Pinocembrin (Synonyms: 乔松素; (+)-Pinocoembrin; Dihydrochrysin; Galangin flavanone)

目录号: HY-N0575 纯度: 99.65%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Pinocembrin ((+)-Pinocoembrin) 是从蜂胶中得到的黄酮类物质，为竞争性的组氨酸脱羧酶 (histidine decarboxylase) 抑制剂，同时为有效的抗过敏剂，具有抗氧化、抗菌、抗炎作用。

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Pinocembrin Chemical Structure

CAS No. : 480-39-7

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥440	In-stock
10 mg	￥400	In-stock
25 mg	￥750	In-stock
50 mg	￥1200	In-stock
100 mg		询价
200 mg		询价

or 大包装询价

* Please select Quantity before adding items.

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Pinocembrin (Standard) 询价

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生物活性
纯度 & 产品资料
参考文献

生物活性

Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 100 μM Compound: 7	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 19689125]
A549	EC₅₀	229 μM Compound: 9	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 12027739]
B16-BL6	IC₅₀	> 100 μM Compound: 7	Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay	[PMID: 19689125]
B16-BL6	EC₅₀	68 μM Compound: 9	Antiproliferative activity against mouse B16-BL6 cells after 72 hrs by MTT assay Antiproliferative activity against mouse B16-BL6 cells after 72 hrs by MTT assay	[PMID: 12027739]
B16-F10	IC₅₀	30.1 μM Compound: 4	Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 72 hrs by XTT assay Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 72 hrs by XTT assay	[PMID: 27720556]
HeLa	IC₅₀	> 100 μM Compound: 7	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 19689125]
HeLa	IC₅₀	≥ 10 μM Compound: pinocembrin	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 19278239]
HeLa	EC₅₀	108 μM Compound: 9	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay	[PMID: 12027739]
HeLa	IC₅₀	6.1 μg/mL Compound: 8	Antiallergic activity in Ca(2+)-stimulated differentiated human HeLa cells assessed as inhibition of cys-leukotriene release after 6 days by ELISA Antiallergic activity in Ca(2+)-stimulated differentiated human HeLa cells assessed as inhibition of cys-leukotriene release after 6 days by ELISA	[PMID: 19942440]
HL-60	ED₅₀	2.87 μM Compound: 10	Inhibition of chymotrypsin-like activity of purified human 20S proteasome in HL60 cells using N-succinyl-Leu-Leu-Val-Tyr-AMC as substrate pre-incubated for 10 mins by fluorimetric assay Inhibition of chymotrypsin-like activity of purified human 20S proteasome in HL60 cells using N-succinyl-Leu-Leu-Val-Tyr-AMC as substrate pre-incubated for 10 mins by fluorimetric assay	[PMID: 21973101]
HT-1080	IC₅₀	72.8 μM Compound: 7	Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay	[PMID: 19689125]
HT-1080	EC₅₀	92.4 μM Compound: 9	Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay	[PMID: 12027739]
HT-29	ED₅₀	> 20 μM Compound: 10	Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay	[PMID: 21973101]
HT-29	ED₅₀	> 20 μM Compound: 10	Induction of apoptosis in human HT-29 cells assessed reduction of mitochondrial membrane potential after 2 hrs by using JC1 staining by fluorescence cell-based assay Induction of apoptosis in human HT-29 cells assessed reduction of mitochondrial membrane potential after 2 hrs by using JC1 staining by fluorescence cell-based assay	[PMID: 21973101]
JEG-3	CC₅₀	250.7 μM Compound: 52	Cytotoxicity against human JEG3 cells by alamarBlue assay Cytotoxicity against human JEG3 cells by alamarBlue assay	[PMID: 31549836]
KB	IC₅₀	99.16 μM Compound: 5a	Cytotoxicity against human KB cells after 3 days by Resazurin Microplate Assay Cytotoxicity against human KB cells after 3 days by Resazurin Microplate Assay	[PMID: 20362442]
NCI-H187	IC₅₀	95.53 μM Compound: 5a	Cytotoxicity against human NCI-H187 cells after 5 days by Resazurin Microplate Assay Cytotoxicity against human NCI-H187 cells after 5 days by Resazurin Microplate Assay	[PMID: 20362442]
RAW264.7	IC₅₀	18.1 μM Compound: 26	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 23743282]

体外研究
(In Vitro)

Pinocembrin (5, 10, 25, 50, 100 or 200 μM, 24 hours) significantly reduces cell viability of RBL-2H3 cells^[1].
Pinocembrin (25 or 50 μM) suppresses iNOS, PGE-2 and COX-2 levels, increases p38-Mapk and IкB-α, and inhibits phosphorylation of IкB-α^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	RBL-2H3 cells
Concentration:	5, 10, 25, 50, 100 or 200 µM
Incubation Time:	24 hours
Result:	Decreased cell viability by ∼50% at ≥ 100 µM. Showed 75% cell viability at lower concentrations.

Clinical Trial

分子量

256.25

Formula

C₁₅H₁₂O₄

CAS 号

480-39-7

性状

固体

颜色

White to yellow

中文名称

松属素；乔松素

结构分类

初始来源

动物

honeybee propolis

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

DMSO 中的溶解度 : 83.33 mg/mL (325.19 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.9024 mL	19.5122 mL	39.0244 mL
5 mM	0.7805 mL	3.9024 mL	7.8049 mL
10 mM	0.3902 mL	1.9512 mL	3.9024 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (8.12 mM); 澄清溶液

此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (8.12 mM); 澄清溶液

此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案三

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (8.12 mM); 澄清溶液

此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.67%

选择批次：

Data Sheet (627 KB) SDS (393 KB)

COA (193 KB) LCMS (88 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Hanieh H, et al. Pinocembrin, a novel histidine decarboxylase inhibitor with anti-allergic potential in in vitro. Eur J Pharmacol. 2017 Nov 5;814:178-186. [Content Brief]

Pinocembrin 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9024 mL	19.5122 mL	39.0244 mL	97.5610 mL
	5 mM	0.7805 mL	3.9024 mL	7.8049 mL	19.5122 mL
	10 mM	0.3902 mL	1.9512 mL	3.9024 mL	9.7561 mL
	15 mM	0.2602 mL	1.3008 mL	2.6016 mL	6.5041 mL
	20 mM	0.1951 mL	0.9756 mL	1.9512 mL	4.8780 mL
	25 mM	0.1561 mL	0.7805 mL	1.5610 mL	3.9024 mL
	30 mM	0.1301 mL	0.6504 mL	1.3008 mL	3.2520 mL
	40 mM	0.0976 mL	0.4878 mL	0.9756 mL	2.4390 mL
	50 mM	0.0780 mL	0.3902 mL	0.7805 mL	1.9512 mL
	60 mM	0.0650 mL	0.3252 mL	0.6504 mL	1.6260 mL
	80 mM	0.0488 mL	0.2439 mL	0.4878 mL	1.2195 mL
	100 mM	0.0390 mL	0.1951 mL	0.3902 mL	0.9756 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pinocembrin480-39-7(+)-Pinocoembrin Dihydrochrysin Galangin flavanone松属素乔松素BacterialReactive Oxygen SpeciesAutophagyInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Pinocembrin (Synonyms: 乔松素; (+)-Pinocoembrin; Dihydrochrysin; Galangin flavanone)

Customer Review

Other Forms of Pinocembrin:

MCE 顾客使用本产品发表的 5 篇科研文献