CDKN2D - cyclin dependent kinase inhibitor 2D Gene

中文名称：细胞周期蛋白依赖性激酶抑制因子 2D

种属: Homo sapiens

同用名: p19; INK4D; p19-INK4D

关于 CDKN2D

功能概要

该基因编码的蛋白质是细胞周期蛋白依赖性激酶抑制剂 INK4 家族的成员。该蛋白已被证明可与 CDK4 或 CDK6 形成稳定的复合物，并阻止 CDK 激酶的激活，从而起到控制细胞周期 G1 进程的细胞生长调节剂的作用。发现该基因转录本的丰度以细胞周期依赖性方式振荡，在 G1 中期表达最低，在 S 期表达最高。该蛋白质所涉及的细胞周期的负调节显示参与抑制神经元增殖以及精子发生。已经报道了该基因的两个可变剪接变体，它们编码相同的蛋白质。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]