H3C1 - H3 clustered histone 1 Gene

中文名称：H3 成簇组蛋白 1

种属: Homo sapiens

同用名: H3/A; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3FA; H3C10; H3C11; H3C12; HIST1H3A

基因 ID: 8350 | 基因类型: protein coding

关于 H3C1

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,020,451-26,020,958 (from NCBI)

This gene has 1 transcript (splice variant), 96 orthologues and 20 paralogues.

功能概要

组蛋白是基本的核蛋白，负责真核生物染色体纤维的核小体结构。这种结构由大约 146 bp 的 DNA 组成，核小体是一个八聚体，由四种核心组蛋白 (H2A、H2B、H3 和 H4) 中的每一种成对组成。染色质纤维通过接头组蛋白 H1 与核小体之间的 DNA 相互作用进一步压缩，形成更高阶的染色质结构。该基因是无内含子的，编码复制依赖组蛋白，该组蛋白是组蛋白 H3 家族的成员。该基因的转录本缺少 polyA 尾巴；相反，它们包含回文终止元素。该基因存在于染色体 6p22-p21.3 上的大组蛋白基因簇中。[RefSeq 提供，2015 年 8 月]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

H3C1 基因产物(1)

mRNA	Protein	Name
NM_003529.3	NP_003520.1	histone H3.1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IDA IDA: 通过直接分析推断	30867594	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10949293	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in epigenetic regulation of gene expression	IDA IDA: 通过直接分析推断	16267050	GOA
acts upstream of positive effect gene expression	IDA IDA: 通过直接分析推断	30867594	GOA
involved in nucleosome assembly	IDA IDA: 通过直接分析推断	14718166	GOA
involved in nucleosome assembly	IMP IMP: 通过突变表型推断	25615412	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of nucleosome	IDA IDA: 通过直接分析推断	14718166	GOA
part of nucleosome	IPI IPI: 通过物理相互作用推断	21812398	GOA
located in nucleus	IDA IDA: 通过直接分析推断	21636898	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	14718166	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

H3C1 蛋白结构

Histone

0
100
136 a.a.

蛋白主名

其他名称

histone H3.1

H3 histone family, member A

H3C1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	H3C1	P68431	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
种属内	H3C1	P68431	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
种属内	H3C1	P68431	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
种属内	H3C1	P68431	PSEN1	Homo sapiens	P49768-2	Y2H Pooling	32814053
种属内	H3C1	P68431	PSEN1	Homo sapiens	P49768-2	Validated Y2H	32814053
种属内	H3C1	P68431	PSEN1	Homo sapiens	P49768-2	Y2H Array	32814053
种属内	H3C1	P68431	SETD7	Homo sapiens	Q8WTS6	NMR	12540855
种属内	H3C1	P68431	SETD7	Homo sapiens	Q8WTS6	Methyltransferase Ass	12540855
种属内	H3C1	P68431	CDYL	Homo sapiens	Q9Y232	Pull Down	16415788
种属内	H3C1	P68431	AIRE	Homo sapiens	O43918	Pull Down	18292755
种属内	H3C1	P68431	AIRE	Homo sapiens	O43918	NMR	18292755
种属内	H3C1	P68431	AIRE	Homo sapiens	O43918	ITC	18292755
种属内	H3C1	P68431	PSEN2	Homo sapiens	P49810	Y2H Array	32814053
种属内	H3C1	P68431	PSEN2	Homo sapiens	P49810	Y2H Pooling	32814053
种属内	H3C1	P68431	PSEN2	Homo sapiens	P49810	Validated Y2H	32814053
种属内	H3C1	P68431	CTSD	Homo sapiens	P07339	Validated Y2H	32814053
种属内	H3C1	P68431	CTSD	Homo sapiens	P07339	Y2H Pooling	32814053
种属内	H3C1	P68431	CTSD	Homo sapiens	P07339	Y2H Array	32814053
种属间	H3C1	P68431	SGF29	Saccharomyces cerevisiae	P25554	SPR	21685874
种属间	H3C1	P68431	SGF29	Saccharomyces cerevisiae	P25554	FPS	21685874
种属间	H3C1	P68431	SGF29	Saccharomyces cerevisiae	P25554	X-Ray Diffraction	21685874
种属内	H3C1	P68431	DNAJC9	Homo sapiens	Q8WXX5	Validated Y2H	32296183
种属内	H3C1	P68431	DNAJC9	Homo sapiens	Q8WXX5	Pull Down	29568061
种属内	H3C1	P68431	DNAJC9	Homo sapiens	Q8WXX5	BioID	29568061
种属内	H3C1	P68431	DNAJC9	Homo sapiens	Q8WXX5	Y2H Array	32296183
种属内	H3C1	P68431	DNAJC9	Homo sapiens	Q8WXX5	TAP	19410544
种属内	H3C1	P68431	DNAJC9	Homo sapiens	Q8WXX5	BioID	25281560
种属内	H3C1	P68431	DNAJC9	Homo sapiens	Q8WXX5	Y2H Prey Pooling	32296183
种属内	H3C1	P68431	PHF20	Homo sapiens	Q9BVI0	Pull Down	16415788
种属内	H3C1	P68431	PHF20	Homo sapiens	Q9BVI0	SPR	16415788
种属内	H3C1	P68431	MPHOSPH8	Homo sapiens	Q99549	Pull Down	20871592
种属内	H3C1	P68431	ING4	Homo sapiens	Q9UNL4	NMR	17157298
种属内	H3C1	P68431	H4C16	Homo sapiens	P62805	Anti Tag CoIP	28514442
种属内	H3C1	P68431	H4C16	Homo sapiens	P62805	TAP	19410544
种属内	H3C1	P68431	H4C16	Homo sapiens	P62805	MAPPIT	25416956
种属内	H3C1	P68431	H4C16	Homo sapiens	P62805	Anti Tag CoIP	19498464
种属内	H3C1	P68431	YWHAZ	Homo sapiens	P63104	CoIP	19766566
种属内	H3C1	P68431	YWHAZ	Homo sapiens	P63104	X-Ray Diffraction	16246723
种属内	H3C1	P68431	YWHAZ	Homo sapiens	P63104	Biochemical	18418070
种属内	H3C1	P68431	MCM2	Homo sapiens	P49736	Anti Tag CoIP	26167883
种属内	H3C1	P68431	MCM2	Homo sapiens	P49736	Anti Tag CoIP	28514442
种属内	H3C1	P68431	FBLIM1	Homo sapiens	Q8WUP2	Y2H Prey Pooling	25416956
种属内	H3C1	P68431	FBLIM1	Homo sapiens	Q8WUP2	Y2H Array	25416956
种属内	H3C1	P68431	TP53BP1	Homo sapiens	Q12888	Pull Down	16415788
种属内	H3C1	P68431	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
种属内	H3C1	P68431	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
种属内	H3C1	P68431	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
种属内	H3C1	P68431	PKM	Homo sapiens	P14618-1	Protein Kinase Assay	24606918
种属内	H3C1	P68431	HTT	Homo sapiens	P42858	Y2H Prey Pooling	23275563
种属内	H3C1	P68431	HTT	Homo sapiens	P42858	Lumier	23275563
种属内	H3C1	P68431	WDR5	Homo sapiens	P61964	ITC	16946699
种属内	H3C1	P68431	KMT2A	Homo sapiens	Q03164	ITC	20541251
种属内	H3C1	P68431	KMT2A	Homo sapiens	Q03164	NMR	20541251
种属内	H3C1	P68431	KMT2A	Homo sapiens	Q03164	Pull Down	20541251
种属内	H3C1	P68431	A2M	Homo sapiens	P01023	Y2H Array	32814053
种属内	H3C1	P68431	A2M	Homo sapiens	P01023	Validated Y2H	32814053
种属内	H3C1	P68431	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
种属内	H3C1	P68431	NASP	Homo sapiens	P49321-2	Anti Tag CoIP	19498464
种属内	H3C1	P68431	NASP	Homo sapiens	P49321-2	Validated Y2H	25416956
种属内	H3C1	P68431	NASP	Homo sapiens	P49321-2	Y2H Array	25416956
种属内	H3C1	P68431	TTR	Homo sapiens	P02766	Validated Y2H	32814053
种属内	H3C1	P68431	TTR	Homo sapiens	P02766	Y2H Array	32814053
种属内	H3C1	P68431	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
种属内	H3C1	P68431	NASP	Homo sapiens	P49321	BioID	29568061
种属内	H3C1	P68431	NASP	Homo sapiens	P49321	Pull Down	29568061
种属内	H3C1	P68431	NASP	Homo sapiens	P49321	TAP	20080577
种属内	H3C1	P68431	NASP	Homo sapiens	P49321	TAP	19410544
种属内	H3C1	P68431	NASP	Homo sapiens	P49321	BioID	25281560
种属内	H3C1	P68431	WFS1	Homo sapiens	O76024	Y2H Array	32814053
种属内	H3C1	P68431	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
种属内	H3C1	P68431	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
种属内	H3C1	P68431	SGF29	Homo sapiens	Q96ES7	X-Ray Diffraction	21685874
种属内	H3C1	P68431	SGF29	Homo sapiens	Q96ES7	FPS	21685874
种属内	H3C1	P68431	SGF29	Homo sapiens	Q96ES7	ITC	21685874
种属内	H3C1	P68431	CBX1	Homo sapiens	P83916	BioID	29568061
种属内	H3C1	P68431	CBX1	Homo sapiens	P83916	Pull Down	16415788
种属内	H3C1	P68431	CBX1	Homo sapiens	P83916	SPR	16415788
种属内	H3C1	P68431	CBX5	Homo sapiens	P45973	BioID	25281560
种属内	H3C1	P68431	CBX5	Homo sapiens	P45973	Pull Down	20871592
种属内	H3C1	P68431	CBX5	Homo sapiens	P45973	Anti Tag CoIP	19498464
种属内	H3C1	P68431	CBX5	Homo sapiens	P45973	Anti Tag CoIP	28514442
种属间	H3C1	P68431	IPL1	Saccharomyces cerevisiae	P38991	Enzymatic Study	10949293
种属内	H3C1	P68431	KDM4A	Homo sapiens	O75164	Pull Down	16415788
种属内	H3C1	P68431	KDM4A	Homo sapiens	O75164	IF	16603238
种属内	H3C1	P68431	KDM4A	Homo sapiens	O75164	SPR	16415788
种属内	H3C1	P68431	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
种属内	H3C1	P68431	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053
种属内	H3C1	P68431	PEX1	Homo sapiens	O43933	Y2H Array	32814053
种属间	H3C1	P68431	rhi	Drosophila melanogaster	Q7JXA8	X-Ray Diffraction	25613572

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 H3C1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72332	Histone H3 Protein, Human	P68431 (A2-A136)	≥95%
HY-P72335	Histone H3 Protein, Human (98a.a, His)	P68431 (P39-A136)	≥95%
HY-P72798	Histone H3 Protein, Human (His)	P68431 (A2-A136)	≥95%

H3C1 抗体

目录号	产品名	应用	反应物种
HY-P80529	Acetyl-Histone H3 (Lys14) Antibody	WB, ICC/IF, IP	Human, Rat
HY-P80530	Acetyl-Histone H3 (Lys27) Antibody	WB, IHC-F, IHC-P, ICC/IF, IP, ChIP	Human
HY-P80531	Acetyl-Histone H3 (Lys4) Antibody	WB, ICC/IF	Human, Mouse
HY-P80643	DiMethyl-Histone H3 Antibody (YA783)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P80922	TriMethyl-Histone H3 (Lys27) Antibody	WB, IHC-F, IHC-P, ICC/IF, IP, ChIP	Human, Rat

关联疾病

疾病名称

别名

Glioma Susceptibility 1

Astrocytoma	GLM1
Glioma, Susceptibility To, Somatic	Glioblastoma, Somatic
Glioma	Glioblastoma Multiforme
Oligodendroglioma	Glioma Somatic
Astrocytic Tumor	GLM
Familial Glioma Of Brain	Gbm
Glioma 1	Glioma, Susceptibility, Type 1
Cerebral Astrocytoma	Glioblastoma
Well Differentiated Oligodendroglioma

Plasma Cell Neoplasm

Plasma Cell Dyscrasia	Paraproteinemias
Plasma Cell Tumour	Plasmacytic Tumor
Multiple Myeloma	Plasmacytoma
Plasma Cell Tumours	Plasma Cells Dyscrasia

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Histone Mutated Tumor

Histone Mutated Tumour

Adult Infiltrating Astrocytic Neoplasm

Adult Infiltrating Astrocytoma

Adult Infiltrating Astrocytic Tumor

Anaplastic Oligodendroglioma, Idh-Mutant And 1p/19q-Codeleted

Diffuse Midline Glioma, H3 K27m-Mutant

Diffuse Intrinsic Pontine Glioma	Dipg
Infiltrative Brainstem Glioma

Brain Stem Cancer

Brain Stem Neoplasms	Malignant Neoplasm Of Brain Stem
Malignant Neoplasm Of Brainstem	Neoplasm Of Adult Brain Stem
Neoplasm Of Brain Stem	Primary Brain Stem Neoplasm
Primary Brain Stem Tumor	Brain Stem Neoplasm
Brain Stem--Cancer	Brain Stem Neoplasms, Primary

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson Gilford Progeria Syndrome
Hutchinson-Gilford Disease	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Childhood Brain Stem Glioma

Pediatric Glioma Of The Brainstem

Brain Stem Glioma

Brainstem Glioma	Brainstem Neuroglial Tumor
Glioma Of Brainstem

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Posterior Fossa Ependymoma

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Adult Astrocytic Tumour

Adult Astrocytoma

Adult Astrocytic Tumors

Pilomyxoid Astrocytoma

Low Grade Glioma

Benign Glioma

Pilocytic Astrocytoma

Juvenile Pilocytic Astrocytoma	Grade I Astrocytic Tumor
Piloid Astrocytoma

Central Nervous System Benign Neoplasm

Benign Neoplasm Of The Central Nervous System

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05966	H3C1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	H3C1	RGD	RGD:1598076
Mus musculus	H3C1	MGD	MGI:2668828

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