RACK1 - receptor for activated C kinase 1 Gene

中文名称：活化 C 激酶 1 受体

种属: Homo sapiens

同用名: H12.3; HLC-7; PIG21; GNB2L1; Gnb2-rs1

基因 ID: 10399 | 基因类型: protein coding

关于 RACK1

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:181,236,897-181,243,906 (from NCBI)

This gene has 35 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in ovary (RPKM 1262.3), lymph node (RPKM 598.8) and 25 other tissues.

功能概要

启用多种功能，包括细胞周期蛋白结合活性；酶结合活性；和蛋白质结构域特异性结合活性。参与多个过程，包括水解酶活性的正调节；调节细胞蛋白质代谢过程；和信号转导的调节。位于多个细胞成分中，包括中体；细胞质的核周区；和吞噬杯。 IRE1-RACK1-PP2A 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including cyclin binding activity; Enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of hydrolase activity; regulation of cellular protein metabolic process; and regulation of signal transduction. Located in several cellular components, including midbody; perinuclear region of cytoplasm; and phagocytic cup. Part of IRE1-RACK1-PP2A complex. [provided by Alliance of Genome Resources, Apr 2022]

RACK1 基因产物(1)

mRNA	Protein	Name
NM_006098.5	NP_006089.1	receptor of activated protein C kinase 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables BH3 domain binding	IDA IDA: 通过直接分析推断	20541605	GOA
enables SH2 domain binding	IDA IDA: 通过直接分析推断	9584165	GOA
enables cyclin binding	IPI IPI: 通过物理相互作用推断	15159402	GOA
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IMP IMP: 通过突变表型推断	19767770	GOA
enables enzyme activator activity	IDA IDA: 通过直接分析推断	20819076	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	20819076	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	24947010	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10849009	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	24947010	GOA
enables protein kinase C binding	IDA IDA: 通过直接分析推断	11279199	GOA
enables protein phosphatase binding	IPI IPI: 通过物理相互作用推断	11278757	GOA
enables protein tyrosine kinase inhibitor activity	IDA IDA: 通过直接分析推断	9584165	GOA
enables receptor tyrosine kinase binding	IDA IDA: 通过直接分析推断	9584165	GOA
enables ribosome binding	IDA IDA: 通过直接分析推断	28132843	GOA
enables signaling adaptor activity	IMP IMP: 通过突变表型推断	20103773	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: 通过突变表型推断	19767770	GOA
involved in cellular response to glucose stimulus	IDA IDA: 通过直接分析推断	20103773	GOA
involved in cellular response to growth factor stimulus	IDA IDA: 通过直接分析推断	20010870	GOA
involved in negative regulation of cell growth	IDA IDA: 通过直接分析推断	9584165	GOA
involved in negative regulation of gene expression	IMP IMP: 通过突变表型推断	19451233	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	IGI IGI: 通过遗传相互作用推断	24947010	GOA
involved in negative regulation of peptidyl-serine phosphorylation	IMP IMP: 通过突变表型推断	20103773	GOA
involved in negative regulation of phagocytosis	IMP IMP: 通过突变表型推断	21347310	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: 通过突变表型推断	19767770	GOA
involved in negative regulation of protein binding	IDA IDA: 通过直接分析推断	20541605	GOA
involved in negative regulation of smoothened signaling pathway	IDA IDA: 通过直接分析推断	32467643	GOA
involved in positive regulation of GTPase activity	IDA IDA: 通过直接分析推断	20499158	GOA
involved in positive regulation of Golgi to plasma membrane protein transport	IMP IMP: 通过突变表型推断	19674157	GOA
involved in positive regulation of apoptotic process	IDA IDA: 通过直接分析推断	20541605	GOA
involved in positive regulation of apoptotic process	IMP IMP: 通过突变表型推断	19767770	GOA
involved in positive regulation of cell migration	IDA IDA: 通过直接分析推断	20499158	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IMP IMP: 通过突变表型推断	19767770	GOA
involved in positive regulation of mitochondrial depolarization	IMP IMP: 通过突变表型推断	19767770	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	19785988	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: 通过直接分析推断	11312657	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: 通过直接分析推断	20541605	GOA
involved in protein ubiquitination	IMP IMP: 通过突变表型推断	28132843	GOA
involved in regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: 通过突变表型推断	20819076	GOA
involved in regulation of cell cycle	IDA IDA: 通过直接分析推断	9584165	GOA
involved in rescue of stalled ribosome	IMP IMP: 通过突变表型推断	28132843	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of IRE1-RACK1-PP2A complex	IDA IDA: 通过直接分析推断	20103773	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	10849009	GOA
located in cytosol	IMP IMP: 通过突变表型推断	19767770	GOA
located in midbody	IDA IDA: 通过直接分析推断	15166316	GOA
located in mitochondrion	IMP IMP: 通过突变表型推断	19767770	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10849009	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	11279199	GOA
located in phagocytic cup	IDA IDA: 通过直接分析推断	21347310	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RACK1 蛋白结构

WD40

0
100
200
317 a.a.

蛋白主名

其他名称

receptor of activated protein C kinase 1

cell proliferation-inducing gene 21 protein

RACK1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RACK1	P63244	GGN	Homo sapiens	Q86UU5	Y2H Prey Pooling	32296183
种属内	RACK1	P63244	GGN	Homo sapiens	Q86UU5	Validated Y2H	32296183
种属内	RACK1	P63244	GGN	Homo sapiens	Q86UU5	Y2H Array	32296183
种属内	RACK1	P63244	LARP4B	Homo sapiens	Q92615	Y2H Prey Pooling	32296183
种属内	RACK1	P63244	LARP4B	Homo sapiens	Q92615	Anti Tag CoIP	28514442
种属内	RACK1	P63244	LARP4B	Homo sapiens	Q92615	Validated Y2H	32296183
种属内	RACK1	P63244	LARP4B	Homo sapiens	Q92615	Y2H Array	32296183
种属内	RACK1	P63244	LARP4B	Homo sapiens	Q92615	Anti Tag CoIP	35271311
种属内	RACK1	P63244	LARP4B	Homo sapiens	Q92615	Y2H	21988832
种属内	RACK1	P63244	USP54	Homo sapiens	Q70EL1-9	Validated Y2H	32296183
种属内	RACK1	P63244	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
种属内	RACK1	P63244	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
种属内	RACK1	P63244	ZSCAN12	Homo sapiens	O43309	Y2H Prey Pooling	32296183
种属内	RACK1	P63244	ZSCAN12	Homo sapiens	O43309	Y2H Array	32296183
种属内	RACK1	P63244	HELZ	Homo sapiens	P42694	Anti Tag CoIP	35271311
种属内	RACK1	P63244	HELZ	Homo sapiens	P42694	Anti Tag CoIP	33961781
种属内	RACK1	P63244	HELZ	Homo sapiens	P42694	Anti Tag CoIP	28514442
种属内	RACK1	P63244	TMEM131	Homo sapiens	Q0P631	Y2H Array	32296183
种属内	RACK1	P63244	TMEM131	Homo sapiens	Q0P631	Y2H Prey Pooling	32296183
种属内	RACK1	P63244	TMEM131	Homo sapiens	Q0P631	Validated Y2H	32296183
种属内	RACK1	P63244	MKRN2	Homo sapiens	Q9H000	Y2H Prey Pooling	32296183
种属内	RACK1	P63244	MKRN2	Homo sapiens	Q9H000	Validated Y2H	32296183
种属内	RACK1	P63244	MKRN2	Homo sapiens	Q9H000	Y2H Array	32296183
种属内	RACK1	P63244	GPBP1	Homo sapiens	Q86WP2	Y2H Array	32296183
种属内	RACK1	P63244	GPBP1	Homo sapiens	Q86WP2	Validated Y2H	32296183
种属内	RACK1	P63244	GPBP1	Homo sapiens	Q86WP2	Y2H Prey Pooling	32296183
种属内	RACK1	P63244	USP10	Homo sapiens	Q14694	Y2H Prey Pooling	32296183
种属内	RACK1	P63244	USP10	Homo sapiens	Q14694	Validated Y2H	32296183
种属内	RACK1	P63244	USP10	Homo sapiens	Q14694	Y2H Array	32296183
种属内	RACK1	P63244	USP10	Homo sapiens	Q14694	Anti Tag CoIP	35271311
种属内	RACK1	P63244	PAG1	Homo sapiens	Q9NWQ8	Anti Bait CoIP	23866081
种属内	RACK1	P63244	ARRDC3	Homo sapiens	Q96B67	Y2H Prey Pooling	32296183
种属内	RACK1	P63244	ARRDC3	Homo sapiens	Q96B67	Validated Y2H	32296183
种属内	RACK1	P63244	ARRDC3	Homo sapiens	Q96B67	Y2H Array	32296183
种属内	RACK1	P63244	LRP12	Homo sapiens	Q9Y561	Y2H	12809483
种属内	RACK1	P63244	RPL7	Homo sapiens	P18124	Density Sedimentation	21376236
种属内	RACK1	P63244	RPL26	Homo sapiens	P61254	Density Sedimentation	21376236
种属内	RACK1	P63244	RPL7	Homo sapiens	P18124	3D-EM	29143818
种属内	RACK1	P63244	RPL7	Homo sapiens	P18124	Anti Tag CoIP	35271311
种属内	RACK1	P63244	RPS3	Homo sapiens	P23396	Anti Bait CoIP	21525958
种属内	RACK1	P63244	RPS3	Homo sapiens	P23396	Anti Tag CoIP	35271311
种属内	RACK1	P63244	RPL7	Homo sapiens	P18124	3D-EM	25901680
种属内	RACK1	P63244	RPL26	Homo sapiens	P61254	3D-EM	25901680
种属内	RACK1	P63244	RPS3	Homo sapiens	P23396	3D-EM	29143818
种属内	RACK1	P63244	RPL26	Homo sapiens	P61254	3D-EM	29143818
种属内	RACK1	P63244	RPS3	Homo sapiens	P23396	3D-EM-Single	32908316
种属内	RACK1	P63244	RPL26	Homo sapiens	P61254	Anti Tag CoIP	35271311
种属内	RACK1	P63244	RPS3	Homo sapiens	P23396	3D-EM	25901680
种属内	RACK1	P63244	VHL	Homo sapiens	P40337	Anti Tag CoIP	20871634
种属内	RACK1	P63244	VHL	Homo sapiens	P40337	Confocal	20871634
种属内	RACK1	P63244	PIAS2	Homo sapiens	O75928	Anti Bait CoIP	22210188
种属内	RACK1	P63244	DYNLL1	Homo sapiens	P63167	Pull Down	18420585
种属内	RACK1	P63244	DYNLL1	Homo sapiens	P63167	Anti Tag CoIP	18420585
种属内	RACK1	P63244	BYSL	Homo sapiens	Q13895	Validated Y2H	32296183
种属内	RACK1	P63244	BYSL	Homo sapiens	Q13895	Anti Tag CoIP	35271311
种属内	RACK1	P63244	CRMP1	Homo sapiens	Q14194	Validated Y2H	32296183
种属内	RACK1	P63244	CRMP1	Homo sapiens	Q14194	Y2H Array	32296183
种属内	RACK1	P63244	CRMP1	Homo sapiens	Q14194	Y2H Prey Pooling	32296183
种属间	RACK1	P63244	Bcl2l11	Mus musculus	O54918-1	Anti Tag CoIP	18420585
种属内	RACK1	P63244	BCL2L11	Homo sapiens	O43521	Anti Bait CoIP	18420585
种属内	RACK1	P63244	AGO2	Homo sapiens	Q9UKV8	Anti Bait CoIP	21525958
种属内	RACK1	P63244	PPID	Homo sapiens	Q08752	Anti Tag CoIP	21146485
种属内	RACK1	P63244	CNOT2	Homo sapiens	Q9NZN8	Y2H Prey Pooling	32296183
种属内	RACK1	P63244	CNOT2	Homo sapiens	Q9NZN8	Validated Y2H	32296183
种属内	RACK1	P63244	CNOT2	Homo sapiens	Q9NZN8	Y2H Array	32296183
种属内	RACK1	P63244	LYN	Homo sapiens	P07948	Anti Bait CoIP	23866081
种属内	RACK1	P63244	EED	Homo sapiens	O75530	Anti Bait CoIP	20080539
种属内	RACK1	P63244	IFNAR2	Homo sapiens	P48551	Anti Bait CoIP	11046044
种属间	RACK1	P63244	bzlf1_ebvb9	Epstein-Barr virus	P03206	Pull Down	10849009
种属间	RACK1	P63244	bzlf1_ebvb9	Epstein-Barr virus	P03206	Anti Bait CoIP	10849009
种属间	RACK1	P63244	bzlf1_ebvb9	Epstein-Barr virus	P03206	Y2H	10849009

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 RACK1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P74606	RACK1 Protein, Human (His-MBP)	P63244 (M1-R317)	≥95%

关联疾病

疾病名称

别名

Melanomatosis

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-141891	M435-1279	Inhibitor	98.43%	否
HY-N10335	Harringtonolide	Inhibitor	≥98.0%	否
HY-162254	EGFR/ACK1-IN-1	Inhibitor	/	否
HY-P0221C	PACAP (1-38) free acid		/	否
HY-P0221B	PACAP (1-38) free acid TFA		/	否
HY-P3879	Protein Kinase C (660-673)		/	否
HY-RS11595	RACK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	RACK1	VGNC	VGNC:102300
Bos taurus	RACK1	VGNC	VGNC:33676
Rattus norvegicus	RACK1	RGD	RGD:69229
Canis familiaris	RACK1	VGNC	VGNC:45309
Mus musculus	RACK1	MGD	MGI:101849
Macaca mulatta	RACK1	VGNC	VGNC:76581
Others	RACK1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RACK1 - receptor for activated C kinase 1 Gene

关于 RACK1

功能概要

RACK1 基因产物(1)

RACK1 蛋白结构

RACK1 蛋白互作信息

重组 RACK1 蛋白

关联疾病

直系同源

热门区域

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RACK1 - receptor for activated C kinase 1 Gene

关于 RACK1

功能概要

RACK1 基因产物(1)

RACK1 蛋白结构

RACK1 蛋白互作信息

重组 RACK1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z