2. Gene
  3. HDAC2 - histone deacetylase 2 Gene

HDAC2 - histone deacetylase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组蛋白脱乙酰酶 2

种属: Rattus norvegicus

基因 ID: 84577 | 基因类型: protein coding

关于 HDAC2

Primary_assembly 20: 40,548,250-40,571,609 forward strand.mRatBN7.2:CM026993.1

This gene has 2 transcripts (splice variants), 205 orthologues, 12 paralogues and is associated with 42 phenotypes. Biased expression in Muscle (RPKM 329.9), Thymus (RPKM 38.1) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括脱乙酰酶活性；热休克蛋白结合活性；和启动子特异性染色质结合活性。参与多个过程，包括细胞分化的正调节；大分子代谢过程的正向调控；和对生物碱的反应。位于染色质；细胞质；和核。用于研究佩罗尼氏病；酒精使用障碍；和焦虑症。支气管炎的生物标志物；慢性阻塞性肺疾病;子宫内膜异位症;肺气肿;和视觉性癫痫。该基因的人类直系同源物与胃癌有关。与人类 HDAC2（组蛋白脱乙酰酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including deacetylase activity; heat shock protein binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of macromolecule metabolic process; and response to alkaloid. Located in chromatin; cytoplasm; and nucleus. Used to study Peyronie's disease; alcohol use disorder; and anxiety disorder. Biomarker of bronchitis; chronic obstructive pulmonary disease; endometriosis; pulmonary emphysema; and visual epilepsy. Human ortholog(s) of this gene implicated in stomach Cancer. Orthologous to human HDAC2 (histone deacetylase 2). [provided by Alliance of Genome Resources, Apr 2022]

HDAC2 基因产物(1)

mRNA Protein Name
NM_053447.1 NP_445899.1 histone deacetylase 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
24441681 RGD
enables deacetylase activity IDA
IDA: 通过直接分析推断
23868068 RGD
enables heat shock protein binding IDA
IDA: 通过直接分析推断
18849323 RGD
enables promoter-specific chromatin binding IDA
IDA: 通过直接分析推断
21586557 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
11516394 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in behavioral response to ethanol IEP
IEP: 通过表达模式推断
23485013 RGD
involved in cardiac muscle hypertrophy IEP
IEP: 通过表达模式推断
19713680 RGD
involved in cellular response to dopamine IEP
IEP: 通过表达模式推断
15731170 RGD
involved in cellular response to heat IEP
IEP: 通过表达模式推断
18849323 RGD
involved in cellular response to hydrogen peroxide IDA
IDA: 通过直接分析推断
19553350 RGD
involved in cellular response to retinoic acid IEP
IEP: 通过表达模式推断
19486889 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
19553350 RGD
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
11516394 RGD
involved in negative regulation of dendritic spine development IMP
IMP: 通过突变表型推断
23485013 RGD
involved in negative regulation of neuron projection development IMP
IMP: 通过突变表型推断
18754010 RGD
involved in negative regulation of peptidyl-lysine acetylation IMP
IMP: 通过突变表型推断
19486889 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
21465537 RGD
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
19553350 RGD
involved in positive regulation of interleukin-1 production IMP
IMP: 通过突变表型推断
22772764 RGD
involved in positive regulation of male mating behavior IMP
IMP: 通过突变表型推断
21586557 RGD
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
22573687 RGD
involved in positive regulation of protein modification process IMP
IMP: 通过突变表型推断
21465537 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
22772764 RGD
involved in protein modification process IMP
IMP: 通过突变表型推断
24441681 RGD
involved in response to alcohol IEP
IEP: 通过表达模式推断
26509893 RGD
involved in response to amphetamine IEP
IEP: 通过表达模式推断
22470541 RGD
involved in response to amyloid-beta IEP
IEP: 通过表达模式推断
24441681 RGD
involved in response to caffeine IEP
IEP: 通过表达模式推断
24717552 RGD
involved in response to cocaine IEP
IEP: 通过表达模式推断
16670375 RGD
involved in response to hyperoxia IEP
IEP: 通过表达模式推断
21905265 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
24595367 RGD
involved in response to nicotine IEP
IEP: 通过表达模式推断
24709674 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
16670375 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
11516394 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HDAC2 蛋白结构

HDAC2

HDAC2: cd10011 (8 - 373)

CobT2

CobT2: cl34772 (385 - 478)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
蛋白主名 其他名称

histone deacetylase 2

相关产品

Approval
生物活性分子 (8)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10221 Vorinostat Inhibitor 99.95% 是
HY-10585 Valproic acid Inhibitor 98.88% 否
HY-15149 Romidepsin Inhibitor 99.98% 否
HY-109015 Tucidinostat Inhibitor 98.60% 否
HY-10585A Valproic acid sodium Inhibitor 98.14% 否
HY-12164 Mocetinostat Inhibitor 99.43% 是
HY-13322 Pracinostat Inhibitor 99.82% 是
HY-10585B Valproic acid (sodium)(2:1) Inhibitor / 否
Clinical Phase
生物活性分子 (17)
目录号 产品名 作用方式
纯度 Phase
HY-12163 Entinostat Inhibitor 99.82% Phase 3
HY-50934 Tacedinaline Inhibitor 99.32% Phase 3
HY-10990 Abexinostat Inhibitor 98.63% Phase 3
HY-14842 Givinostat Inhibitor 98.16% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-100748 Zabadinostat Inhibitor 99.81% Phase 2
HY-16012A Domatinostat Inhibitor 99.43% Phase 2
HY-101780 Tinostamustine Inhibitor 99.42% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-10223 CUDC-101 Inhibitor 98.84% Phase 1
HY-15994 Citarinostat Inhibitor 99.30% Phase 1
HY-124295 MPT0E028 Inhibitor 99.63% Phase 1
Pre-clinical Phase
生物活性分子 (107)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18998 LMK-235 Inhibitor 99.61% 否
HY-N0931 Santacruzamate A Inhibitor 99.04% 否
HY-13428 Tubacin Inhibitor 99.54% 否
HY-18613 CAY10603 Inhibitor ≥98.0% 否
HY-19327 ACY-738 Inhibitor 99.92% 否
HY-16699 Nexturastat A Inhibitor 98.28% 否
HY-19618 BRD3308 Inhibitor 98.82% 否
HY-100719 BRD-6929 Inhibitor 99.04% 否
HY-104008 ACY-957 Inhibitor 99.66% 否
HY-115475 SW-100 Inhibitor 99.59% 否
HY-111400 SR-4370 Inhibitor 99.95% 否
HY-19328 ACY-775 Inhibitor 99.69% 否
HY-18976 UF010 99.84% 否
HY-100871 WT-161 Inhibitor 98.36% 否
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.54% 否
HY-18712 BG45 Inhibitor 99.96% 否
HY-19747 HPOB Inhibitor 99.80% 否
HY-116818 Crebinostat Inhibitor 99.79% 否
HY-117709 BRD6688 Inhibitor 98.90% 否
HY-10585R Valproic acid (Standard) Inhibitor / 否
HY-18700 BRD73954 Inhibitor ≥98.0% 否
HY-100384 NKL 22 Inhibitor 97.27% 否
HY-117583 cis-BG47 Inhibitor 98.02% 否
HY-146346 HD-TAC7 Inhibitor 98.75% 否
HY-110280 MC1742 Inhibitor 99.20% 否
HY-146153 HDAC-IN-40 Inhibitor 98.71% 否
HY-102083 BRD4884 Inhibitor ≥99.0% 否
HY-124053 BRD2492 Inhibitor 99.18% 否
HY-131708A FNDR-20123 Inhibitor 98.08% 否
HY-156422 KPZ560 Inhibitor / 否
HY-157388 CARM1/HDAC2-IN-1 Inhibitor / 否
HY-152174 HDAC-IN-52 Inhibitor 99.46% 否
HY-117554 BRD9757 Inhibitor 99.75% 否
HY-151464 SHP2/HDAC-IN-1 Inhibitor / 否
HY-128582 PI3K/HDAC-IN-1 Inhibitor / 否
HY-131708 FNDR-20123 free base Inhibitor / 否
HY-146678 HDAC6-IN-5 Inhibitor / 否
HY-143497 HDAC1/2 and CDK2-IN-1 Inhibitor / 否
HY-150109 Purinostat mesylate Inhibitor / 否
HY-146679 HDAC6-IN-6 Inhibitor / 否
HY-161778 ZG-126 Inhibitor / 否
HY-133147 HDAC3/6-IN-2 Inhibitor / 否
HY-146392 HDAC-IN-39 Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-151897 HDAC-IN-49 Inhibitor / 否
HY-149946 HDAC-IN-57 Inhibitor / 否
HY-152173 HDAC-IN-51 Inhibitor / 否
HY-151261 HDAC6-IN-13 Inhibitor 98.08% 否
HY-152225 MC2625 Inhibitor / 否
HY-162769 HDAC3-IN-5 Inhibitor / 否
HY-115941 HDAC-IN-9 Inhibitor / 否
HY-145852 Top/HDAC-IN-2 Inhibitor / 否
HY-169226 HDAC6-IN-51 Inhibitor / 否
HY-146159 PI3K/HDAC-IN-2 Inhibitor / 否
HY-154855 HDAC-IN-56 Inhibitor / 否
HY-144654 HDAC/Top-IN-1 Inhibitor / 否
HY-147934 HDAC8-IN-3 Inhibitor / 否
HY-162910 HDAC-IN-79 Inhibitor / 否
HY-146684 HDAC-IN-36 Inhibitor / 否
HY-163207 sEH/HDAC6-IN-1 Inhibitor / 否
HY-144332 PHD2/HDACs-IN-1 Inhibitor / 否
HY-163834 HDAC6-IN-47 Inhibitor / 否
HY-151896 HDAC6-IN-14 Inhibitor / 否
HY-109015S Tucidinostat-d4 Inhibitor / 否
HY-146160 PARP-1/HDAC-IN-1 Inhibitor / 否
HY-150577 HDAC-IN-45 Inhibitor / 否
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / 否
HY-151248 HDAC2-IN-1 Inhibitor / 否
HY-162630 HDAC6-IN-44 Inhibitor / 否
HY-149721 HDAC4-IN-1 Inhibitor / 否
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / 否
HY-149029 TH-6 Inhibitor 95.00% 否
HY-163282 NB512 Inhibitor / 否
HY-125645 M122 Inhibitor / 否
HY-152146 HDAC-IN-50 Inhibitor / 否
HY-151569 SAHA-OH Inhibitor / 否
HY-157481 HDAC1-IN-6 Inhibitor / 否
HY-144293 HDAC-IN-31 Inhibitor / 否
HY-146276 CDK/HDAC-IN-2 Inhibitor / 否
HY-161783 HDAC6-IN-45 Inhibitor / 否
HY-144395 HDAC6-IN-4 Inhibitor / 否
HY-159171 sEH/HDAC6-IN-2 Inhibitor / 否
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / 否
HY-147840 HDAC-IN-41 Inhibitor / 否
HY-162487 HDAC-IN-72 Inhibitor / 否
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / 否
HY-163430 HDAC-IN-71 Inhibitor / 否
HY-161667 GSK-3β/HDAC-IN-1 Inhibitor / 否
HY-144292 HDAC-IN-30 Inhibitor / 否
HY-144297 HDAC1-IN-3 Inhibitor / 否
HY-10585G Valproic acid (GMP) Inhibitor / 否
HY-163803 CM-444 Inhibitor / 否
HY-15144B (S)-Trichostatin A Inhibitor / 否
HY-146351 HDAC-IN-38 Inhibitor / 否
HY-152226 MC2590 Inhibitor / 否
HY-161524 HDAC6-IN-43 Inhibitor / 否
HY-149208 HDAC-IN-53 Inhibitor / 否
HY-151443 HDAC-IN-47 Inhibitor / 否
HY-157740 XSJ-10 Inhibitor / 否
HY-117374 HDAC3-IN-1 Inhibitor / 否
HY-147966 HDAC-IN-43 Inhibitor / 否
HY-162955 LSD1/HDAC-IN-1 Inhibitor / 否
HY-19754A CRA-026440 hydrochloride Inhibitor 98.14% 否
HY-168650 ROCK/HDAC-IN-1 Inhibitor / 否
HY-143877 NN-390 Inhibitor / 否
HY-117583A BG47 Inhibitor / 否
HY-19754 CRA-026440 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens HDAC2 NCBI NCBI:3066
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