811]
ACHN GI50
0.006 μM
Compound: CA4, NSC 613729
Growth inhibition of human ACHN cells after 48 hrs by SRB assay
Growth inhibition of human ACHN cells after 48 hrs by SRB assay
[PMID: 24387982]
ACHN GI50
0.006 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human ACHN cells after 48 hrs by SRB assay
Growth inhibition of human ACHN cells after 48 hrs by SRB assay
[PMID: 22982122]
ACHN GI50
0.006 μM
Compound: CA4; NSC 613729
Cytotoxicity against human ACHN cells by SRB assay
Cytotoxicity against human ACHN cells by SRB assay
[PMID: 26257861]
ACHN IC50
0.17 μM
Compound: 2a, CA-4
Cytotoxicity against human ACHN cells after 48 hrs by MTT assay
Cytotoxicity against human ACHN cells after 48 hrs by MTT assay
[PMID: 22543234]
ACHN IC50
1.6 nM
Compound: CA4
Antiproliferative activity against drug resistant ACHN cell line expressing MDR1 by Alamar Blue assay
Antiproliferative activity against drug resistant ACHN cell line expressing MDR1 by Alamar Blue assay
[PMID: 17286393]
ACHN GI50
6.14 nM
Compound: CA4
Growth inhibition of human ACHN cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human ACHN cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
AGS IC50
0.04 μM
Compound: 1, CA-4
Cytotoxicity against human AGS cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human AGS cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23566762]
AGS IC50
0.064 μM
Compound: CA-4
Cytotoxicity against human AGS cells after 48 hrs by MTT assay
Cytotoxicity against human AGS cells after 48 hrs by MTT assay
[PMID: 24238904]
AU565 IC50
4.4 nM
Compound: 4, CA4
Antiproliferative activity against human AU565 after 48 hrs by spectrophotometry
Antiproliferative activity against human AU565 after 48 hrs by spectrophotometry
[PMID: 21774499]
B16 IC50
0.002 μM
Compound: 2, CA-4
Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay
[PMID: 21524832]
B16 IC50
0.003 μM
Compound: CA4
Cytotoxicity against mouse B16 cells after 48 hrs by MTT assay
Cytotoxicity against mouse B16 cells after 48 hrs by MTT assay
[PMID: 23369686]
B16 IC50
0.003 μM
Compound: 1, CA4
Cytotoxicity against mouse B16 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against mouse B16 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 22647220]
B16 IC50
0.003 μM
Compound: CA-4
Cytotoxicity against mouse B16 cells assessed as cell viability after 48 hrs by MTT test
Cytotoxicity against mouse B16 cells assessed as cell viability after 48 hrs by MTT test
[PMID: 18583138]
B16 IC50
0.003 μM
Compound: 1, CA-4
Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay
[PMID: 18226429]
B16 IC50
0.005 μM
Compound: CA4
Cytotoxicity against mouse B16 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against mouse B16 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 21112130]
B16 IC50
56 μM
Compound: CA-4
Cytotoxicity against mouse B16 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against mouse B16 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33479639]
B16-F10 IC50
0.014 μM
Compound: CA-4
Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 34455231]
B16-F10 IC50
0.05 μM
Compound: CA-4
Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
[PMID: 33280898]
B16-F10 IC50
0.4 μg/mL
Compound: 1, CA-4
Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay
Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay
[PMID: 21440448]
B16-F10 IC50
0.4 μg/mL
Compound: 2, CA-4
Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT based ELISA assay
Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT based ELISA assay
[PMID: 21783370]
B16-F10 IC50
0.42 μg/mL
Compound: 2, CA-4
Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay
Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay
[PMID: 24916028]
B16-F10 IC50
0.42 μM
Compound: CA-4
Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay
Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay
[PMID: 25703297]
B16-F10 IC50
0.75 μg/mL
Compound: CA-4
Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay
Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay
[PMID: 22192936]
Bel-7402 IC50
0.003 μM
Compound: CA-4
Cytotoxicity against human Bel7402 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human Bel7402 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 27149641]
Bel-7402 IC50
0.011 μM
Compound: 1; CA-4
Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
Bel-7402 IC50
0.011 μM
Compound: 1; CA-4
Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay
Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay
[PMID: 30530194]
Bel-7402 GI50
0.012 μM
Compound: CA-4
Antiproliferative activity against human Bel7402 cells after 48 hrs by MTT assay
Antiproliferative activity against human Bel7402 cells after 48 hrs by MTT assay
10.1039/C5MD00139K
Bel-7402 IC50
0.013 μM
Compound: CA-4
Antiproliferative activity against human Bel7402 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human Bel7402 cells measured after 48 hrs by MTT assay
[PMID: 27721152]
Bel-7402 IC50
0.02 μM
Compound: 1; CA-4
Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay
[PMID: 27919655]
Bel-7402 IC50
0.058 μM
Compound: 1; CA-4
Antiproliferative activity against ADR-resistant human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against ADR-resistant human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
Bel-7402 IC50
0.084 μM
Compound: CA-4
Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay
Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay
[PMID: 32113125]
Bel-7402 IC50
1.718 μM
Compound: CA4
Cytotoxicity against human Bel7402 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human Bel7402 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23708012]
Bel-7402 IC50
1.72 μM
Compound: CA-4
Anticancer activity against human Bel7402 cells after 72 hrs
Anticancer activity against human Bel7402 cells after 72 hrs
[PMID: 19713108]
Bel-7402 IC50
10 nM
Compound: 1
Antiproliferative activity against human Bel7402 cells after 72 hrs
Antiproliferative activity against human Bel7402 cells after 72 hrs
[PMID: 17034133]
BeWo IC50
12.74 μM
Compound: CA-4
Cytotoxicity against human Bewo cells after 48 hrs by MTT assay
Cytotoxicity against human Bewo cells after 48 hrs by MTT assay
10.1039/C3MD00372H
BJ IC50
28.6 nM
Compound: 7; CA-4
Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 31401010]
BMEC IC50
3.7 nM
Compound: 1, CA-4
Cytotoxicity against BMEC by sulforhodamine B test
Cytotoxicity against BMEC by sulforhodamine B test
[PMID: 18783207]
BT-474 IC50
3.9 nM
Compound: 3
Cytotoxicity against human BT474 cells assessed as cell viability after 4 days by MTS assay
Cytotoxicity against human BT474 cells assessed as cell viability after 4 days by MTS assay
[PMID: 24210503]
BT-549 IC50
1.71 nM
Compound: CA-4
Cytotoxicity against human BT549 cells after 72 hrs by MTT assay
Cytotoxicity against human BT549 cells after 72 hrs by MTT assay
[PMID: 30472600]
BT-549 GI50
10 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human BT549 cells after 48 hrs by SRB assay
Growth inhibition of human BT549 cells after 48 hrs by SRB assay
[PMID: 22982122]
BT-549 IC50
3.5 nM
Compound: 4, CA4
Antiproliferative activity against human BT549 after 48 hrs by spectrophotometry
Antiproliferative activity against human BT549 after 48 hrs by spectrophotometry
[PMID: 21774499]
BXPC-3 IC50
< 50 nM
Compound: CA-4
Cytotoxicity against human BxPC3 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human BxPC3 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23981529]
BXPC-3 GI50
0.39 μg/mL
Compound: 1a, CA4
Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay
[PMID: 22324723]
BXPC-3 GI50
0.39 μg/mL
Compound: 2a
Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay
[PMID: 19719153]
BXPC-3 GI50
0.39 μg/mL
Compound: Z-1b
Cytotoxicity against human BxPC3 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human BxPC3 cells after 48 hrs by sulforhodamine B assay
[PMID: 19709889]
BXPC-3 GI50
0.39 μg/mL
Compound: 1a, CA4
Cytotoxicity against human BxPC3 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human BxPC3 cells after 48 hrs by sulforhodamine B assay
[PMID: 16252907]
BXPC-3 GI50
0.39 μg/mL
Compound: 3, CA4
Antitumor activity against human BxPC3 cells by sulforhodamine B assay
Antitumor activity against human BxPC3 cells by sulforhodamine B assay
[PMID: 19228038]
BXPC-3 GI50
0.39 μM
Compound: CA4, combretastatin A4
Cytotoxicity against human BXPC3 cells after 48 hrs by SRB assay
Cytotoxicity against human BXPC3 cells after 48 hrs by SRB assay
[PMID: 18303849]
CA46 IC50
20 nM
Compound: CA-4
Antiproliferative activity against human CA46 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human CA46 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 25050880]
CAKI-1 GI50
0.025 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human Caki1 cells after 48 hrs by SRB assay
Growth inhibition of human Caki1 cells after 48 hrs by SRB assay
[PMID: 22982122]
CAKI-1 GI50
0.025 μM
Compound: CA-4
Growth inhibition of human Caki1 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human Caki1 cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
CAKI-1 GI50
0.026 μM
Compound: CA4, NSC 613729
Growth inhibition of human CAKI-1 cells after 48 hrs by SRB assay
Growth inhibition of human CAKI-1 cells after 48 hrs by SRB assay
[PMID: 24387982]
CAKI-1 GI50
0.026 μM
Compound: CA4; NSC 613729
Cytotoxicity against human CAKI-1 cells by SRB assay
Cytotoxicity against human CAKI-1 cells by SRB assay
[PMID: 26257861]
CAKI-1 GI50
25.94 nM
Compound: CA4
Growth inhibition of human CAKI-1 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human CAKI-1 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
CAL-27 IC50
3.01 nM
Compound: CA-4
Antiproliferative activity against human CAL-27 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human CAL-27 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
[PMID: 35576703]
Calu-1 IC50
2.78 μM
Compound: Combretastatin A-4
Antiproliferative activity against human Calu-1 cells incubated for 24 hrs by MTT assay
Antiproliferative activity against human Calu-1 cells incubated for 24 hrs by MTT assay
[PMID: 32992133]
Calu-6 IC50
0.94 nM
Compound: 4, CA4
Antiproliferative activity against human Calu6 after 48 hrs by spectrophotometry
Antiproliferative activity against human Calu6 after 48 hrs by spectrophotometry
[PMID: 21774499]
Cancer cell lines IC50
30 nM
Compound: combretastatin A-4
Cell growth inhibition against HR, human gastric cancer cells using MTS assay
Cell growth inhibition against HR, human gastric cancer cells using MTS assay
[PMID: 12036364]
Cancer cell lines IC50
8520 nM
Compound: combretastatin A-4
Cell growth inhibition against NUGC3 human stomach cancer cells using MTS assay
Cell growth inhibition against NUGC3 human stomach cancer cells using MTS assay
[PMID: 12036364]
CAPAN-1 IC50
0.84 μM
Compound: COMB
Cytotoxicity against human Capan1 cells after 48 hrs by XTT assay
Cytotoxicity against human Capan1 cells after 48 hrs by XTT assay
[PMID: 30017114]
CCRF-CEM IC50
> 100 μM
Compound: 2, CA-4
Cytotoxicity against human CEM cells by alamar blue assay
Cytotoxicity against human CEM cells by alamar blue assay
[PMID: 22137934]
CCRF-CEM IC50
0.001 μM
Compound: CA-4
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
[PMID: 22676247]
CCRF-CEM IC50
0.0016 μM
Compound: CA4
Cytotoxicity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23708012]
CCRF-CEM IC50
0.002 μM
Compound: 1, CA-4
Antiproliferative activity against human CEM cells after 2 days by coulter counter analysis
Antiproliferative activity against human CEM cells after 2 days by coulter counter analysis
[PMID: 22027100]
CCRF-CEM IC50
0.002 μM
Compound: CA-4;1a
Antiproliferative activity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 33550186]
CCRF-CEM GI50
0.002 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human CCRF-CEM cells after 48 hrs by SRB assay
Growth inhibition of human CCRF-CEM cells after 48 hrs by SRB assay
[PMID: 22982122]
CCRF-CEM IC50
0.002 μM
Compound: CA-4
Anticancer activity against human CCRF-CEM cells after 72 hrs
Anticancer activity against human CCRF-CEM cells after 72 hrs
[PMID: 19713108]
CCRF-CEM GI50
0.003 μM
Compound: CA4, NSC 613729
Growth inhibition of human CCRF-CEM cells after 48 hrs by SRB assay
Growth inhibition of human CCRF-CEM cells after 48 hrs by SRB assay
[PMID: 24387982]
CCRF-CEM GI50
0.003 μM
Compound: CA4; NSC 613729
Cytotoxicity against human CCRF-CEM cells by SRB assay
Cytotoxicity against human CCRF-CEM cells by SRB assay
[PMID: 26257861]
CCRF-CEM IC50
0.708 nM
Compound: 7; CA-4
Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 31401010]
CCRF-CEM IC50
1.9 nM
Compound: 1, CA-4
Antiproliferative activity against human CEM cells after 2 days by coulter counting
Antiproliferative activity against human CEM cells after 2 days by coulter counting
[PMID: 20579891]
CCRF-CEM IC50
1.9 nM
Compound: 1a, CA-4
Cytotoxicity against human CEM/0 cells assessed as growth inhibition after 48 hrs by coulter counting analysis
Cytotoxicity against human CEM/0 cells assessed as growth inhibition after 48 hrs by coulter counting analysis
[PMID: 24164557]
CCRF-CEM IC50
1.9 nM
Compound: 1, CA4
Cytotoxicity against human CEM cells after 2 days
Cytotoxicity against human CEM cells after 2 days
[PMID: 19736015]
CCRF-CEM IC50
1.9 nM
Compound: 1, CA-4
Antiproliferative activity against human CEM cells after 2 days
Antiproliferative activity against human CEM cells after 2 days
[PMID: 18755591]
CCRF-CEM IC50
1.9 nM
Compound: CA-4, 1
Antiproliferative effect against human CEM cells after 3 days
Antiproliferative effect against human CEM cells after 3 days
[PMID: 17419607]
CCRF-CEM IC50
12 nM
Compound: 1, CA-4
Antiproliferative activity against human CEM cells after 2 days by coulter counter method
Antiproliferative activity against human CEM cells after 2 days by coulter counter method
[PMID: 19663386]
CCRF-CEM IC50
12 nM
Compound: 1a, CA-4
Growth inhibition of human CCRF-CEM cells after 72 hrs by MTT assay
Growth inhibition of human CCRF-CEM cells after 72 hrs by MTT assay
[PMID: 25025853]
CCRF-CEM IC50
2 nM
Compound: 1; CA-4
Antiproliferative activity against human CEM cells after 3 days by Coulter counter method
Antiproliferative activity against human CEM cells after 3 days by Coulter counter method
[PMID: 29220790]
CCRF-CEM GI50
2.62 nM
Compound: CA4
Growth inhibition of human CCRF-CEM cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human CCRF-CEM cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
CEM-DNR IC50
319 nM
Compound: 7; CA-4
Cytotoxicity against human CEM/DNR cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human CEM/DNR cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 31401010]
COLO 205 IC50
0.001 μM
Compound: CA-4
Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31174062]
COLO 205 IC50
0.001 μM
Compound: CA-4
Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability by MTT assay
Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability by MTT assay
[PMID: 31362922]
COLO 205 GI50
0.025 μM
Compound: 1; CA-4
Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 27161282]
COLO 205 GI50
0.1 μM
Compound: CA4, NSC 613729
Growth inhibition of human COLO205 cells after 48 hrs by SRB assay
Growth inhibition of human COLO205 cells after 48 hrs by SRB assay
[PMID: 24387982]
COLO 205 GI50
0.1 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human COLO205 cells after 48 hrs by SRB assay
Growth inhibition of human COLO205 cells after 48 hrs by SRB assay
[PMID: 22982122]
COLO 205 GI50
0.1 μM
Compound: CA4; NSC 613729
Cytotoxicity against human COLO205 cells by SRB assay
Cytotoxicity against human COLO205 cells by SRB assay
[PMID: 26257861]
COLO 205 GI50
0.221 μM
Compound: CA-4
Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
COLO 205 GI50
100 nM
Compound: CA4
Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
COLO 205 IC50
2756 nM
Compound: combretastatin A-4
Cell growth inhibition against colo 205 human colon cancer cells using tetrazolium dye reduction (MTS) assay
Cell growth inhibition against colo 205 human colon cancer cells using tetrazolium dye reduction (MTS) assay
[PMID: 12036364]
Colon 26 IC50
0.44 μM
Compound: CA-4
Antiproliferative activity against mouse Colon 26 cells measured after 72 hrs by MTT assay
Antiproliferative activity against mouse Colon 26 cells measured after 72 hrs by MTT assay
[PMID: 27187864]
Colon 26 IC50
18 nM
Compound: Combrestatin A-4
Growth inhibition of colon 26 adenocarcinoma cells by 50 %.
Growth inhibition of colon 26 adenocarcinoma cells by 50 %.
[PMID: 9685242]
CPT30 cell line IC50
6.9 nM
Compound: CA-4
Inhibitory concentration against camptothecin (CPT) resistant cell line using tetrazolium dye reduction assay (MTT)
Inhibitory concentration against camptothecin (CPT) resistant cell line using tetrazolium dye reduction assay (MTT)
[PMID: 12467626]
CT26 IC50
45.1 nM
Compound: CA-4
Antiproliferative activity against mouse CT26 cells after 72 hrs by CCK8 assay
Antiproliferative activity against mouse CT26 cells after 72 hrs by CCK8 assay
[PMID: 30006162]
DLD-1 IC50
3.3 nM
Compound: 1, CA-4
Growth inhibition of human DLD1 cells after 48 hrs by SRB assay
Growth inhibition of human DLD1 cells after 48 hrs by SRB assay
[PMID: 24900453]
DLD-1 IC50
36 nM
Compound: combretastatin A-4
Cell growth inhibition against DLD-1 human colon cancer cells using MTS assay
Cell growth inhibition against DLD-1 human colon cancer cells using MTS assay
[PMID: 12036364]
DMS-79 IC50
124 nM
Compound: 1
Antiproliferative activity against human DMS79 cells after 72 hrs
Antiproliferative activity against human DMS79 cells after 72 hrs
[PMID: 17034133]
DU-145 GI50
0.00054 μM
Compound: 2, CA4
Cytotoxicity against human DU145 cells by SRB assay
Cytotoxicity against human DU145 cells by SRB assay
[PMID: 24016002]
DU-145 GI50
0.00054 μM
Compound: CA4
Growth inhibition of human DU145 cells by sulforhodamine B assay
Growth inhibition of human DU145 cells by sulforhodamine B assay
[PMID: 23772309]
DU-145 GI50
0.0008 μg/mL
Compound: CA4
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
[PMID: 18710804]
DU-145 GI50
0.0008 μg/mL
Compound: 1a, CA4
Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay
[PMID: 22324723]
DU-145 GI50
0.0008 μg/mL
Compound: 2a
Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay
[PMID: 19719153]
DU-145 GI50
0.0008 μg/mL
Compound: 1a, CA4
Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
[PMID: 16252907]
DU-145 GI50
0.0008 μg/mL
Compound: 3, CA4
Antitumor activity against human DU145 cells by sulforhodamine B assay
Antitumor activity against human DU145 cells by sulforhodamine B assay
[PMID: 19228038]
DU-145 GI50
0.0008 μM
Compound: CA4, combretastatin A4
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
[PMID: 18303849]
DU-145 GI50
0.001 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human DU145 cells after 48 hrs by SRB assay
Growth inhibition of human DU145 cells after 48 hrs by SRB assay
[PMID: 22982122]
DU-145 GI50
0.001 μM
Compound: 1, CA4
Cytotoxicity against human DU145 cells by SRB assay
Cytotoxicity against human DU145 cells by SRB assay
[PMID: 20496923]
DU-145 GI50
0.002 μM
Compound: CA4
Growth inhibition of human DU145 after 48 hrs by SRB assay
Growth inhibition of human DU145 after 48 hrs by SRB assay
[PMID: 18722127]
DU-145 GI50
0.00327 μM
Compound: CA4
Cytotoxicity against human DU145 cells assessed as growth inhibition measured after 48 hrs by SRB assay
Cytotoxicity against human DU145 cells assessed as growth inhibition measured after 48 hrs by SRB assay
[PMID: 31059248]
DU-145 GI50
0.00327 μM
Compound: CA4, CA4P
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
[PMID: 24183586]
DU-145 GI50
0.00484 μM
Compound: CA4
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
[PMID: 23993969]
DU-145 GI50
0.00602 μM
Compound: CA4
Cytotoxicity against human DU145 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human DU145 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
[PMID: 31534659]
DU-145 IC50
0.007 μM
Compound: 1; CA-4
Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
[PMID: 26970659]
DU-145 GI50
0.046 μM
Compound: 1; CA-4
Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 27161282]
DU-145 IC50
0.069 μM
Compound: 2A; CA-4
Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
[PMID: 28034647]
DU-145 GI50
0.07 μM
Compound: 2; CA4
Antiproliferative activity against human DU145 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human DU145 cells after 48 hrs by sulforhodamine B assay
[PMID: 27515320]
DU-145 IC50
0.12 μM
Compound: 2a; CA-4
Cytotoxicity against human DU145 cells assessed as cell viability after 48 hrs by SRB assay
Cytotoxicity against human DU145 cells assessed as cell viability after 48 hrs by SRB assay
10.1039/C5MD00155B
DU-145 GI50
0.27 μM
Compound: CA-4
Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
[PMID: 29227648]
DU-145 IC50
0.28 μM
Compound: CA-4; B
Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
[PMID: 28774575]
DU-145 GI50
2 nM
Compound: CA4
Anticancer activity against human DU145 cells after 24 hrs by SRB assay
Anticancer activity against human DU145 cells after 24 hrs by SRB assay
[PMID: 19733085]
DU-145 GI50
2.5 nM
Compound: 1, CA-4
Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
[PMID: 21920767]
DU-145 IC50
32 nM
Compound: combretastatin A-4
Cell growth inhibition against DU-145 human prostate cancer cells using MTS assay
Cell growth inhibition against DU-145 human prostate cancer cells using MTS assay
[PMID: 12036364]
DU-145 IC50
4 nM
Compound: 4, CA4
Antiproliferative activity against human DU145 after 48 hrs by spectrophotometry
Antiproliferative activity against human DU145 after 48 hrs by spectrophotometry
[PMID: 21774499]
DU-145 IC50
57 μg/mL
Compound: 1'
Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
[PMID: 17373779]
DU-145 GI50
6.02 nM
Compound: CA4
Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 26852340]
DU-145 GI50
8 x 10-4 μg/mL
Compound: Z-1b
Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
[PMID: 19709889]
DU-145 IC50
9.3 nM
Compound: 1
Antiproliferative activity against human DU145 cells after 72 hrs
Antiproliferative activity against human DU145 cells after 72 hrs
[PMID: 17034133]
EA.hy 926 IC50
0.01 μM
Compound: CA4
Cytotoxicity against human EA.hy 926 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Cytotoxicity against human EA.hy 926 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 31958738]
EA.hy 926 IC50
0.17 μM
Compound: CA-4
Growth inhibition of human EAhy926 cells measured after 72 hrs by MTT assay
Growth inhibition of human EAhy926 cells measured after 72 hrs by MTT assay
[PMID: 27187864]
EA.hy 926 IC50
11 nM
Compound: CA-4
Growth inhibition of human EAhy926 cells after 72 hrs by MTT assay
Growth inhibition of human EAhy926 cells after 72 hrs by MTT assay
[PMID: 27116710]
ECa-109 cell line IC50
4.5 μM
Compound: CA-4
Cytotoxicity against human ECA109 cells after 48 hrs by MTT assay
Cytotoxicity against human ECA109 cells after 48 hrs by MTT assay
[PMID: 19665898]
ECV-304 IC50
< 1 μg/mL
Compound: 1'
Cytotoxicity against human ECV304 cells after 72 hrs by MTT assay
Cytotoxicity against human ECV304 cells after 72 hrs by MTT assay
[PMID: 17373779]
EKVX GI50
0.079 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human EKVX cells after 48 hrs by SRB assay
Growth inhibition of human EKVX cells after 48 hrs by SRB assay
[PMID: 22982122]
EKVX GI50
0.086 μM
Compound: CA4, NSC 613729
Growth inhibition of human EKVX cells after 48 hrs by SRB assay
Growth inhibition of human EKVX cells after 48 hrs by SRB assay
[PMID: 24387982]
EKVX GI50
85.7 nM
Compound: CA4
Growth inhibition of human EKVX cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human EKVX cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
EMT6 IC50
495 nM
Compound: CA-4
Antiproliferative activity against drug resistant mouse EMT6/AR1 cells incubated for 24 hrs by sulforhodamine B assay
Antiproliferative activity against drug resistant mouse EMT6/AR1 cells incubated for 24 hrs by sulforhodamine B assay
[PMID: 26938120]
Epithelial cell IC50
10 mM
Compound: 2a
Cytotoxicity against in CD1 mouse mammary epithelial cells after 72 hrs by alamar blue dye assay
Cytotoxicity against in CD1 mouse mammary epithelial cells after 72 hrs by alamar blue dye assay
[PMID: 21080725]
FaDu IC50
1.9 nM
Compound: 1
Antiproliferative activity against human CEM cells after 72 hrs
Antiproliferative activity against human CEM cells after 72 hrs
[PMID: 17034133]
FaDu IC50
5.05 nM
Compound: CA-4
Antiproliferative activity against human FaDu cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human FaDu cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
[PMID: 35576703]
Fibroblast IC50
> 100 μM
Compound: 2, CA-4
Cytotoxicity against human fibroblast cells by alamar blue assay
Cytotoxicity against human fibroblast cells by alamar blue assay
[PMID: 22137934]
Fibroblast IC50
5.48 μM
Compound: CA-4
Growth inhibition of primary chicken fibroblasts after 48 hrs by MTT assay
Growth inhibition of primary chicken fibroblasts after 48 hrs by MTT assay
[PMID: 27116710]
FM3A IC50
0.042 μM
Compound: 1, CA-4
Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter analysis
Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter analysis
[PMID: 22027100]
FM3A IC50
42 nM
Compound: 1; CA-4
Antiproliferative activity against mouse FM3A cells after 2 days by Coulter counter method
Antiproliferative activity against mouse FM3A cells after 2 days by Coulter counter method
[PMID: 29220790]
FM3A IC50
42 nM
Compound: 1, CA-4
Antiproliferative activity against mouse FM3A cells after 2 days by coulter counting
Antiproliferative activity against mouse FM3A cells after 2 days by coulter counting
[PMID: 20579891]
FM3A IC50
42 nM
Compound: 1, CA-4
Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter method
Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter method
[PMID: 19663386]
FM3A IC50
42 nM
Compound: 1, CA4
Cytotoxicity against mouse FM3A0 cells after 2 days
Cytotoxicity against mouse FM3A0 cells after 2 days
[PMID: 19736015]
FM3A IC50
42 nM
Compound: 1, CA-4
Antiproliferative activity against mouse FM3A cells after 2 days
Antiproliferative activity against mouse FM3A cells after 2 days
[PMID: 18755591]
FM3A IC50
42 nM
Compound: CA-4, 1
Antiproliferative effect against mouse FM3A cells after 2 days
Antiproliferative effect against mouse FM3A cells after 2 days
[PMID: 17419607]
H22 IC50
0.008 μM
Compound: CA-4; 1
Antiproliferative activity against human H22 cells after 72 hrs by MTT assay
Antiproliferative activity against human H22 cells after 72 hrs by MTT assay
[PMID: 30344902]
H22 IC50
0.015 μM
Compound: 1; CA-4
Antiproliferative activity against mouse H22 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against mouse H22 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
H69AR IC50
2.5 nM
Compound: CA4
Antiproliferative activity against drug resistant H69AR cell line expressing MRP1 by Alamar Blue assay
Antiproliferative activity against drug resistant H69AR cell line expressing MRP1 by Alamar Blue assay
[PMID: 17286393]
HA22T cell line IC50
2708 nM
Compound: combretastatin A-4
Cell growth inhibition against HA22T human liver cancer cells using MTS assay
Cell growth inhibition against HA22T human liver cancer cells using MTS assay
[PMID: 12036364]
HaCaT IC50
0.0014 μM
Compound: CA-4
Antiproliferative activity against human HaCaT cells after 72 hrs by SRB assay
Antiproliferative activity against human HaCaT cells after 72 hrs by SRB assay
[PMID: 30201525]
HaCaT IC50
0.0034 μM
Compound: CA-4
Antiproliferative activity against human HaCaT cells assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay
Antiproliferative activity against human HaCaT cells assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay
[PMID: 34837817]
HaCaT IC50
0.06 μM
Compound: CA-4
Antiproliferative activity against human HaCaT cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HaCaT cells measured after 72 hrs by MTT assay
[PMID: 27187864]
HaCaT IC50
0.19 μM
Compound: 1a; CA-4
Cytotoxicity against human HaCaT cells after 48 hrs by MTT assay
Cytotoxicity against human HaCaT cells after 48 hrs by MTT assay
[PMID: 29291446]
HaCaT IC50
1 nM
Compound: cis CA-4
Antiproliferative activity against human HaCaT cells assessed as cell viability by MTT assay
Antiproliferative activity against human HaCaT cells assessed as cell viability by MTT assay
[PMID: 23063401]
HBL-100 IC50
0.003 μM
Compound: 2, CA-4
Cytotoxicity against human HBL100 cells after 72 hrs by MTT assay
Cytotoxicity against human HBL100 cells after 72 hrs by MTT assay
[PMID: 18805012]
HBL-100 IC50
3 nM
Compound: CA-4
Cytotoxicity against human HBL100 cells after 72 hrs by MTT assay
Cytotoxicity against human HBL100 cells after 72 hrs by MTT assay
[PMID: 21488686]
HCC 2998 GI50
0.063 μM
Compound: CA4, NSC 613729
Growth inhibition of human HCC2998 cells after 48 hrs by SRB assay
Growth inhibition of human HCC2998 cells after 48 hrs by SRB assay
[PMID: 24387982]
HCC 2998 GI50
0.063 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human HCC2998 cells after 48 hrs by SRB assay
Growth inhibition of human HCC2998 cells after 48 hrs by SRB assay
[PMID: 22982122]
HCC 2998 GI50
0.063 μM
Compound: CA4; NSC 613729
Cytotoxicity against human HCC2998 cells by SRB assay
Cytotoxicity against human HCC2998 cells by SRB assay
[PMID: 26257861]
HCC 2998 GI50
63.4 nM
Compound: CA4
Growth inhibition of human HCC2998 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HCC2998 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
HCT-116 IC50
0.00074 μM
Compound: CA4
Cytotoxicity against human HCT116 cells assessed as reduction of [3H]thymidine incorporation after 72 hrs by scintillation counting
Cytotoxicity against human HCT116 cells assessed as reduction of [3H]thymidine incorporation after 72 hrs by scintillation counting
[PMID: 21955454]
HCT-116 IC50
0.001 μM
Compound: CA4
Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay
[PMID: 21112130]
HCT-116 IC50
0.001 μM
Compound: CA-4
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31174062]
HCT-116 IC50
0.001 μM
Compound: CA-4
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 22676247]
HCT-116 IC50
0.001 μM
Compound: CA-4
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability by MTT assay
[PMID: 31362922]
HCT-116 IC50
0.0011 μM
Compound: CA-4
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 35635956]
HCT-116 IC50
0.002 μM
Compound: CA4
Cytotoxicity against human HCT-116 p53 mutant cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Cytotoxicity against human HCT-116 p53 mutant cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 31958738]
HCT-116 IC50
0.003 μM
Compound: CA4
Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay
[PMID: 19211248]
HCT-116 IC50
0.003 μM
Compound: CA4
Cytotoxicity against wild type human HCT-116 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Cytotoxicity against wild type human HCT-116 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 31958738]
HCT-116 GI50
0.003 μM
Compound: CA4, NSC 613729
Growth inhibition of human HCT116 cells after 48 hrs by SRB assay
Growth inhibition of human HCT116 cells after 48 hrs by SRB assay
[PMID: 24387982]
HCT-116 GI50
0.003 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human HCT116 cells after 48 hrs by SRB assay
Growth inhibition of human HCT116 cells after 48 hrs by SRB assay
[PMID: 22982122]
HCT-116 GI50
0.003 μM
Compound: CA4; NSC 613729
Cytotoxicity against human HCT116 cells by SRB assay
Cytotoxicity against human HCT116 cells by SRB assay
[PMID: 26257861]
HCT-116 GI50
0.003 μM
Compound: CA-4
Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
HCT-116 IC50
0.004 μM
Compound: CA-4
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 33581556]
HCT-116 IC50
0.004 μM
Compound: CA4
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 25462279]
HCT-116 IC50
0.0047 μM
Compound: 6a; CA-4
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay
[PMID: 34458740]
HCT-116 IC50
0.005 μM
Compound: CA-4
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31185410]
HCT-116 GI50
0.006 μM
Compound: CA-4
Antiproliferative activity against human HCT-116 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 31865012]
HCT-116 IC50
0.006 μM
Compound: CA4
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23708012]
HCT-116 IC50
0.006 μM
Compound: CA-4
Antiproliferative activity against human HCT116 cells by MTT assay
Antiproliferative activity against human HCT116 cells by MTT assay
[PMID: 29126741]
HCT-116 IC50
0.006 μM
Compound: CA-4
Anticancer activity against human HCT116 cells after 72 hrs
Anticancer activity against human HCT116 cells after 72 hrs
[PMID: 19713108]
HCT-116 IC50
0.008 μM
Compound: 1; CA-4
Antiproliferative activity against human HCT-116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells after 48 hrs by MTT assay
[PMID: 35065411]
HCT-116 IC50
0.008 μM
Compound: CA-4
Antiproliferative activity against human HCT-116 assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 34175541]
HCT-116 IC50
0.01 μM
Compound: CA-4
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 35834904]
HCT-116 IC50
0.01 μM
Compound: 2; CA-4
Antiproliferative activity against human HCT116 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
[PMID: 32912434]
HCT-116 IC50
0.029 μM
Compound: 1; CA-4
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
[PMID: 33421913]
HCT-116 IC50
0.0794 nM
Compound: 7; CA-4
Cytotoxicity against p53 deficient human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against p53 deficient human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 31401010]
HCT-116 IC50
0.11 μM
Compound: CA-4
Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTT assay
[PMID: 32035399]
HCT-116 IC50
0.232 nM
Compound: CA-4
Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTS assay
Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTS assay
[PMID: 31541870]
HCT-116 IC50
0.547 nM
Compound: 7; CA-4
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 31401010]
HCT-116 IC50
0.93 μM
Compound: CA-4
Antiproliferative activity against human HCT116 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
[PMID: 31830637]
HCT-116 IC50
1.1 μM
Compound: 1; CA-4
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay
[PMID: 35398303]
HCT-116 GI50
2 nM
Compound: 1
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 27707624]
HCT-116 GI50
2 nM
Compound: CA-4
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by resazurin dye-based fluorimetric analysis
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by resazurin dye-based fluorimetric analysis
[PMID: 24681982]
HCT-116 GI50
2 nM
Compound: 1a, CA-4
Growth inhibition of human HCT116 cells after 72 hrs by Victor microtiter plate fluorimeter analysis
Growth inhibition of human HCT116 cells after 72 hrs by Victor microtiter plate fluorimeter analysis
[PMID: 23353744]
HCT-116 GI50
2 nM
Compound: CA-4
Cytotoxicity against human HCT116 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis
Cytotoxicity against human HCT116 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis
[PMID: 22449653]
HCT-116 IC50
2 nM
Compound: CA-4
Cytotoxicity against human HCT116 cells after 72 hrs
Cytotoxicity against human HCT116 cells after 72 hrs
[PMID: 20627378]
HCT-116 GI50
2.1 nM
Compound: CA-4
Cytotoxicity against human HCT116 cells after 72 hrs by CellTitre-Blue assay
Cytotoxicity against human HCT116 cells after 72 hrs by CellTitre-Blue assay
[PMID: 25528337]
HCT-116 IC50
2.2 nM
Compound: CA-4
Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay
[PMID: 30525602]
HCT-116 IC50
2.3 nM
Compound: CA-4
Antiproliferative activity against human HCT116 cells after 72 hrs by resazurin-based fluorescence assay
Antiproliferative activity against human HCT116 cells after 72 hrs by resazurin-based fluorescence assay
[PMID: 29202409]
HCT-116 IC50
2.3 nM
Compound: CA-4
Cytotoxicity against human HCT116 cells after 72 hrs
Cytotoxicity against human HCT116 cells after 72 hrs
[PMID: 19530698]
HCT-116 GI50
2.4 nM
Compound: CA4
Antiproliferative activity against human HCT-116 cells after 72 hrs by CellTiter Glo assay
Antiproliferative activity against human HCT-116 cells after 72 hrs by CellTiter Glo assay
[PMID: 35797900]
HCT-116 GI50
2.4 nM
Compound: CA-4
Antiproliferation activity against human HCT116 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferation activity against human HCT116 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 33201714]
HCT-116 IC50
2.6 nM
Compound: 1; CA-4
Antiproliferative activity against human HCT116 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay
Antiproliferative activity against human HCT116 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay
[PMID: 33038796]
HCT-116 IC50
2.6 nM
Compound: CA-4
Growth inhibition of human HCT116 cells expressing wild type p53 after 72 hrs by MTT assay
Growth inhibition of human HCT116 cells expressing wild type p53 after 72 hrs by MTT assay
[PMID: 27116710]
HCT-116 IC50
212 nM
Compound: CA-4
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 31610375]
HCT-116 GI50
3.28 nM
Compound: CA4
Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
HCT-116 IC50
3.4 nM
Compound: CA-4
Growth inhibition of p53 null human HCT116 cells after 72 hrs by MTT assay
Growth inhibition of p53 null human HCT116 cells after 72 hrs by MTT assay
[PMID: 27116710]
HCT-116 IC50
5 nM
Compound: 2
Cytotoxicity against human HCT116 assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay
Cytotoxicity against human HCT116 assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay
[PMID: 23214452]
HCT-116 IC50
6.1 μM
Compound: 2; CA-4
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36334455]
HCT-116 IC50
6.1 μM
Compound: CA-4
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 33895499]
HCT-116 IC50
6.1 μM
Compound: CA-4
Cytotoxicity against human HCT116 cells assessed as inhibition of cell growth after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as inhibition of cell growth after 48 hrs by MTT assay
[PMID: 30448234]
HCT-116 IC50
6.1 μM
Compound: CA-4
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 28410492]
HCT-116 IC50
6.1 μM
Compound: CA-4
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 27810596]
HCT-116 IC50
6.8 nM
Compound: CA-4
Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay
[PMID: 36471625]
HCT-116 IC50
7 nM
Compound: CA-4
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 28792756]
HCT-116 IC50
9 μM
Compound: CA-4
Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 assay
Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 assay
[PMID: 30108925]
HCT-116 IC50
9.12 μM
Compound: CA-4; B
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 28774575]
HCT-15 GI50
< 0.01 μM
Compound: 1, CA-4
Growth inhibition of human HCT15 cells after 3 days by crystal violet staining
Growth inhibition of human HCT15 cells after 3 days by crystal violet staining
[PMID: 19954252]
HCT-15 IC50
0.001 μM
Compound: CA4
Antiproliferative activity against human HCT15 cells after 72 hrs by MTS assay
Antiproliferative activity against human HCT15 cells after 72 hrs by MTS assay
[PMID: 21112130]
HCT-15 GI50
0.003 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human HCT15 cells after 48 hrs by SRB assay
Growth inhibition of human HCT15 cells after 48 hrs by SRB assay
[PMID: 22982122]
HCT-15 GI50
0.004 μM
Compound: CA4, NSC 613729
Growth inhibition of human HCT15 cells after 48 hrs by SRB assay
Growth inhibition of human HCT15 cells after 48 hrs by SRB assay
[PMID: 24387982]
HCT-15 GI50
0.004 μM
Compound: CA4; NSC 613729
Cytotoxicity against human HCT15 cells by SRB assay
Cytotoxicity against human HCT15 cells by SRB assay
[PMID: 26257861]
HCT-15 GI50
0.004 μM
Compound: CA-4
Growth inhibition of human HCT15 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HCT15 cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
HCT-15 IC50
2.5 nM
Compound: CA4
Antiproliferative activity against drug resistant HCT15 cell line expressing MDR1 by Alamar Blue assay
Antiproliferative activity against drug resistant HCT15 cell line expressing MDR1 by Alamar Blue assay
[PMID: 17286393]
HCT-15 IC50
3 nM
Compound: 2
Cytotoxicity against human HCT15 cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay
Cytotoxicity against human HCT15 cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay
[PMID: 23214452]
HCT-15 IC50
3.2 nM
Compound: CA-4
Antiproliferative activity against human HCT15 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HCT15 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 31610372]
HCT-15 GI50
3.66 nM
Compound: CA4
Growth inhibition of human HCT15 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HCT15 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
HCT-15 IC50
39 nM
Compound: 2, CSA4
Cytotoxicity against human HCT15 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay
Cytotoxicity against human HCT15 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay
[PMID: 25025991]
HCT-15 IC50
8.87 μM
Compound: CA-4; B
Antiproliferative activity against human HCT15 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT15 cells after 48 hrs by MTT assay
[PMID: 28774575]
HCT-8 IC50
0.0017 μM
Compound: CA-4
Cytotoxicity against human HCT8 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human HCT8 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 27149641]
HCT-8 IC50
0.01 μM
Compound: 1; CA-4
Antiproliferative activity against human HCT8 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HCT8 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 30981112]
HCT-8 IC50
0.011 μM
Compound: 1; CA-4
Antiproliferative activity against human HCT-8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
HCT-8 IC50
0.011 μM
Compound: 1; CA-4
Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay
[PMID: 30530194]
HCT-8 IC50
0.015 μM
Compound: CA-4
Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay
[PMID: 30525584]
HCT-8 IC50
0.015 μM
Compound: CA-4; 1
Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay
[PMID: 30344902]
HCT-8 IC50
0.023 μM
Compound: CA-4
Antiproliferative activity against human HCT-8 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT-8 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34649064]
HCT-8 IC50
0.027 μM
Compound: 1; CA-4
Antiproliferative activity against human HCT8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 32853870]
HCT-8 IC50
0.087 μM
Compound: 1; CA-4
Antiproliferative activity against taxol-resistant human HCT-8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against taxol-resistant human HCT-8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
HEK293 IC50
0.01 μM
Compound: 12
Cytotoxicity against HEK293 cells after 68 hrs by MTT assay
Cytotoxicity against HEK293 cells after 68 hrs by MTT assay
[PMID: 32243160]
HEK293 IC50
1.73 μM
Compound: 1; CA-4
Antiproliferative activity against HEK293 cells after 24 hrs by SRB assay
Antiproliferative activity against HEK293 cells after 24 hrs by SRB assay
[PMID: 29268127]
HEK293 IC50
11 μM
Compound: CA-4
Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
[PMID: 33280898]
HEK293 IC50
25 μM
Compound: 1a, CoA4
Cytotoxicity against HEK293 cells assessed as growth inhibition after 3 days by MTT assay
Cytotoxicity against HEK293 cells assessed as growth inhibition after 3 days by MTT assay
[PMID: 24145138]
HEK293 IC50
25 μM
Compound: CoA4
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 25240870]
HEK293 IC50
25 μM
Compound: CA-4
Antiproliferative activity against HEK293 cells by MTT assay
Antiproliferative activity against HEK293 cells by MTT assay
[PMID: 30502686]
HEK293 IC50
25000 nM
Compound: CA-4
Antiproliferative activity against HEK293 cells after 2 days by MTT assay
Antiproliferative activity against HEK293 cells after 2 days by MTT assay
[PMID: 29432949]
HEK293 IC50
45.69 μM
Compound: 2; CA-4
Antiproliferative activity against HEK293 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against HEK293 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36334455]
HEK293 IC50
45.69 μM
Compound: CA-4
Antiproliferative activity against human HEK293 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human HEK293 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 33895499]
HEK293 IC50
45.69 μM
Compound: CA-4
Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 48 hrs by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 48 hrs by MTT assay
[PMID: 33022479]
HEK293 IC50
45.69 μM
Compound: CA-4
Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay
Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay
[PMID: 32717486]
HEK293 IC50
45.69 μM
Compound: 1; CA-4
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth by MTT assay
[PMID: 35398303]
HEK293 IC50
5.7 μg/mL
Compound: 1'
Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay
Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay
[PMID: 17373779]
HEK-293T CC50
> 300 μM
Compound: CA-4
Cytotoxicity against HEK293T cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against HEK293T cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 30041136]
HEK-293T CC50
1.44 μM
Compound: CA-4
Antiproliferative activity against human HEK293T cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HEK293T cells incubated for 48 hrs by MTT assay
[PMID: 32035399]
HEK-293T CC50
162.35 μM
Compound: CA-4
Cytotoxicity against HEK293T cells after 24 hrs by MTT assay
Cytotoxicity against HEK293T cells after 24 hrs by MTT assay
[PMID: 30606674]
HEK-293T IC50
9 μM
Compound: CA-4
Inhibition of tubulin polymerization in HEK293T cell lysate after 15 mins by spectrophotometry
Inhibition of tubulin polymerization in HEK293T cell lysate after 15 mins by spectrophotometry
10.1039/C3MD00357D
HeLa IC50
0.00051 μM
Compound: 1, CA4
Cytotoxicity against human HeLa cells by MTT assay
Cytotoxicity against human HeLa cells by MTT assay
[PMID: 19879758]
HeLa IC50
0.0009 μM
Compound: CA-4
Cytotoxicity against human HeLa cells after 72 hrs by resazurin based fluorescence assay
Cytotoxicity against human HeLa cells after 72 hrs by resazurin based fluorescence assay
[PMID: 24669888]
HeLa IC50
0.0014 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 35635956]
HeLa IC50
0.002 μM
Compound: 1, CA-4
Antiproliferative activity against human HeLa cells after 2 days by coulter counter analysis
Antiproliferative activity against human HeLa cells after 2 days by coulter counter analysis
[PMID: 22027100]
HeLa IC50
0.002 μM
Compound: CA-4, 1a
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
[PMID: 20338766]
HeLa GI50
0.0028 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
10.1039/C5MD00139K
HeLa IC50
0.0029 μM
Compound: 6a; CA-4
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay
[PMID: 34458740]
HeLa IC50
0.0029 μM
Compound: 1, CA-4
Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
[PMID: 19894742]
HeLa IC50
0.003 μM
Compound: 1; CA4
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
[PMID: 32063430]
HeLa IC50
0.003 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31185410]
HeLa IC50
0.003 μM
Compound: CA4
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
[PMID: 25462279]
HeLa IC50
0.003 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells after 72 hrs by XTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by XTT assay
[PMID: 30216850]
HeLa IC50
0.003 μM
Compound: Combretastatin A-4
Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 72 hrs by XTT assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 72 hrs by XTT assay
[PMID: 26092446]
HeLa IC50
0.003 μM
Compound: II, CA-4
Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
[PMID: 19939521]
HeLa IC50
0.003 μM
Compound: CA4
Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
[PMID: 19647439]
HeLa IC50
0.003 μM
Compound: CA4
Cytotoxicity against human HeLa cells after 72 hrs by XTT method
Cytotoxicity against human HeLa cells after 72 hrs by XTT method
[PMID: 18502133]
HeLa IC50
0.0033 μM
Compound: 1, CA-4
Antiproliferative activity against human HeLa cells expressing wild type beta3 tubulin after 48 hrs by SRB assay
Antiproliferative activity against human HeLa cells expressing wild type beta3 tubulin after 48 hrs by SRB assay
[PMID: 19894742]
HeLa IC50
0.004 μM
Compound: CA-4
Antiproliferative activity against human HeLa assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human HeLa assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 34175541]
HeLa IC50
0.004 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 33581556]
HeLa IC50
0.004 μM
Compound: 2
Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23809851]
HeLa IC50
0.004 μM
Compound: CA-4;1a
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 33550186]
HeLa IC50
0.004 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
[PMID: 30633509]
HeLa IC50
0.0042 μM
Compound: 2; CA-4
Antiproliferation activity against human HeLa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay
Antiproliferation activity against human HeLa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay
[PMID: 35339837]
HeLa IC50
0.0042 μM
Compound: 2; CA-4
Antiproliferative activity against human HeLa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay
[PMID: 35339837]
HeLa IC50
0.0047 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells measured after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells measured after 48 hrs by MTT assay
[PMID: 32717486]
HeLa IC50
0.005 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 33895499]
HeLa IC50
0.005 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells assessed as reduction in cell growth after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell growth after 48 hrs by MTT assay
[PMID: 33022479]
HeLa IC50
0.005 μM
Compound: 2A; CA-4
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 28034647]
HeLa IC50
0.005 μM
Compound: 1; CA-4
Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
[PMID: 33421913]
HeLa IC50
0.005 μM
Compound: 1; CA-4
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth by MTT assay
[PMID: 35398303]
HeLa IC50
0.007 μM
Compound: CA-4
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 35447432]
HeLa IC50
0.007 μM
Compound: CA-4
Cytotoxicity against human HeLa cells assessed as inhibition of cell growth after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell growth after 48 hrs by MTT assay
[PMID: 30448234]
HeLa IC50
0.007 μM
Compound: 2; CA-4
Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
[PMID: 32912434]
HeLa IC50
0.007 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells by MTT assay
Antiproliferative activity against human HeLa cells by MTT assay
[PMID: 29126741]
HeLa GI50
0.008 μM
Compound: 1; CA-4
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 27161282]
HeLa IC50
0.009 μM
Compound: 8; CA-4
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 72 hrs by SRB assay
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 72 hrs by SRB assay
[PMID: 34454126]
HeLa IC50
0.0093 μM
Compound: 3; CA-4
Growth inhibition of human HeLa cells incubated for 72 hrs by MTT assay
Growth inhibition of human HeLa cells incubated for 72 hrs by MTT assay
[PMID: 27172319]
HeLa IC50
0.01 μM
Compound: 1; CA-4
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 29306206]
HeLa IC50
0.012 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells measured after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells measured after 48 hrs by MTT assay
[PMID: 27721152]
HeLa IC50
0.012 μM
Compound: CA-4
Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 27149641]
HeLa IC50
0.013 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
[PMID: 29172084]
HeLa IC50
0.016 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34649064]
HeLa IC50
0.018 μM
Compound: CA-4
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
[PMID: 25192811]
HeLa IC50
0.023 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 34455231]
HeLa IC50
0.06 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
[PMID: 33280898]
HeLa GI50
0.06 μM
Compound: 2; CA4
Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay
[PMID: 27515320]
HeLa GI50
0.084 μM
Compound: Combretastatin
Antiproliferative activity against human HeLa cells after 48 hrs by SRB cell proliferation assay
Antiproliferative activity against human HeLa cells after 48 hrs by SRB cell proliferation assay
[PMID: 29089233]
HeLa GI50
0.092 μM
Compound: CA-4
Growth inhibition of human HeLa cells after 48 hrs by MTT assay
Growth inhibition of human HeLa cells after 48 hrs by MTT assay
[PMID: 30041136]
HeLa IC50
0.11 μM
Compound: 1a; CA-4
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
[PMID: 29291446]
HeLa IC50
0.15 μM
Compound: 2a; CA-4
Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by SRB assay
Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by SRB assay
10.1039/C5MD00155B
HeLa IC50
0.2 μM
Compound: 2, CSA4
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 22044164]
HeLa IC50
0.21 μM
Compound: CA-4
Anticancer activity against human HeLa cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Anticancer activity against human HeLa cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 31954880]
HeLa IC50
0.23 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 28410492]
HeLa IC50
0.24 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells after 24 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 24 hrs by MTT assay
[PMID: 30606674]
HeLa CC50
0.428 nM
Compound: CA4
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by cell titer blue assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by cell titer blue assay
[PMID: 31413794]
HeLa IC50
0.53 μM
Compound: CA-4
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
[PMID: 28803799]
HeLa IC50
1.347 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTS assay
Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTS assay
[PMID: 31541870]
HeLa EC50
1.4 nM
Compound: 5, (Z)-5, CA-4, Combretastatin A-4
Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTS assay
Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTS assay
10.1039/C0MD00095G
HeLa IC50
1.43 μM
Compound: 1; CA-4
Antiproliferative activity against human HeLa cells after 24 hrs by SRB assay
Antiproliferative activity against human HeLa cells after 24 hrs by SRB assay
[PMID: 29268127]
HeLa IC50
1.44 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells after 24 to 48 hrs by CKK8 assay
Antiproliferative activity against human HeLa cells after 24 to 48 hrs by CKK8 assay
[PMID: 25105922]
HeLa IC50
1.7 nM
Compound: 1, CA-4
Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 21696175]
HeLa IC50
1.8 nM
Compound: CA
Growth inhibition of wild type human HeLa cells after 96 hrs incubation by sulforhodamine B technique
Growth inhibition of wild type human HeLa cells after 96 hrs incubation by sulforhodamine B technique
[PMID: 24900865]
HeLa IC50
1.8 μM
Compound: CA
Growth inhibition of human HeLa cells measured after 96 hrs by sulforhodamine B assay
Growth inhibition of human HeLa cells measured after 96 hrs by sulforhodamine B assay
[PMID: 27894589]
HeLa IC50
1.9 nM
Compound: 1, CA-4
Antiproliferative activity against human HeLa cells after 2 days by coulter counting
Antiproliferative activity against human HeLa cells after 2 days by coulter counting
[PMID: 20579891]
HeLa IC50
1.9 nM
Compound: 1, CA-4
Antiproliferative activity against human HeLa cells after 2 days by coulter counter method
Antiproliferative activity against human HeLa cells after 2 days by coulter counter method
[PMID: 19663386]
HeLa IC50
1.9 nM
Compound: 1a, CA-4
Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by coulter counting analysis
Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by coulter counting analysis
[PMID: 24164557]
HeLa IC50
1.9 nM
Compound: 1, CA4
Cytotoxicity against human HeLa cells after 2 days
Cytotoxicity against human HeLa cells after 2 days
[PMID: 19736015]
HeLa IC50
10 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 32339854]
HeLa IC50
11.33 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay
Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay
[PMID: 30108925]
HeLa IC50
14.2 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay
Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay
[PMID: 30006162]
HeLa IC50
14.83 μM
Compound: CA-4
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
10.1039/C3MD00372H
HeLa IC50
2 nM
Compound: 1; CA-4
Antiproliferative activity against human HeLa cells after 4 days by Coulter counter method
Antiproliferative activity against human HeLa cells after 4 days by Coulter counter method
[PMID: 29220790]
HeLa IC50
2.1 nM
Compound: CA-4
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
[PMID: 23356786]
HeLa IC50
2.1 μM
Compound: CA-4
Antiproliferative activity against human HeLa cells by MTT assay
Antiproliferative activity against human HeLa cells by MTT assay
[PMID: 30502686]
HeLa IC50
2.2 nM
Compound: 2, CA-4
Cytotoxicity against human HeLa cells after 48 hrs by WST-8 assay
Cytotoxicity against human HeLa cells after 48 hrs by WST-8 assay
[PMID: 22727370]
HeLa IC50
2.5 nM
Compound: CA
Growth inhibition of human HeLa cells overexpressing beta-3 after 96 hrs incubation by sulforhodamine B technique
Growth inhibition of human HeLa cells overexpressing beta-3 after 96 hrs incubation by sulforhodamine B technique
[PMID: 24900865]
HeLa IC50
2.5 μM
Compound: CA
Growth inhibition of human HeLa cells over expressing beta3-tubulin measured after 96 hrs by sulforhodamine B assay
Growth inhibition of human HeLa cells over expressing beta3-tubulin measured after 96 hrs by sulforhodamine B assay
[PMID: 27894589]
HeLa IC50
2.7 μM
Compound: CA-4
Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
[PMID: 18790642]
HeLa IC50
2.78 μM
Compound: Combretastatin A-4
Antiproliferative activity against human HeLa cells incubated for 24 hrs by MTT assay
Antiproliferative activity against human HeLa cells incubated for 24 hrs by MTT assay
[PMID: 32992133]
HeLa IC50
20 nM
Compound: 2
Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23214452]
HeLa IC50
2100 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells after 2 days by MTT assay
Antiproliferative activity against human HeLa cells after 2 days by MTT assay
[PMID: 29432949]
HeLa IC50
25 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells incubated for 24 hrs by sulforhodamine B assay
Antiproliferative activity against human HeLa cells incubated for 24 hrs by sulforhodamine B assay
[PMID: 26938120]
HeLa IC50
3 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth after 72 hrs by XTT assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth after 72 hrs by XTT assay
[PMID: 33328100]
HeLa IC50
3.3 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
[PMID: 27213719]
HeLa IC50
3.3 nM
Compound: CA-4
Antiproliferative activity against multidrug resistant human HeLa cells expressing wild type beta3 tubulin after 48 hrs by SRB assay
Antiproliferative activity against multidrug resistant human HeLa cells expressing wild type beta3 tubulin after 48 hrs by SRB assay
[PMID: 27213719]
HeLa IC50
3.3 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells overexpressing betaIII-tubulin assessed as inhibition of cell growth by SRB assay
Antiproliferative activity against human HeLa cells overexpressing betaIII-tubulin assessed as inhibition of cell growth by SRB assay
[PMID: 36889150]
HeLa IC50
3.3 nM
Compound: CA-4
Antiproliferative activity against wild type human HeLa cells assessed as inhibition of cell growth by SRB assay
Antiproliferative activity against wild type human HeLa cells assessed as inhibition of cell growth by SRB assay
[PMID: 36889150]
HeLa IC50
3.3 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay
[PMID: 30297118]
HeLa IC50
3.3 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells expressing wild type beta3 tubulin after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HeLa cells expressing wild type beta3 tubulin after 48 hrs by sulforhodamine B assay
[PMID: 30297118]
HeLa IC50
3.3 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human HeLa cells after 72 hrs by sulforhodamine B assay
[PMID: 30098869]
HeLa IC50
3.3 nM
Compound: CA-4
Cytotoxicity against human HeLa cells assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
HeLa IC50
3.3 nM
Compound: CA-4
Cytotoxicity against human HeLa cells over expressing WT-beta3 assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human HeLa cells over expressing WT-beta3 assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
HeLa IC50
3.8 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 28792756]
HeLa IC50
4 nM
Compound: CA-4
Cytotoxicity against human HeLa cells expressing beta3-tubulin containing alanine residue at 227 after 72 hrs by MTS assay
Cytotoxicity against human HeLa cells expressing beta3-tubulin containing alanine residue at 227 after 72 hrs by MTS assay
[PMID: 24087857]
HeLa IC50
4 nM
Compound: 1a; CA-4
Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 31400707]
HeLa IC50
4 nM
Compound: 1a, CA-4
Growth inhibition of human HeLa cells after 72 hrs by MTT assay
Growth inhibition of human HeLa cells after 72 hrs by MTT assay
[PMID: 25025853]
HeLa IC50
4 nM
Compound: 1, CA-4
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
[PMID: 23445496]
HeLa IC50
4 nM
Compound: CA-4, 1a, 1
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
[PMID: 23117171]
HeLa IC50
4 nM
Compound: 1, CA-4
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 22578111]
HeLa IC50
4 nM
Compound: 1
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
[PMID: 22136312]
HeLa IC50
4 nM
Compound: 1, CA-4
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 21663319]
HeLa IC50
4 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
[PMID: 20420439]
HeLa IC50
4 nM
Compound: 1a, CA-4
Antiproliferative activity against human HeLa cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test
Antiproliferative activity against human HeLa cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test
[PMID: 25785605]
HeLa IC50
4.1 nM
Compound: CA-4
Cytotoxicity against human HeLa cells after 72 hrs by MTS assay
Cytotoxicity against human HeLa cells after 72 hrs by MTS assay
[PMID: 24087857]
HeLa IC50
4.7 nM
Compound: 1; CA-4
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition by MTT assay
[PMID: 33636303]
HeLa IC50
4.7 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells assessed as decrease in cell growth measured after 48 hrs by SRB method
Antiproliferative activity against human HeLa cells assessed as decrease in cell growth measured after 48 hrs by SRB method
[PMID: 33310545]
HeLa IC50
4.7 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
[PMID: 23895532]
HeLa IC50
4.7 nM
Compound: CA-4
Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 23332369]
HeLa IC50
4.7 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells by SRB assay
Antiproliferative activity against human HeLa cells by SRB assay
[PMID: 29655610]
HeLa IC50
5 μM
Compound: 2; CA-4
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36334455]
HeLa IC50
5.2 nM
Compound: CA-4
Inhibition of beta-3 tubulin (unknown origin) transfected in human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay
Inhibition of beta-3 tubulin (unknown origin) transfected in human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 23332369]
HeLa IC50
5.36 μM
Compound: Combretastatin
Antiproliferative activity in human HeLa cells assessed as reduction in cell number incubated for 48 hrs by SRB assay
Antiproliferative activity in human HeLa cells assessed as reduction in cell number incubated for 48 hrs by SRB assay
[PMID: 30108756]
HeLa IC50
5.6 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay
[PMID: 25882519]
HeLa IC50
5.7 nM
Compound: CA-4
Inhibition of beta3 tubulin overexpressed in human HeLa cells after 48 hrs by SRB assay
Inhibition of beta3 tubulin overexpressed in human HeLa cells after 48 hrs by SRB assay
[PMID: 23895532]
HeLa IC50
5.7 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells expressing wild type beta3 tubulin by SRB assay
Antiproliferative activity against human HeLa cells expressing wild type beta3 tubulin by SRB assay
[PMID: 29655610]
HeLa IC50
5.7 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells overexpressing wild type beta3 tubulin after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HeLa cells overexpressing wild type beta3 tubulin after 48 hrs by sulforhodamine B assay
[PMID: 25882519]
HeLa IC50
5.8 μM
Compound: CA 4
Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay
[PMID: 28684120]
HeLa EC50
9 nM
Compound: CA-4
Inhibition of Tubulin polymerization in human HeLa cells assessed as decrease in dynamic tyrosinated microtubules after 2 hrs by microplate reader analysis
Inhibition of Tubulin polymerization in human HeLa cells assessed as decrease in dynamic tyrosinated microtubules after 2 hrs by microplate reader analysis
[PMID: 26602281]
HeLa IC50
9.2 nM
Compound: CA-4
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 31610372]
HEp-2 IC50
0.0052 μM
Compound: CA-4, 1a
Cytotoxicity against human cisplatin-resistant Hep2 cells after 72 hrs by MTT assay
Cytotoxicity against human cisplatin-resistant Hep2 cells after 72 hrs by MTT assay
[PMID: 20338766]
HEp-2 IC50
0.0055 μM
Compound: CA-4, 1a
Cytotoxicity against human Hep2 cells after 72 hrs by MTT assay
Cytotoxicity against human Hep2 cells after 72 hrs by MTT assay
[PMID: 20338766]
HEp-2 IC50
5 μg/mL
Compound: 1'
Cytotoxicity against human Hep2 cells after 72 hrs by MTT assay
Cytotoxicity against human Hep2 cells after 72 hrs by MTT assay
[PMID: 17373779]
Hepatocyte CC50
178.32 μM
Compound: CA-4
Cytotoxicity against mouse primary hepatocytes after 24 hrs by MTT assay
Cytotoxicity against mouse primary hepatocytes after 24 hrs by MTT assay
[PMID: 30606674]
HepG2 EC50
< 0.03 μM
Compound: CA-4
Cell cycle arrest in human HepG2 cells assessed as increase in G2/M phase cells after 20 hrs by flow cytometry using propidium iodide staining
Cell cycle arrest in human HepG2 cells assessed as increase in G2/M phase cells after 20 hrs by flow cytometry using propidium iodide staining
[PMID: 19713108]
HepG2 GI50
0.002 μM
Compound: CA-4
Antiproliferative activity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 31865012]
HepG2 IC50
0.002 μM
Compound: CA-4
Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay
Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay
[PMID: 32113125]
HepG2 IC50
0.002 μM
Compound: 1; CA-4
Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
[PMID: 27919655]
HepG2 IC50
0.0021 μM
Compound: 3; CA-4
Growth inhibition of human HepG2 cells incubated for 72 hrs by MTT assay
Growth inhibition of human HepG2 cells incubated for 72 hrs by MTT assay
[PMID: 27172319]
HepG2 IC50
0.0029 μM
Compound: 6a; CA-4
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay
[PMID: 34458740]
HepG2 IC50
0.006 μM
Compound: 2; CA-4
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
[PMID: 32912434]
HepG2 IC50
0.006 μM
Compound: CA4
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23708012]
HepG2 IC50
0.006 μM
Compound: CA-4
Anticancer activity against human HepG2 cells after 72 hrs
Anticancer activity against human HepG2 cells after 72 hrs
[PMID: 19713108]
HepG2 IC50
0.007 μM
Compound: 8; CA-4
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by SRB assay
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by SRB assay
[PMID: 34454126]
HepG2 IC50
0.008 μM
Compound: CA-4
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 25192811]
HepG2 IC50
0.009 μM
Compound: CA4
Growth inhibition of human HepG2 cells after 48 hrs by MTT assay
Growth inhibition of human HepG2 cells after 48 hrs by MTT assay
[PMID: 29509413]
HepG2 IC50
0.009 μM
Compound: 2A; CA-4
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 28034647]
HepG2 IC50
0.009 μM
Compound: 1; CA-4
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 30530194]
HepG2 IC50
0.009 μM
Compound: CA-4
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay
[PMID: 33010448]
HepG2 IC50
0.01 μM
Compound: CA-4
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 34455231]
HepG2 IC50
0.01 μM
Compound: 1; CA-4
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
HepG2 IC50
0.012 μM
Compound: 1; CA-4
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 30981112]
HepG2 IC50
0.012 μM
Compound: CA-4
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 30525584]
HepG2 IC50
0.012 μM
Compound: CA-4; 2
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 30176537]
HepG2 IC50
0.023 μM
Compound: 1; CA-4
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 26970659]
HepG2 IC50
0.031 μM
Compound: 1; CA-4
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 32853870]
HepG2 GI50
0.08 μM
Compound: 2; CA4
Antiproliferative activity against human HepG2 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HepG2 cells after 48 hrs by sulforhodamine B assay
[PMID: 27515320]
HepG2 IC50
0.09 μM
Compound: CA4
Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay
[PMID: 35551039]
HepG2 IC50
0.11 μM
Compound: CA-4
Growth inhibition of human HepG2 cells measured after 72 hrs by MTT assay
Growth inhibition of human HepG2 cells measured after 72 hrs by MTT assay
[PMID: 27187864]
HepG2 IC50
0.16 μM
Compound: CA-4
Antiproliferative activity against mouse HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against mouse HepG2 cells after 48 hrs by MTT assay
[PMID: 24909678]
HepG2 IC50
0.17 μM
Compound: CA-4
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 25828827]
HepG2 GI50
0.17 μM
Compound: CA-4
Growth inhibition of human HepG2 cells after 48 hrs by MTT assay
Growth inhibition of human HepG2 cells after 48 hrs by MTT assay
[PMID: 30041136]
HepG2 IC50
0.19 μg/mL
Compound: 1, CA-4
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 21440448]
HepG2 IC50
0.19 μM
Compound: CA-4
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 22512906]
HepG2 IC50
0.19 μM
Compound: CA4
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 29396364]
HepG2 IC50
0.27 μM
Compound: CA-4
Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay
[PMID: 32035399]
HepG2 IC50
0.28 μM
Compound: 1; CA-4
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
[PMID: 33421913]
HepG2 IC50
0.33 μM
Compound: CA-4
Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay
[PMID: 30606674]
HepG2 IC50
0.39 μM
Compound: CA-4
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
[PMID: 31830637]
HepG2 IC50
0.41 μM
Compound: CA-4
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 36252396]
HepG2 IC50
0.54 μg/mL
Compound: CA-4
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 22192936]
HepG2 IC50
0.59 μM
Compound: CA-4
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
[PMID: 33280898]
HepG2 IC50
16.04 μM
Compound: CA-4
Antiproliferative activity against human HepG2 cells after 72 hrs by CCK-8 assay
Antiproliferative activity against human HepG2 cells after 72 hrs by CCK-8 assay
[PMID: 30108925]
HepG2 IC50
2.39 μM
Compound: CA4
Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
[PMID: 35964428]
HepG2 IC50
2.41 μM
Compound: CA-4
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
[PMID: 31536891]
HepG2 IC50
2.41 μM
Compound: CA-4
Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 29031074]
HepG2 IC50
3 nM
Compound: CA-4
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 31610375]
HepG2 IC50
3.45 μM
Compound: Combretastatin A-4
Antiproliferative activity against human HepG2 cells incubated for 24 hrs by MTT assay
Antiproliferative activity against human HepG2 cells incubated for 24 hrs by MTT assay
[PMID: 32992133]
HepG2 IC50
3.9 nM
Compound: CA-4
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 28792756]
HepG2 IC50
4.3 μM
Compound: CA 4
Antiproliferative activity against human HepG2 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HepG2 cells after 48 hrs by sulforhodamine B assay
[PMID: 28684120]
HepG2 IC50
5.25 μM
Compound: 1; CA-4
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth by MTT assay
[PMID: 35398303]
HepG2 IC50
5.29 μM
Compound: CA-4
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 33895499]
HepG2 IC50
5.29 μM
Compound: CA-4
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 27810596]
HepG2 GI50
6.1 nM
Compound: CA-4
Antiproliferation activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferation activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 33201714]
HepG2 IC50
7.32 μM
Compound: 133
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 34826681]
HepG2 GI50
7.4 μM
Compound: CA-4
Growth inhibition of human HepG2 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay
Growth inhibition of human HepG2 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay
[PMID: 26070164]
HK-2 IC50
116 μM
Compound: 2; CA-4
Cytotoxicity against HK-2 cells assessed as reduction in cell growth measured after 24 hrs by microplate reader analysis
Cytotoxicity against HK-2 cells assessed as reduction in cell growth measured after 24 hrs by microplate reader analysis
[PMID: 35339837]
HL-60 IC50
< 0.03 μM
Compound: CA-4
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
10.1039/C3MD00372H
HL-60 IC50
0.001 μM
Compound: CA-4;1a
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 33550186]
HL-60 IC50
0.0013 μM
Compound: CA-4
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 35635956]
HL-60 IC50
0.0019 μM
Compound: 2; CA-4
Antiproliferative activity against combretastatin A-4 resistant human HL-60 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay
Antiproliferative activity against combretastatin A-4 resistant human HL-60 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay
[PMID: 28254699]
HL-60 IC50
0.002 μM
Compound: II, CA-4
Cytotoxicity against human HL60 cells after 72 hrs by XTT assay
Cytotoxicity against human HL60 cells after 72 hrs by XTT assay
[PMID: 19939521]
HL-60 IC50
0.002 μM
Compound: CA4
Cytotoxicity against human HL60 cells after 72 hrs by XTT assay
Cytotoxicity against human HL60 cells after 72 hrs by XTT assay
[PMID: 19647439]
HL-60 IC50
0.013 μM
Compound: CA-4
Antiproliferative activity against human HL60 cells after 72 hrs by XTT assay
Antiproliferative activity against human HL60 cells after 72 hrs by XTT assay
[PMID: 30216850]
HL-60 IC50
0.013 μM
Compound: Combretastatin A-4
Cytotoxicity against human HL60 cells assessed as inhibition of cell proliferation after 72 hrs by XTT assay
Cytotoxicity against human HL60 cells assessed as inhibition of cell proliferation after 72 hrs by XTT assay
[PMID: 26092446]
HL-60 IC50
0.032 μM
Compound: CA4
Cytotoxicity against human HL60 cells after 72 hrs by XTT method
Cytotoxicity against human HL60 cells after 72 hrs by XTT method
[PMID: 18502133]
HL-60 IC50
0.1 nM
Compound: CA4
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 20731355]
HL-60 IC50
0.251 nM
Compound: CA-4
Antiproliferative activity against human HL60 cells incubated for 48 hrs by MTS assay
Antiproliferative activity against human HL60 cells incubated for 48 hrs by MTS assay
[PMID: 31541870]
HL-60 IC50
0.56 μM
Compound: CA-4
Antiproliferative activity against human HL60 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
[PMID: 31536891]
HL-60 IC50
0.56 μM
Compound: CA-4
Cytotoxicity in human HL60 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity in human HL60 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 29031074]
HL-60 IC50
1 nM
Compound: 1a; CA-4
Antiproliferative activity against human HL60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human HL60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 31400707]
HL-60 IC50
1 nM
Compound: 1, CA-4
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 23445496]
HL-60 IC50
1 nM
Compound: CA-4, 1a, 1
Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay
[PMID: 23117171]
HL-60 IC50
1 nM
Compound: 1, CA-4
Antiproliferative activity against human HL60 cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HL60 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 22578111]
HL-60 IC50
1 nM
Compound: 1
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 22136312]
HL-60 IC50
1 nM
Compound: 1, CA-4
Antiproliferative activity against human HL60 cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HL60 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 21663319]
HL-60 IC50
1 nM
Compound: CA-4
Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay
[PMID: 20420439]
HL-60 IC50
1 nM
Compound: 1a, CA-4
Antiproliferative activity against human HL60 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test
Antiproliferative activity against human HL60 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test
[PMID: 25785605]
HL-60 IC50
13 nM
Compound: CA-4
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth after 72 hrs by XTT assay
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth after 72 hrs by XTT assay
[PMID: 33328100]
HL-60 GI50
31.6 nM
Compound: 1, CA-4
Cytotoxicity against human HL60 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HL60 cells after 48 hrs by sulforhodamine B assay
[PMID: 21920767]
HL-60 IC50
4 nM
Compound: CA-4
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 20690624]
HL-60 IC50
4 μM
Compound: CA-4
Antiproliferative activity against human HL60 cells by MTT assay
Antiproliferative activity against human HL60 cells by MTT assay
[PMID: 30502686]
HL-60 IC50
4000 nM
Compound: CA-4
Antiproliferative activity against human HL60 cells after 2 days by MTT assay
Antiproliferative activity against human HL60 cells after 2 days by MTT assay
[PMID: 29432949]
HL-60(TB) GI50
0.002 μM
Compound: CA4, NSC 613729
Growth inhibition of human HL-60(TB) cells after 48 hrs by SRB assay
Growth inhibition of human HL-60(TB) cells after 48 hrs by SRB assay
[PMID: 24387982]
HL-60(TB) GI50
0.002 μM
Compound: CA4; NSC 613729
Cytotoxicity against human HL-60(TB) cells by SRB assay
Cytotoxicity against human HL-60(TB) cells by SRB assay
[PMID: 26257861]
HL-60(TB) GI50
0.002 μM
Compound: CA-4
Growth inhibition of human HL-60(TB) cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HL-60(TB) cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
HL-60(TB) GI50
2.16 nM
Compound: CA4
Growth inhibition of human HL-60(TB) cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HL-60(TB) cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
HMEC-1 IC50
3.4 μM
Compound: CA-4
Antiproliferative activity against HMEC1 cells by MTT assay
Antiproliferative activity against HMEC1 cells by MTT assay
[PMID: 30502686]
HMEC-1 IC50
3400 nM
Compound: CA-4
Antiproliferative activity against HMEC1 cells after 2 days by MTT assay
Antiproliferative activity against HMEC1 cells after 2 days by MTT assay
[PMID: 29432949]
HN-6 IC50
4.43 nM
Compound: CA-4
Antiproliferative activity against human HN-6 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HN-6 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
[PMID: 35576703]
HONE1 cell line IC50
4 nM
Compound: combretastatin A-4
Cell growth inhibition against Hone-1 human NPC cancer cells using MTS assay
Cell growth inhibition against Hone-1 human NPC cancer cells using MTS assay
[PMID: 12036364]
HONE1 cell line IC50
6.5 nM
Compound: CA-4
Inhibitory concentration against human NPC cancer cell line using tetrazolium dye reduction assay (MTT)
Inhibitory concentration against human NPC cancer cell line using tetrazolium dye reduction assay (MTT)
[PMID: 12467626]
HOP-62 GI50
0.002 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human HOP62 cells after 48 hrs by SRB assay
Growth inhibition of human HOP62 cells after 48 hrs by SRB assay
[PMID: 22982122]
HOP-62 GI50
0.002 μM
Compound: CA-4
Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
HOP-62 GI50
0.003 μM
Compound: CA4, NSC 613729
Growth inhibition of human HOP62 cells after 48 hrs by SRB assay
Growth inhibition of human HOP62 cells after 48 hrs by SRB assay
[PMID: 24387982]
HOP-62 GI50
0.003 μM
Compound: CA4; NSC 613729
Cytotoxicity against human HOP62 cells by SRB assay
Cytotoxicity against human HOP62 cells by SRB assay
[PMID: 26257861]
HOP-62 GI50
0.15 μM
Compound: 1; CA-4
Antiproliferative activity against human HOP-62 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human HOP-62 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 27161282]
HOP-62 GI50
2.65 nM
Compound: CA4
Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
HOP-92 GI50
0.002 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human HOP92 cells after 48 hrs by SRB assay
Growth inhibition of human HOP92 cells after 48 hrs by SRB assay
[PMID: 22982122]
HOP-92 GI50
0.003 μM
Compound: CA4, NSC 613729
Growth inhibition of human HOP92 cells after 48 hrs by SRB assay
Growth inhibition of human HOP92 cells after 48 hrs by SRB assay
[PMID: 24387982]
HOP-92 GI50
0.003 μM
Compound: CA4; NSC 613729
Cytotoxicity against human HOP92 cells by SRB assay
Cytotoxicity against human HOP92 cells by SRB assay
[PMID: 26257861]
HOP-92 GI50
2.73 nM
Compound: CA4
Growth inhibition of human HOP92 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HOP92 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
Hs-578T GI50
0.001 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human Hs578T cells after 48 hrs by SRB assay
Growth inhibition of human Hs578T cells after 48 hrs by SRB assay
[PMID: 22982122]
Hs-578T IC50
1.36 nM
Compound: CA-4
Cytotoxicity against human Hs578T cells after 72 hrs by MTT assay
Cytotoxicity against human Hs578T cells after 72 hrs by MTT assay
[PMID: 30472600]
HT-1080 IC50
0.0026 μM
Compound: CA-4
Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay
Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay
[PMID: 34837817]
HT-1080 IC50
0.0076 μM
Compound: 1a, CA-4
Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay
Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay
[PMID: 25233100]
HT-1080 IC50
0.008 μM
Compound: 1a, CA-4
Cytotoxicity against human HT1080 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HT1080 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 25529737]
HT-1080 IC50
0.009 μM
Compound: 1; CA-4
Cytotoxicity against human HT1080 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human HT1080 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 27994764]
HT-1080 IC50
0.01 μM
Compound: CA-4
Antiproliferative activity against human HT1080 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HT1080 cells measured after 72 hrs by MTT assay
[PMID: 27428395]
HT-1080 IC50
0.011 μM
Compound: 1a; CA-4
Anti-proliferative activity against human HT1080 cells after 72 hrs by MTT assay
Anti-proliferative activity against human HT1080 cells after 72 hrs by MTT assay
10.1039/C5MD00028A
HT-1080 IC50
0.016 μM
Compound: 2; CA-4
Antiproliferative activity against human HT1080 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HT1080 cells assessed as reduction in cell viability after 72 hrs by MTT assay
10.1039/C5MD00150A
HT-1080 IC50
0.016 μM
Compound: CA-4
Antiproliferative activity against human HT-1080 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HT-1080 cells measured after 72 hrs by MTT assay
[PMID: 31787361]
HT-1080 IC50
0.016 μM
Compound: 2; CA-4
Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay
Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay
[PMID: 30245397]
HT-1080 IC50
0.051 μM
Compound: 1; CA-4
Antiproliferative activity against human HT1080 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HT1080 cells measured after 72 hrs by MTT assay
[PMID: 30901597]
HT-1080 IC50
0.07 μM
Compound: CA4
Cytotoxicity against human HT1080 cells assessed as cell viability after 72 hrs by resazurin reduction assay
Cytotoxicity against human HT1080 cells assessed as cell viability after 72 hrs by resazurin reduction assay
[PMID: 26599530]
HT-1080 IC50
1.8 nM
Compound: CA-4
Antiproliferative activity against human HT1080 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HT1080 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
[PMID: 26069928]
HT-1080 IC50
2.2 nM
Compound: CA-4
Antiproliferative activity against human HT-1080 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HT-1080 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay
[PMID: 33472119]
HT-22 CC50
13.9 μM
Compound: CA-4
Cytotoxicity against mouse HT22 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against mouse HT22 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32832031]
HT-22 CC50
14.5 μM
Compound: CA-4
Cytotoxicity against mouse HT-22 cells measured after 48 hrs by MTT assay
Cytotoxicity against mouse HT-22 cells measured after 48 hrs by MTT assay
[PMID: 36150341]
HT-29 IC50
> 1 μM
Compound: CA-4
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay
[PMID: 34837817]
HT-29 IC50
> 10 μM
Compound: 2, CSA4
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 22044164]
HT-29 IC50
> 10000 nM
Compound: CA4
Antiproliferative activity against human HT-29 cells after 72 hrs by CellTiter Glo assay
Antiproliferative activity against human HT-29 cells after 72 hrs by CellTiter Glo assay
[PMID: 35797900]
HT-29 IC50
> 5000 nM
Compound: CA-4
Growth inhibition of combretastatin A-4 resistant human HT-29 cells after 72 hrs by MTT assay
Growth inhibition of combretastatin A-4 resistant human HT-29 cells after 72 hrs by MTT assay
[PMID: 27116710]
HT-29 IC50
> 8000 nM
Compound: 1; CA-4
Antiproliferative activity against human HT-29 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay
Antiproliferative activity against human HT-29 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay
[PMID: 33038796]
HT-29 IC50
> 8000 nM
Compound: CA-4
Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
[PMID: 30525602]
HT-29 IC50
0.001 μM
Compound: CA-4
Growth inhibition of human HT-29 cells by MTT assay
Growth inhibition of human HT-29 cells by MTT assay
[PMID: 25689111]
HT-29 IC50
0.002 μM
Compound: CA4
Cytotoxicity against human HT29 cells after 72 hrs by XTT method
Cytotoxicity against human HT29 cells after 72 hrs by XTT method
[PMID: 18502133]
HT-29 IC50
0.013 μM
Compound: CA4
Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
[PMID: 21112130]
HT-29 IC50
0.03 μM
Compound: Combretastatin A-4
Cytotoxicity against human HT-29 cells assessed as inhibition of cell proliferation after 72 hrs by XTT assay
Cytotoxicity against human HT-29 cells assessed as inhibition of cell proliferation after 72 hrs by XTT assay
[PMID: 26092446]
HT-29 IC50
0.032 μM
Compound: CA-4
Antiproliferative activity against human HT-29 cells after 72 hrs by XTT assay
Antiproliferative activity against human HT-29 cells after 72 hrs by XTT assay
[PMID: 30216850]
HT-29 IC50
0.032 μM
Compound: II, CA-4
Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay
[PMID: 19939521]
HT-29 IC50
0.032 μM
Compound: CA4
Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay
[PMID: 19647439]
HT-29 IC50
0.032 μM
Compound: CA-4
Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay
[PMID: 18790642]
HT-29 IC50
0.049 μM
Compound: 1; CA-4
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
[PMID: 26970659]
HT-29 IC50
0.05 μM
Compound: CA-4
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
[PMID: 28622907]
HT-29 IC50
0.06 μM
Compound: CA-4
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
[PMID: 29407949]
HT-29 GI50
0.1 μM
Compound: CA4, NSC 613729
Growth inhibition of human HT-29 cells after 48 hrs by SRB assay
Growth inhibition of human HT-29 cells after 48 hrs by SRB assay
[PMID: 24387982]
HT-29 GI50
0.1 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human HT-29 cells after 48 hrs by SRB assay
Growth inhibition of human HT-29 cells after 48 hrs by SRB assay
[PMID: 22982122]
HT-29 GI50
0.1 μM
Compound: CA4; NSC 613729
Cytotoxicity against human HT-29 cells by SRB assay
Cytotoxicity against human HT-29 cells by SRB assay
[PMID: 26257861]
HT-29 GI50
0.118 μM
Compound: CA-4
Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
HT-29 IC50
0.18 μM
Compound: 1, CA-4
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23566762]
HT-29 GI50
0.2 μM
Compound: CA-4
Antiproliferative activity against human HT-29 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells incubated for 48 hrs by MTT assay
[PMID: 32832031]
HT-29 GI50
0.26 μM
Compound: CA-4
Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 48 hrs by SRB assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 48 hrs by SRB assay
[PMID: 27040661]
HT-29 IC50
0.31 μM
Compound: CA-4
Antiproliferative activity against human HT29 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HT29 cells incubated for 48 hrs by MTT assay
[PMID: 32035399]
HT-29 IC50
0.4 μM
Compound: 2, CA-4
Cytotoxicity against human HT-29 cells by alamar blue assay
Cytotoxicity against human HT-29 cells by alamar blue assay
[PMID: 22137934]
HT-29 IC50
0.42 μM
Compound: CA-4
Antiproliferative activity against human HT-29 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells measured after 48 hrs by MTT assay
[PMID: 36150341]
HT-29 IC50
0.42 μM
Compound: CA4
Cytotoxicity against human HT-29 cells assessed as cell viability after 72 hrs by resazurin reduction assay
Cytotoxicity against human HT-29 cells assessed as cell viability after 72 hrs by resazurin reduction assay
[PMID: 26599530]
HT-29 IC50
0.43 μM
Compound: CA-4
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 35447432]
HT-29 IC50
0.49 μM
Compound: CA-4
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 36252396]
HT-29 IC50
0.72 μM
Compound: CA4
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 30108866]
HT-29 IC50
0.93 μM
Compound: Combretastatin A-4
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
[PMID: 30108703]
HT-29 IC50
0.93 μM
Compound: Combretastatin-A4
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
[PMID: 27487568]
HT-29 IC50
0.93 μM
Compound: 2a, CA-4
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
[PMID: 22543234]
HT-29 IC50
1 μM
Compound: CA-4
Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay
[PMID: 23810282]
HT-29 IC50
1.58 μM
Compound: CA-4
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
[PMID: 24238904]
HT-29 IC50
1.96 μM
Compound: CA-4
Antiproliferative activity against human HT29 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human HT29 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 33895499]
HT-29 IC50
1.96 μM
Compound: CA-4
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth after 48 hrs by MTT assay
[PMID: 30448234]
HT-29 IC50
1.96 μM
Compound: CA-4
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 27810596]
HT-29 IC50
1.96 μM
Compound: 1; CA-4
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth by MTT assay
[PMID: 35398303]
HT-29 IC50
1.963 μM
Compound: CA-4
Antiproliferative activity against human HT-29 cells assessed as reduction in cell growth after 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell growth after 48 hrs by MTT assay
[PMID: 33022479]
HT-29 GI50
100 nM
Compound: CA4
Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
HT-29 IC50
118 nM
Compound: 1, combretastatin A-4, CA-4
Cytotoxic activity against human HT29 cells after 72 hrs by sulforhodamine B test
Cytotoxic activity against human HT29 cells after 72 hrs by sulforhodamine B test
[PMID: 18396857]
HT-29 IC50
118 nM
Compound: 1, CA-4
Cytotoxicity against human HT29 cells by sulforhodamine B test
Cytotoxicity against human HT29 cells by sulforhodamine B test
[PMID: 18783207]
HT-29 IC50
12000 nM
Compound: 2, CA-4
Cytotoxicity against human HT-29 cells after 48 hrs by resazurin assay
Cytotoxicity against human HT-29 cells after 48 hrs by resazurin assay
[PMID: 22727370]
HT-29 IC50
130 nM
Compound: 2
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23214452]
HT-29 IC50
2.61 μM
Compound: CA-4
Antiproliferative activity against CA-4-resistant human HT-29 cells measured after 72 hrs by MTT assay
Antiproliferative activity against CA-4-resistant human HT-29 cells measured after 72 hrs by MTT assay
[PMID: 27187864]
HT-29 IC50
270 nM
Compound: CA-4
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23981529]
HT-29 IC50
3.1 μM
Compound: CA-4;1a
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 33550186]
HT-29 IC50
3.1 μM
Compound: CA-4
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
[PMID: 30633509]
HT-29 IC50
30.5 nM
Compound: CA-4
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 31610372]
HT-29 IC50
305 nM
Compound: CA-4
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by XTT assay
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by XTT assay
[PMID: 33328100]
HT-29 IC50
3100 nM
Compound: 1a; CA-4
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 31400707]
HT-29 IC50
3100 nM
Compound: 1a, CA-4
Growth inhibition of human HT-29 cells after 72 hrs by MTT assay
Growth inhibition of human HT-29 cells after 72 hrs by MTT assay
[PMID: 25025853]
HT-29 IC50
3100 nM
Compound: 1, CA-4
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
[PMID: 23445496]
HT-29 IC50
3100 nM
Compound: CA-4, 1a, 1
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
[PMID: 23117171]
HT-29 IC50
3100 nM
Compound: 1, CA-4
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 22578111]
HT-29 IC50
3100 nM
Compound: 1
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
[PMID: 22136312]
HT-29 IC50
3100 nM
Compound: 1, CA-4
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 21663319]
HT-29 IC50
3100 nM
Compound: 1a, CA-4
Antiproliferative activity against human HT-29 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test
Antiproliferative activity against human HT-29 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test
[PMID: 25785605]
HT-29 IC50
3600 nM
Compound: CA4
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
[PMID: 20731355]
HT-29 IC50
390.8 nM
Compound: CA-4
Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTT assay
[PMID: 36471625]
HT-29 IC50
4.165 μM
Compound: CA-4; D-613729
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
[PMID: 31954879]
HT-29 IC50
4.165 μM
Compound: 2; CA-4
Antiproliferative activity against combretastatin A-4 resistant human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
Antiproliferative activity against combretastatin A-4 resistant human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
[PMID: 28254699]
HT-29 IC50
4.2 μM
Compound: 1a, CoA4
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 3 days by MTT assay
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 3 days by MTT assay
[PMID: 24145138]
HT-29 IC50
4.2 μM
Compound: CoA4
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 25240870]
HT-29 IC50
4.2 μM
Compound: CA-4
Antiproliferative activity against human HT-29 cells by MTT assay
Antiproliferative activity against human HT-29 cells by MTT assay
[PMID: 30502686]
HT-29 IC50
4200 nM
Compound: CA-4
Antiproliferative activity against human HT-29 cells after 2 days by MTT assay
Antiproliferative activity against human HT-29 cells after 2 days by MTT assay
[PMID: 29432949]
HT-29 IC50
5 μg/mL
Compound: 1'
Cytotoxicity against human HT29 cells after 72 hrs by MTT assay
Cytotoxicity against human HT29 cells after 72 hrs by MTT assay
[PMID: 17373779]
HT-29 IC50
5.1 nM
Compound: CA-4
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay
[PMID: 33472119]
HT-29 IC50
538 nM
Compound: 1, CA-4
Growth inhibition of combretastatin-resistant human HT-29 cells after 48 hrs by SRB assay
Growth inhibition of combretastatin-resistant human HT-29 cells after 48 hrs by SRB assay
[PMID: 24900453]
HT-29 IC50
54 nM
Compound: 4
Antiproliferative activity against human HT29 cell line by methylene blue dye assay
Antiproliferative activity against human HT29 cell line by methylene blue dye assay
[PMID: 17034147]
HT-29 IC50
560 nM
Compound: CA-4
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
[PMID: 26069928]
HT-29 IC50
61 nM
Compound: 2, CA-4
Antiproliferative activity against human HT-29 cells after 48 hrs by SRB assay
Antiproliferative activity against human HT-29 cells after 48 hrs by SRB assay
[PMID: 21920638]
HT-29 IC50
61 nM
Compound: 1, CA-4
Antiproliferative activity against human HT-29 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HT-29 cells after 48 hrs by sulforhodamine B assay
[PMID: 21604746]
HT-29 GI50
631 nM
Compound: 1, CA-4
Cytotoxicity against human HT29 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HT29 cells after 48 hrs by sulforhodamine B assay
[PMID: 21920767]
HT-29 IC50
835 nM
Compound: 1a, CA4
Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue dye assay
Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue dye assay
[PMID: 20148562]
HT-29 IC50
87.2 nM
Compound: 1, CA4
Cytotoxicity against human HT-29 cells after 72 hrs by methylene blue assay
Cytotoxicity against human HT-29 cells after 72 hrs by methylene blue assay
[PMID: 24657567]
HT-29 IC50
94 nM
Compound: 2, CA4
Growth inhibition of human HT-29 cells after 72 hrs by methylene blue assay
Growth inhibition of human HT-29 cells after 72 hrs by methylene blue assay
[PMID: 22060033]
HT-29 IC50
94 nM
Compound: 1, CA4
Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue assay
Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue assay
[PMID: 21641700]
Huh-7 CC50
1.05 nM
Compound: CA4
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability measured after 72 hrs by cell titer blue assay
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability measured after 72 hrs by cell titer blue assay
[PMID: 31413794]
Huh-7 CC50
38.3 μM
Compound: CA4
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability measured after 24 hrs by cell titer blue assay
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability measured after 24 hrs by cell titer blue assay
[PMID: 31413794]
Huh-7 IC50
4 nM
Compound: CA-4
Antiproliferative activity against human Huh-7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human Huh-7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 32339854]
Huh-7 IC50
430 nM
Compound: CA-4
Antiproliferative activity against human HuH7 cells incubated for 24 hrs by sulforhodamine B assay
Antiproliferative activity against human HuH7 cells incubated for 24 hrs by sulforhodamine B assay
[PMID: 26938120]
HuTu80 IC50
1.37 nM
Compound: CA-4
Antiproliferative activity in human HuTu 80 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity in human HuTu 80 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 22329561]
HUVEC IC50
> 100000 nM
Compound: CA-4
Cytotoxicity against HUVEC assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against HUVEC assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 31610372]
HUVEC IC50
0.005 μM
Compound: 1, CA-4
Cytotoxicity against HUVEC after 72 hrs by crystal violet staining
Cytotoxicity against HUVEC after 72 hrs by crystal violet staining
[PMID: 19954252]
HUVEC IC50
0.005 μM
Compound: Combretastatin A-4, IODWF
Cytotoxicity against HUVEC assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against HUVEC assessed as cell viability after 48 hrs by MTT assay
[PMID: 24012378]
HUVEC IC50
0.01 μM
Compound: 1, CA-4
Vascular disrupting activity in HUVEC assessed as change in cell morphology with detachment form substrate after 1 hr by crystal violet staining-based inverted light microscopy
Vascular disrupting activity in HUVEC assessed as change in cell morphology with detachment form substrate after 1 hr by crystal violet staining-based inverted light microscopy
[PMID: 19954252]
HUVEC IC50
0.4 μM
Compound: 1, CA-4
Cytotoxicity against HUVEC after 1 hr by crystal violet staining
Cytotoxicity against HUVEC after 1 hr by crystal violet staining
[PMID: 19954252]
HUVEC EC50
0.9 nM
Compound: 5, (Z)-5, CA-4, Combretastatin A-4
Antivascular activity in growth factor-induced HUVEC after 45 hrs xCELLigence analysis
Antivascular activity in growth factor-induced HUVEC after 45 hrs xCELLigence analysis
10.1039/C0MD00095G
HUVEC IC50
0.98 μM
Compound: CA-4
Cytotoxicity against HUVEC cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Cytotoxicity against HUVEC cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 31954880]
HUVEC IC50
1 nM
Compound: 2, CSA4
Growth inhibition of HUVEC cells after 48 hrs by MTT assay
Growth inhibition of HUVEC cells after 48 hrs by MTT assay
[PMID: 22044164]
HUVEC IC50
1.7 nM
Compound: CA-4
Antiproliferative activity against HUVEC after 72 hrs by MTS assay
Antiproliferative activity against HUVEC after 72 hrs by MTS assay
[PMID: 30525602]
HUVEC EC50
1.9 nM
Compound: 5, (Z)-5, CA-4, Combretastatin A-4
Antivascular activity in growth factor-induced HUVEC after 24 hrs xCELLigence analysis
Antivascular activity in growth factor-induced HUVEC after 24 hrs xCELLigence analysis
10.1039/C0MD00095G
HUVEC IC50
2.2 nM
Compound: 1, CA-4, combretastatin
Antivascular activity against HUVEC cells assessed as cell growth inhibition measured every 30 mins for 21 hrs by xCELLigence assay
Antivascular activity against HUVEC cells assessed as cell growth inhibition measured every 30 mins for 21 hrs by xCELLigence assay
[PMID: 22304851]
HUVEC IC50
2.2 nM
Compound: 1, CA-4
Antivascular activity against HUVEC after 24 hrs by xCELLigence assays
Antivascular activity against HUVEC after 24 hrs by xCELLigence assays
[PMID: 24900453]
HUVEC IC50
2.4 nM
Compound: CA-4
Cytotoxicity against HUVEC after 48 hrs using resazurin by microplate fluorometer analysis
Cytotoxicity against HUVEC after 48 hrs using resazurin by microplate fluorometer analysis
[PMID: 22185476]
HUVEC IC50
2.5 nM
Compound: 3
Cytotoxicity against HUVEC assessed as cell viability after 4 days by MTS assay
Cytotoxicity against HUVEC assessed as cell viability after 4 days by MTS assay
[PMID: 24210503]
HUVEC EC50
3.2 nM
Compound: 5, (Z)-5, CA-4, Combretastatin A-4
Antiproliferative activity against growth factor-induced HUVEC assessed as growth inhibition after 48 hrs by MTS assay
Antiproliferative activity against growth factor-induced HUVEC assessed as growth inhibition after 48 hrs by MTS assay
10.1039/C0MD00095G
HUVEC IC50
3.34 nM
Compound: 1, CA-4
Antiproliferative activity against activated HUVECs after 48 hrs by CCK-8 assay
Antiproliferative activity against activated HUVECs after 48 hrs by CCK-8 assay
[PMID: 23360369]
HUVEC IC50
3.6 nM
Compound: 4, CA4
Antiproliferative activity against HUVEC grown in presence of growth factors after 48 hrs by spectrophotometry
Antiproliferative activity against HUVEC grown in presence of growth factors after 48 hrs by spectrophotometry
[PMID: 21774499]
HUVEC IC50
3.9 nM
Compound: 4, CA4
Antiproliferative activity against HUVEC grown in absence of growth factors after 48 hrs by spectrophotometry
Antiproliferative activity against HUVEC grown in absence of growth factors after 48 hrs by spectrophotometry
[PMID: 21774499]
HUVEC IC50
4.17 nM
Compound: 7; CA-4
Cytotoxicity against HUVEC assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against HUVEC assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 31401010]
HUVEC IC50
8.9 nM
Compound: 1, CA-4
Antiproliferative activity against quesicent HUVECs after 48 hrs by CCK-8 assay
Antiproliferative activity against quesicent HUVECs after 48 hrs by CCK-8 assay
[PMID: 23360369]
IGROV-1 GI50
0.015 μM
Compound: CA4, NSC 613729
Growth inhibition of human IGROV1 cells after 48 hrs by SRB assay
Growth inhibition of human IGROV1 cells after 48 hrs by SRB assay
[PMID: 24387982]
IGROV-1 GI50
0.015 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human IGROV1 cells after 48 hrs by SRB assay
Growth inhibition of human IGROV1 cells after 48 hrs by SRB assay
[PMID: 22982122]
IGROV-1 GI50
0.015 μM
Compound: CA4; NSC 613729
Cytotoxicity against human IGROV1 cells by SRB assay
Cytotoxicity against human IGROV1 cells by SRB assay
[PMID: 26257861]
IGROV-1 GI50
14.56 nM
Compound: CA4
Growth inhibition of human IGROV1 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human IGROV1 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
IMR-32 IC50
5.72 μM
Compound: Combretastatin
Antiproliferative activity in human IMR32 cells assessed as reduction in cell number incubated for 48 hrs by SRB assay
Antiproliferative activity in human IMR32 cells assessed as reduction in cell number incubated for 48 hrs by SRB assay
[PMID: 30108756]
Ishikawa IC50
20.1 μM
Compound: CA-4
Cytotoxicity against human Ishikawa cells after 48 hrs by MTT assay
Cytotoxicity against human Ishikawa cells after 48 hrs by MTT assay
10.1039/C3MD00372H
Jurkat IC50
0.005 μM
Compound: CA-4
Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay
Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay
[PMID: 30633509]
Jurkat IC50
5 nM
Compound: 1a, CA-4
Growth inhibition of human Jurkat cells after 72 hrs by MTT assay
Growth inhibition of human Jurkat cells after 72 hrs by MTT assay
[PMID: 25025853]
Jurkat IC50
5 nM
Compound: 1, CA-4
Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay
Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay
[PMID: 23445496]
Jurkat IC50
5 nM
Compound: CA-4, 1a, 1
Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay
Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay
[PMID: 23117171]
Jurkat IC50
5 nM
Compound: 1, CA-4
Antiproliferative activity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 22578111]
Jurkat IC50
5 nM
Compound: 1
Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay
Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay
[PMID: 22136312]
Jurkat IC50
5 nM
Compound: 1, CA-4
Antiproliferative activity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 21663319]
Jurkat IC50
5 nM
Compound: CA-4
Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay
Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay
[PMID: 20420439]
Jurkat IC50
5 nM
Compound: 1a, CA-4
Antiproliferative activity against human Jurkat cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test
Antiproliferative activity against human Jurkat cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test
[PMID: 25785605]
Jurkat E6.1 IC50
0.00608 μM
Compound: 3, CA4
Anticancer activity against human Jurkat E6-1 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay
Anticancer activity against human Jurkat E6-1 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay
[PMID: 25466200]
K562 IC50
< 0.1 μM
Compound: CA-4
Growth inhibition of human K562 cells measured after 72 hrs by MTT assay
Growth inhibition of human K562 cells measured after 72 hrs by MTT assay
[PMID: 27187864]
K562 GI50
0.002 μM
Compound: CA4, NSC 613729
Growth inhibition of human K562 cells after 48 hrs by SRB assay
Growth inhibition of human K562 cells after 48 hrs by SRB assay
[PMID: 24387982]
K562 GI50
0.002 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human K562 cells after 48 hrs by SRB assay
Growth inhibition of human K562 cells after 48 hrs by SRB assay
[PMID: 22982122]
K562 GI50
0.002 μM
Compound: CA4; NSC 613729
Cytotoxicity against human K562 cells by SRB assay
Cytotoxicity against human K562 cells by SRB assay
[PMID: 26257861]
K562 GI50
0.002 μM
Compound: CA-4
Growth inhibition of human K562 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human K562 cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
K562 IC50
0.003 μM
Compound: Combretastatin A-4
Antiproliferative activity against human K562 cells assessed as reduction in cell proliferation after 3 days by 3H-thymidine incorporation assay
Antiproliferative activity against human K562 cells assessed as reduction in cell proliferation after 3 days by 3H-thymidine incorporation assay
[PMID: 27212068]
K562 IC50
0.005 μM
Compound: CA-4
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 35926141]
K562 IC50
0.007 μM
Compound: 1; CA-4
Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
K562 IC50
0.007 μM
Compound: 1; CA-4
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
[PMID: 30530194]
K562 IC50
0.009 μM
Compound: 1; CA-4
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 32853870]
K562 IC50
0.01 μM
Compound: 1, CA-4
Cytotoxicity against human K562 cells after 5 days by MTT assay
Cytotoxicity against human K562 cells after 5 days by MTT assay
[PMID: 20708408]
K562 IC50
0.01 μM
Compound: 1, CA-4
Cytotoxicity against human K562 cells after 5 days by MTT assay
Cytotoxicity against human K562 cells after 5 days by MTT assay
[PMID: 18396050]
K562 IC50
0.011 μM
Compound: 1; CA-4
Antiproliferative activity against human K562 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 30981112]
K562 IC50
0.011 μM
Compound: CA-4
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
[PMID: 30525584]
K562 IC50
0.013 μM
Compound: CA-4
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
[PMID: 29172084]
K562 IC50
0.015 μM
Compound: CA-4; 1
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
[PMID: 30344902]
K562 IC50
0.021 μM
Compound: CA-4; 2
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
[PMID: 30176537]
K562 IC50
0.0282 nM
Compound: 7; CA-4
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 31401010]
K562 GI50
0.031 μM
Compound: 1; CA-4
Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 27161282]
K562 IC50
0.046 μM
Compound: CA-4
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
[PMID: 19665898]
K562 IC50
0.61 μM
Compound: CA-4
Antiproliferative activity against human K562 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human K562 cells incubated for 48 hrs by MTT assay
[PMID: 32035399]
K562 IC50
1 μM
Compound: 6
Cytotoxicity against human K562 cells assessed as growth inhibition after 5 days by MTT assay
Cytotoxicity against human K562 cells assessed as growth inhibition after 5 days by MTT assay
[PMID: 28143677]
K562 IC50
1.5 μM
Compound: CA-4
Inhibition of tubulin polymerization in human K562 cells by fluorometric analysis
Inhibition of tubulin polymerization in human K562 cells by fluorometric analysis
[PMID: 21342735]
K562 IC50
11.2 nM
Compound: CA-4
Antiproliferative activity against human K562 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells measured after 72 hrs by MTT assay
[PMID: 36471625]
K562 IC50
2.3 nM
Compound: 1, CA-4
Antiproliferative activity against human K562 cells by MTT assay
Antiproliferative activity against human K562 cells by MTT assay
[PMID: 23010271]
K562 GI50
2.36 nM
Compound: CA4
Growth inhibition of human K562 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human K562 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
K562 IC50
25 nM
Compound: CA4
Antiproliferative activity against imatinib-resistant human K562 cells over expressing MDR1 after 72 hrs by CellTiter Glo assay
Antiproliferative activity against imatinib-resistant human K562 cells over expressing MDR1 after 72 hrs by CellTiter Glo assay
[PMID: 35797900]
K562 IC50
3.2 μM
Compound: 2, CA4
Antiproliferative activity against human K562 cells after 5 days by MTT assay
Antiproliferative activity against human K562 cells after 5 days by MTT assay
[PMID: 19837594]
K562 IC50
3.6 nM
Compound: CA-4
Cytotoxicity against human K562 cells after 72 hrs
Cytotoxicity against human K562 cells after 72 hrs
[PMID: 19530698]
K562 IC50
4 nM
Compound: CA-4
Cytotoxicity against human K562 cells after 48 hrs by SRB assay
Cytotoxicity against human K562 cells after 48 hrs by SRB assay
[PMID: 30784885]
K562 GI50
4 nM
Compound: 1
Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 27707624]
K562 GI50
4 nM
Compound: CA-4
Cytotoxicity against human K562 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis
Cytotoxicity against human K562 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis
[PMID: 22449653]
K562 GI50
4.3 nM
Compound: CA-4
Cytotoxicity against human K562 cells after 72 hrs by CellTitre-Blue assay
Cytotoxicity against human K562 cells after 72 hrs by CellTitre-Blue assay
[PMID: 25528337]
K562 IC50
4.8 nM
Compound: CA-4
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
[PMID: 23356786]
K562 IC50
5 nM
Compound: CA-4
Antiproliferative activity against human K562 cells after 72 hrs by MTS assay
Antiproliferative activity against human K562 cells after 72 hrs by MTS assay
[PMID: 30525602]
K562 IC50
5 nM
Compound: 1, CA-4
Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 21663319]
K562 IC50
5 nM
Compound: CA-4
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
[PMID: 20420439]
K562 IC50
5.5 nM
Compound: CA4
Antiproliferative activity against human K562 cells after 72 hrs by CellTiter Glo assay
Antiproliferative activity against human K562 cells after 72 hrs by CellTiter Glo assay
[PMID: 35797900]
K562 IC50
5.5 nM
Compound: 1; CA-4
Antiproliferative activity against human K562 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay
Antiproliferative activity against human K562 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay
[PMID: 33038796]
K562 IC50
6 nM
Compound: CA-4
Antiproliferative activity against human K562 cells after 72 hrs by resazurin-based fluorescence assay
Antiproliferative activity against human K562 cells after 72 hrs by resazurin-based fluorescence assay
[PMID: 29202409]
K562 IC50
6.15 μM
Compound: CA-4
Antiproliferative activity against drug resistant human K562 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against drug resistant human K562 cells incubated for 48 hrs by MTT assay
[PMID: 32035399]
K562 IC50
610 nM
Compound: 1; CA-4
Antiproliferative activity against human K562 cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity against human K562 cells assessed as cell growth inhibition by MTT assay
[PMID: 33636303]
K562/VCR IC50
0.057 μM
Compound: 1; CA-4
Antiproliferative activity against VCR resistant human K562/VCR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against VCR resistant human K562/VCR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
K562/VCR IC50
0.057 μM
Compound: 1; CA-4
Antiproliferative activity against human VCR-resistant K562/VCR cells after 72 hrs by MTT assay
Antiproliferative activity against human VCR-resistant K562/VCR cells after 72 hrs by MTT assay
[PMID: 30530194]
K-562R IC50
23 nM
Compound: CA-4
Antiproliferative activity against human K562R cells after 72 hrs by resazurin-based fluorescence assay
Antiproliferative activity against human K562R cells after 72 hrs by resazurin-based fluorescence assay
[PMID: 29202409]
K-562R IC50
25 nM
Compound: 1; CA-4
Antiproliferative activity against human K562R cells assessed as cell viability after 24 hrs by Celltiter-Glo assay
Antiproliferative activity against human K562R cells assessed as cell viability after 24 hrs by Celltiter-Glo assay
[PMID: 33038796]
K-562R IC50
25 nM
Compound: CA-4
Antiproliferative activity against human K562R cells after 72 hrs by MTS assay
Antiproliferative activity against human K562R cells after 72 hrs by MTS assay
[PMID: 30525602]
KB IC50
< 1 μg/mL
Compound: 1'
Cytotoxicity against human KB cells after 72 hrs by MTT assay
Cytotoxicity against human KB cells after 72 hrs by MTT assay
[PMID: 17373779]
KB GI50
0.0036 μM
Compound: CA-4
Antiproliferative activity against human KB cells assessed as cell growth inhibition by SRB assay
Antiproliferative activity against human KB cells assessed as cell growth inhibition by SRB assay
[PMID: 26242242]
KB IC50
0.007 μM
Compound: CA-4
Antiproliferative activity against human KB cells measured after 72 hrs by MTT assay
Antiproliferative activity against human KB cells measured after 72 hrs by MTT assay
[PMID: 27428395]
KB IC50
0.011 μM
Compound: 1; CA-4
Antiproliferative activity against human KB cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human KB cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 30981112]
KB IC50
0.011 μM
Compound: 1; CA-4
Antiproliferative activity against human KB cells after 72 hrs by MTT assay
Antiproliferative activity against human KB cells after 72 hrs by MTT assay
[PMID: 30530194]
KB IC50
0.012 μM
Compound: CA-4
Antiproliferative activity against human KB cells after 72 hrs by MTT assay
Antiproliferative activity against human KB cells after 72 hrs by MTT assay
[PMID: 30525584]
KB IC50
0.012 μM
Compound: CA-4; 1
Antiproliferative activity against human KB cells after 72 hrs by MTT assay
Antiproliferative activity against human KB cells after 72 hrs by MTT assay
[PMID: 30344902]
KB IC50
0.013 μM
Compound: 1a, CA-4
Cytotoxicity against human KB cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human KB cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 25529737]
KB IC50
0.013 μM
Compound: 1a, CA-4
Antiproliferative activity against human KB cells after 72 hrs by MTT assay
Antiproliferative activity against human KB cells after 72 hrs by MTT assay
[PMID: 25233100]
KB IC50
0.016 μM
Compound: 1a; CA-4
Anti-proliferative activity against human KB cells after 72 hrs by MTT assay
Anti-proliferative activity against human KB cells after 72 hrs by MTT assay
10.1039/C5MD00028A
KB IC50
0.25 μM
Compound: 1; CA-4
Antiproliferative activity against human KB cells measured after 72 hrs by MTT assay
Antiproliferative activity against human KB cells measured after 72 hrs by MTT assay
[PMID: 30901597]
KB IC50
1.5 nM
Compound: 4
Antiproliferative activity against human KB cell line by methylene blue dye assay
Antiproliferative activity against human KB cell line by methylene blue dye assay
[PMID: 17034147]
KB IC50
2 nM
Compound: 2, CA4
Growth inhibition of human KB cells after 72 hrs by methylene blue assay
Growth inhibition of human KB cells after 72 hrs by methylene blue assay
[PMID: 22060033]
KB IC50
2 nM
Compound: 1, CA4
Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay
Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay
[PMID: 21641700]
KB IC50
2.2 nM
Compound: 1, CA4
Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay
Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay
[PMID: 18588280]
KB IC50
2.4 nM
Compound: 1a, CA4
Antiproliferative activity against human KB cells after 72 hrs by methylene blue dye assay
Antiproliferative activity against human KB cells after 72 hrs by methylene blue dye assay
[PMID: 20148562]
KB IC50
2.5 nM
Compound: 1, CA4
Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay
Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay
[PMID: 26160020]
KB IC50
2.5 nM
Compound: 1, CA4
Cytotoxicity against human KB cells after 72 hrs by methylene blue assay
Cytotoxicity against human KB cells after 72 hrs by methylene blue assay
[PMID: 24657567]
KB GI50
3.6 nM
Compound: CA-4
Antiproliferative activity against human KB cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human KB cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
[PMID: 34917259]
KB GI50
3.6 nM
Compound: CA-4
Antiproliferative activity against human KB cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Antiproliferative activity against human KB cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
[PMID: 31938468]
KB IC50
6 nM
Compound: CA-4
Cytotoxicity against vincristine-resistant human KB cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against vincristine-resistant human KB cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23981529]
KB IC50
6.2 nM
Compound: CA-4
Inhibitory concentration against human oral cancer cell line (KB) using tetrazolium dye reduction assay (MTT)
Inhibitory concentration against human oral cancer cell line (KB) using tetrazolium dye reduction assay (MTT)
[PMID: 12467626]
KB IC50
7 nM
Compound: CA-4
Inhibitory concentration against taxol resistant cell line (KBs5) at a concentration of 50 nM using tetrazolium dye reduction assay (MTT)
Inhibitory concentration against taxol resistant cell line (KBs5) at a concentration of 50 nM using tetrazolium dye reduction assay (MTT)
[PMID: 12467626]
KB IC50
7.3 nM
Compound: CA-4
Inhibitory concentration against camptothecin (CPT) resistant cell line (KB-100) using tetrazolium dye reduction assay (MTT)
Inhibitory concentration against camptothecin (CPT) resistant cell line (KB-100) using tetrazolium dye reduction assay (MTT)
[PMID: 12467626]
KB IC50
7.9 nM
Compound: CA-4
Inhibitory concentration against VP16 resistant cell line (KB-7D) using tetrazolium dye reduction assay (MTT)
Inhibitory concentration against VP16 resistant cell line (KB-7D) using tetrazolium dye reduction assay (MTT)
[PMID: 12467626]
KB IC50
8 nM
Compound: CA-4
Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23981529]
KB IC50
9.5 nM
Compound: CA-4
Inhibitory concentration against vincristine-resistant cell line (KB-Vin 10) using tetrazolium dye reduction assay (MTT)
Inhibitory concentration against vincristine-resistant cell line (KB-Vin 10) using tetrazolium dye reduction assay (MTT)
[PMID: 12467626]
KB 3-1 IC50
0.01 μM
Compound: 12
Cytotoxicity against human KB3-1 cells after 68 hrs by MTT assay
Cytotoxicity against human KB3-1 cells after 68 hrs by MTT assay
[PMID: 32243160]
KB-V1 IC50
0.004 μM
Compound: CA4
Cytotoxicity against multidrug resistant human KB-V1 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Cytotoxicity against multidrug resistant human KB-V1 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 31958738]
KB-V1 IC50
0.4 nM
Compound: CA4
Cytotoxicity against human vinblastine-resistant KBV1 cells after 72 hrs by MTT assay
Cytotoxicity against human vinblastine-resistant KBV1 cells after 72 hrs by MTT assay
[PMID: 20731355]
KM12 GI50
0.005 μM
Compound: CA4, NSC 613729
Growth inhibition of human KM12 cells after 48 hrs by SRB assay
Growth inhibition of human KM12 cells after 48 hrs by SRB assay
[PMID: 24387982]
KM12 GI50
0.005 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human KM12 cells after 48 hrs by SRB assay
Growth inhibition of human KM12 cells after 48 hrs by SRB assay
[PMID: 22982122]
KM12 GI50
0.005 μM
Compound: CA4; NSC 613729
Cytotoxicity against human KM12 cells by SRB assay
Cytotoxicity against human KM12 cells by SRB assay
[PMID: 26257861]
KM12 GI50
4.99 nM
Compound: CA4
Growth inhibition of human KM12 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human KM12 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
KM-20L2 GI50
0.061 μg/mL
Compound: 1a, CA4
Growth inhibition of human KM20L2 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human KM20L2 cells after 48 hrs by sulforhodamine B assay
[PMID: 22324723]
KM-20L2 GI50
0.061 μg/mL
Compound: 1a, CA4
Cytotoxicity against human KM20L2 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human KM20L2 cells after 48 hrs by sulforhodamine B assay
[PMID: 16252907]
KM-20L2 GI50
0.34 μg/mL
Compound: 2a
Growth inhibition of human KM20L2 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human KM20L2 cells after 48 hrs by sulforhodamine B assay
[PMID: 19719153]
KM-20L2 GI50
0.34 μg/mL
Compound: Z-1b
Cytotoxicity against human KM20L2 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human KM20L2 cells after 48 hrs by sulforhodamine B assay
[PMID: 19709889]
KM-20L2 GI50
0.34 μg/mL
Compound: 3, CA4
Antitumor activity against human KM20L2 cells by sulforhodamine B assay
Antitumor activity against human KM20L2 cells by sulforhodamine B assay
[PMID: 19228038]
KM-20L2 GI50
0.34 μM
Compound: CA4, combretastatin A4
Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay
Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay
[PMID: 18303849]
KYSE-150 cell line IC50
0.6 μM
Compound: 1; CA4
Antiproliferative activity against human KYSE-150 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human KYSE-150 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
[PMID: 32063430]
KYSE-450 IC50
0.012 μM
Compound: CA-4
Antiproliferative activity against human KYSE-450 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human KYSE-450 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 35834904]
L02 IC50
0.0103 μM
Compound: CA-4
Antiproliferative activity against human L-O2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human L-O2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34428056]
L02 IC50
0.046 μM
Compound: 1; CA-4
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
L02 IC50
0.046 μM
Compound: 1; CA-4
Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay
Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay
[PMID: 30530194]
L02 IC50
0.095 μM
Compound: 1; CA-4
Cytotoxicity against human LO2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human LO2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 30981112]
L02 IC50
0.095 μM
Compound: CA-4
Cytotoxicity against human LO2 cells after 72 hrs by MTT assay
Cytotoxicity against human LO2 cells after 72 hrs by MTT assay
[PMID: 30525584]
L02 IC50
0.095 μM
Compound: CA-4; 1
Cytotoxicity against human LO2 cells after 72 hrs by MTT assay
Cytotoxicity against human LO2 cells after 72 hrs by MTT assay
[PMID: 30344902]
L02 IC50
0.18 μM
Compound: CA4
Antiproliferative activity against human L02 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human L02 cells measured after 48 hrs by MTT assay
[PMID: 35551039]
L02 CC50
0.36 μM
Compound: CA-4
Antiproliferative activity against human LO2 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human LO2 cells incubated for 48 hrs by MTT assay
[PMID: 32035399]
L02 IC50
1.71 μM
Compound: CA-4
Cytotoxicity against human LO2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Cytotoxicity against human LO2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
[PMID: 31830637]
L02 IC50
3.27 μM
Compound: CA-4
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 36252396]
L02 GI50
332.6 nM
Compound: CA-4
Cytotoxicity against human L02 cells assessed as assessed as cell growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 33201714]
L1210 IC50
0.002 μM
Compound: 1, CA-4
Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay
Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay
[PMID: 18226429]
L1210 IC50
0.003 μM
Compound: 1, CA-4
Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter analysis
Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter analysis
[PMID: 22027100]
L1210 IC50
0.003 μM
Compound: 2, CA-4
Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay
Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay
[PMID: 21524832]
L1210 IC50
2.3 nM
Compound: 2, CA4
Antiproliferative activity against mouse L1210 cells after 5 days by MTT assay
Antiproliferative activity against mouse L1210 cells after 5 days by MTT assay
[PMID: 19837594]
L1210 IC50
2.8 nM
Compound: 1, CA-4
Antiproliferative activity against mouse L1210 cells after 2 days by coulter counting
Antiproliferative activity against mouse L1210 cells after 2 days by coulter counting
[PMID: 20579891]
L1210 IC50
2.8 nM
Compound: 1, CA-4
Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter method
Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter method
[PMID: 19663386]
L1210 IC50
2.8 nM
Compound: 1a, CA-4
Cytotoxicity against mouse L1210 cells assessed as growth inhibition after 48 hrs by coulter counting analysis
Cytotoxicity against mouse L1210 cells assessed as growth inhibition after 48 hrs by coulter counting analysis
[PMID: 24164557]
L1210 IC50
2.8 nM
Compound: 1, CA4
Cytotoxicity against mouse L1210 cells after 2 days
Cytotoxicity against mouse L1210 cells after 2 days
[PMID: 19736015]
L1210 IC50
2.8 nM
Compound: 1, CA-4
Antiproliferative activity against mouse L1210 cells after 2 days
Antiproliferative activity against mouse L1210 cells after 2 days
[PMID: 18755591]
L1210 IC50
3 nM
Compound: 1; CA-4
Antiproliferative activity against mouse L1210 cells after 2 days by Coulter counter method
Antiproliferative activity against mouse L1210 cells after 2 days by Coulter counter method
[PMID: 29220790]
L132 IC50
< 1 μg/mL
Compound: 1'
Cytotoxicity against human L132 cells after 72 hrs by MTT assay
Cytotoxicity against human L132 cells after 72 hrs by MTT assay
[PMID: 17373779]
L929 IC50
0.82 μM
Compound: 2; CA-4
Antiproliferative activity against mouse L929 cells after 72 hrs by MTT assay
Antiproliferative activity against mouse L929 cells after 72 hrs by MTT assay
[PMID: 30245397]
LoVo IC50
0.017 μM
Compound: CA-4
Antiproliferative activity against human LoVo cells measured after 48 hrs by MTT assay
Antiproliferative activity against human LoVo cells measured after 48 hrs by MTT assay
[PMID: 27721152]
LoVo IC50
2.4 nM
Compound: CA-4
Antiproliferative activity against human LoVo cells after 48 hrs by MTT assay
Antiproliferative activity against human LoVo cells after 48 hrs by MTT assay
[PMID: 28792756]
LoVo IC50
2.9 nM
Compound: 4, CA4
Antiproliferative activity against human LoVo after 48 hrs by spectrophotometry
Antiproliferative activity against human LoVo after 48 hrs by spectrophotometry
[PMID: 21774499]
LOX IMVI GI50
0.003 μM
Compound: CA4, NSC 613729
Growth inhibition of human LOXIMVI cells after 48 hrs by SRB assay
Growth inhibition of human LOXIMVI cells after 48 hrs by SRB assay
[PMID: 24387982]
LOX IMVI GI50
0.003 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human LOXIMVI cells after 48 hrs by SRB assay
Growth inhibition of human LOXIMVI cells after 48 hrs by SRB assay
[PMID: 22982122]
LOX IMVI GI50
0.003 μM
Compound: CA4; NSC 613729
Cytotoxicity against human LOXIMVI cells by SRB assay
Cytotoxicity against human LOXIMVI cells by SRB assay
[PMID: 26257861]
LOX IMVI GI50
3.25 nM
Compound: CA4
Growth inhibition of human LOXIMVI cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human LOXIMVI cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
M14 GI50
0.002 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human M14 cells after 48 hrs by SRB assay
Growth inhibition of human M14 cells after 48 hrs by SRB assay
[PMID: 22982122]
M14 GI50
0.003 μM
Compound: CA4, NSC 613729
Growth inhibition of human M14 cells after 48 hrs by SRB assay
Growth inhibition of human M14 cells after 48 hrs by SRB assay
[PMID: 24387982]
M14 GI50
0.003 μM
Compound: CA4; NSC 613729
Cytotoxicity against human M14 cells by SRB assay
Cytotoxicity against human M14 cells by SRB assay
[PMID: 26257861]
M14 GI50
2.78 nM
Compound: CA4
Growth inhibition of human M14 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human M14 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
M21 IC50
0.0019 μM
Compound: CA-4
Antiproliferative activity against human M21 cells assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay
Antiproliferative activity against human M21 cells assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay
[PMID: 34837817]
M21 IC50
1.6 nM
Compound: CA-4
Antiproliferative activity against human M21 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human M21 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
[PMID: 26069928]
M21 IC50
2.2 nM
Compound: CA-4
Antiproliferative activity against human M21 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human M21 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay
[PMID: 33472119]
M21 IC50
4.3 nM
Compound: 2, CA-4
Antiproliferative activity against human M21 cells after 48 hrs by SRB assay
Antiproliferative activity against human M21 cells after 48 hrs by SRB assay
[PMID: 21920638]
M21 IC50
4.3 nM
Compound: 1, CA-4
Antiproliferative activity against human M21 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human M21 cells after 48 hrs by sulforhodamine B assay
[PMID: 21604746]
Malme-3M GI50
0.019 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human MALME-3M cells after 48 hrs by SRB assay
Growth inhibition of human MALME-3M cells after 48 hrs by SRB assay
[PMID: 22982122]
Malme-3M GI50
0.02 μM
Compound: CA4, NSC 613729
Growth inhibition of human MALME-3M cells after 48 hrs by SRB assay
Growth inhibition of human MALME-3M cells after 48 hrs by SRB assay
[PMID: 24387982]
Malme-3M GI50
19.5 nM
Compound: CA4
Growth inhibition of human MALME-3M cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human MALME-3M cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
MC-38 IC50
0.08 μM
Compound: CA-4
Antiproliferative activity against mouse MC38 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
Antiproliferative activity against mouse MC38 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
[PMID: 33280898]
MCF-10A GI50
< 1 x 10-6 μM
Compound: CA-4
Growth inhibition of human MCF10A cells after 72 hrs by MTT assay
Growth inhibition of human MCF10A cells after 72 hrs by MTT assay
[PMID: 28284864]
MCF-10A IC50
0.0016 μM
Compound: 1
Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 96 hrs by MTT assay
Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 96 hrs by MTT assay
[PMID: 30935796]
MCF-10A IC50
0.099 μM
Compound: CA-4
Antiproliferative activity against human MCF-10A cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF-10A cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34428056]
MCF-10A IC50
1.17 μM
Compound: CA-4
Antiproliferative activity against human MCF10A cells measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF10A cells measured after 72 hrs by MTT assay
[PMID: 27187864]
MCF7 IC50
0.002 μM
Compound: 1
Antiproliferative activity against ER positive human MCF7 cells expressing low level of CYP assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against ER positive human MCF7 cells expressing low level of CYP assessed as reduction in cell viability measured after 96 hrs by MTT assay
[PMID: 30935796]
MCF7 IC50
0.002 μM
Compound: 1
Antiproliferative activity against TCCD-induced ER positive human MCF7 cells expressing CYP1A1 assessed as reduction in cell viability after 96 hrs by MTT assay
Antiproliferative activity against TCCD-induced ER positive human MCF7 cells expressing CYP1A1 assessed as reduction in cell viability after 96 hrs by MTT assay
[PMID: 30935796]
MCF7 IC50
0.0021 μM
Compound: CA-4
Antiproliferative activity against CYP1A1 expressing human MCF7 cells after 72 hrs by SRB assay
Antiproliferative activity against CYP1A1 expressing human MCF7 cells after 72 hrs by SRB assay
[PMID: 30201525]
MCF7 IC50
0.0024 μM
Compound: 1, CA4
Cytotoxicity against human MCF7 cells by MTT assay
Cytotoxicity against human MCF7 cells by MTT assay
[PMID: 19879758]
MCF7 IC50
0.0025 μM
Compound: Combretastatin A-4, IODWF
Antiproliferative activity against human MCF7 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 24012378]
MCF7 IC50
0.003 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay
[PMID: 32113125]
MCF7 IC50
0.0031 μM
Compound: CA-4
Antiproliferative activity against human MCF7/ADR cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7/ADR cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34428056]
MCF7 IC50
0.0031 μM
Compound: 2, CA-4
Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 72 hrs by MTT assay
[PMID: 20933304]
MCF7 IC50
0.0035 μM
Compound: 2; CA-4
Antiproliferative activity against combretastatin A-4 resistant human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay
Antiproliferative activity against combretastatin A-4 resistant human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay
[PMID: 28254699]
MCF7 IC50
0.0039 μM
Compound: 2; CA-4
Antiproliferative activity against human MCF7 cells assessed as cell viability pre-incubated for 24 hrs with CO2 followed by compound addition after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell viability pre-incubated for 24 hrs with CO2 followed by compound addition after 72 hrs by MTT assay
[PMID: 26680364]
MCF7 IC50
0.004 μM
Compound: CA-4; D-613729
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
[PMID: 31954879]
MCF7 IC50
0.004 μM
Compound: 1, CA-4
Cytotoxicity against human MCF7 cells after 3 days
Cytotoxicity against human MCF7 cells after 3 days
[PMID: 24139940]
MCF7 IC50
0.0048 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34428056]
MCF7 IC50
0.005 μM
Compound: 4, CA-4
Antiproliferative activity against ER expressing human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against ER expressing human MCF7 cells after 72 hrs by MTT assay
[PMID: 21840628]
MCF7 IC50
0.005 μM
Compound: 1; CA-4
Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay
[PMID: 27919655]
MCF7 GI50
0.005 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human MCF7 cells after 48 hrs by SRB assay
Growth inhibition of human MCF7 cells after 48 hrs by SRB assay
[PMID: 22982122]
MCF7 IC50
0.0052 μM
Compound: 2a
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 21080725]
MCF7 IC50
0.006 μM
Compound: CA-4
Cytotoxicity against human MCF7 cells after 96 hrs by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 96 hrs by sulforhodamine B assay
[PMID: 23810282]
MCF7 IC50
0.009 μM
Compound: CA-4
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 35447432]
MCF7 IC50
0.01 μM
Compound: CA4
Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
[PMID: 32731188]
MCF7 IC50
0.01 μM
Compound: CA-4
Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 34175541]
MCF7 IC50
0.011 μM
Compound: 8; CA-4
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by SRB assay
[PMID: 34454126]
MCF7 IC50
0.0125 μM
Compound: 3; CA-4
Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay
Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay
[PMID: 27172319]
MCF7 IC50
0.013 μM
Compound: CA-4
Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 27149641]
MCF7 IC50
0.013 μM
Compound: CSA-4
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 21036623]
MCF7 IC50
0.013 μM
Compound: CSA-4
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 20493717]
MCF7 GI50
0.018 μM
Compound: CA-4
Growth inhibition of human MCF7 cells after 3 days by MTT assay
Growth inhibition of human MCF7 cells after 3 days by MTT assay
[PMID: 27031215]
MCF7 IC50
0.019 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 34455231]
MCF7 GI50
0.025 μM
Compound: CA-4
Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 48 hrs by SRB assay
[PMID: 27040661]
MCF7 GI50
0.026 μM
Compound: CA4
Growth inhibition of MCF7 cells after 48 hrs
Growth inhibition of MCF7 cells after 48 hrs
[PMID: 17360188]
MCF7 IC50
0.029 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34649064]
MCF7 IC50
0.029 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells measured after 48 hrs by MTT assay
[PMID: 27721152]
MCF7 IC50
0.029 μM
Compound: CA4
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23708012]
MCF7 IC50
0.03 μM
Compound: CA-4
Anticancer activity against human MCF7 cells after 72 hrs
Anticancer activity against human MCF7 cells after 72 hrs
[PMID: 19713108]
MCF7 IC50
0.032 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells after 24 hrs by SRB assay
Antiproliferative activity against human MCF7 cells after 24 hrs by SRB assay
[PMID: 20006519]
MCF7 IC50
0.032 μM
Compound: Combretastatin A-4
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
[PMID: 32302879]
MCF7 GI50
0.033 μM
Compound: 1; CA-4
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 27161282]
MCF7 IC50
0.034 μM
Compound: 1; CA-4
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
[PMID: 33421913]
MCF7 IC50
0.04 μM
Compound: CA-4
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by MTT assay
[PMID: 33010448]
MCF7 IC50
0.041 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth after 48 hrs by MTT assay
[PMID: 33022479]
MCF7 IC50
0.041 μM
Compound: 1; CA4
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
[PMID: 32063430]
MCF7 IC50
0.041 μM
Compound: CA-4
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth after 48 hrs by MTT assay
[PMID: 30448234]
MCF7 IC50
0.041 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 28410492]
MCF7 IC50
0.042 μM
Compound: CA4
Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by resazurin reduction assay
Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by resazurin reduction assay
[PMID: 26599530]
MCF7 IC50
0.043 μM
Compound: 2A; CA-4
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 28034647]
MCF7 IC50
0.046 μM
Compound: 1; CA-4
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 26970659]
MCF7 IC50
0.072 μM
Compound: CA-4
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 25192811]
MCF7 IC50
0.09 μM
Compound: 12
Cytotoxicity against human MCF7 cells after 68 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 68 hrs by MTT assay
[PMID: 32243160]
MCF7 IC50
0.098 μM
Compound: 2
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23809851]
MCF7 IC50
0.12 μM
Compound: CA4
Antiproliferative activity against human MCF7 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells measured after 48 hrs by MTT assay
[PMID: 35551039]
MCF7 IC50
0.12 μM
Compound: CA-4
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 28803046]
MCF7 IC50
0.134 μM
Compound: 2a; CA-4
Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by SRB assay
10.1039/C5MD00155B
MCF7 IC50
0.14 μM
Compound: 6a; CA-4
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay
[PMID: 34458740]
MCF7 GI50
0.14 μM
Compound: CA-4
Growth inhibition of human MCF7 cells after 48 hrs by MTT assay
Growth inhibition of human MCF7 cells after 48 hrs by MTT assay
[PMID: 30041136]
MCF7 IC50
0.17 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells measured after 48 hrs by MTT assay
[PMID: 32717486]
MCF7 IC50
0.17 μM
Compound: 1a; CA-4
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 29291446]
MCF7 IC50
0.18 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
[PMID: 30606674]
MCF7 IC50
0.18 μM
Compound: Combretastatin A-4
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 30108703]
MCF7 IC50
0.18 μM
Compound: Combretastatin-A4
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 27487568]
MCF7 IC50
0.18 μM
Compound: 2a, CA-4
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 22543234]
MCF7 IC50
0.2 μM
Compound: 1
Cytotoxicity against human MCF7 cells after 72 hrs by MTS/PMS assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTS/PMS assay
[PMID: 30230828]
MCF7 IC50
0.21 μg/mL
Compound: 2, CA-4
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 24916028]
MCF7 IC50
0.21 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 25703297]
MCF7 IC50
0.25 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
[PMID: 32035399]
MCF7 IC50
0.31 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 25828827]
MCF7 IC50
0.31 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 24909678]
MCF7 IC50
0.37 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
[PMID: 31536891]
MCF7 IC50
0.4 μM
Compound: 1, CA-4
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23566762]
MCF7 IC50
0.41 μg/mL
Compound: CA-4
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 22261027]
MCF7 IC50
0.41 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 22512906]
MCF7 IC50
0.42 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 34311158]
MCF7 IC50
0.43 μg/mL
Compound: CA-4
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 22503741]
MCF7 IC50
0.46 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 36252396]
MCF7 IC50
0.48 μg/mL
Compound: CA-4
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 22192936]
MCF7 IC50
0.49 μM
Compound: CA-4
Antiproliferative activity against drug-resistant human MCF7 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against drug-resistant human MCF7 cells incubated for 48 hrs by MTT assay
[PMID: 32035399]
MCF7 IC50
0.67 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells after 72 hrs by CCK-8 assay
Antiproliferative activity against human MCF7 cells after 72 hrs by CCK-8 assay
[PMID: 30108925]
MCF7 IC50
0.67 μM
Compound: CA-4
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 24238904]
MCF7 IC50
1 μM
Compound: 1a, CoA4
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 3 days by MTT assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 3 days by MTT assay
[PMID: 24145138]
MCF7 IC50
1 μM
Compound: CoA4
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 25240870]
MCF7 IC50
1 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells by MTT assay
Antiproliferative activity against human MCF7 cells by MTT assay
[PMID: 30502686]
MCF7 IC50
1.04 nM
Compound: CA-4
Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTS assay
Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTS assay
[PMID: 31541870]
MCF7 IC50
1.11 nM
Compound: CA-4
Antiproliferative activity in human MCF7 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity in human MCF7 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 22329561]
MCF7 IC50
1.23 μM
Compound: CA-4
Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 26974371]
MCF7 IC50
1.5 μM
Compound: CA-4
Inhibition of tubulin polymerization in human MCF7 cells by fluorometric analysis
Inhibition of tubulin polymerization in human MCF7 cells by fluorometric analysis
[PMID: 21342735]
MCF7 IC50
1.9 nM
Compound: CA-4
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay
[PMID: 33472119]
MCF7 IC50
1000 nM
Compound: CA-4
Antiproliferative activity against human MCF7 cells after 2 days by MTT assay
Antiproliferative activity against human MCF7 cells after 2 days by MTT assay
[PMID: 29432949]
MCF7 IC50
11 nM
Compound: 4, CA4
Antiproliferative activity against human MCF7 cells assessed after 48 hrs by spectrophotometry
Antiproliferative activity against human MCF7 cells assessed after 48 hrs by spectrophotometry
[PMID: 21774499]
MCF7 IC50
11 nM
Compound: 2g
Growth inhibition of human MCF7 after 48 hrs by sulforhodamine B method
Growth inhibition of human MCF7 after 48 hrs by sulforhodamine B method
[PMID: 16124759]
MCF7 IC50
11 nM
Compound: 1
Cytotoxicity was determined by inhibition of cell growth of MCF-7 human breast carcinoma cell
Cytotoxicity was determined by inhibition of cell growth of MCF-7 human breast carcinoma cell
[PMID: 11527727]
MCF7 IC50
12 nM
Compound: 1
Antiproliferative activity against human MCF7 cells after 72 hrs
Antiproliferative activity against human MCF7 cells after 72 hrs
[PMID: 17034133]
MCF7 IC50
13 nM
Compound: 2, CSA4
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 26132075]
MCF7 IC50
13 nM
Compound: CSA4
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 3 days by trypan blue exclusion assay
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 3 days by trypan blue exclusion assay
[PMID: 28523104]
MCF7 IC50
13 nM
Compound: 2
Cytotoxicity against human MCF7 cells assessed as growth inhibition by trypan blue exclusion assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition by trypan blue exclusion assay
[PMID: 23214452]
MCF7 IC50
13 nM
Compound: 2, CSA4
Cytotoxicity against human MCF7 cells after 96 hrs by Giemsa staining-based light microscopy
Cytotoxicity against human MCF7 cells after 96 hrs by Giemsa staining-based light microscopy
[PMID: 25025991]
MCF7 IC50
13 nM
Compound: 2, CSA4
Growth inhibition of human MCF7 cells after 96 hrs
Growth inhibition of human MCF7 cells after 96 hrs
[PMID: 22044164]
MCF7 IC50
14 nM
Compound: CA-4
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 28792756]
MCF7 IC50
17 nM
Compound: 2a, CAS4
Growth inhibition of human MCF7 cells after 48 hrs
Growth inhibition of human MCF7 cells after 48 hrs
[PMID: 17497841]
MCF7 IC50
17 nM
Compound: 6, combretastatin A-4
Growth inhibition of human MCF7 cells assessed as G2/M DNA content after 48 hrs
Growth inhibition of human MCF7 cells assessed as G2/M DNA content after 48 hrs
[PMID: 15566282]
MCF7 IC50
170 nM
Compound: 1; CA-4
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition by MTT assay
[PMID: 33636303]
MCF7 IC50
172 nM
Compound: CA4
Antiproliferative activity against human MCF7 cells after 72 hrs by CellTiter Glo assay
Antiproliferative activity against human MCF7 cells after 72 hrs by CellTiter Glo assay
[PMID: 35797900]
MCF7 IC50
18 nM
Compound: CA-4
Antiproliferative activity against human MCF7 cells incubated for 48 hrs by sulforhodamine B assay
Antiproliferative activity against human MCF7 cells incubated for 48 hrs by sulforhodamine B assay
[PMID: 26938120]
MCF7 IC50
2.1 nM
Compound: CA-4
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
[PMID: 26069928]
MCF7 IC50
2.5 nM
Compound: 2, CSA4
Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay
[PMID: 19601594]
MCF7 IC50
2.5 μM
Compound: CA-4
Inhibition of tubulin polymerization in human MCF7 cells assessed as suppression of protein assembly after 15 mins by spectrophotometric analysis
Inhibition of tubulin polymerization in human MCF7 cells assessed as suppression of protein assembly after 15 mins by spectrophotometric analysis
[PMID: 27994737]
MCF7 IC50
220 nM
Compound: CA-4
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23981529]
MCF7 IC50
25 nM
Compound: combretastatin A-4
Cell growth inhibition against MCF-7 human breast cancer cells using MTS assay
Cell growth inhibition against MCF-7 human breast cancer cells using MTS assay
[PMID: 12036364]
MCF7 IC50
25.51 μM
Compound: CA-4
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
10.1039/C3MD00372H
MCF7 IC50
3 nM
Compound: CA-4
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 30472600]
MCF7 IC50
3 nM
Compound: 1, CA-4
Growth inhibition of human MCF7 cells after 48 hrs by SRB assay
Growth inhibition of human MCF7 cells after 48 hrs by SRB assay
[PMID: 24900453]
MCF7 IC50
3.45 μM
Compound: Combretastatin A-4
Antiproliferative activity against human MCF7 cells incubated for 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 24 hrs by MTT assay
[PMID: 32992133]
MCF7 IC50
370 nM
Compound: 1a; CA-4
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 31400707]
MCF7 IC50
370 nM
Compound: 1a, CA-4
Growth inhibition of human MCF7 cells after 72 hrs by MTT assay
Growth inhibition of human MCF7 cells after 72 hrs by MTT assay
[PMID: 25025853]
MCF7 IC50
370 nM
Compound: 1, CA-4
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 23445496]
MCF7 IC50
370 nM
Compound: CA-4, 1a, 1
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 23117171]
MCF7 IC50
370 nM
Compound: 1, CA-4
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 22578111]
MCF7 IC50
370 nM
Compound: 1
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 22136312]
MCF7 IC50
370 nM
Compound: 1, CA-4
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 21663319]
MCF7 IC50
370 nM
Compound: CA-4
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 20420439]
MCF7 IC50
370 nM
Compound: 1a, CA-4
Antiproliferative activity against human MCF7 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test
Antiproliferative activity against human MCF7 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test
[PMID: 25785605]
MCF7 IC50
39.1 nM
Compound: CA-4
Antiproliferative activity against human MCF7 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human MCF7 cells after 72 hrs by CCK8 assay
[PMID: 30006162]
MCF7 GI50
39.8 nM
Compound: 1, CA-4
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
[PMID: 21920767]
MCF7 IC50
4.2 μM
Compound: CA 4
Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B assay
[PMID: 28684120]
MCF7 IC50
4.63 μM
Compound: Combretastatin
Antiproliferative activity in human MCF7 cells assessed as reduction in cell number incubated for 48 hrs by SRB assay
Antiproliferative activity in human MCF7 cells assessed as reduction in cell number incubated for 48 hrs by SRB assay
[PMID: 30108756]
MCF7 IC50
4.85 μM
Compound: 133
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 34826681]
MCF7 IC50
48.9 μM
Compound: 2, CA-4
Cytotoxicity against human MCF7 cells by alamar blue assay
Cytotoxicity against human MCF7 cells by alamar blue assay
[PMID: 22137934]
MCF7 IC50
5 nM
Compound: 2
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 23454513]
MCF7 IC50
5 nM
Compound: CSA4
Growth inhibition of human MCF7 cells after 96 hrs by trypan blue exclusion assay
Growth inhibition of human MCF7 cells after 96 hrs by trypan blue exclusion assay
[PMID: 29730191]
MCF7 IC50
5.6 nM
Compound: 2, CA-4
Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay
[PMID: 21920638]
MCF7 IC50
5.6 nM
Compound: 1, CA-4
Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B assay
[PMID: 21604746]
MCF7 IC50
5.9 nM
Compound: CA-4
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
[PMID: 36471625]
MCF7 IC50
69.6 μM
Compound: CA4
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 29396364]
MCF7 IC50
8 nM
Compound: 1; CA-4
Antiproliferative activity against human MCF7 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay
Antiproliferative activity against human MCF7 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay
[PMID: 33038796]
MCF7 IC50
8 nM
Compound: CA-4
Antiproliferative activity against human MCF7 cells after 72 hrs by resazurin-based fluorescence assay
Antiproliferative activity against human MCF7 cells after 72 hrs by resazurin-based fluorescence assay
[PMID: 29202409]
MCF7 GI50
84 nM
Compound: CA-4
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
[PMID: 34917259]
MCF7 GI50
84 nM
Compound: CA-4
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
[PMID: 31938468]
MCF7 IC50
9 nM
Compound: CA4
Darktoxicity against human MCF7 cells incubated for 24 hrs followed by 30 mins incubation in dark measured after 3 days by MTT assay
Darktoxicity against human MCF7 cells incubated for 24 hrs followed by 30 mins incubation in dark measured after 3 days by MTT assay
[PMID: 23631389]
MCF7 GI50
9.4 μM
Compound: CA-4
Growth inhibition of human MCF7 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay
Growth inhibition of human MCF7 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay
[PMID: 26070164]
MDA-MB-231 GI50
0.001 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human MDA-MB-231 cells after 48 hrs by SRB assay
Growth inhibition of human MDA-MB-231 cells after 48 hrs by SRB assay
[PMID: 22982122]
MDA-MB-231 IC50
0.002 μM
Compound: CA-4
Antiproliferative activity against human MDA-MB-231 cells by MTT assay
Antiproliferative activity against human MDA-MB-231 cells by MTT assay
[PMID: 29126741]
MDA-MB-231 IC50
0.0024 μM
Compound: CA-4
Antiproliferative activity against CYP1A1 deficient human MDA-MB-231 cells after 72 hrs by SRB assay
Antiproliferative activity against CYP1A1 deficient human MDA-MB-231 cells after 72 hrs by SRB assay
[PMID: 30201525]
MDA-MB-231 IC50
0.0028 μM
Compound: CA-4
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by resazurin based fluorescence assay
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by resazurin based fluorescence assay
[PMID: 24669888]
MDA-MB-231 GI50
0.002806 μM
Compound: CA-4
Growth inhibition of human MDA-MB-231 cells after 72 hrs by MTT assay
Growth inhibition of human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 28284864]
MDA-MB-231 IC50
0.0045 μM
Compound: CA-4
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CCK8 assay
[PMID: 30006162]
MDA-MB-231 IC50
0.008 μM
Compound: 1; CA-4
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 29306206]
MDA-MB-231 IC50
0.01 μM
Compound: 1; CA-4
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 30981112]
MDA-MB-231 IC50
0.011 μM
Compound: 1; CA-4
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 30530194]
MDA-MB-231 IC50
0.012 μM
Compound: 1; CA-4
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 35065411]
MDA-MB-231 IC50
0.013 μM
Compound: CA-4
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 35447432]
MDA-MB-231 IC50
0.015 μM
Compound: 1; CA-4
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
MDA-MB-231 IC50
0.015 μM
Compound: CA-4
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 30525584]
MDA-MB-231 IC50
0.015 μM
Compound: CA-4; 1
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 30344902]
MDA-MB-231 IC50
0.017 μM
Compound: 1; CA4
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
[PMID: 32063430]
MDA-MB-231 GI50
0.021 μM
Compound: CA-4
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
10.1039/C5MD00139K
MDA-MB-231 IC50
0.03 μM
Compound: Combretastatin A-4
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell proliferation after 3 days by 3H-thymidine incorporation assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell proliferation after 3 days by 3H-thymidine incorporation assay
[PMID: 27212068]
MDA-MB-231 IC50
0.043 μM
Compound: 4, CA-4
Antiproliferative activity against ER-independent human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against ER-independent human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 21840628]
MDA-MB-231 IC50
0.043 μM
Compound: 2a
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 21080725]
MDA-MB-231 IC50
0.043 μM
Compound: 2, CA-4
Antiproliferative activity against estrogen receptor deficient human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against estrogen receptor deficient human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 20933304]
MDA-MB-231 GI50
0.045 μM
Compound: CA-4
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 29227648]
MDA-MB-231 GI50
0.046 μM
Compound: Combretastatin
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by SRB cell proliferation assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by SRB cell proliferation assay
[PMID: 29089233]
MDA-MB-231 IC50
0.09 μM
Compound: CA-4
Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
[PMID: 32035399]
MDA-MB-231 IC50
0.1 μM
Compound: 1, CA-4
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
10.1039/C2MD20085F
MDA-MB-231 IC50
0.17 μM
Compound: CA-4
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 28803046]
MDA-MB-231 IC50
0.56 μM
Compound: 1a; CA-4
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 29291446]
MDA-MB-231 IC50
0.92 μM
Compound: 1; CA-4
Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by SRB assay
[PMID: 29268127]
MDA-MB-231 IC50
13.5 nM
Compound: CA-4
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 31610372]
MDA-MB-231 IC50
270 μM
Compound: CA-4
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 28410492]
MDA-MB-231 IC50
3 nM
Compound: CA4
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter Glo assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter Glo assay
[PMID: 35797900]
MDA-MB-231 GI50
3 nM
Compound: CA-4
Cytotoxicity against human MDA-MB-231 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis
Cytotoxicity against human MDA-MB-231 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis
[PMID: 22449653]
MDA-MB-231 IC50
3 nM
Compound: CA-4
Cytotoxicity against human MDA-MB-231 cells after 72 hrs
Cytotoxicity against human MDA-MB-231 cells after 72 hrs
[PMID: 19530698]
MDA-MB-231 IC50
3.17 nM
Compound: CA-4
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 30472600]
MDA-MB-231 IC50
3.2 nM
Compound: 4, CA4
Antiproliferative activity against human MDA-MB-231 after 48 hrs by spectrophotometry
Antiproliferative activity against human MDA-MB-231 after 48 hrs by spectrophotometry
[PMID: 21774499]
MDA-MB-231 GI50
3.2 nM
Compound: CA-4
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by CellTitre-Blue assay
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by CellTitre-Blue assay
[PMID: 25528337]
MDA-MB-231 IC50
3.4 nM
Compound: CA-4
Antiproliferative activity against human MDA-MB-231 cells by SRB assay
Antiproliferative activity against human MDA-MB-231 cells by SRB assay
[PMID: 29655610]
MDA-MB-231 IC50
331 nM
Compound: CA-4
Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by sulforhodamine B assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by sulforhodamine B assay
[PMID: 26938120]
MDA-MB-231 IC50
4 nM
Compound: CA-4
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by alamar blue assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by alamar blue assay
[PMID: 19117761]
MDA-MB-231 IC50
4.1 nM
Compound: CA-4
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 28792756]
MDA-MB-231 IC50
4.5 nM
Compound: 1a; CA-4
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 31400707]
MDA-MB-231 IC50
6 nM
Compound: 1, CA-4
Cytotoxicity against human MDA-MB-231 cells assessed as [3H]thymidine incorporation after 72 hrs by microplate scintillation counter
Cytotoxicity against human MDA-MB-231 cells assessed as [3H]thymidine incorporation after 72 hrs by microplate scintillation counter
[PMID: 18396050]
MDA-MB-231 IC50
8 nM
Compound: CA-4
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 32339854]
MDA-MB-231 GI50
8.2 nM
Compound: CA-4
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
[PMID: 34917259]
MDA-MB-231 GI50
8.2 nM
Compound: CA-4
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
[PMID: 31938468]
MDA-MB-435 IC50
0.001 μM
Compound: CA-4
Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay
[PMID: 22676247]
MDA-MB-435 GI50
0.001 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human MDA-MB-435 cells after 48 hrs by SRB assay
Growth inhibition of human MDA-MB-435 cells after 48 hrs by SRB assay
[PMID: 22982122]
MDA-MB-435 GI50
0.003 μM
Compound: CA-4
Growth inhibition of human MDA-MB-435 cells after 72 hrs by MTT assay
Growth inhibition of human MDA-MB-435 cells after 72 hrs by MTT assay
[PMID: 27031215]
MDA-MB-435 IC50
0.003 μM
Compound: 1, CA-4
Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by SRB assay
Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by SRB assay
[PMID: 19894742]
MDA-MB-435 GI50
3 nM
Compound: 1
Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 27707624]
MDA-MB-435 IC50
3.4 nM
Compound: CA-4
Antiproliferative activity against human MDA-MB-435 cell line assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay
Antiproliferative activity against human MDA-MB-435 cell line assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay
[PMID: 33310545]
MDA-MB-435 IC50
3.4 nM
Compound: CA-4
Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 23332369]
MDA-MB-435 IC50
3.4 nM
Compound: CA4
Antiproliferative activity against human MDA-MB-435 cells by SRB assay
Antiproliferative activity against human MDA-MB-435 cells by SRB assay
[PMID: 21786793]
MDA-MB-435 GI50
31.6 nM
Compound: 1, CA-4
Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay
[PMID: 21920767]
MDA-MB-435 EC50
4.4 nM
Compound: CA-4
Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 27213719]
MDA-MB-435 IC50
4.4 nM
Compound: CA-4
Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth by SRB assay
Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth by SRB assay
[PMID: 36889150]
MDA-MB-435 IC50
4.4 nM
Compound: CA-4
Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay
[PMID: 30297118]
MDA-MB-435 IC50
4.4 nM
Compound: CA-4
Antiproliferative activity against human MDA-MB-435 cells after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human MDA-MB-435 cells after 72 hrs by sulforhodamine B assay
[PMID: 30098869]
MDA-MB-435 IC50
4.4 nM
Compound: CA-4
Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability by Sulforhodamine B assay
Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
MDA-MB-435 IC50
5 nM
Compound: CA-4
Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay
[PMID: 25882519]
MDA-MB-468 IC50
0.003 μM
Compound: 1
Antiproliferative activity against ER negative human MDA-MB-468 cells expressing CYP1A1 and CYP1B1 assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against ER negative human MDA-MB-468 cells expressing CYP1A1 and CYP1B1 assessed as reduction in cell viability measured after 96 hrs by MTT assay
[PMID: 30935796]
MDA-MB-468 IC50
1.1 nM
Compound: 3
Cytotoxicity against human MDA-MB-468 cells assessed as cell viability after 4 days by MTS assay
Cytotoxicity against human MDA-MB-468 cells assessed as cell viability after 4 days by MTS assay
[PMID: 24210503]
MDA-MB-468 IC50
1.55 nM
Compound: CA-4
Cytotoxicity against human MDA-MB-468 cells after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-468 cells after 72 hrs by MTT assay
[PMID: 30472600]
MDA-MB-468 IC50
16 nM
Compound: CA4
Phototoxicity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 24 hrs followed by LED illumination by MTT assay
Phototoxicity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 24 hrs followed by LED illumination by MTT assay
[PMID: 35964428]
MDA-MB-468 IC50
3.1 nM
Compound: 1, CA-4
Antiproliferative activity against human MDA-MB-468 cells expressing NQO1 by MTT assay
Antiproliferative activity against human MDA-MB-468 cells expressing NQO1 by MTT assay
[PMID: 23010271]
MDA-MB-468 IC50
6.5 nM
Compound: CA-4
Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 31610372]
MES-SA IC50
1.6 nM
Compound: CA4
Antiproliferative activity against drug sensitive Messa cell line by Alamar Blue assay
Antiproliferative activity against drug sensitive Messa cell line by Alamar Blue assay
[PMID: 17286393]
MES-SA IC50
2.7 nM
Compound: 2, CSA4
Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay
[PMID: 26132075]
MES-SA IC50
2.7 nM
Compound: 2
Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay
Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay
[PMID: 23214452]
MES-SA IC50
2.7 nM
Compound: 2, CSA4
Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay
Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay
[PMID: 25025991]
MES-SA IC50
3 nM
Compound: CA-4
Antiproliferative activity against human MES-SA cells after 72 hrs by resazurin assay
Antiproliferative activity against human MES-SA cells after 72 hrs by resazurin assay
[PMID: 26602281]
MES-SA/Dx5 IC50
1.4 nM
Compound: CA4
Antiproliferative activity against drug resistant Messa/DX5 cell line expressing MDR1 by Alamar Blue assay
Antiproliferative activity against drug resistant Messa/DX5 cell line expressing MDR1 by Alamar Blue assay
[PMID: 17286393]
MES-SA/Dx5 IC50
2.6 nM
Compound: 2, CSA4
Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay
[PMID: 26132075]
MES-SA/Dx5 IC50
2.6 nM
Compound: 2
Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay
Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay
[PMID: 23214452]
MES-SA/Dx5 IC50
2.6 nM
Compound: 2, CSA4
Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay
Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay
[PMID: 25025991]
MES-SA/Dx5 IC50
3 nM
Compound: CA-4
Antiproliferative activity against multidrug-resistant human MES-SA/Dx5 cells assessed as reduction in cell viability incubated for 72 hrs by prestoblue dye based assay
Antiproliferative activity against multidrug-resistant human MES-SA/Dx5 cells assessed as reduction in cell viability incubated for 72 hrs by prestoblue dye based assay
[PMID: 33618157]
MES-SA/Dx5 IC50
4 nM
Compound: combretastatin A-4
Cell growth inhibition against,MES-SA/DX5 human uterine cancer cells using MTS assay
Cell growth inhibition against,MES-SA/DX5 human uterine cancer cells using MTS assay
[PMID: 12036364]
MES-SA/Dx5 IC50
5 nM
Compound: combretastatin A-4
Cell growth inhibition against MES-SA human uterine cancer cells using MTS assay
Cell growth inhibition against MES-SA human uterine cancer cells using MTS assay
[PMID: 12036364]
MGC-803 IC50
0.002 μM
Compound: 8; CA-4
Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition after 72 hrs by SRB assay
Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition after 72 hrs by SRB assay
[PMID: 34454126]
MGC-803 IC50
0.006 μM
Compound: 6a; CA-4
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay
[PMID: 34458740]
MGC-803 IC50
0.008 μM
Compound: CA-4
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 35834904]
MGC-803 IC50
0.53 μM
Compound: CA-4
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 36252396]
MGC-803 IC50
1.76 μM
Compound: CA-4
Antiproliferative activity against human MGC803 cells after 72 hrs by CCK-8 assay
Antiproliferative activity against human MGC803 cells after 72 hrs by CCK-8 assay
[PMID: 30108925]
MGC-803 IC50
8.9 nM
Compound: CA-4
Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
[PMID: 28792756]
MHCC97H IC50
0.008 μM
Compound: CA-4
Antiproliferative activity against human MHCC97H cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MHCC97H cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34649064]
MIA PaCa-2 IC50
< 1 μg/mL
Compound: 1'
Cytotoxicity against human MiaPaCa2 cells after 72 hrs by MTT assay
Cytotoxicity against human MiaPaCa2 cells after 72 hrs by MTT assay
[PMID: 17373779]
MIA PaCa-2 IC50
0.003 μM
Compound: 1; CA-4
Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
[PMID: 27919655]
MIA PaCa-2 IC50
0.0072 μM
Compound: CA-4, 1a
Cytotoxicity against human MIAPaCa2 cells after 72 hrs by MTT assay
Cytotoxicity against human MIAPaCa2 cells after 72 hrs by MTT assay
[PMID: 20338766]
MIA PaCa-2 IC50
0.087 μM
Compound: 2a; CA-4
Cytotoxicity against human MIAPaCa2 cells assessed as cell viability after 48 hrs by SRB assay
Cytotoxicity against human MIAPaCa2 cells assessed as cell viability after 48 hrs by SRB assay
10.1039/C5MD00155B
MIA PaCa-2 IC50
2.1 nM
Compound: CA-4
Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33618157]
MIA PaCa-2 IC50
8 nM
Compound: CA-4
Cytotoxicity against human MIAPaCa2 cells after 48 hrs by alamar blue assay
Cytotoxicity against human MIAPaCa2 cells after 48 hrs by alamar blue assay
[PMID: 19117761]
MIA PaCa-2 IC50
8 nM
Compound: CA4
Antiproliferative activity against human MIA PaCa-2 cells after 72 hrs by CellTiter Glo assay
Antiproliferative activity against human MIA PaCa-2 cells after 72 hrs by CellTiter Glo assay
[PMID: 35797900]
MIA PaCa-2 IC50
8 nM
Compound: 1; CA-4
Antiproliferative activity against human MiaPaca2 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay
Antiproliferative activity against human MiaPaca2 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay
[PMID: 33038796]
MKN-45 IC50
0.0081 μM
Compound: 6a; CA-4
Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay
Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay
[PMID: 34458740]
MKN-45 IC50
0.11 μM
Compound: CA-4
Cytotoxicity against human MKN45 cells after 72 hrs by MTT assay
Cytotoxicity against human MKN45 cells after 72 hrs by MTT assay
[PMID: 28622907]
MKN-45 IC50
0.21 μM
Compound: CA-4
Antiproliferative activity against human MKN45 cells after 72 hrs by MTT assay
Antiproliferative activity against human MKN45 cells after 72 hrs by MTT assay
[PMID: 29407949]
MKN-45 IC50
3.2 nM
Compound: 1, CA4
Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue assay
Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue assay
[PMID: 26160020]
MKN-45 IC50
3.2 nM
Compound: 1, CA4
Cytotoxicity against human MKN45 cells after 72 hrs by methylene blue assay
Cytotoxicity against human MKN45 cells after 72 hrs by methylene blue assay
[PMID: 24657567]
MKN-45 IC50
4.8 nM
Compound: 2, CA4
Growth inhibition of human MKN45 cells after 72 hrs by methylene blue assay
Growth inhibition of human MKN45 cells after 72 hrs by methylene blue assay
[PMID: 22060033]
MKN-45 IC50
4.8 nM
Compound: 1, CA4
Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue assay
Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue assay
[PMID: 21641700]
MKN-45 IC50
4.9 nM
Compound: 1a, CA4
Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue dye assay
Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue dye assay
[PMID: 20148562]
MKN-45 IC50
5.6 nM
Compound: 1, CA4
Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay
Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay
[PMID: 18588280]
MKN-45 IC50
52 nM
Compound: 4
Antiproliferative activity against human MKN45 cell line by methylene blue dye assay
Antiproliferative activity against human MKN45 cell line by methylene blue dye assay
[PMID: 17034147]
MOLT-3 IC50
9.3 nM
Compound: 1
Antiproliferative activity against human Molt3 cells after 72 hrs
Antiproliferative activity against human Molt3 cells after 72 hrs
[PMID: 17034133]
MOLT-4 GI50
0.003 μM
Compound: CA4, NSC 613729
Growth inhibition of human MOLT4 cells after 48 hrs by SRB assay
Growth inhibition of human MOLT4 cells after 48 hrs by SRB assay
[PMID: 24387982]
MOLT-4 GI50
0.003 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human MOLT4 cells after 48 hrs by SRB assay
Growth inhibition of human MOLT4 cells after 48 hrs by SRB assay
[PMID: 22982122]
MOLT-4 GI50
0.003 μM
Compound: CA4; NSC 613729
Cytotoxicity against human MOLT4 cells by SRB assay
Cytotoxicity against human MOLT4 cells by SRB assay
[PMID: 26257861]
MOLT-4 IC50
0.016 μM
Compound: 1, CA-4
Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter analysis
Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter analysis
[PMID: 22027100]
MOLT-4 IC50
1.6 nM
Compound: CA-4, 1
Antiproliferative effect against human Molt4/C8 cells after 3 days
Antiproliferative effect against human Molt4/C8 cells after 3 days
[PMID: 17419607]
MOLT-4 IC50
16 nM
Compound: 1, CA-4
Antiproliferative activity against human Molt4/C8 cells after 2 days by coulter counting
Antiproliferative activity against human Molt4/C8 cells after 2 days by coulter counting
[PMID: 20579891]
MOLT-4 IC50
16 nM
Compound: 1, CA-4
Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter method
Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter method
[PMID: 19663386]
MOLT-4 IC50
16 nM
Compound: 1a, CA-4
Cytotoxicity against human Molt4/C8 cells assessed as growth inhibition after 48 hrs by coulter counting analysis
Cytotoxicity against human Molt4/C8 cells assessed as growth inhibition after 48 hrs by coulter counting analysis
[PMID: 24164557]
MOLT-4 IC50
16 nM
Compound: 1, CA4
Cytotoxicity against human Molt4/C8 cells after 2 days
Cytotoxicity against human Molt4/C8 cells after 2 days
[PMID: 19736015]
MOLT-4 IC50
16 nM
Compound: 1, CA-4
Antiproliferative activity against human Molt4/C8 cells after 2 days
Antiproliferative activity against human Molt4/C8 cells after 2 days
[PMID: 18755591]
MOLT-4 GI50
3.27 nM
Compound: CA4
Growth inhibition of human MOLT4 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human MOLT4 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
MRC5 IC50
2.8 nM
Compound: 1, CA-4
Growth inhibition of human MRC5 cells after 48 hrs by SRB assay
Growth inhibition of human MRC5 cells after 48 hrs by SRB assay
[PMID: 24900453]
MV4-11 IC50
0.00627 μM
Compound: 3, CA4
Anticancer activity against human MV4-11 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay
Anticancer activity against human MV4-11 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay
[PMID: 25466200]
MX1 IC50
52 nM
Compound: CA-4
Cytotoxicity against human MX1 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MX1 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23981529]
MX1 IC50
71 nM
Compound: CA-4
Cytotoxicity against taxol-resistant human MX1 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against taxol-resistant human MX1 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23981529]
NCI/ADR-RES GI50
0.001 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human NCI/ADR-RES cells after 48 hrs by SRB assay
Growth inhibition of human NCI/ADR-RES cells after 48 hrs by SRB assay
[PMID: 22982122]
NCI/ADR-RES EC50
0.0015 μM
Compound: CA4
Cell cycle arrest in NCI/ADR (MDR) cells by accumulation at G2/M phase
Cell cycle arrest in NCI/ADR (MDR) cells by accumulation at G2/M phase
[PMID: 16377187]
NCI/ADR-RES GI50
1 nM
Compound: CA4
Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
NCI/ADR-RES IC50
1.3 nM
Compound: 2
Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition by trypan blue exclusion assay
Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition by trypan blue exclusion assay
[PMID: 23214452]
NCI/ADR-RES IC50
1.3 nM
Compound: 2, CSA4
Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy
Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy
[PMID: 25025991]
NCI/ADR-RES IC50
1.3 nM
Compound: 2, CSA4
Growth inhibition of doxorubicin-resistant human NCI-ADR-RES cells overexpressing P-glycoprotein after 96 hrs
Growth inhibition of doxorubicin-resistant human NCI-ADR-RES cells overexpressing P-glycoprotein after 96 hrs
[PMID: 22044164]
NCI/ADR-RES IC50
1.3 μM
Compound: CA
Growth inhibition of human NCI/ADR-RES cells over expressing Pgp measured after 96 hrs by sulforhodamine B assay
Growth inhibition of human NCI/ADR-RES cells over expressing Pgp measured after 96 hrs by sulforhodamine B assay
[PMID: 27894589]
NCI/ADR-RES IC50
1.8 nM
Compound: 2, CSA4
Cytotoxicity against Pgp overexpressing human NCI-ADR-RES cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against Pgp overexpressing human NCI-ADR-RES cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 26132075]
NCI/ADR-RES IC50
3.5 nM
Compound: CSA4
Growth inhibition of human NCI/ADR-RES cells after 96 hrs by trypan blue exclusion assay
Growth inhibition of human NCI/ADR-RES cells after 96 hrs by trypan blue exclusion assay
[PMID: 29730191]
NCI/ADR-RES EC50
5000 nM
Compound: C A-4
Cytotoxicity against human NCI-ADR-RES cells assessed as inhibition of cell proliferation by SRB assay
Cytotoxicity against human NCI-ADR-RES cells assessed as inhibition of cell proliferation by SRB assay
[PMID: 24801610]
NCI-H1299 IC50
> 100 μM
Compound: CA-4
Antiproliferative activity against human NCI-H1299 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human NCI-H1299 cells measured after 48 hrs by MTT assay
[PMID: 36150341]
NCI-H1299 IC50
0.0062 μM
Compound: 2
Cytotoxicity against human H1299 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human H1299 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23809851]
NCI-H1299 GI50
5 nM
Compound: CA-4
Cytotoxicity against human H1299 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis
Cytotoxicity against human H1299 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis
[PMID: 22449653]
NCI-H1299 IC50
5 nM
Compound: CA-4
Cytotoxicity against human H1299 cells after 72 hrs
Cytotoxicity against human H1299 cells after 72 hrs
[PMID: 19530698]
NCI-H1299 GI50
5.1 nM
Compound: CA-4
Cytotoxicity against human H1299 cells after 72 hrs by CellTitre-Blue assay
Cytotoxicity against human H1299 cells after 72 hrs by CellTitre-Blue assay
[PMID: 25528337]
NCI-H1437 IC50
0.03 μM
Compound: CA-4
Antiproliferative activity against human NCI-H1437 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human NCI-H1437 cells measured after 48 hrs by MTT assay
[PMID: 36150341]
NCI-H226 GI50
0.003 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human NCI-H226 cells after 48 hrs by SRB assay
Growth inhibition of human NCI-H226 cells after 48 hrs by SRB assay
[PMID: 22982122]
NCI-H226 GI50
0.004 μM
Compound: CA4, NSC 613729
Growth inhibition of human NCI-H226 cells after 48 hrs by SRB assay
Growth inhibition of human NCI-H226 cells after 48 hrs by SRB assay
[PMID: 24387982]
NCI-H226 GI50
3.81 nM
Compound: CA4
Growth inhibition of human NCI-H226 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-H226 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
NCI-H23 GI50
0.003 μM
Compound: CA4, NSC 613729
Growth inhibition of human NCI-H23 cells after 48 hrs by SRB assay
Growth inhibition of human NCI-H23 cells after 48 hrs by SRB assay
[PMID: 24387982]
NCI-H23 GI50
0.003 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human NCI-H23 cells after 48 hrs by SRB assay
Growth inhibition of human NCI-H23 cells after 48 hrs by SRB assay
[PMID: 22982122]
NCI-H23 GI50
0.003 μM
Compound: CA4; NSC 613729
Cytotoxicity against human NCI-H23 cells by SRB assay
Cytotoxicity against human NCI-H23 cells by SRB assay
[PMID: 26257861]
NCI-H23 GI50
3.42 nM
Compound: CA4
Growth inhibition of human NCI-H23 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-H23 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
NCI-H322M GI50
0.003 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human NCI-H322M cells after 48 hrs by SRB assay
Growth inhibition of human NCI-H322M cells after 48 hrs by SRB assay
[PMID: 22982122]
NCI-H322M GI50
0.007 μM
Compound: CA4, NSC 613729
Growth inhibition of human NCI-H322M cells after 48 hrs by SRB assay
Growth inhibition of human NCI-H322M cells after 48 hrs by SRB assay
[PMID: 24387982]
NCI-H322M GI50
7.45 nM
Compound: CA4
Growth inhibition of human NCI-H322M cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-H322M cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
NCI-H460 GI50
< 0.01 μM
Compound: 1, CA-4
Growth inhibition of human NCI-H460 cells after 3 days by crystal violet staining
Growth inhibition of human NCI-H460 cells after 3 days by crystal violet staining
[PMID: 19954252]
NCI-H460 GI50
0.0006 μg/mL
Compound: CA4
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
[PMID: 18710804]
NCI-H460 GI50
0.0006 μg/mL
Compound: 1a, CA4
Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay
[PMID: 22324723]
NCI-H460 GI50
0.0006 μg/mL
Compound: 2a
Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay
[PMID: 19719153]
NCI-H460 GI50
0.0006 μg/mL
Compound: 1a, CA4
Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay
[PMID: 16252907]
NCI-H460 GI50
0.0006 μg/mL
Compound: 3, CA4
Antitumor activity against human NCI-H460 cells by sulforhodamine B assay
Antitumor activity against human NCI-H460 cells by sulforhodamine B assay
[PMID: 19228038]
NCI-H460 GI50
0.0006 μM
Compound: CA4, combretastatin A4
Cytotoxicity against human NCIH460 cells after 48 hrs by SRB assay
Cytotoxicity against human NCIH460 cells after 48 hrs by SRB assay
[PMID: 18303849]
NCI-H460 GI50
0.002 μM
Compound: CA4
Growth inhibition of human NCI-H460 after 48 hrs by SRB assay
Growth inhibition of human NCI-H460 after 48 hrs by SRB assay
[PMID: 18722127]
NCI-H460 GI50
0.00223 μM
Compound: CA4
Cytotoxicity against human NCI-H460 cells assessed as growth inhibition measured after 48 hrs by SRB assay
Cytotoxicity against human NCI-H460 cells assessed as growth inhibition measured after 48 hrs by SRB assay
[PMID: 31059248]
NCI-H460 GI50
0.00223 μM
Compound: CA4, CA4P
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
[PMID: 24183586]
NCI-H460 GI50
0.0028 μM
Compound: 2, CA4
Cytotoxicity against human NCI-H460 cells by SRB assay
Cytotoxicity against human NCI-H460 cells by SRB assay
[PMID: 24016002]
NCI-H460 GI50
0.0028 μM
Compound: CA4
Growth inhibition of human NCI-H460 cells by sulforhodamine B assay
Growth inhibition of human NCI-H460 cells by sulforhodamine B assay
[PMID: 23772309]
NCI-H460 GI50
0.003 μM
Compound: CA4, NSC 613729
Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay
Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay
[PMID: 24387982]
NCI-H460 GI50
0.00449 μM
Compound: CA4
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
[PMID: 23993969]
NCI-H460 GI50
0.005 μM
Compound: CA4
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
[PMID: 31534659]
NCI-H460 GI50
0.007 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay
Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay
[PMID: 22982122]
NCI-H460 IC50
0.01 μM
Compound: 12
Cytotoxicity against human NCI-H460 cells after 68 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells after 68 hrs by MTT assay
[PMID: 32243160]
NCI-H460 IC50
0.048 μM
Compound: CA-4; B
Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay
[PMID: 28774575]
NCI-H460 IC50
0.076 μM
Compound: CA-4
Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay
[PMID: 34311158]
NCI-H460 IC50
0.08 μM
Compound: CA-4
Antiproliferative activity against human H460 cells after 72 hrs by MTT assay
Antiproliferative activity against human H460 cells after 72 hrs by MTT assay
[PMID: 29407949]
NCI-H460 IC50
0.08 μM
Compound: CA-4
Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay
[PMID: 28622907]
NCI-H460 IC50
1.2 nM
Compound: 1, CA-4
Cytotoxicity against human H460 cells by sulforhodamine B test
Cytotoxicity against human H460 cells by sulforhodamine B test
[PMID: 18783207]
NCI-H460 IC50
1.24 nM
Compound: 1, combretastatin A-4, CA-4
Cytotoxic activity against human NCI-H460 cells after 72 hrs by sulforhodamine B test
Cytotoxic activity against human NCI-H460 cells after 72 hrs by sulforhodamine B test
[PMID: 18396857]
NCI-H460 IC50
1.9 nM
Compound: 4
Antiproliferative activity against human H460 cell line by methylene blue dye assay
Antiproliferative activity against human H460 cell line by methylene blue dye assay
[PMID: 17034147]
NCI-H460 IC50
2.3 nM
Compound: 1, CA4
Antiproliferative activity against human H460 cells after 72 hrs by methylene blue assay
Antiproliferative activity against human H460 cells after 72 hrs by methylene blue assay
[PMID: 21641700]
NCI-H460 IC50
2.6 nM
Compound: 1a, CA4
Antiproliferative activity against human H460 cells after 72 hrs by methylene blue dye assay
Antiproliferative activity against human H460 cells after 72 hrs by methylene blue dye assay
[PMID: 20148562]
NCI-H460 IC50
2.8 nM
Compound: 1, CA4
Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay
Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay
[PMID: 18588280]
NCI-H460 GI50
3.11 nM
Compound: CA4
Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
NCI-H460 IC50
35.81 μM
Compound: 3; CA-4
Growth inhibition of human NCI-H460 cells incubated for 48 hrs by MTT assay
Growth inhibition of human NCI-H460 cells incubated for 48 hrs by MTT assay
[PMID: 27172319]
NCI-H460 IC50
4.4 μM
Compound: 2, CA-4
Cytotoxicity against human NCI-H460 cells by alamar blue assay
Cytotoxicity against human NCI-H460 cells by alamar blue assay
[PMID: 22137934]
NCI-H460 GI50
5 nM
Compound: CA4
Cytotoxicity against human NCI-H460 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human NCI-H460 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 26852340]
NCI-H460 GI50
6 x 10-4 μg/mL
Compound: Z-1b
Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay
[PMID: 19709889]
NCI-H522 GI50
0.001 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human NCI-H522 cells after 48 hrs by SRB assay
Growth inhibition of human NCI-H522 cells after 48 hrs by SRB assay
[PMID: 22982122]
NCI-H522 GI50
0.002 μM
Compound: CA4, NSC 613729
Growth inhibition of human NCI-H522 cells after 48 hrs by SRB assay
Growth inhibition of human NCI-H522 cells after 48 hrs by SRB assay
[PMID: 24387982]
NCI-H522 GI50
0.002 μM
Compound: CA4; NSC 613729
Cytotoxicity against human NCI-H522 cells by SRB assay
Cytotoxicity against human NCI-H522 cells by SRB assay
[PMID: 26257861]
NCI-H522 GI50
0.002 μM
Compound: CA-4
Growth inhibition of human NCI-H522 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-H522 cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
NCI-H522 GI50
2.18 nM
Compound: CA4
Growth inhibition of human NCI-H522 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-H522 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
NCI-H69 IC50
1.7 nM
Compound: CA4
Antiproliferative activity against drug sensitive NCI-H69 cell line by Alamar Blue assay
Antiproliferative activity against drug sensitive NCI-H69 cell line by Alamar Blue assay
[PMID: 17286393]
NCI-N87 IC50
11 nM
Compound: CA4
Antiproliferative activity against human NCI-N87 cells after 72 hrs by CellTiter Glo assay
Antiproliferative activity against human NCI-N87 cells after 72 hrs by CellTiter Glo assay
[PMID: 35797900]
NCI-N87 IC50
2.5 nM
Compound: 3
Cytotoxicity against human NCI-N87 cells assessed as cell viability after 4 days by MTS assay
Cytotoxicity against human NCI-N87 cells assessed as cell viability after 4 days by MTS assay
[PMID: 24210503]
NCM460 IC50
> 20 μM
Compound: 3, CA4
Cytotoxicity against human NCM460 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay
Cytotoxicity against human NCM460 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay
[PMID: 25466200]
NCM460 IC50
12 μM
Compound: CA-4
Cytotoxicity against human NCM460 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
Cytotoxicity against human NCM460 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
[PMID: 33280898]
NCM460 CC50
2.3 μM
Compound: CA-4
Cytotoxicity against human NCM460 cells measured after 48 hrs by MTT assay
Cytotoxicity against human NCM460 cells measured after 48 hrs by MTT assay
[PMID: 36150341]
NIH3T3 IC50
0.02 μM
Compound: 1, CA-4
Cytotoxicity against mouse NIH/3T3 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against mouse NIH/3T3 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23566762]
NIH3T3 IC50
0.097 μM
Compound: CA-4
Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by MTT assay
Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by MTT assay
[PMID: 24238904]
OVCAR IC50
3.3 nM
Compound: 1, CA-4
Cytotoxicity against human OVCAR cells assessed as [3H]thymidine incorporation after 72 hrs by microplate scintillation counter
Cytotoxicity against human OVCAR cells assessed as [3H]thymidine incorporation after 72 hrs by microplate scintillation counter
[PMID: 18396050]
OVCAR-3 GI50
0.001 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human OVCAR3 cells after 48 hrs by SRB assay
Growth inhibition of human OVCAR3 cells after 48 hrs by SRB assay
[PMID: 22982122]
OVCAR-3 GI50
0.002 μM
Compound: CA4, NSC 613729
Growth inhibition of human OVCAR3 cells after 48 hrs by SRB assay
Growth inhibition of human OVCAR3 cells after 48 hrs by SRB assay
[PMID: 24387982]
OVCAR-3 GI50
0.002 μM
Compound: CA4; NSC 613729
Cytotoxicity against human OVCAR3 cells by SRB assay
Cytotoxicity against human OVCAR3 cells by SRB assay
[PMID: 26257861]
OVCAR-3 GI50
0.002 μM
Compound: CA-4
Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
OVCAR-3 GI50
2.1 nM
Compound: CA4
Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
OVCAR-3 EC50
3.45 nM
Compound: CA4
Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by WST8 assay
Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by WST8 assay
[PMID: 28197314]
OVCAR-3 GI50
39.8 nM
Compound: 1, CA-4
Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay
[PMID: 21920767]
OVCAR-4 GI50
0.014 μM
Compound: CA4, NSC 613729
Growth inhibition of human OVCAR4 cells after 48 hrs by SRB assay
Growth inhibition of human OVCAR4 cells after 48 hrs by SRB assay
[PMID: 24387982]
OVCAR-4 GI50
0.014 μM
Compound: CA4; NSC 613729
Cytotoxicity against human OVCAR4 cells by SRB assay
Cytotoxicity against human OVCAR4 cells by SRB assay
[PMID: 26257861]
OVCAR-4 GI50
0.015 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human OVCAR4 cells after 48 hrs by SRB assay
Growth inhibition of human OVCAR4 cells after 48 hrs by SRB assay
[PMID: 22982122]
OVCAR-4 GI50
14.42 nM
Compound: CA4
Growth inhibition of human OVCAR4 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human OVCAR4 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
OVCAR-5 GI50
0.1 μM
Compound: CA4, NSC 613729
Growth inhibition of human OVCAR5 cells after 48 hrs by SRB assay
Growth inhibition of human OVCAR5 cells after 48 hrs by SRB assay
[PMID: 24387982]
OVCAR-5 GI50
0.1 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human OVCAR5 cells after 48 hrs by SRB assay
Growth inhibition of human OVCAR5 cells after 48 hrs by SRB assay
[PMID: 22982122]
OVCAR-5 GI50
100 nM
Compound: CA4
Growth inhibition of human OVCAR5 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human OVCAR5 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
OVCAR-8 GI50
0.003 μM
Compound: CA4, NSC 613729
Growth inhibition of human OVCAR8 cells after 48 hrs by SRB assay
Growth inhibition of human OVCAR8 cells after 48 hrs by SRB assay
[PMID: 24387982]
OVCAR-8 GI50
0.003 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human OVCAR8 cells after 48 hrs by SRB assay
Growth inhibition of human OVCAR8 cells after 48 hrs by SRB assay
[PMID: 22982122]
OVCAR-8 IC50
1.3 nM
Compound: 2
Cytotoxicity against human OVCAR8 cells assessed as growth inhibition by trypan blue exclusion assay
Cytotoxicity against human OVCAR8 cells assessed as growth inhibition by trypan blue exclusion assay
[PMID: 23214452]
OVCAR-8 IC50
1.3 nM
Compound: 2, CSA4
Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy
Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy
[PMID: 25025991]
OVCAR-8 IC50
1.3 nM
Compound: 2, CSA4
Growth inhibition of human OVCAR8 cells overexpressing P-glycoprotein after 96 hrs
Growth inhibition of human OVCAR8 cells overexpressing P-glycoprotein after 96 hrs
[PMID: 22044164]
OVCAR-8 IC50
1.3 μM
Compound: CA
Growth inhibition of human OVCAR8 cells measured after 96 hrs by sulforhodamine B assay
Growth inhibition of human OVCAR8 cells measured after 96 hrs by sulforhodamine B assay
[PMID: 27894589]
OVCAR-8 IC50
2.8 nM
Compound: 2, CSA4
Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 26132075]
OVCAR-8 GI50
2.99 nM
Compound: CA4
Growth inhibition of human OVCAR8 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human OVCAR8 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
OVCAR-8 IC50
4 nM
Compound: CSA4
Growth inhibition of human OVCAR8 cells after 96 hrs by trypan blue exclusion assay
Growth inhibition of human OVCAR8 cells after 96 hrs by trypan blue exclusion assay
[PMID: 29730191]
OVCAR-8 EC50
5.5 nM
Compound: C A-4
Cytotoxicity against human OVCAR8 cells assessed as inhibition of cell proliferation by SRB assay
Cytotoxicity against human OVCAR8 cells assessed as inhibition of cell proliferation by SRB assay
[PMID: 24801610]
P388 ED50
0.0003 μg/mL
Compound: 1a, CA4
Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay
[PMID: 16252907]
P388 ED50
0.0003 μg/mL
Compound: 1a, CA4
Growth inhibition of mouse P388 cells after 48 hrs by Z1 Beckman/Coulter particle counter analysis
Growth inhibition of mouse P388 cells after 48 hrs by Z1 Beckman/Coulter particle counter analysis
[PMID: 22324723]
P388 IC50
0.0026 μM
Compound: Combrestatin A4
Cytotoxicity against mouse P388 cells assessed as growth inhibition after 5 days by MTT assay
Cytotoxicity against mouse P388 cells assessed as growth inhibition after 5 days by MTT assay
10.1039/C2MD20199B
P388 ED50
3 x 10-2 μg/mL
Compound: Z-1b
Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay
[PMID: 19709889]
P388 IC50
3.1 nM
Compound: 2, CA4
Antiproliferative activity against mouse P388 cells after 5 days by MTT assay
Antiproliferative activity against mouse P388 cells after 5 days by MTT assay
[PMID: 19837594]
PA-1 IC50
< 1 μg/mL
Compound: 1'
Cytotoxicity against human PA1 cells after 72 hrs by MTT assay
Cytotoxicity against human PA1 cells after 72 hrs by MTT assay
[PMID: 17373779]
PANC-1 IC50
0.16 μM
Compound: COMB
Cytotoxicity against human PANC1 cells after 72 hrs by XTT assay
Cytotoxicity against human PANC1 cells after 72 hrs by XTT assay
[PMID: 30017114]
PBL IC50
> 10 μM
Compound: CA-4
Cytotoxicity against human PBL cells assessed as reduction in cell viability after 72 hrs by MTS assay
Cytotoxicity against human PBL cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 29202409]
PBL IC50
0.1 μM
Compound: CA-4
Cytotoxicity against human PBL cells assessed as reduction in cell proliferation after 72 hrs by MTT assay
Cytotoxicity against human PBL cells assessed as reduction in cell proliferation after 72 hrs by MTT assay
[PMID: 29202409]
PBMC IC50
0.011 μM
Compound: CA4
Inhibition of LPS-induced TNFalpha production in human PBMC preincubated 1 hr prior to LPS stimulation measured after 18 to 20 hrs by ELISA
Inhibition of LPS-induced TNFalpha production in human PBMC preincubated 1 hr prior to LPS stimulation measured after 18 to 20 hrs by ELISA
[PMID: 21955454]
PC-3 GI50
0.001 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human PC3 cells after 48 hrs by SRB assay
Growth inhibition of human PC3 cells after 48 hrs by SRB assay
[PMID: 22982122]
PC-3 GI50
0.001 μM
Compound: CA-4
Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
PC-3 IC50
0.0034 μM
Compound: 3; CA-4
Growth inhibition of human PC3 cells incubated for 72 hrs by MTT assay
Growth inhibition of human PC3 cells incubated for 72 hrs by MTT assay
[PMID: 27172319]
PC-3 IC50
0.007 μM
Compound: CA-4
Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
[PMID: 28803799]
PC-3 GI50
0.014 μM
Compound: CA-4
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
10.1039/C5MD00139K
PC-3 IC50
0.026 μM
Compound: CA-4
Antiproliferative activity against human PC3 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells measured after 48 hrs by MTT assay
[PMID: 27721152]
PC-3 IC50
0.4 μM
Compound: 2, CSA4
Antiproliferative activity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 22044164]
PC-3 IC50
0.4 μM
Compound: CA-4
Anticancer activity against human PC3 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Anticancer activity against human PC3 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 31954880]
PC-3 IC50
1 μM
Compound: CA-4
Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay
[PMID: 23810282]
PC-3 IC50
2.8 nM
Compound: 1
Antiproliferative activity against human PC3 cells after 72 hrs
Antiproliferative activity against human PC3 cells after 72 hrs
[PMID: 17034133]
PC-3 IC50
2.9 nM
Compound: 1, CA-4
Growth inhibition of human PC3 cells after 48 hrs by SRB assay
Growth inhibition of human PC3 cells after 48 hrs by SRB assay
[PMID: 24900453]
PC-3 IC50
22.03 μM
Compound: CA-4
Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 27810596]
PC-3 IC50
3.53 μM
Compound: CA-4; B
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 28774575]
PC-3 IC50
5.4 μM
Compound: CA-4
Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
[PMID: 19665898]
RKO IC50
0.78 μM
Compound: CA-4
Antiproliferative activity against human RKO cells measured after 48 hrs by MTT assay
Antiproliferative activity against human RKO cells measured after 48 hrs by MTT assay
[PMID: 36150341]
RKO IC50
9.8 nM
Compound: CA-4
Antiproliferative activity against human RKO cells after 48 hrs by MTT assay
Antiproliferative activity against human RKO cells after 48 hrs by MTT assay
[PMID: 28792756]
RL IC50
1.4 nM
Compound: CA-4
Antiproliferative activity against human RL cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human RL cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33618157]
RPMI-8226 GI50
0.003 μM
Compound: CA4, NSC 613729
Growth inhibition of human RPMI8226 cells after 48 hrs by SRB assay
Growth inhibition of human RPMI8226 cells after 48 hrs by SRB assay
[PMID: 24387982]
RPMI-8226 GI50
0.003 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human RPMI8226 cells after 48 hrs by SRB assay
Growth inhibition of human RPMI8226 cells after 48 hrs by SRB assay
[PMID: 22982122]
RPMI-8226 GI50
0.003 μM
Compound: CA4; NSC 613729
Cytotoxicity against human RPMI8226 cells by SRB assay
Cytotoxicity against human RPMI8226 cells by SRB assay
[PMID: 26257861]
RPMI-8226 GI50
3.42 nM
Compound: CA4
Growth inhibition of human RPMI8226 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human RPMI8226 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
RS4-11 IC50
0.001 μM
Compound: CA-4
Antiproliferative activity against human RS4:11 cells after 72 hrs by MTT assay
Antiproliferative activity against human RS4:11 cells after 72 hrs by MTT assay
[PMID: 30633509]
RS4-11 IC50
0.8 nM
Compound: 1a, CA-4
Antiproliferative activity against human RS4:11 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test
Antiproliferative activity against human RS4:11 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test
[PMID: 25785605]
RT-112 IC50
0.0216 μM
Compound: CA-4, 1a
Cytotoxicity against human RT112 cells after 72 hrs by MTT assay
Cytotoxicity against human RT112 cells after 72 hrs by MTT assay
[PMID: 20338766]
RXF 393 GI50
0.002 μM
Compound: CA4, NSC 613729
Growth inhibition of human RXF393 cells after 48 hrs by SRB assay
Growth inhibition of human RXF393 cells after 48 hrs by SRB assay
[PMID: 24387982]
RXF 393 GI50
0.002 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human RXF393 cells after 48 hrs by SRB assay
Growth inhibition of human RXF393 cells after 48 hrs by SRB assay
[PMID: 22982122]
RXF 393 GI50
2.37 nM
Compound: CA4
Growth inhibition of human RXF393 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human RXF393 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
SAOS-2 IC50
0.0114 μM
Compound: 3, CA4
Anticancer activity against human Saos2 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay
Anticancer activity against human Saos2 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay
[PMID: 25466200]
SEM IC50
0.005 μM
Compound: CA-4;1a
Antiproliferative activity against human SEM cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human SEM cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 33550186]
SEM IC50
5 nM
Compound: 1a, CA-4
Growth inhibition of human SEM cells after 72 hrs by MTT assay
Growth inhibition of human SEM cells after 72 hrs by MTT assay
[PMID: 25025853]
SEM IC50
5 nM
Compound: 1, CA-4
Cytotoxicity against human SEM cells after 72 hrs by MTT assay
Cytotoxicity against human SEM cells after 72 hrs by MTT assay
[PMID: 23445496]
SEM IC50
5.1 nM
Compound: 1a; CA-4
Antiproliferative activity against human SEM cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human SEM cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 31400707]
SF-188 IC50
0.021 μM
Compound: CA4
Cytotoxicity against human SF188 cells assessed as cell viability after 72 hrs by resazurin reduction assay
Cytotoxicity against human SF188 cells assessed as cell viability after 72 hrs by resazurin reduction assay
[PMID: 26599530]
SF-268 GI50
< 0.001 μg/mL
Compound: 1a, CA4
Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay
[PMID: 22324723]
SF-268 GI50
< 0.001 μg/mL
Compound: 1a, CA4
Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay
[PMID: 16252907]
SF-268 GI50
> 0.01 μg/mL
Compound: 2a
Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay
[PMID: 19719153]
SF-268 GI50
> 1 x 10-2 μg/mL
Compound: Z-1b
Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay
[PMID: 19709889]
SF-268 GI50
0.006 μM
Compound: CA4, NSC 613729
Growth inhibition of human SF268 cells after 48 hrs by SRB assay
Growth inhibition of human SF268 cells after 48 hrs by SRB assay
[PMID: 24387982]
SF-268 GI50
0.006 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human SF268 cells after 48 hrs by SRB assay
Growth inhibition of human SF268 cells after 48 hrs by SRB assay
[PMID: 22982122]
SF-268 GI50
0.006 μM
Compound: CA4; NSC 613729
Cytotoxicity against human SF268 cells by SRB assay
Cytotoxicity against human SF268 cells by SRB assay
[PMID: 26257861]
SF-268 GI50
5.7 nM
Compound: CA4
Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
SF-295 GI50
0.003 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human SF295 cells after 48 hrs by SRB assay
Growth inhibition of human SF295 cells after 48 hrs by SRB assay
[PMID: 22982122]
SF-295 GI50
0.004 μM
Compound: CA4, NSC 613729
Growth inhibition of human SF295 cells after 48 hrs by SRB assay
Growth inhibition of human SF295 cells after 48 hrs by SRB assay
[PMID: 24387982]
SF-295 GI50
0.004 μM
Compound: CA4; NSC 613729
Cytotoxicity against human SF295 cells by SRB assay
Cytotoxicity against human SF295 cells by SRB assay
[PMID: 26257861]
SF-295 GI50
0.004 μM
Compound: CA-4
Growth inhibition of human SF295 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SF295 cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
SF-295 GI50
3.87 nM
Compound: CA4
Growth inhibition of human SF295 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SF295 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
SF-295 GI50
63.1 nM
Compound: 1, CA-4
Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay
[PMID: 21920767]
SF-539 GI50
0.002 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human SF539 cells after 48 hrs by SRB assay
Growth inhibition of human SF539 cells after 48 hrs by SRB assay
[PMID: 22982122]
SF-539 GI50
0.003 μM
Compound: CA4, NSC 613729
Growth inhibition of human SF539 cells after 48 hrs by SRB assay
Growth inhibition of human SF539 cells after 48 hrs by SRB assay
[PMID: 24387982]
SF-539 GI50
0.003 μM
Compound: CA4; NSC 613729
Cytotoxicity against human SF539 cells by SRB assay
Cytotoxicity against human SF539 cells by SRB assay
[PMID: 26257861]
SF-539 GI50
2.54 nM
Compound: CA4
Growth inhibition of human SF539 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SF539 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
SGC-7901 IC50
0.012 μM
Compound: 1; CA-4
Cytotoxicity against human SGC7901 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human SGC7901 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 27994764]
SGC-7901 IC50
0.012 μM
Compound: 2; CA-4
Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay
Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay
[PMID: 30245397]
SGC-7901 IC50
0.024 μM
Compound: 2; CA-4
Antiproliferative activity against human SGC7901 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human SGC7901 cells assessed as reduction in cell viability after 72 hrs by MTT assay
10.1039/C5MD00150A
SGC-7901 IC50
0.024 μM
Compound: 1a; CA-4
Anti-proliferative activity against human SGC7901 cells after 72 hrs by MTT assay
Anti-proliferative activity against human SGC7901 cells after 72 hrs by MTT assay
10.1039/C5MD00028A
SGC-7901 IC50
0.024 μM
Compound: CA-4
Antiproliferative activity against human SGC-7901 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human SGC-7901 cells measured after 72 hrs by MTT assay
[PMID: 31787361]
SGC-7901 IC50
0.026 μM
Compound: CA-4
Antiproliferative activity against human SGC7901 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human SGC7901 cells measured after 72 hrs by MTT assay
[PMID: 27428395]
SGC-7901 IC50
0.028 μM
Compound: 1a, CA-4
Cytotoxicity against human SGC7901 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human SGC7901 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 25529737]
SGC-7901 IC50
0.028 μM
Compound: 1a, CA-4
Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay
Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay
[PMID: 25233100]
SGC-7901 IC50
0.13 μM
Compound: 1; CA-4
Antiproliferative activity against human SGC7901 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human SGC7901 cells measured after 72 hrs by MTT assay
[PMID: 30901597]
SH-SY5Y IC50
1.6 nM
Compound: 1, CA-4
Cytotoxicity against SHSY5Y cell line by MTT assay
Cytotoxicity against SHSY5Y cell line by MTT assay
[PMID: 16913727]
SH-SY5Y IC50
2.3 nM
Compound: 1, CA-4
Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 21696175]
SH-SY5Y IC50
2.7 nM
Compound: 1, CA-4
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 25584687]
SiHa IC50
> 100 μM
Compound: CA-4
Cytotoxicity against human SiHa cells after 48 hrs by MTT assay
Cytotoxicity against human SiHa cells after 48 hrs by MTT assay
10.1039/C3MD00372H
SiHa IC50
0.029 μM
Compound: 2; CA-4
Antiproliferation activity against human SiHa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay
Antiproliferation activity against human SiHa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay
[PMID: 35339837]
SiHa IC50
0.029 μM
Compound: 2; CA-4
Antiproliferative activity against human SiHa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay
Antiproliferative activity against human SiHa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay
[PMID: 35339837]
SK-BR-3 IC50
0.008 μM
Compound: CA4
Cytotoxicity against human SKBR3 cells assessed as cell viability after 72 hrs by resazurin reduction assay
Cytotoxicity against human SKBR3 cells assessed as cell viability after 72 hrs by resazurin reduction assay
[PMID: 26599530]
SK-BR-3 IC50
5.1 nM
Compound: 1, CA-4
Cytotoxicity against human SK-BR3 cells assessed as [3H]thymidine incorporation after 72 hrs by microplate scintillation counter
Cytotoxicity against human SK-BR3 cells assessed as [3H]thymidine incorporation after 72 hrs by microplate scintillation counter
[PMID: 18396050]
SK-MEL-2 GI50
0.003 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human SK-MEL-2 cells after 48 hrs by SRB assay
Growth inhibition of human SK-MEL-2 cells after 48 hrs by SRB assay
[PMID: 22982122]
SK-MEL-2 GI50
0.004 μM
Compound: CA4, NSC 613729
Growth inhibition of human SK-MEL-2 cells after 48 hrs by SRB assay
Growth inhibition of human SK-MEL-2 cells after 48 hrs by SRB assay
[PMID: 24387982]
SK-MEL-2 GI50
0.004 μM
Compound: CA4; NSC 613729
Cytotoxicity against human SK-MEL-2 cells by SRB assay
Cytotoxicity against human SK-MEL-2 cells by SRB assay
[PMID: 26257861]
SK-MEL-2 GI50
4.37 nM
Compound: CA4
Growth inhibition of human SK-MEL-2 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SK-MEL-2 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
SK-MEL-28 GI50
0.007 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human SK-MEL-28 cells after 48 hrs by SRB assay
Growth inhibition of human SK-MEL-28 cells after 48 hrs by SRB assay
[PMID: 22982122]
SK-MEL-28 GI50
0.008 μM
Compound: CA4, NSC 613729
Growth inhibition of human SK-MEL-28 cells after 48 hrs by SRB assay
Growth inhibition of human SK-MEL-28 cells after 48 hrs by SRB assay
[PMID: 24387982]
SK-MEL-28 GI50
0.008 μM
Compound: CA4; NSC 613729
Cytotoxicity against human SK-MEL-28 cells by SRB assay
Cytotoxicity against human SK-MEL-28 cells by SRB assay
[PMID: 26257861]
SK-MEL-28 GI50
8.07 nM
Compound: CA4
Growth inhibition of human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
SK-MEL-5 GI50
0.003 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human SK-MEL-5 cells after 48 hrs by SRB assay
Growth inhibition of human SK-MEL-5 cells after 48 hrs by SRB assay
[PMID: 22982122]
SK-MEL-5 GI50
0.003 μM
Compound: CA-4
Growth inhibition of human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
SK-MEL-5 GI50
0.004 μM
Compound: CA4, NSC 613729
Growth inhibition of human SK-MEL-5 cells after 48 hrs by SRB assay
Growth inhibition of human SK-MEL-5 cells after 48 hrs by SRB assay
[PMID: 24387982]
SK-MEL-5 GI50
0.004 μM
Compound: CA4; NSC 613729
Cytotoxicity against human SK-MEL-5 cells by SRB assay
Cytotoxicity against human SK-MEL-5 cells by SRB assay
[PMID: 26257861]
SK-MEL-5 GI50
3.54 nM
Compound: CA4
Growth inhibition of human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
SK-OV-3 GI50
0.00013 μM
Compound: CA4
Growth inhibition of human SK-OV-3 after 48 hrs by SRB assay
Growth inhibition of human SK-OV-3 after 48 hrs by SRB assay
[PMID: 18722127]
SK-OV-3 GI50
0.00042 μM
Compound: 2, CA4
Cytotoxicity against human SKOV3 cells by SRB assay
Cytotoxicity against human SKOV3 cells by SRB assay
[PMID: 24016002]
SK-OV-3 GI50
0.00042 μM
Compound: CA4
Growth inhibition of human SKOV3 cells by sulforhodamine B assay
Growth inhibition of human SKOV3 cells by sulforhodamine B assay
[PMID: 23772309]
SK-OV-3 IC50
0.001 μM
Compound: CA-4
Growth inhibition of human SKOV3 cells by MTT assay
Growth inhibition of human SKOV3 cells by MTT assay
[PMID: 25689111]
SK-OV-3 IC50
0.0033 μM
Compound: 1, CA-4
Antiproliferative activity against human SKOV3 cells after 48 hrs by SRB assay
Antiproliferative activity against human SKOV3 cells after 48 hrs by SRB assay
[PMID: 19894742]
SK-OV-3 IC50
0.0035 μM
Compound: 1, CA-4
Antiproliferative activity against human SKOV3 cells expressing adenoviral MDR1 after 48 hrs by SRB assay
Antiproliferative activity against human SKOV3 cells expressing adenoviral MDR1 after 48 hrs by SRB assay
[PMID: 19894742]
SK-OV-3 GI50
0.00455 μM
Compound: CA4
Cytotoxicity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by SRB assay
Cytotoxicity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by SRB assay
[PMID: 31059248]
SK-OV-3 GI50
0.00455 μM
Compound: CA4, CA4P
Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay
Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay
[PMID: 24183586]
SK-OV-3 GI50
0.00506 μM
Compound: CA4
Cytotoxicity against human SKOV3 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human SKOV3 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
[PMID: 31534659]
SK-OV-3 GI50
0.00533 μM
Compound: CA4
Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay
Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay
[PMID: 23993969]
SK-OV-3 IC50
0.0059 μM
Compound: CA-4
Antiproliferative activity against human SKOV3 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human SKOV3 cells after 72 hrs by CCK8 assay
[PMID: 30006162]
SK-OV-3 IC50
0.012 μM
Compound: 1; CA-4
Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay
Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay
[PMID: 29306206]
SK-OV-3 GI50
0.059 μM
Compound: CA4, NSC 613729
Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay
Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay
[PMID: 24387982]
SK-OV-3 GI50
0.059 μM
Compound: CA4; NSC 613729
Cytotoxicity against human SKOV3 cells by SRB assay
Cytotoxicity against human SKOV3 cells by SRB assay
[PMID: 26257861]
SK-OV-3 GI50
0.063 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay
Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay
[PMID: 22982122]
SK-OV-3 IC50
0.38 μM
Compound: 1a; CA-4
Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay
Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay
[PMID: 29291446]
SK-OV-3 IC50
0.5 μM
Compound: CA-4
Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 36252396]
SK-OV-3 EC50
1.2 nM
Compound: 5, (Z)-5, CA-4, Combretastatin A-4
Cytotoxicity against human SKOV3 cells assessed as cell viability after 48 hrs by MTS assay
Cytotoxicity against human SKOV3 cells assessed as cell viability after 48 hrs by MTS assay
10.1039/C0MD00095G
SK-OV-3 IC50
1.7 nM
Compound: 1, CA-4, combretastatin
Cytotoxicity against human SKOV3 cells after 48 hrs by MTS assay
Cytotoxicity against human SKOV3 cells after 48 hrs by MTS assay
[PMID: 22304851]
SK-OV-3 IC50
1.7 nM
Compound: 1, CA-4
Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay
Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay
[PMID: 24900453]
SK-OV-3 IC50
11.5 nM
Compound: CA-4
Inhibition of MDR1 (unknown origin) transfected in human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay
Inhibition of MDR1 (unknown origin) transfected in human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 23332369]
SK-OV-3 IC50
22 nM
Compound: CA-4
Cytotoxicity against human SKOV3 cells expressing MDR1 after 72 hrs by MTS assay
Cytotoxicity against human SKOV3 cells expressing MDR1 after 72 hrs by MTS assay
[PMID: 24087857]
SK-OV-3 EC50
3.1 nM
Compound: 5, (Z)-5, CA-4, Combretastatin A-4
Cytotoxicity against taxol-resistant human SKOV3 cells assessed as cell viability after 48 hrs by MTS assay
Cytotoxicity against taxol-resistant human SKOV3 cells assessed as cell viability after 48 hrs by MTS assay
10.1039/C0MD00095G
SK-OV-3 GI50
31.6 μM
Compound: 1; CA-4
Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 27161282]
SK-OV-3 IC50
4.2 nM
Compound: 1, CA-4
Growth inhibition of paclitaxel-resistant human SKOV3 cells after 48 hrs by SRB assay
Growth inhibition of paclitaxel-resistant human SKOV3 cells after 48 hrs by SRB assay
[PMID: 24900453]
SK-OV-3 IC50
4.5 nM
Compound: CA-4
Antiproliferative activity against human SK-OV-3 cells assessed as decrease in cell growth measured after 48 hrs by SRB method
Antiproliferative activity against human SK-OV-3 cells assessed as decrease in cell growth measured after 48 hrs by SRB method
[PMID: 33310545]
SK-OV-3 IC50
4.5 nM
Compound: CA-4
Antiproliferative activity against human SKOV3 cells after 48 hrs by SRB assay
Antiproliferative activity against human SKOV3 cells after 48 hrs by SRB assay
[PMID: 23895532]
SK-OV-3 IC50
4.5 nM
Compound: CA-4
Antiproliferative activity against human SKOV3 cells by SRB assay
Antiproliferative activity against human SKOV3 cells by SRB assay
[PMID: 29655610]
SK-OV-3 GI50
5.06 nM
Compound: CA4
Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 26852340]
SK-OV-3 IC50
5.5 nM
Compound: 4, CA4
Antiproliferative activity against human SKOV3 after 48 hrs by spectrophotometry
Antiproliferative activity against human SKOV3 after 48 hrs by spectrophotometry
[PMID: 21774499]
SK-OV-3 IC50
5.5 nM
Compound: CA-4
Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 27213719]
SK-OV-3 IC50
5.5 nM
Compound: CA-4
Antiproliferative activity against wild type human SK-OV-3 cells assessed as inhibition of cell growth by SRB assay
Antiproliferative activity against wild type human SK-OV-3 cells assessed as inhibition of cell growth by SRB assay
[PMID: 36889150]
SK-OV-3 IC50
5.5 nM
Compound: CA-4
Antiproliferative activity against human SKOV3 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human SKOV3 cells after 48 hrs by sulforhodamine B assay
[PMID: 30297118]
SK-OV-3 IC50
5.5 nM
Compound: CA-4
Antiproliferative activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
[PMID: 30098869]
SK-OV-3 IC50
5.5 nM
Compound: CA-4
Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
SK-OV-3 GI50
58.88 nM
Compound: CA4
Growth inhibition of human SKOV3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SKOV3 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
SK-OV-3 IC50
6 nM
Compound: CA4
Antiproliferative activity against human SK-OV-3 cells after 72 hrs by CellTiter Glo assay
Antiproliferative activity against human SK-OV-3 cells after 72 hrs by CellTiter Glo assay
[PMID: 35797900]
SK-OV-3 IC50
6.1 nM
Compound: CA-4
Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay
Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay
[PMID: 24087857]
SK-OV-3 IC50
6.9 nM
Compound: CA-4
Antiproliferative activity against human SKOV3 cells overexpressing wild type beta3 tubulin after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human SKOV3 cells overexpressing wild type beta3 tubulin after 48 hrs by sulforhodamine B assay
[PMID: 25882519]
SK-OV-3 IC50
7.2 nM
Compound: CA-4
Antiproliferative activity against multidrug resistant human SKOV3 cells expressing MDR1-M6/6 after 48 hrs by SRB assay
Antiproliferative activity against multidrug resistant human SKOV3 cells expressing MDR1-M6/6 after 48 hrs by SRB assay
[PMID: 27213719]
SK-OV-3 IC50
7.2 nM
Compound: CA-4
Antiproliferative activity against human SK-OV-3 cells overexpressing MDR-1-M6/6 assessed as inhibition of cell growth by SRB assay
Antiproliferative activity against human SK-OV-3 cells overexpressing MDR-1-M6/6 assessed as inhibition of cell growth by SRB assay
[PMID: 36889150]
SK-OV-3 IC50
7.2 nM
Compound: CA-4
Cytotoxicity against human SK-OV-3 cells over expressing MDR1-6/6 assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human SK-OV-3 cells over expressing MDR1-6/6 assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
SK-OV-3 IC50
9.7 nM
Compound: CA-4
Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 23332369]
SMMC-7721 IC50
0.0038 μM
Compound: CA-4
Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay
Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay
[PMID: 29172084]
SMMC-7721 IC50
0.289 μM
Compound: CA4
Cytotoxicity against human SMMC7721 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human SMMC7721 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23708012]
SMMC-7721 IC50
0.29 μM
Compound: CA-4
Anticancer activity against human SMMC7721 cells after 72 hrs
Anticancer activity against human SMMC7721 cells after 72 hrs
[PMID: 19713108]
SMMC-7721 IC50
1.72 μM
Compound: CA-4
Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay
Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay
[PMID: 29407949]
SMMC-7721 IC50
1.92 μM
Compound: CA-4
Cytotoxicity against human SMMC7721 cells after 72 hrs by MTT assay
Cytotoxicity against human SMMC7721 cells after 72 hrs by MTT assay
[PMID: 28622907]
SMMC-7721 IC50
3.22 μM
Compound: CA-4
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
[PMID: 19665898]
SN12C GI50
0.006 μM
Compound: CA4, NSC 613729
Growth inhibition of human SN12C cells after 48 hrs by SRB assay
Growth inhibition of human SN12C cells after 48 hrs by SRB assay
[PMID: 24387982]
SN12C GI50
0.006 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human SN12C cells after 48 hrs by SRB assay
Growth inhibition of human SN12C cells after 48 hrs by SRB assay
[PMID: 22982122]
SN12C GI50
5.98 nM
Compound: CA4
Growth inhibition of human SN12C cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SN12C cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
SNB-19 GI50
0.003 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human SNB19 cells after 48 hrs by SRB assay
Growth inhibition of human SNB19 cells after 48 hrs by SRB assay
[PMID: 22982122]
SNB-19 GI50
0.004 μM
Compound: CA4, NSC 613729
Growth inhibition of human SNB19 cells after 48 hrs by SRB assay
Growth inhibition of human SNB19 cells after 48 hrs by SRB assay
[PMID: 24387982]
SNB-19 GI50
0.004 μM
Compound: CA4; NSC 613729
Cytotoxicity against human SNB19 cells by SRB assay
Cytotoxicity against human SNB19 cells by SRB assay
[PMID: 26257861]
SNB-19 GI50
3.85 nM
Compound: CA4
Growth inhibition of human SNB19 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SNB19 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
SNB-75 GI50
0.007 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human SNB75 cells after 48 hrs by SRB assay
Growth inhibition of human SNB75 cells after 48 hrs by SRB assay
[PMID: 22982122]
SNB-75 GI50
0.008 μM
Compound: CA4, NSC 613729
Growth inhibition of human SNB75 cells after 48 hrs by SRB assay
Growth inhibition of human SNB75 cells after 48 hrs by SRB assay
[PMID: 24387982]
SNB-75 GI50
0.008 μM
Compound: CA4; NSC 613729
Cytotoxicity against human SNB75 cells by SRB assay
Cytotoxicity against human SNB75 cells by SRB assay
[PMID: 26257861]
SNB-75 GI50
0.008 μM
Compound: CA-4
Growth inhibition of human SNB75 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SNB75 cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
SNB-75 GI50
7.91 nM
Compound: CA4
Growth inhibition of human SNB75 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SNB75 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
SNU-423 IC50
6 nM
Compound: CA-4
Cytotoxicity against human SNU423 cells after 48 hrs by alamar blue assay
Cytotoxicity against human SNU423 cells after 48 hrs by alamar blue assay
[PMID: 19117761]
SR GI50
0.003 μM
Compound: CA4, NSC 613729
Growth inhibition of human SR cells after 48 hrs by SRB assay
Growth inhibition of human SR cells after 48 hrs by SRB assay
[PMID: 24387982]
SR GI50
0.003 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human SR cells after 48 hrs by SRB assay
Growth inhibition of human SR cells after 48 hrs by SRB assay
[PMID: 22982122]
SR GI50
0.003 μM
Compound: CA4; NSC 613729
Cytotoxicity against human SR cells by SRB assay
Cytotoxicity against human SR cells by SRB assay
[PMID: 26257861]
SR GI50
0.003 μM
Compound: CA-4
Growth inhibition of human SR cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SR cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
SR GI50
2.99 nM
Compound: CA4
Growth inhibition of human SR cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SR cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
SW1990 IC50
0.25 μM
Compound: CA4
Cytotoxicity against human SW1990 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human SW1990 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23708012]
SW1990 IC50
0.25 μM
Compound: CA-4
Anticancer activity against human SW1990 cells after 72 hrs
Anticancer activity against human SW1990 cells after 72 hrs
[PMID: 19713108]
SW48 IC50
3.32 nM
Compound: CA-4
Antiproliferative activity in human SW48 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity in human SW48 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 22329561]
SW480 IC50
18.2 nM
Compound: CA-4
Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
[PMID: 23356786]
SW480 IC50
3.63 nM
Compound: CA-4
Antiproliferative activity in human SW480 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity in human SW480 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 22329561]
SW-620 IC50
0.003 μM
Compound: CA-4
Antiproliferative activity against human SW620 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human SW620 cells measured after 48 hrs by MTT assay
[PMID: 36150341]
SW-620 GI50
0.003 μM
Compound: CA4, NSC 613729
Growth inhibition of human SW620 cells after 48 hrs by SRB assay
Growth inhibition of human SW620 cells after 48 hrs by SRB assay
[PMID: 24387982]
SW-620 GI50
0.003 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human SW620 cells after 48 hrs by SRB assay
Growth inhibition of human SW620 cells after 48 hrs by SRB assay
[PMID: 22982122]
SW-620 GI50
0.003 μM
Compound: CA4; NSC 613729
Cytotoxicity against human SW620 cells by SRB assay
Cytotoxicity against human SW620 cells by SRB assay
[PMID: 26257861]
SW-620 IC50
0.023 μM
Compound: CA-4, 1a
Cytotoxicity against human SW620 cells after 72 hrs by MTT assay
Cytotoxicity against human SW620 cells after 72 hrs by MTT assay
[PMID: 20338766]
SW-620 IC50
1.52 nM
Compound: CA-4
Antiproliferative activity in human SW620 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity in human SW620 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 22329561]
SW-620 GI50
3.04 nM
Compound: CA4
Growth inhibition of human SW620 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SW620 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
T-24 IC50
0.0087 μM
Compound: CA-4, 1a
Cytotoxicity against human T24 cells after 72 hrs by MTT assay
Cytotoxicity against human T24 cells after 72 hrs by MTT assay
[PMID: 20338766]
T47D IC50
0.0019 μM
Compound: CA-4
Antiproliferative activity against human T47D cells measured after 48 hrs by MTT assay
Antiproliferative activity against human T47D cells measured after 48 hrs by MTT assay
[PMID: 32717486]
T47D IC50
0.021 μM
Compound: 2; CA-4
Antiproliferative activity against human T47D cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human T47D cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36334455]
T47D IC50
0.027 μM
Compound: CA-4
Antiproliferative activity against human T47D cells assessed as cell growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human T47D cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 33895499]
T47D IC50
1.89 nM
Compound: CA-4
Cytotoxicity against human T47D cells after 72 hrs by MTT assay
Cytotoxicity against human T47D cells after 72 hrs by MTT assay
[PMID: 30472600]
T47D GI50
10 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human T47D cells after 48 hrs by SRB assay
Growth inhibition of human T47D cells after 48 hrs by SRB assay
[PMID: 22982122]
T47D IC50
14.6 nM
Compound: CA-4
Antiproliferative activity against human T47D cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human T47D cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 31610372]
T84 IC50
23.43 nM
Compound: CA-4
Antiproliferative activity in human T84 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity in human T84 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 22329561]
T98G IC50
0.011 μM
Compound: CA4
Cytotoxicity against human T98G cells assessed as cell viability after 72 hrs by resazurin reduction assay
Cytotoxicity against human T98G cells assessed as cell viability after 72 hrs by resazurin reduction assay
[PMID: 26599530]
TK-10 GI50
0.1 μM
Compound: CA4, NSC 613729
Growth inhibition of human TK10 cells after 48 hrs by SRB assay
Growth inhibition of human TK10 cells after 48 hrs by SRB assay
[PMID: 24387982]
TK-10 GI50
0.1 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human TK10 cells after 48 hrs by SRB assay
Growth inhibition of human TK10 cells after 48 hrs by SRB assay
[PMID: 22982122]
TK-10 GI50
100 nM
Compound: CA4
Growth inhibition of human TK10 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human TK10 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
TSGH 9201 IC50
38 nM
Compound: 4
Antiproliferative activity against human TSGH stomach carcinoma cell line by methylene blue dye assay
Antiproliferative activity against human TSGH stomach carcinoma cell line by methylene blue dye assay
[PMID: 17034147]
U-251 GI50
0.004 μM
Compound: CA4, NSC 613729
Growth inhibition of human U251 cells after 48 hrs by SRB assay
Growth inhibition of human U251 cells after 48 hrs by SRB assay
[PMID: 24387982]
U-251 GI50
0.004 μM
Compound: CA4; NSC 613729
Cytotoxicity against human U251 cells by SRB assay
Cytotoxicity against human U251 cells by SRB assay
[PMID: 26257861]
U-251 GI50
0.004 μM
Compound: CA-4
Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay
[PMID: 27031215]
U-251 GI50
0.007 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human U251cells after 48 hrs by SRB assay
Growth inhibition of human U251cells after 48 hrs by SRB assay
[PMID: 22982122]
U-251 IC50
0.03 μM
Compound: CA-4
Antiproliferative activity against human U-251 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human U-251 cells measured after 48 hrs by MTT assay
[PMID: 36150341]
U-251 IC50
0.13 μM
Compound: CA-4
Antiproliferative activity against human U-251 cells after 48 hrs by MTT assay
Antiproliferative activity against human U-251 cells after 48 hrs by MTT assay
[PMID: 34311158]
U-251 GI50
0.17 μM
Compound: CA-4
Antiproliferative activity against human U251 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human U251 cells incubated for 48 hrs by MTT assay
[PMID: 32832031]
U-251 IC50
0.54 μM
Compound: CA-4
Antiproliferative activity against human U251 cells after 24 to 48 hrs by CKK8 assay
Antiproliferative activity against human U251 cells after 24 to 48 hrs by CKK8 assay
[PMID: 25105922]
U-251 GI50
4.03 nM
Compound: CA4
Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
U2OS IC50
0.0141 μM
Compound: 3, CA4
Anticancer activity against human U2OS cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay
Anticancer activity against human U2OS cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay
[PMID: 25466200]
U2OS IC50
0.766 nM
Compound: 7; CA-4
Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 31401010]
U-87MG ATCC IC50
0.011 μM
Compound: CA-4
Antiproliferative activity against human U-87 MG cells measured after 48 hrs by MTT assay
Antiproliferative activity against human U-87 MG cells measured after 48 hrs by MTT assay
[PMID: 36150341]
U-87MG ATCC IC50
0.48 μM
Compound: CA-4
Antiproliferative activity against human U87 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human U87 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
[PMID: 31830637]
U-87MG ATCC IC50
2.6 nM
Compound: 4, CA4
Antiproliferative activity against human U87MG after 48 hrs by spectrophotometry
Antiproliferative activity against human U87MG after 48 hrs by spectrophotometry
[PMID: 21774499]
U-87MG ATCC IC50
3 nM
Compound: CA-4
Antiproliferative activity against human U87 cells after 72 hrs by resazurin-based fluorescence assay
Antiproliferative activity against human U87 cells after 72 hrs by resazurin-based fluorescence assay
[PMID: 29202409]
U-87MG ATCC IC50
4 nM
Compound: CA-4
Antiproliferative activity against human U87MG cells after 72 hrs by MTS assay
Antiproliferative activity against human U87MG cells after 72 hrs by MTS assay
[PMID: 30525602]
U-87MG ATCC IC50
9.75 μM
Compound: CA-4; B
Antiproliferative activity against human U87 cells after 48 hrs by MTT assay
Antiproliferative activity against human U87 cells after 48 hrs by MTT assay
[PMID: 28774575]
U-937 IC50
> 10 μM
Compound: CA4
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins
[PMID: 21955454]
U-937 IC50
0.001 μM
Compound: 8; CA-4
Antiproliferative activity against human U-937 cells assessed as cell growth inhibition after 72 hrs by CCK8 assay
Antiproliferative activity against human U-937 cells assessed as cell growth inhibition after 72 hrs by CCK8 assay
[PMID: 34454126]
UACC-257 GI50
0.003 μM
Compound: CA4, NSC 613729
Growth inhibition of human UACC257 cells after 48 hrs by SRB assay
Growth inhibition of human UACC257 cells after 48 hrs by SRB assay
[PMID: 24387982]
UACC-257 GI50
0.003 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human UACC257 cells after 48 hrs by SRB assay
Growth inhibition of human UACC257 cells after 48 hrs by SRB assay
[PMID: 22982122]
UACC-257 GI50
3.02 nM
Compound: CA4
Growth inhibition of human UACC257 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human UACC257 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
UACC-62 GI50
0.005 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human UACC62 cells after 48 hrs by SRB assay
Growth inhibition of human UACC62 cells after 48 hrs by SRB assay
[PMID: 22982122]
UACC-62 GI50
0.006 μM
Compound: CA4, NSC 613729
Growth inhibition of human UACC62 cells after 48 hrs by SRB assay
Growth inhibition of human UACC62 cells after 48 hrs by SRB assay
[PMID: 24387982]
UACC-62 GI50
0.006 μM
Compound: CA4; NSC 613729
Cytotoxicity against human UACC62 cells by SRB assay
Cytotoxicity against human UACC62 cells by SRB assay
[PMID: 26257861]
UACC-62 GI50
5.51 nM
Compound: CA4
Growth inhibition of human UACC62 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human UACC62 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
UO-31 GI50
0.019 μM
Compound: CA4, NSC 613729
Growth inhibition of human UO31 cells after 48 hrs by SRB assay
Growth inhibition of human UO31 cells after 48 hrs by SRB assay
[PMID: 24387982]
UO-31 GI50
0.019 μM
Compound: 2, combretastatin A-4, CA-4, NSC 613729
Growth inhibition of human UO31 cells after 48 hrs by SRB assay
Growth inhibition of human UO31 cells after 48 hrs by SRB assay
[PMID: 22982122]
UO-31 GI50
0.019 μM
Compound: CA4; NSC 613729
Cytotoxicity against human UO31 cells by SRB assay
Cytotoxicity against human UO31 cells by SRB assay
[PMID: 26257861]
UO-31 GI50
19.41 nM
Compound: CA4
Growth inhibition of human UO31 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human UO31 cells after 48 hrs by sulforhodamine B assay
[PMID: 24388833]
WI-38 IC50
31.57 μM
Compound: 1; CA-4
Cytotoxicity against human WI-38 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human WI-38 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
[PMID: 33421913]
体外研究
(In Vitro)

Combretastatin A4 phosphate (≥ 50 μM) 显着增加膜联蛋白-V 结合细胞的百分比,并显着降低前向散射。 Combretastatin A4 phosphate 不会明显增加溶血。数百 μM Combretastatin A4 phosphate 可显着增强 Fluo3 荧光。通过去除细胞外 Ca2+,Combretastatin A4 phosphate (100 μM) 对膜联蛋白-V 结合的作用显着减弱,但并未消除。 Combretastatin A4 phosphate (≥ 50 μM) 显着降低 GSH 丰度和 ATP 水平,但不会显着增加 ROS 或神经酰胺[2]。共封装阿霉素-考布他汀-A4 磷酸盐 (1:10) 的聚合物囊体对人鼻咽表皮癌 (KB) 细胞表现出强烈的协同细胞毒性[3]。用 Combretastatin A4 phosphate 预处理不会影响 3-D 培养物中 VM 的量以及这些关键分子的表达[4]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

给药后 30 分钟的 DBP 和 MBP 在用 Combretastatin A4 disodium phosphate 120 mg/10 mL/kg 处理的大鼠中较高。Combretastatin A4 phosphate 和 Combretastatin A4 在用 Combretastatin A4 disodium phosphate 120 mg/10 mL/kg 处理的大鼠中的毒代动力学参数被指出,并且 Combretastatin A4 的 Cmax、T1/2 和 AUC0-inf 值为 156±13 μM,5.87±1.69 h,89.4±10.1 h· μM[1]。在体内,W256 肿瘤在 Combretastatin A4 phosphate 处理后表现出明显的瘤内缺氧,并伴有 VM 形成增加。Combretastatin A4 phosphate 仅在 2 天内表现出肿瘤生长延迟,但随后肿瘤快速再生。VM 密度与第 8 天的肿瘤体积和肿瘤重量呈正相关。Combretastatin A4 phosphate 引起缺氧,通过 HIF-1α/EphA2/PI3K/基质金属蛋白酶 (MMP) 信号通路诱导 W256 肿瘤中 VM 形成,导致随之而来的再生受损的肿瘤[4]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

316.35

Formula

C18H20O5

CAS 号
性状

固体

颜色

White to off-white

中文名称

康普瑞汀

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验: 

DMSO 中的溶解度 : 100 mg/mL (316.11 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1611 mL 15.8053 mL 31.6106 mL
5 mM 0.6322 mL 3.1611 mL 6.3221 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验:

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 3 mg/mL (9.48 mM); 澄清溶液

    此方案可获得 ≥ 3 mg/mL(饱和度未知)的澄清溶液。

    1 mL 工作液为例,取 100 μL 30.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;再向上述体系中加入 50 μL Tween-80,混合均匀;然后再继续加入 450 μL 生理盐水 定容至 1 mL

    生理盐水的配制:将 0.9 g 氯化钠,溶解于 ddH₂O 并定容至 100 mL,可以得到澄清透明的生理盐水溶液。
  • 方案 二

    请依序添加每种溶剂: 10% DMSO    90% Corn Oil

    Solubility: ≥ 3 mg/mL (9.48 mM); 澄清溶液

    此方案可获得 ≥ 3 mg/mL(饱和度未知)的澄清溶液,此方案实验周期在半个月以上的动物实验酌情使用。

    1 mL 工作液为例,取 100 μL 30.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
请输入您的动物体内配方组成:
%
DMSO +
+
%
Tween-80 +
%
Saline
如果您的动物是免疫缺陷鼠或者体弱鼠,建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
方案所需 助溶剂 包括:DMSO ,均可在 MCE 网站选购。 Tween 80,均可在 MCE 网站选购。
计算结果
工作液所需浓度 : mg/mL
储备液配制方法 : mg 药物溶于 μL  DMSO(母液浓度为 mg/mL)。
您所需的储备液浓度超过该产品的实测溶解度,以下方案仅供参考,如有需要,请与 MCE 中国技术支持联系。
动物实验体内工作液的配制方法 : 取 μL DMSO 储备液,加入 μL  μL ,混合均匀至澄清,再加 μL Tween 80,混合均匀至澄清,再加 μL 生理盐水
连续给药周期超过半月以上,请谨慎选择该方案。
请确保第一步储备液溶解至澄清状态,从左到右依次添加助溶剂。您可采用超声加热 (超声清洗仪,建议频次 20-40 kHz),涡旋吹打等方式辅助溶解。
纯度 & 产品资料

纯度: 99.76%

参考文献
Animal Administration
[1]

Rats: Rats are administered a single intravenous dose of Combretastatin A4 disodium phosphate at 120 mg/10 mL/kg by bolus infusion (n=3). Blood is taken via the jugular vein and collected in heparin-coated tubes at 10 minutes and 1, 3, 6, and 24 hours after administration. Plasma is separated by centrifugation immediately after sampling. After centrifugation, an aliquot of plasma is mixed with the equivalent volume of 1% formic acid and stored at −20°C. The thawed plasma samples are purified by solid-phase extraction, and the plasma concentrations of combretastatin A4 phosphate (free base of Combretastatin A4 disodium phosphate; Combretastatin A4 phosphate) and combretastatin A4 (the metabolite of Combretastatin A4 disodium phosphate; Combretastatin A4 ) are determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Toxicokinetic parameters [maximum concentration (Cmax), terminal half-life (T1/2), and area under the concentration-time curve from time zero to infinity (AUC0-inf)] are obtained by non-compartmental analysis using Phoenix WinNonlin 6.3.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1611 mL 15.8053 mL 31.6106 mL 79.0264 mL
5 mM 0.6322 mL 3.1611 mL 6.3221 mL 15.8053 mL
10 mM 0.3161 mL 1.5805 mL 3.1611 mL 7.9026 mL
15 mM 0.2107 mL 1.0537 mL 2.1074 mL 5.2684 mL
20 mM 0.1581 mL 0.7903 mL 1.5805 mL 3.9513 mL
25 mM 0.1264 mL 0.6322 mL 1.2644 mL 3.1611 mL
30 mM 0.1054 mL 0.5268 mL 1.0537 mL 2.6342 mL
40 mM 0.0790 mL 0.3951 mL 0.7903 mL 1.9757 mL
50 mM 0.0632 mL 0.3161 mL 0.6322 mL 1.5805 mL
60 mM 0.0527 mL 0.2634 mL 0.5268 mL 1.3171 mL
80 mM 0.0395 mL 0.1976 mL 0.3951 mL 0.9878 mL
100 mM 0.0316 mL 0.1581 mL 0.3161 mL 0.7903 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Combretastatin A4
目录号:
HY-N2146
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