ROCK2 - Rho associated coiled-coil containing protein kinase 2 Gene

中文名称：含 Rho 相关卷曲螺旋蛋白激酶 2

种属: Homo sapiens

同用名: ROCK-II

基因 ID: 9475 | 基因类型: protein coding

关于 ROCK2

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:11,179,759-11,345,437 (from NCBI)

This gene has 12 transcripts (splice variants), 309 orthologues and 5 paralogues. Ubiquitous expression in fat (RPKM 15.2), colon (RPKM 13.4) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种丝氨酸/苏氨酸激酶，可调节胞质分裂、平滑肌收缩、肌动蛋白应力纤维和粘着斑的形成，以及 c-Fos 血清反应元件的激活。这种蛋白质是 ROCK1 的同工酶，是小 GTP 酶 Rho 的靶标。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-Fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]

ROCK2 基因产物(6)

mRNA	Protein	Name
XM_011510417.3	XP_011508719.1	rho-associated protein kinase 2 isoform X3
XM_017005379.3	XP_016860868.1	rho-associated protein kinase 2 isoform X3
XM_017005378.3	XP_016860867.1	rho-associated protein kinase 2 isoform X2
XM_005246190.4	XP_005246247.1	rho-associated protein kinase 2 isoform X1
NM_004850.5	NP_004841.2	rho-associated protein kinase 2 isoform 1
NM_001321643.2	NP_001308572.1	rho-associated protein kinase 2 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables Rho-dependent protein serine/threonine kinase activity	IMP IMP: 通过突变表型推断	24065547	GOA
enables endopeptidase activator activity	IMP IMP: 通过突变表型推断	24305806	GOA
enables protease binding	IPI IPI: 通过物理相互作用推断	24305806	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17015463	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	16574662	GOA
enables protein serine/threonine kinase activity	IMP IMP: 通过突变表型推断	24305806	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	25816133	GOA
involved in cellular response to testosterone stimulus	IMP IMP: 通过突变表型推断	24065547	GOA
involved in centrosome duplication	IMP IMP: 通过突变表型推断	17015463	GOA
involved in cortical actin cytoskeleton organization	IGI IGI: 通过遗传相互作用推断	25816133	GOA
involved in cortical actin cytoskeleton organization	IMP IMP: 通过突变表型推断	25816133	GOA
involved in modulation by host of viral process	IMP IMP: 通过突变表型推断	19376974	GOA
involved in negative regulation of angiogenesis	IMP IMP: 通过突变表型推断	19181962	GOA
involved in negative regulation of bicellular tight junction assembly	IGI IGI: 通过遗传相互作用推断	25816133	GOA
involved in negative regulation of nitric oxide biosynthetic process	IMP IMP: 通过突变表型推断	29353861	GOA
involved in negative regulation of protein localization to lysosome	IMP IMP: 通过突变表型推断	24305806	GOA
involved in positive regulation of amyloid precursor protein catabolic process	IMP IMP: 通过突变表型推断	24305806	GOA
involved in positive regulation of amyloid-beta formation	IMP IMP: 通过突变表型推断	24305806	GOA
involved in positive regulation of cell migration	IMP IMP: 通过突变表型推断	20232393	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: 通过突变表型推断	24065547	GOA
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	24065547	GOA
involved in positive regulation of protein localization to early endosome	IMP IMP: 通过突变表型推断	24305806	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: 通过突变表型推断	24065547	GOA
involved in positive regulation of stress fiber assembly	IMP IMP: 通过突变表型推断	20232393	GOA
involved in protein localization to plasma membrane	IGI IGI: 通过遗传相互作用推断	25816133	GOA
involved in protein localization to plasma membrane	IMP IMP: 通过突变表型推断	25816133	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	18559669	GOA
involved in regulation of establishment of endothelial barrier	IGI IGI: 通过遗传相互作用推断	25816133	GOA
involved in regulation of establishment of endothelial barrier	IMP IMP: 通过突变表型推断	25816133	GOA
involved in regulation of keratinocyte differentiation	IMP IMP: 通过突变表型推断	19997641	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in centrosome	IDA IDA: 通过直接分析推断	17015463	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: 通过直接分析推断	15121898	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ROCK2 蛋白结构

Pkinase

HR1

Rho_Binding

0
300
600
900
1200
1388 a.a.

蛋白主名

其他名称

rho-associated protein kinase 2

p164 ROCK-2

rho-associated, coiled-coil-containing protein kinase II

ROCK2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ROCK2	O75116	STAT3	Homo sapiens	P40763	Anti Bait CoIP	30413785
种属内	ROCK2	O75116	STAT3	Homo sapiens	P40763	CH-IP	30413785
种属内	ROCK2	O75116	APP	Homo sapiens	P05067	Validated Y2H	32814053
种属内	ROCK2	O75116	APP	Homo sapiens	P05067	Y2H Array	32814053
种属内	ROCK2	O75116	APP	Homo sapiens	P05067	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

ROCK2 抗体

目录号	产品名	应用	反应物种
HY-P81922	ROCK2 Antibody (YA1667)	WB, ICC/IF	Human, Rat

关联疾病

疾病名称

别名

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Hepatomas
Liver Neoplasm	Liver Carcinoma
Liver And Intrahepatic Biliary Tract Carcinoma	Malignant Hepatobiliary Neoplasm
Adult Primary Hepatocellular Carcinoma	Hepatoblastoma
Carcinoma Of Liver	Malignant Liver Tumour
Malignant Hepatic Tumour

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Ureteral Obstruction

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Idiopathic Pulmonary Hypertension
Idiopathic Pulmonary Arterial Hypertension	Pulmonary Htn - [Hypertension]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

相关产品

Approval

生物活性分子 (12)

目录号	产品名	作用方式	纯度	是否罕见病
HY-10071	Y-27632	Inhibitor	99.91%	否
HY-10583	Y-27632 dihydrochloride	Inhibitor	99.98%	否
HY-10341	Fasudil Hydrochloride	Inhibitor	99.96%	是
HY-15307	Belumosudil	Inhibitor	99.83%	是
HY-15685	Ripasudil	Inhibitor	99.95%	否
HY-13911	Hydroxyfasudil	Inhibitor	98.78%	否
HY-15307A	Belumosudil mesylate	Inhibitor	99.89%	是
HY-13911A	Hydroxyfasudil hydrochloride	Inhibitor	98.88%	否
HY-10341A	Fasudil	Inhibitor	/	否
HY-10341B	Fasudil hydrochloride semihydrate	Inhibitor	/	否
HY-10341C	Fasudil dihydrochloride	Inhibitor	/	否
HY-15685A	Ripasudil free base	Inhibitor	/	否

Clinical Phase

生物活性分子 (6)

目录号	产品名	作用方式	纯度	Phase
HY-109191	Sovesudil	Inhibitor	98.54%	Phase 3
HY-109191A	Sovesudil hydrochloride	Inhibitor	99.45%	Phase 3
HY-12659	LX7101	Inhibitor	99.75%	Phase 2
HY-15687A	SAR407899	Inhibitor	99.60%	Phase 2
HY-15687	SAR407899 hydrochloride	Inhibitor	99.14%	Phase 2
HY-16071	AT13148	Inhibitor	99.21%	Phase 1

Pre-clinical Phase

生物活性分子 (39)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-15392	Chroman 1	Inhibitor	99.42%	否
HY-15556	GSK269962A	Inhibitor	99.83%	否
HY-15720A	H-1152 dihydrochloride	Inhibitor	99.09%	否
HY-119937	ROCK inhibitor-2	Inhibitor	99.92%	否
HY-103045	CMPD101	Inhibitor	98.95%	否
HY-15755	RKI-1447	Inhibitor	98.29%	否
HY-13300	SR-3677	Inhibitor	99.83%	否
HY-15720	H-1152	Inhibitor	98.63%	否
HY-18713	CRT0066854	Inhibitor	99.54%	否
HY-10319	BAY-549	Inhibitor	99.46%	否
HY-108518	SB-772077B dihydrochloride	Inhibitor	≥99.0%	否
HY-12437	BDP5290	Inhibitor	98.80%	否
HY-150640	Rho-Kinase-IN-2	Inhibitor	99.29%	否
HY-100270	Rho-Kinase-IN-1	Inhibitor	99.91%	否
HY-16758	Verosudil	Inhibitor	99.18%	否
HY-110339	RKI-1447 dihydrochloride	Inhibitor	98.04%	否
HY-103620	ROCK2-IN-2	Inhibitor	98.02%	否
HY-126275	HSD1590	Inhibitor	99.54%	否
HY-18713A	CRT0066854 hydrochloride	Inhibitor	99.29%	否
HY-U00351	ROCK-IN-1	Inhibitor	98.17%	否
HY-122011	PF-4950834	Inhibitor	/	否
HY-149266	THK01	Inhibitor	99.80%	否
HY-15392A	Chroman 1 dihydrochloride	Inhibitor	99.11%	否
HY-14227	LIMK-IN-1	Inhibitor	99.33%	否
HY-107209	RKI-1313	Inhibitor	98.2%	否
HY-153564	ROCK-IN-6	Inhibitor	/	否
HY-15720B	Glycyl H-1152 hydrochloride	Inhibitor	/	否
HY-13300A	SR-3677 dihydrochloride	Inhibitor	/	否
HY-125221	DJ4	Inhibitor	98.48%	否
HY-167832	PT109	Inhibitor	/	否
HY-145294	ROCK2-IN-5	Inhibitor	/	否
HY-162798	ROCK2-IN-9	Inhibitor	/	否
HY-15556A	GSK269962A hydrochloride	Inhibitor	/	否
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	否
HY-16758A	Verosudil hydrochloride	Inhibitor	/	否
HY-149700	ROCK2-IN-7		/	否
HY-162596	NRL-1049	Inhibitor	/	否
HY-12659B	LX7101 monohydrochloride	Inhibitor	/	否
HY-103045A	CMPD101 hydrochloride	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	ROCK2	VGNC	VGNC:34082
Mus musculus	ROCK2	MGD	MGI:107926
Felis catus	ROCK2	VGNC	VGNC:64715
Rattus norvegicus	ROCK2	RGD	RGD:3590
Macaca mulatta	ROCK2	VGNC	VGNC:76714
Canis familiaris	ROCK2	VGNC	VGNC:49640
Others	ROCK2	NCBI

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