Isoliquiritigenin (Synonyms: 异甘草素; GU17; ISL; Isoliquiritigen; SJ000286237)

目录号: HY-N0102 纯度: 98.07%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Isoliquiritigenin 是从甘草中分到的黄酮类化合物，具有抗肿瘤的活性，能够抑制 aldose reductase 的活性，IC₅₀ 值为 320 nM。Isoliquiritigenin 是一种流感病毒 (influenza virus) 复制的有效抑制剂，EC₅₀ 为 24.7 μM。

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Isoliquiritigenin Chemical Structure

CAS No. : 961-29-5

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥500	In-stock
1 mg	￥140	In-stock
5 mg	￥281	In-stock
10 mg	￥450	In-stock
50 mg	￥900	In-stock
100 mg	￥1400	In-stock
200 mg	￥2100	In-stock
500 mg		询价
1 g		询价

or 大包装询价

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Customer Review

Other Forms of Isoliquiritigenin:

Isoliquiritigenin (Standard) 询价

MCE 顾客使用本产品发表的 18 篇科研文献

IHC

: Isoliquiritigenin purchased from MCE. Usage Cited in: Onco Targets Ther. 2018 Mar 22;11:1633-1642. [Abstract]; Isoliquiritigenin (ILQ) treatment affects the expression level of apoptosis-related proteins.

: Isoliquiritigenin purchased from MCE. Usage Cited in: Chemotherapy. 2018 Jun 22;63(3):155-161. [Abstract]; Western blot analysis of the effect on Bcl2, Bax, and active Caspase-3 protein expression in Isoliquiritigenin (ISL) treated U2OS cells.

: Isoliquiritigenin purchased from MCE. Usage Cited in: Oncol Lett. 2018 Nov;16(5):6133-6139. [Abstract]; Western blot analysis of the expression of E cadherin, N cadherin and vimentin in A549 cells following treatment with Isoliquiritigenin (ISL) for 48 h.

: Isoliquiritigenin purchased from MCE. Usage Cited in: Am J Transl Res. 2018 Dec 15;10(12):4141-4151. [Abstract]; ISL inhibits phosphorylation of IκB-α following LPS stimulation. The expressions of IκB-α and p-IκB are measured by western blot. The samples are harvested from cells and mice. The results show that ISL could effectively decrease protein levels of p-IκB in HK₂ of the LPS-induced mice but increase IκB-α.

: Isoliquiritigenin purchased from MCE. Usage Cited in: Am J Transl Res. 2018 Dec 15;10(12):4141-4151. [Abstract]; The expression of CD68, CD206, iNOS, MPO is determined by immunohistochemistry in four animal groups. LPS increases the expression of CD68, iNOS and MPO but decreases the expression of CD206 in murine kidney, while ISL reduces the expression of CD68, iNOS and MPO then increases the expression of CD206 in mice kidney after LPS injection.

: Isoliquiritigenin purchased from MCE. Usage Cited in: Open Life Sci. 2017; 12: 300–307; Western blot assays detect apoptosis-related protein expression of Bax, Bcl-2, active caspase-3.

Isoliquiritigenin 相关产品

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生物活性
纯度 & 产品资料
参考文献

生物活性

Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC₅₀ of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC₅₀ of 24.7 μM.

IC₅₀ & Target

IC50: 320 nM (Aldose reductase)

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
3T3-L1	IC₅₀	96.4 μM Compound: 10	Antiadipogenic activity against mouse 3T3L1 cells assessed as inhibition of differentiation after 7 days by oil-red O staining Antiadipogenic activity against mouse 3T3L1 cells assessed as inhibition of differentiation after 7 days by oil-red O staining	[PMID: 19757853]
A549	IC₅₀	> 20 μM Compound: 3	Inhibition of TNFalpha induced NF-kappaB activation in human A549 cells by luciferase reporter gene assay Inhibition of TNFalpha induced NF-kappaB activation in human A549 cells by luciferase reporter gene assay	[PMID: 19883086]
A549	IC₅₀	52.58 μM Compound: ISL	Antiproliferation activity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay Antiproliferation activity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay	[PMID: 34186178]
A549	IC₅₀	85 μM Compound: 20	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 21696954]
A549	GI₅₀	87 μM Compound: 11	Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 32345458]
A549	IC₅₀	98.9 μM Compound: 28	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 18440233]
B16-BL6	IC₅₀	80.5 μM Compound: 28	Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay	[PMID: 18440233]
BV-2	IC₅₀	> 100 μM Compound: 8	Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay	[PMID: 28911817]
C2C12	IC₅₀	26.34 μg/mL Compound: 11	Cytotoxicity against mouse C2C12 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against mouse C2C12 cells assessed as reduction in cell viability by MTT assay	[PMID: 33412152]
C-33-A	IC₅₀	32.83 μM Compound: 2	Cytotoxicity against human C33A cells assessed as reduction in cell viability after 72 hrs Cytotoxicity against human C33A cells assessed as reduction in cell viability after 72 hrs	[PMID: 31539776]
Ca-Ski	IC₅₀	39.09 μM Compound: 2	Cytotoxicity against human CaSki cells assessed as reduction in cell viability after 72 hrs Cytotoxicity against human CaSki cells assessed as reduction in cell viability after 72 hrs	[PMID: 31539776]
CHO	IC₅₀	45.9 μM Compound: 13	Cytotoxicity against CHO cells by MTT assay Cytotoxicity against CHO cells by MTT assay	[PMID: 19572738]
HCT-116	GI₅₀	39 μM Compound: 11	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 32345458]
HEK-293T	IC₅₀	3.42 μg/mL Compound: 6	Inhibition of oseltamivir-resistant H1N1 swine influenza virus neuraminidase H274Y mutant activity expressed in HEK293T cells after 2 hrs by spectrofluorometry Inhibition of oseltamivir-resistant H1N1 swine influenza virus neuraminidase H274Y mutant activity expressed in HEK293T cells after 2 hrs by spectrofluorometry	[PMID: 21123068]
HEK-293T	IC₅₀	3.48 μg/mL Compound: 6	Inhibition of wild type H1N1 swine influenza virus neuraminidase activity expressed in HEK293T cells after 2 hrs by spectrofluorometry Inhibition of wild type H1N1 swine influenza virus neuraminidase activity expressed in HEK293T cells after 2 hrs by spectrofluorometry	[PMID: 21123068]
HeLa	IC₅₀	58.1 μM Compound: 2	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31539776]
HeLa	IC₅₀	58.1 μM Compound: 2	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs	[PMID: 31539776]
HeLa	IC₅₀	82.6 μM Compound: 28	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 18440233]
HepG2	IC₅₀	27.71 μM Compound: ISL	Antiproliferation activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay Antiproliferation activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay	[PMID: 34186178]
HT-1080	IC₅₀	76.7 μM Compound: 28	Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay	[PMID: 18440233]
Huh-7	CC₅₀	> 50 μM Compound: 24	Cytotoxicity against human Huh7.5.1 cells by MTT assay Cytotoxicity against human Huh7.5.1 cells by MTT assay	[PMID: 22445328]
Huh-7	EC₅₀	36.1 μM Compound: 24	Antiviral activity against HCV JFH-1 J399EM infected in Human Huh7.5.1 cells assessed as suppression of viral replication after 72 hrs by EGFP assay Antiviral activity against HCV JFH-1 J399EM infected in Human Huh7.5.1 cells assessed as suppression of viral replication after 72 hrs by EGFP assay	[PMID: 22445328]
HUVEC	IC₅₀	41.17 μM Compound: Isoliquiritigein	Toxicity against HUVEC incubated for 48 hrs by MTT assay Toxicity against HUVEC incubated for 48 hrs by MTT assay	[PMID: 25590864]
J774.1	IC₅₀	29.3 μM Compound: 16	Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs by Griess reagent assay Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs by Griess reagent assay	[PMID: 15974608]
K562	IC₅₀	29.27 μM Compound: Isoliquiritigein	Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay	[PMID: 25590864]
K562	IC₅₀	32 μM Compound: Isoliquiritigenin	Inhibition of NF-kappaB transactivation in TNF-alpha-stimulated human K562 cells preincubated for 2 hrs followed by TNF-alpha challenge measured after 6 hrs by dual luciferase reporter gene assay Inhibition of NF-kappaB transactivation in TNF-alpha-stimulated human K562 cells preincubated for 2 hrs followed by TNF-alpha challenge measured after 6 hrs by dual luciferase reporter gene assay	[PMID: 24775915]
KB	CC₅₀	12 μM Compound: 10c	Compound concentration required to reduce the exponential growth of KB cells by 50% Compound concentration required to reduce the exponential growth of KB cells by 50%	[PMID: 9767632]
L02	IC₅₀	> 1000 μM Compound: 2	Cytotoxicity against human LO2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human LO2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31539776]
Lewis lung carcinoma cell line	IC₅₀	84 μM Compound: 28	Cytotoxicity against mouse LLC cells after 72 hrs by MTT assay Cytotoxicity against mouse LLC cells after 72 hrs by MTT assay	[PMID: 18440233]
LoVo	IC₅₀	57 μM Compound: 20	Cytotoxicity against human LoVo cells after 72 hrs by MTT assay Cytotoxicity against human LoVo cells after 72 hrs by MTT assay	[PMID: 21696954]
MCF-10A	IC₅₀	25 μM Compound: Isoliquiritin	Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 to 96 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 to 96 hrs by MTT assay	[PMID: 33257172]
MCF7	IC₅₀	> 10 μM Compound: Isoliquiritigenin	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26690274]
MCF7	GI₅₀	> 100 μM Compound: 11	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 32345458]
MCF7	IC₅₀	17.67 μM Compound: ISL	Antiproliferation activity against human MCF-7 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay Antiproliferation activity against human MCF-7 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay	[PMID: 34186178]
MDA-MB-231	IC₅₀	> 10 μM Compound: Isoliquiritigenin	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26690274]
MDA-MB-231	IC₅₀	10.86 μM Compound: ISL	Antiproliferation activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay Antiproliferation activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay	[PMID: 34186178]
MDA-MB-231	IC₅₀	25 μM Compound: Isoliquiritin	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 to 96 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 to 96 hrs by MTT assay	[PMID: 33257172]
MT4	CC₅₀	7.4 μM Compound: 10c	Compound concentration required to reduce the exponential growth of MT-4 cells by 50% Compound concentration required to reduce the exponential growth of MT-4 cells by 50%	[PMID: 9767632]
NIH3T3	IC₅₀	4.8 μM Compound: 1c	Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay	[PMID: 21112783]
PANC-1	IC₅₀	3.3 μM Compound: 9	Cytotoxicity against human PANC1 cells after 72 hrs by WST8 assay Cytotoxicity against human PANC1 cells after 72 hrs by WST8 assay	[PMID: 28495081]
PC-12	IC₅₀	17.8 μM Compound: 2	Cytotoxicity against rat PC12 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against rat PC12 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31539776]
PC-3	IC₅₀	99 μM Compound: 20	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 21696954]
RAW264.7	IC₅₀	3.4 μg/mL Compound: 202	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reagent based assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reagent based assay	[PMID: 31255927]
RAW264.7	IC₅₀	72 μM Compound: 12	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 23743282]
SiHa	IC₅₀	53.76 μM Compound: 2	Cytotoxicity against human SiHa cells assessed as reduction in cell viability after 72 hrs Cytotoxicity against human SiHa cells assessed as reduction in cell viability after 72 hrs	[PMID: 31539776]
SiHa	IC₅₀	53.8 μM Compound: 2	Cytotoxicity against human SiHa cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human SiHa cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31539776]
SK-MEL-28	IC₅₀	75 μM Compound: 20	Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay	[PMID: 21696954]
U-373MG ATCC	IC₅₀	68 μM Compound: 20	Cytotoxicity against human U373 cells after 72 hrs by MTT assay Cytotoxicity against human U373 cells after 72 hrs by MTT assay	[PMID: 21696954]
Vero	IC₅₀	31.25 μg/mL Compound: 30	Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth after 72 hrs by MTT assay	[PMID: 22169259]
Vero	CC₅₀	463.65 μg/mL Compound: 30	Cytotoxicity against african green monkey Vero cells assessed as cell death after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells assessed as cell death after 72 hrs by MTT assay	[PMID: 22169259]

体外研究
(In Vitro)

Isoliquiritigenin 可通过抑制大鼠晶状体醛糖还原酶 (IC₅₀=320 nM) 和山梨醇在人红细胞中的积累 (IC₅₀=2.0 μM) 来预防糖尿病并发症^[1]。Isoliquiritigenin (100 μM) 显著抑制缺氧诱导的心肌细胞 TPS 和 TR90 延长。与载体组相比，Isoliquiritigenin 显著触发 AMPK Thr172 磷酸化。Isoliquiritigenin 处理还在心肌细胞中诱导细胞外信号调节激酶 (ERK) 信号通路。Isoliquiritigenin 处理可显著降低缺氧/复氧期间离体心肌细胞的胞内 ROS 水平^[3]。Isoliquiritigenin 不仅能下调 IL-6 表达，还能显著降低磷酸化 ERK 和 STAT3 的水平，并能抑制重组人 IL-6 诱导的 ERK 和 STAT3 磷酸化水平，它们是 IL-6 信号调节网络中的关键信号蛋白^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Isoliquiritigenin 显示浓度依赖性抑制由各种类型的兴奋剂诱导的小鼠空肠强直收缩，如 CCh (1 mM)、KCl (60 mM) 和 BaCl₂ (0.3 mM)。 IC₅₀ 值分别为 4.96±1.97 mM、4.03±1.34 mM 和 3.70±0.58 mM^[2]。Isoliquiritigenin 在 MM 异种移植模型中表现出显著的抗肿瘤活性，并协同增强阿霉素的抗骨髓瘤活性^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

256.25

Formula

C₁₅H₁₂O₄

CAS 号

961-29-5

性状

固体

颜色

Light yellow to yellow

中文名称

异甘草素

结构分类

初始来源

微生物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

溶解性数据

细胞实验：

DMSO 中的溶解度 : ≥ 100 mg/mL (390.24 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

Ethanol 中的溶解度 : 100 mg/mL (390.24 mM; 超声助溶)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.9024 mL	19.5122 mL	39.0244 mL
5 mM	0.7805 mL	3.9024 mL	7.8049 mL
10 mM	0.3902 mL	1.9512 mL	3.9024 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C储存时，请在1年内使用， -20°C储存时，请在6个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.76 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.76 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案三

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.76 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。
方案四

请依序添加每种溶剂： 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.76 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 EtOH 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案五

请依序添加每种溶剂： 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.76 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 EtOH 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案六

请依序添加每种溶剂： 10% EtOH 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.76 mM); 悬浊液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的均匀悬浊液，悬浊液可用于口服和腹腔注射。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 EtOH 储备液加到 900 μL 玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 98.07%

选择批次：

Data Sheet (652 KB) SDS (393 KB)

COA (190 KB) HNMR (248 KB) RP-HPLC (278 KB) LCMS (93 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Aida K, et al. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56(3):254-8. [Content Brief]

[2]. Sato Y, et al. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. Biol Pharm Bull. 2007 Jan;30(1):145-9. [Content Brief]

[3]. Zhang X. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm. 2013;2013:390890. [Content Brief]

[4]. Chen X, et al. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med (Berl). 2012 Nov;90(11):1311-9. [Content Brief]

[5]. Traboulsi H, et al. The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection. Antimicrob Agents Chemother. 2015 Oct;59(10):6317-27. [Content Brief]

Isoliquiritigenin 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO / Ethanol	1 mM	3.9024 mL	19.5122 mL	39.0244 mL	97.5610 mL
	5 mM	0.7805 mL	3.9024 mL	7.8049 mL	19.5122 mL
	10 mM	0.3902 mL	1.9512 mL	3.9024 mL	9.7561 mL
	15 mM	0.2602 mL	1.3008 mL	2.6016 mL	6.5041 mL
	20 mM	0.1951 mL	0.9756 mL	1.9512 mL	4.8780 mL
	25 mM	0.1561 mL	0.7805 mL	1.5610 mL	3.9024 mL
	30 mM	0.1301 mL	0.6504 mL	1.3008 mL	3.2520 mL
	40 mM	0.0976 mL	0.4878 mL	0.9756 mL	2.4390 mL
	50 mM	0.0780 mL	0.3902 mL	0.7805 mL	1.9512 mL
	60 mM	0.0650 mL	0.3252 mL	0.6504 mL	1.6260 mL
	80 mM	0.0488 mL	0.2439 mL	0.4878 mL	1.2195 mL
	100 mM	0.0390 mL	0.1951 mL	0.3902 mL	0.9756 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isoliquiritigenin961-29-5GU17 ISL Isoliquiritigen SJ000286237异甘草素GU 17GU-17SJ000286237SJ 000286237SJ-000286237Aldose ReductaseInfluenza VirusAutophagyApoptosisInhibitorinhibitorinhibit

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Isoliquiritigenin (Synonyms: 异甘草素; GU17; ISL; Isoliquiritigen; SJ000286237)

Customer Review

Other Forms of Isoliquiritigenin:

MCE 顾客使用本产品发表的 18 篇科研文献

Isoliquiritigenin 相关产品

•相关化合物库:

•同靶点产品:

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生物活性

纯度 & 产品资料

参考文献

摩尔计算器

稀释计算器

Isoliquiritigenin 相关分类

完整储备液配制表

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Isoliquiritigenin (Synonyms: 异甘草素; GU17; ISL; Isoliquiritigen; SJ000286237)

Customer Review

Other Forms of Isoliquiritigenin:

Isoliquiritigenin 相关抗体

MCE 顾客使用本产品发表的 18 篇科研文献

Isoliquiritigenin 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

生物活性

纯度 & 产品资料

参考文献

Isoliquiritigenin 相关抗体:

摩尔计算器

稀释计算器

Isoliquiritigenin 相关分类

完整储备液配制表

Keywords:

您最近查看的产品:

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