2. Gene
  3. Rock2 - Rho-associated coiled-coil containing protein kinase 2 Gene

Rock2 - Rho-associated coiled-coil containing protein kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含 Rho 相关卷曲螺旋蛋白激酶 2

种属: Rattus norvegicus

同用名: ROK; ROCK-II

基因 ID: 25537 | 基因类型: protein coding

关于 Rock2

Primary_assembly 6: 39,679,082-39,774,031 forward strand.mRatBN7.2:CM026979.1

This gene has 4 transcripts (splice variants), 309 orthologues, 5 paralogues and is associated with 9 phenotypes. Biased expression in Heart (RPKM 488.3), Lung (RPKM 32.5) and 9 other tissues.

功能概要

预计该基因编码的蛋白可启动 Rho 依赖性蛋白丝氨酸/苏氨酸激酶活性。参与多个过程，包括心肌肥大的正调节；结缔组织置换的正调节；和细胞因子产生的正调节。作用于 Rho 蛋白信号转导的上游或内部。预测定位于细胞质核糖核蛋白颗粒；胞质溶胶；和纺锤体极中心体。预计在几种细胞成分中具有活性，包括 Schaffer 侧支 - CA1 突触；中心体；和谷氨酸能突触。与人 ROCK2 同源（Rho 相关的卷曲螺旋含有蛋白激酶 2）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable Rho-dependent protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cardiac muscle hypertrophy; positive regulation of connective tissue replacement; and positive regulation of cytokine production. Acts upstream of or within Rho protein signal transduction. Predicted to be located in cytoplasmic ribonucleoprotein granule; cytosol; and spindle pole centrosome. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; centrosome; and glutamatergic synapse. Orthologous to human ROCK2 (Rho associated coiled-coil containing protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Rock2 基因产物(1)

mRNA Protein Name
NM_013022.2 NP_037154.2 rho-associated protein kinase 2

Rock2 蛋白结构

STKc_ROCK2

STKc_ROCK2: cd05621 (38 - 416)

Smc

Smc: cl34174 (436 - 1100)

ROCK_SBD

ROCK_SBD: cd22250 (855 - 935)

PH_ROCK

PH_ROCK: cd01242 (1207 - 1313)

C1_ROCK2

C1_ROCK2: cd20875 (1306 - 1376)

  • 0
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  • 1473 a.a.
蛋白主名 其他名称

rho-associated protein kinase 2

ROKalpha

Rho-associated coiled-coil forming kinase 2

RhoA - binding serine/threosine kinase alpha (ROK - alpha)

p150 ROK-alpha

p164 ROCK-2

rho-associated, coiled-coil-containing protein kinase 2

rho-associated, coiled-coil-containing protein kinase II

rhoA-binding kinase 2

Rock2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Rock2 Q62868 MYL12A Homo sapiens P19105
Protein Kinase Assay
21457715
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Approval
生物活性分子 (12)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10071 Y-27632 Inhibitor 99.91% 否
HY-10583 Y-27632 dihydrochloride Inhibitor 99.98% 否
HY-10341 Fasudil Hydrochloride Inhibitor 99.96% 是
HY-15307 Belumosudil Inhibitor 99.83% 是
HY-15685 Ripasudil Inhibitor 99.95% 否
HY-13911 Hydroxyfasudil Inhibitor 98.78% 否
HY-15307A Belumosudil mesylate Inhibitor 99.89% 是
HY-13911A Hydroxyfasudil hydrochloride Inhibitor 98.88% 否
HY-10341A Fasudil Inhibitor / 否
HY-10341B Fasudil hydrochloride semihydrate Inhibitor / 否
HY-10341C Fasudil dihydrochloride Inhibitor / 否
HY-15685A Ripasudil free base Inhibitor / 否
Clinical Phase
生物活性分子 (6)
目录号 产品名 作用方式
纯度 Phase
HY-109191 Sovesudil Inhibitor 98.54% Phase 3
HY-109191A Sovesudil hydrochloride Inhibitor 99.45% Phase 3
HY-12659 LX7101 Inhibitor 99.75% Phase 2
HY-15687A SAR407899 Inhibitor 99.60% Phase 2
HY-15687 SAR407899 hydrochloride Inhibitor 99.14% Phase 2
HY-16071 AT13148 Inhibitor 99.21% Phase 1
Pre-clinical Phase
生物活性分子 (39)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15392 Chroman 1 Inhibitor 99.42% 否
HY-15556 GSK269962A Inhibitor 99.83% 否
HY-15720A H-1152 dihydrochloride Inhibitor 99.09% 否
HY-119937 ROCK inhibitor-2 Inhibitor 99.92% 否
HY-103045 CMPD101 Inhibitor 98.95% 否
HY-15755 RKI-1447 Inhibitor 98.29% 否
HY-15720 H-1152 Inhibitor 98.63% 否
HY-13300 SR-3677 Inhibitor 99.83% 否
HY-18713 CRT0066854 Inhibitor 99.54% 否
HY-10319 BAY-549 Inhibitor 99.46% 否
HY-108518 SB-772077B dihydrochloride Inhibitor ≥99.0% 否
HY-12437 BDP5290 Inhibitor 98.80% 否
HY-150640 Rho-Kinase-IN-2 Inhibitor 99.29% 否
HY-100270 Rho-Kinase-IN-1 Inhibitor 99.91% 否
HY-16758 Verosudil Inhibitor 99.18% 否
HY-110339 RKI-1447 dihydrochloride Inhibitor 98.04% 否
HY-103620 ROCK2-IN-2 Inhibitor 98.02% 否
HY-126275 HSD1590 Inhibitor 99.54% 否
HY-18713A CRT0066854 hydrochloride Inhibitor 99.29% 否
HY-U00351 ROCK-IN-1 Inhibitor 98.17% 否
HY-149266 THK01 Inhibitor 99.80% 否
HY-15392A Chroman 1 dihydrochloride Inhibitor 99.11% 否
HY-14227 LIMK-IN-1 Inhibitor 99.33% 否
HY-107209 RKI-1313 Inhibitor 98.2% 否
HY-153564 ROCK-IN-6 Inhibitor / 否
HY-15720B Glycyl H-1152 hydrochloride Inhibitor / 否
HY-13300A SR-3677 dihydrochloride Inhibitor / 否
HY-125221 DJ4 Inhibitor 98.48% 否
HY-167832 PT109 Inhibitor / 否
HY-145294 ROCK2-IN-5 Inhibitor / 否
HY-162798 ROCK2-IN-9 Inhibitor / 否
HY-15556A GSK269962A hydrochloride Inhibitor / 否
HY-122011 PF-4950834 Inhibitor / 否
HY-168650 ROCK/HDAC-IN-1 Inhibitor / 否
HY-16758A Verosudil hydrochloride Inhibitor / 否
HY-149700 ROCK2-IN-7 / 否
HY-162596 NRL-1049 Inhibitor / 否
HY-12659B LX7101 monohydrochloride Inhibitor / 否
HY-103045A CMPD101 hydrochloride Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rock2 NCBI NCBI:9475
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