2. Gene
  3. Mmp2 - matrix metallopeptidase 2 Gene

Mmp2 - matrix metallopeptidase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：基质金属肽酶 2

种属: Mus musculus

同用名: GelA; Clg4a; MMP-2

基因 ID: 17390 | 基因类型: protein coding

关于 Mmp2

Chromosome 8: 93,553,919-93,580,048 forward strand.GRCm39:CM001001.3

This gene has 4 transcripts (splice variants), 210 orthologues, 23 paralogues and is associated with 73 phenotypes. Broad expression in mammary gland adult (RPKM 186.), subcutaneous fat pad adult (RPKM 13.) and 15 other tissues.

功能概要

该基因编码细胞外基质降解酶基质金属蛋白酶家族的一个成员，这些酶参与组织重塑、伤口修复、动脉粥样硬化进展和肿瘤侵袭。编码的前原蛋白经过蛋白水解加工，产生成熟的锌依赖性内肽酶，可水解胶原蛋白、明胶、层粘连蛋白、纤连蛋白和弹性蛋白。缺乏编码蛋白的小鼠表现出抑制血管生成和减弱人类多中心骨质溶解与关节炎的特征，包括骨骼和颅面发育异常。 [RefSeq 提供，2016 年 2 月]

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme that hydrolyzes collagens, gelatins, laminin, fibronectin and elastin. Mice lacking the encoded protein exhibit suppressed angiogenesis and attenuated features of human multicentric osteolysis with arthritis including abnormal skeletal and craniofacial development. [provided by RefSeq, Feb 2016]

Mmp2 基因产物(1)

mRNA Protein Name
NM_008610.3 NP_032636.1 72 kDa type IV collagenase preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables metalloendopeptidase activity IDA
IDA: 通过直接分析推断
12419962 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within blood vessel maturation IGI
IGI: 通过遗传相互作用推断
11747814 MGI
acts upstream of or within bone trabecula formation IGI
IGI: 通过遗传相互作用推断
17440987 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: 通过直接分析推断
20548288 MGI
acts upstream of or within cellular response to reactive oxygen species IMP
IMP: 通过突变表型推断
17561096 MGI
acts upstream of or within collagen catabolic process IMP
IMP: 通过突变表型推断
17440987 MGI
acts upstream of or within embryo implantation IDA
IDA: 通过直接分析推断
18556655 MGI
acts upstream of or within face morphogenesis IGI
IGI: 通过遗传相互作用推断
17440987 MGI
acts upstream of or within intramembranous ossification IGI
IGI: 通过遗传相互作用推断
17440987 MGI
acts upstream of or within positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
17561096 MGI
involved in response to amyloid-beta IDA
IDA: 通过直接分析推断
28912710 MGI
acts upstream of or within response to hypoxia IDA
IDA: 通过直接分析推断
17382917 MGI
acts upstream of or within skeletal system morphogenesis IGI
IGI: 通过遗传相互作用推断
17440987 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
17349656 MGI
located in sarcomere IDA
IDA: 通过直接分析推断
17349656 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mmp2 蛋白结构

PG_binding_1

PG_binding_1: pfam01471 (69 - 96)

Peptidase_M10

Peptidase_M10: pfam00413 (117 - 445)

FN2

FN2: smart00059 (225 - 273)

FN2

FN2: smart00059 (283 - 331)

FN2

FN2: smart00059 (341 - 389)

HX

HX: cd00094 (467 - 661)

  • 0
  • 200
  • 400
  • 600
  • 662 a.a.
蛋白主名 其他名称

72 kDa type IV collagenase

72 kDa gelatinase

72kD gelatinase

72kD type IV collagenase

72kDa gelatinase

72kDa type IV collagenase

gelatinase A

matrix metalloproteinase 2

重组 Mmp2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73810 MMP-2 Protein, Mouse (HEK293, His) NP_032636.1 (M409-C662) ≥95%

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0689A Indinavir sulfate 99.97% 是
HY-B0493 Niflumic acid Inhibitor 99.88% 否
HY-B0689 Indinavir / 否
HY-B0689B Indinavir sulfate ethanolate / 否
Clinical Phase
生物活性分子 (8)
目录号 产品名 作用方式
纯度 Phase
HY-12169 Marimastat Inhibitor ≥98.0% Phase 3
HY-12170 Prinomastat 99.27% Phase 3
HY-12170A Prinomastat hydrochloride 98.18% Phase 3
HY-15768 Ilomastat Inhibitor 98.39% Phase 2
HY-10398 CTS-1027 Inhibitor 99.19% Phase 2
HY-106992 S 3304 Inhibitor 99.11% Phase 2
HY-19485 XL-784 Inhibitor 98.13% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (86)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0431 Astragaloside IV Inhibitor 99.93% 否
HY-122022 JR-AB2-011 Inhibitor 99.16% 否
HY-13564 Batimastat Inhibitor 98.92% 否
HY-12354 SB-3CT Inhibitor 99.59% 否
HY-122214 AC-73 Inducer 99.89% 否
HY-110397 KP-457 Inhibitor 99.18% 否
HY-103444 ARP-100 Inhibitor ≥99.0% 否
HY-N0069 Solamargine 99.97% 否
HY-W068119A N-(2-Aminoethyl)maleimide hydrochloride 99.97% 否
HY-N0532 Morroniside Inhibitor 99.88% 否
HY-107394 UK 356618 Inhibitor 98.91% 否
HY-N0084 Betulinaldehyde Inhibitor 98.72% 否
HY-107428 PD-166793 Inhibitor 99.45% 否
HY-131498 MOCAc-PLGL(Dpa)AR 99.86% 否
HY-P3513 β-Neo-Endorphin Activator 98.22% 否
HY-112546 MMP-2 Inhibitor I Inhibitor 99.23% 否
HY-120213 YH-306 98.01% 否
HY-P0273A Histatin 5 TFA Inhibitor 99.98% 否
HY-107639 UK-370106 Inhibitor ≥99.0% 否
HY-124373 ND-336 Inhibitor 95.4% 否
HY-101535 ARP101 Inhibitor 99.39% 否
HY-116399 MMP-2/MMP-9-IN-1 Inhibitor 99.25% 否
HY-117970 MMPI-1154 Inhibitor 99.87% 否
HY-12168 Tanomastat Inhibitor 99.5% 否
HY-122506 Salviolone Inhibitor 99.61% 否
HY-146754 MMP2-IN-1 99.18% 否
HY-148571 TP0597850 Inhibitor 99.09% 否
HY-114911 Feprazone Inhibitor 99.88% 否
HY-147031 JAMM protein inhibitor 2 Inhibitor 98.20% 否
HY-147745 MMP2-IN-2 Inhibitor 98.80% 否
HY-147746 MMP2-IN-3 Inhibitor 99.64% 否
HY-P2213A GPLGIAGQ TFA Inducer 98.40% 否
HY-W001925 7-Methoxy-1-tetralone 99.93% 否
HY-110116 SD-2590 hydrochloride Inhibitor 99.1% 否
HY-131417 cis-ACCP Inhibitor ≥97.0% 否
HY-N5136 25(R,S)-Ruscogenin Inhibitor 98.59% 否
HY-P1789A CTTHWGFTLC, CYCLIC TFA Inhibitor 98.91% 否
HY-110397G KP-457 (GMP) Inhibitor / 否
HY-111172 Inotilone Inhibitor / 否
HY-114785 BPHA Inhibitor / 否
HY-120349 LL-Z1640-4 Inhibitor / 否
HY-12168B (Rac)-Tanomastat Inhibitor / 否
HY-124373A (R)-ND-336 Inhibitor / 否
HY-130076 MMP-2 Inhibitor II Inhibitor / 否
HY-136699 Excisanin A / 否
HY-14240 PG 116800 Inhibitor / 否
HY-143407 FAK-IN-3 Inhibitor / 否
HY-147867 MMP-2/9-IN-1 Inhibitor / 否
HY-147936 TP0556351 Inhibitor / 否
HY-149378 MMP13-IN-5 Inhibitor / 否
HY-152030 Tubulin/MMP-IN-2 / 否
HY-154698 Homouridine / 否
HY-155201 YJ182 Inhibitor / 否
HY-155721 22-(4′-py)-JA Inhibitor / 否
HY-156247 IVMT-Rx-3 Inhibitor / 否
HY-157382 AChE-IN-51 Inhibitor / 否
HY-161707 MMP2-IN-4 Inhibitor / 否
HY-162038 RXP03 Inhibitor / 否
HY-162344 Ir-CA Inducer / 否
HY-164525 SD-7300 Inhibitor / 否
HY-168560 MMP Inhibitor 4 Inhibitor / 否
HY-168605 DH-18 / 否
HY-77813S Benzyl isothiocyanate-d7 / 否
HY-N10176 D-Isofloridoside Inhibitor / 否
HY-N7385 Nudol / 否
HY-P1789 CTTHWGFTLC, CYCLIC Inhibitor / 否
HY-P2213 GPLGIAGQ Inducer / 否
HY-P3477 Mca-PLA-Nva-Dap(Dnp)-AR-NH2 / 否
HY-P3513A β-Neo-Endorphin acetate Activator / 否
HY-P4574 VPLSLYSG / 否
HY-P5380 TNO211 / 否
HY-RS08537 MMP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08538 Mmp2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08539 Mmp2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W011085 CP-471474 Inhibitor / 否
HY-W277900 2-Methoxy-2,4-diphenylfuran-3-one / 否
HY-119110 LY52 Inhibitor / 否
HY-119185 AZD-6605 / 否
HY-123130 ABT-770 Inhibitor / 否
HY-124341 ND-378 Inhibitor / 否
HY-13564A Batimastat sodium salt Inhibitor / 否
HY-18694 CGS 27023A Inhibitor / 否
HY-N13208 Stevia Powder / 否
HY-114396 BR351 Inhibitor / 否
HY-P0273 Histatin 5 Inhibitor / 否
HY-43586 BR351 precursor Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mmp2 NCBI NCBI:4313
Rattus norvegicus Mmp2 NCBI NCBI:81686
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z