CSK - C-terminal Src kinase Gene

中文名称：C 端 Src 激酶

种属: Homo sapiens

基因 ID: 1445 | 基因类型: protein coding

关于 CSK

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,782,080-74,803,197 (from NCBI)

This gene has 14 transcripts (splice variants), 279 orthologues and 32 paralogues. Broad expression in lymph node (RPKM 63.0), spleen (RPKM 47.7) and 24 other tissues.

功能概要

由该基因编码的蛋白质参与多种途径，包括 Src 家族激酶的调节。它通过与蛋白酪氨酸磷酸酶 22 型非受体 (PTPN22) 基因编码的蛋白质相关联，在 T 细胞活化中发挥重要作用。该蛋白质还磷酸化多种底物上的 C 末端酪氨酸残基，包括由 Src 原癌基因、非受体酪氨酸激酶基因编码的蛋白质。磷酸化抑制 Src 家族酪氨酸激酶的激酶活性。已发现该基因中的内含子多态性 (rs34933034) 会影响 B 细胞活化，并与系统性红斑狼疮 (SLE) 相关。可变剪接导致多个转录本变体。[RefSeq 提供，2017 年 8 月]

The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine Phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the Src proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

CSK 基因产物(13)

mRNA	Protein	Name
NM_001127190.2	NP_001120662.1	tyrosine-protein kinase CSK isoform 1
NM_001354988.2	NP_001341917.1	tyrosine-protein kinase CSK isoform 1
NM_001387089.1	NP_001374018.1	tyrosine-protein kinase CSK isoform 1
NM_001387090.1	NP_001374019.1	tyrosine-protein kinase CSK isoform 1
NM_001387091.1	NP_001374020.1	tyrosine-protein kinase CSK isoform 1
NM_001387092.1	NP_001374021.1	tyrosine-protein kinase CSK isoform 1
NM_001387093.1	NP_001374022.1	tyrosine-protein kinase CSK isoform 1
NM_001387094.1	NP_001374023.1	tyrosine-protein kinase CSK isoform 6
NM_001387095.1	NP_001374024.1	tyrosine-protein kinase CSK isoform 2
NM_001387096.1	NP_001374025.1	tyrosine-protein kinase CSK isoform 3
NM_001387097.1	NP_001374026.1	tyrosine-protein kinase CSK isoform 4
NM_001387098.1	NP_001374027.1	tyrosine-protein kinase CSK isoform 5
NM_004383.3	NP_004374.1	tyrosine-protein kinase CSK isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	19888460	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7507203	GOA
enables protein kinase A catalytic subunit binding	IPI IPI: 通过物理相互作用推断	17911601	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of Golgi to plasma membrane protein transport	IDA IDA: 通过直接分析推断	20605918	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IPI IPI: 通过物理相互作用推断	10790433	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CSK 蛋白结构

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
450 a.a.

蛋白主名

其他名称

tyrosine-protein kinase CSK

C-Src kinase

CSK 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CSK	P41240	PTPRC	Homo sapiens	P08575	Phosphatase Assay	19167335
种属内	CSK	P41240	FRK	Homo sapiens	P42685	TAP	23455922
种属内	CSK	P41240	FRK	Homo sapiens	P42685	Anti Tag CoIP	28514442
种属内	CSK	P41240	PAG1	Homo sapiens	Q9NWQ8	Pull Down	10790433
种属内	CSK	P41240	TNS2	Homo sapiens	Q63HR2	TAP	23455922
种属内	CSK	P41240	PAG1	Homo sapiens	Q9NWQ8	Anti Tag CoIP	33961781
种属内	CSK	P41240	TNS3	Homo sapiens	Q68CZ2	Anti Tag CoIP	31980649
种属内	CSK	P41240	PAG1	Homo sapiens	Q9NWQ8	Anti Tag CoIP	28514442
种属内	CSK	P41240	TNS2	Homo sapiens	Q63HR2	Pull Down	32707033
种属内	CSK	P41240	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
种属内	CSK	P41240	PAG1	Homo sapiens	Q9NWQ8	Pull Down	32707033
种属内	CSK	P41240	FRK	Homo sapiens	P42685	Anti Tag CoIP	33961781
种属内	CSK	P41240	IGF1R	Homo sapiens	P08069	Y2H	10026153
种属内	CSK	P41240	IGF1R	Homo sapiens	P08069	CoIP	10026153
种属内	CSK	P41240	PXN	Homo sapiens	P49023	Anti Bait CoIP	14665621
种属内	CSK	P41240	PXN	Homo sapiens	P49023	Anti Tag CoIP	31980649
种属内	CSK	P41240	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
种属内	CSK	P41240	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
种属内	CSK	P41240	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
种属内	CSK	P41240	KANK4	Homo sapiens	Q5T7N3	Y2H Array	32296183
种属内	CSK	P41240	KANK4	Homo sapiens	Q5T7N3	Y2H Prey Pooling	32296183
种属内	CSK	P41240	KANK4	Homo sapiens	Q5T7N3	Validated Y2H	32296183
种属间	CSK	P41240	SRC	Gallus gallus	P00523	X-Ray Diffraction	18614016
种属间	CSK	P41240	SRC	Gallus gallus	P00523	Protein Kinase Assay	15683240
种属间	CSK	P41240	SRC	Gallus gallus	P00523	SPR	18614016
种属间	CSK	P41240	lspA1	Haemophilus ducreyi	Q7VLE8	Protein Kinase Assay	24902122
种属间	CSK	P41240	lspA1	Haemophilus ducreyi	Q7VLE8	Pull Down	24902122

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CSK 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72956	CSK Protein, Human (sf9, GST)	P41240 (M1-L450)	≥95%

关联疾病

疾病名称

别名

Osteopetrosis

Marble Bone Disease	Albers-Schonberg Disease
Osteopetroses	Marble Bones
Osteopetrosis And Related Disorders	Congenital Osteopetrosis
Marble Bone	Albers-Schoenberg Disease
Albers-Schonberg Osteopetrosis	Osteosclerosis Fragilis
Ivory Bones

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Cd45 Deficiency

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-15196	TAK-285	Inhibitor	99.70%	Phase 1

目录号	产品名	作用方式	纯度	Phase
HY-P9928A	Alirocumab (anti-PCSK9)	Inhibitor	98.24%	Phase 4

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P1180A	Pam3CSK4 TFA	Agonist	99.66%	否
HY-108471	CU-CPT22	Inhibitor	≥99.0%	否
HY-112146	MMG-11	Antagonist	99.11%	否
HY-130254	CSK-IN-1	Inhibitor	98.61%	否
HY-122113	PD173952		99.44%	否
HY-148063	DB0614		98.80%	否
HY-P1181A	Pam2CSK4 TFA	Agonist	99.28%	否
HY-137345	DB-3-291	Inhibitor	98.03%	否
HY-130504	Propargyl-PEG1-acid		≥97.0%	否
HY-148061	DB1113		99.28%	否
HY-112146A	MMG-11 quarterhydrate	Antagonist	99.09%	否
HY-P1180	Pam3CSK4	Agonist	/	否
HY-P10527	CSK substrate		/	否
HY-P1180B	Pam3CSK4 trihydrochloride		/	否
HY-P1181	Pam2CSK4	Agonist	/	否
HY-P1405	Pam3CSK4-Biotin	Agonist	/	否
HY-RS03238	CSK Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CSK	RGD	RGD:1308800
Mus musculus	CSK	MGD	MGI:88537
Macaca mulatta	CSK	VGNC	VGNC:81380
Canis familiaris	CSK	VGNC	VGNC:39661
Felis catus	CSK	VGNC	VGNC:61220
Bos taurus	CSK	VGNC	VGNC:27761
Macaca fascicularis	CSK	NCBI	NCBI:102131034
Others	CSK	NCBI

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CSK - C-terminal Src kinase Gene

关于 CSK

功能概要

CSK 基因产物(13)

CSK 蛋白结构

CSK 蛋白互作信息

重组 CSK 蛋白

关联疾病

直系同源

热门区域

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CSK - C-terminal Src kinase Gene

关于 CSK

功能概要

CSK 基因产物(13)

CSK 蛋白结构

CSK 蛋白互作信息

重组 CSK 蛋白

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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Z