Quinacrine (Synonyms: Acriquine)

目录号: HY-13735 纯度: 98.20%: FAQs
Data Sheet SDS COA 产品使用指南技术支持

Quinacrine (Acriquine) 是一种抗疟疾和抗癌剂。Quinacrine 还抑制人醛氧化酶 (aldehyde oxidase) (IC₅₀: 3.3 μM)。Quinacrine 对核酸具有亲和力，并对固定细胞中的 DNA 和 RNA 染色 (Ex/Em: 436/525 nm)。

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Quinacrine Chemical Structure

CAS No. : 83-89-6

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥385	In-stock
5 mg	￥350	In-stock
10 mg	￥640	In-stock
25 mg	￥1280	In-stock
50 mg	￥2060	In-stock
100 mg	￥3300	In-stock
200 mg		询价
500 mg		询价

or 大包装询价

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Customer Review

Other Forms of Quinacrine:

l-Atabrine dihydrochloride In-stock
d-Atabrine dihydrochloride In-stock
Quinacrine dihydrochloride In-stock
Quinacrine hydrochloride hydrate In-stock
Quinacrine methanesulfonate 询价
Quinacrine acetate 询价

MCE 顾客使用本产品发表的 4 篇科研文献

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Na_v1.1 Na_v1.2 Na_v1.3 Na_v1.4 Na_v1.5 Na_v1.6 Na_v1.7 Na_v1.8

生物活性
纯度 & 产品资料
参考文献

生物活性

Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC₅₀: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm)^[1]^[2]^[3]^[4]^[7].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
184B5	IC₅₀	4.96 μM Compound: Quinacrine	Antiproliferative activity against human 184B5 cells after 48 hrs by SRB assay Antiproliferative activity against human 184B5 cells after 48 hrs by SRB assay	[PMID: 29232580]
184B5	IC₅₀	4.96 μM Compound: QC	Cytotoxicity against human 184B5 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human 184B5 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 28586716]
BHK-21	CC₅₀	18.59 μM Compound: 40	Cytotoxicity against BHK21 cells after 24 to 48 hrs by CCK8 assay Cytotoxicity against BHK21 cells after 24 to 48 hrs by CCK8 assay	[PMID: 31549836]
BHK-21	CC₅₀	19.8 μM Compound: 18	Cytotoxicity against hamster BHK-21 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Cytotoxicity against hamster BHK-21 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 36940609]
HeLa	IC₅₀	1.05 μM Compound: Quinacrine	Antiviral activity against Ebolavirus infected in human HeLa cells assessed as reduction in viral replication incubated for 48 hrs by luminescence based assay Antiviral activity against Ebolavirus infected in human HeLa cells assessed as reduction in viral replication incubated for 48 hrs by luminescence based assay	[PMID: 32832035]
Hepatocyte	IC₅₀	3 x 10⁴ nM Compound: Quinacrine	Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs	[PMID: 18212104]
HepG2	EC₅₀	10.44 μM Compound: Quinacrine	Cytotoxicity against human HepG2 cells after 48 hrs by Alamar Blue-based assay Cytotoxicity against human HepG2 cells after 48 hrs by Alamar Blue-based assay	[PMID: 28740614]
HepG2	EC₅₀	10.44 μM Compound: Quinacrine	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by Alamar blue assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by Alamar blue assay	[PMID: 27992217]
HepG2	EC₅₀	11.9 μM Compound: Quinacrine	Cytotoxicity against human HepG2 cells assessed as cell viability after 48 hrs by alamar blue assay Cytotoxicity against human HepG2 cells assessed as cell viability after 48 hrs by alamar blue assay	[PMID: 27788467]
HepG2	CC₅₀	7.6 μM Compound: Quinacrine	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by alamar blue dye based assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by alamar blue dye based assay	[PMID: 33479683]
HepG2	EC₅₀	7653.7 μM Compound: Quinacrine	Cytotoxicity against human HepG2 cells after 48 hrs by alamar blue assay Cytotoxicity against human HepG2 cells after 48 hrs by alamar blue assay	[PMID: 30655955]
HepG2	CC₅₀	9.78 μM Compound: Quinacrine	Cytotoxicity against human HepG2 cells after 48 hrs by Alamar Blue assay Cytotoxicity against human HepG2 cells after 48 hrs by Alamar Blue assay	[PMID: 24354316]
HT-1080	IC₅₀	29 μM Compound: Quinacrine	Anticancer activity against human HT-1080 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay Anticancer activity against human HT-1080 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay	[PMID: 36208544]
HT-22	EC₅₀	9.09 μM Compound: Quinacrine	Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay	[PMID: 24602904]
HT-29	IC₅₀	55 μM Compound: Quinacrine	Concentration required to inhibit colony formation by 50% in human colon carcinoma HT-29 cells Concentration required to inhibit colony formation by 50% in human colon carcinoma HT-29 cells	[PMID: 8289202]
MCF7	IC₅₀	4.19 μM Compound: Quinacrine	Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 29232580]
MCF7	IC₅₀	4.19 μM Compound: QC	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 28586716]
MCF7	IC₅₀	7.5 μM Compound: Quinacrine	Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 30684866]
MDA-MB-231	IC₅₀	3.25 μM Compound: Quinacrine	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by SRB assay	[PMID: 29232580]
MDA-MB-231	IC₅₀	3.25 μM Compound: QC	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 28586716]
MDA-MB-468	IC₅₀	3.96 μM Compound: Quinacrine	Antiproliferative activity against human MDA-MB-468 cells after 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-468 cells after 48 hrs by SRB assay	[PMID: 29232580]
MDA-MB-468	IC₅₀	3.96 μM Compound: QC	Cytotoxicity against human MDA-MB-468 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-468 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 28586716]
N2a #58 F3	EC₅₀	1.88 μM Compound: Quinacrine	Antiprion activity against human prion protein Fukuoka-1 infected mouse F3 cells assessed as reduction of PrPSc level by Western blot method Antiprion activity against human prion protein Fukuoka-1 infected mouse F3 cells assessed as reduction of PrPSc level by Western blot method	[PMID: 21531054]
ScN2a	EC₅₀	0.23 μM Compound: Quinacrine	Antiprion activity against mouse prion protein RML infected mouse ScN2a cells assessed as reduction of PrPSc level by Western blot method Antiprion activity against mouse prion protein RML infected mouse ScN2a cells assessed as reduction of PrPSc level by Western blot method	[PMID: 21531054]
ScN2a	EC₅₀	0.23 μM Compound: quinacrine	Antiprion activity against scrapie prion protein RML infected mouse ScN2a cells assessed as reduction of scrapie prion protein accumulation by immunoblot analysis Antiprion activity against scrapie prion protein RML infected mouse ScN2a cells assessed as reduction of scrapie prion protein accumulation by immunoblot analysis	[PMID: 18556207]
ScN2a	EC₅₀	0.3 μM Compound: Quinacrine	Antiprion activity against Scrapie prion protein-mediated scrapie in RML mouse ScN2a cells assessed as reduction of PrP-Sc level after 6 days by immunoblotting Antiprion activity against Scrapie prion protein-mediated scrapie in RML mouse ScN2a cells assessed as reduction of PrP-Sc level after 6 days by immunoblotting	[PMID: 19842664]
SH-SY5Y	IC₅₀	8.57 μM Compound: Quinacrine	Anticancer activity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay Anticancer activity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay	[PMID: 36208544]
U-251	IC₅₀	5 μM Compound: 81	Antiproliferative activity against human U251 cells by MTT assay Antiproliferative activity against human U251 cells by MTT assay	[PMID: 30583248]
U2OS	EC₅₀	0.25 μM Compound: 157	Inhibition of autophagy in human U2OS cells expressing tfLC3 incubated for 3 hrs by fluorescent microscopy Inhibition of autophagy in human U2OS cells expressing tfLC3 incubated for 3 hrs by fluorescent microscopy	[PMID: 36283182]
Ventricular myocyte	IC₅₀	5.2 μM Compound: Mepacrine	Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes	[PMID: 22761000]
Vero	IC₅₀	> 50 μM Compound: Quinacrine	Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr	10.1101/2020.03.20.999730
Vero	CC₅₀	14.71 μM Compound: Quinacrine	Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr	10.1101/2020.03.20.999730
WIL2-NS	CC₅₀	4.8 μM Compound: Quinacrine	Cytotoxicity against human WIL2-NS cells assessed as reduction in cell viability after 48 hrs by alamar blue dye based assay Cytotoxicity against human WIL2-NS cells assessed as reduction in cell viability after 48 hrs by alamar blue dye based assay	[PMID: 33479683]

体外研究
(In Vitro)

Quinacrine 抑制人和兔醛氧化酶，IC₅₀ 分别为 3.3 μM 和 10 μM^[2]。
Quinacrine 阻断电压依赖性钠通道 (IC₅₀: 3.3 μM)^[3]。
Quinacrine (100 μM) 也是一种 PLA2 抑制剂^[4]。
Quinacrine (0-20 μM, 24 h) 抑制 SGC-7901 细胞的生长，并诱导细胞凋亡^[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[7]

Cell Line:	SGC-7901 cell
Concentration:	0, 5, 10, 15, 20 μM
Incubation Time:	24 h
Result:	Inhibited cell growth with an IC₅₀ value of 16.18 μM.

体内研究
(In Vivo)

Quinacrine (3-30 mg/kg，i.p.，每日一次，连续三天) 对甘油诱导的大鼠急性肾损伤具有保护作用^[5]。
Quinacrine (2.5-10 mg/kg，i.p.，每天一次，连续八周) 对环孢菌素引起的大鼠肾毒性具有保护作用^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Acute kidney injury rat model^[5]
Dosage:	3-30 mg/kg
Administration:	i.p.
Result:	Attenuated glycerol induced structural and functional changes in kidney.

Clinical Trial

分子量

399.96

Formula

C₂₃H₃₀ClN₃O

CAS 号

83-89-6

性状

油状物

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : 50 mg/mL (125.01 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5003 mL	12.5013 mL	25.0025 mL
5 mM	0.5001 mL	2.5003 mL	5.0005 mL
10 mM	0.2500 mL	1.2501 mL	2.5003 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (12.50 mM); 澄清溶液

此方案可获得 ≥ 5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 50.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 98.20%

选择批次：

Data Sheet (654 KB) SDS (558 KB)

COA (289 KB) HNMR (136 KB) RP-HPLC (168 KB) LCMS (105 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Vogtherr M, et al. Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein. J Med Chem. 2003 Aug 14;46(17):3563-4. [Content Brief]

[2]. Pryde DC, et al. Aldehyde oxidase: an enzyme of emerging importance in drug discovery. J Med Chem. 2010 Dec 23;53(24):8441-60. [Content Brief]

[3]. McNeal ET, et al. [3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. J Med Chem. 1985 Mar;28(3):381-8. [Content Brief]

[4]. Caro AA,et al. Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells. J Biol Chem. 2003 Sep 5;278(36):33866-77. [Content Brief]

[5]. Al Asmari AK, et al. Protective effect of quinacrine against glycerol-induced acute kidney injury in rats. BMC Nephrol. 2017 Jan 28;18(1):41. [Content Brief]

[6]. al Khader A, et al. Quinacrine attenuates cyclosporine-induced nephrotoxicity in rats. Transplantation. 1996 Aug 27;62(4):427-35. [Content Brief]

[7]. Wu X, et al. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb;73(1-2):52-64. [Content Brief]

Quinacrine 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5003 mL	12.5013 mL	25.0025 mL	62.5063 mL
	5 mM	0.5001 mL	2.5003 mL	5.0005 mL	12.5013 mL
	10 mM	0.2500 mL	1.2501 mL	2.5003 mL	6.2506 mL
	15 mM	0.1667 mL	0.8334 mL	1.6668 mL	4.1671 mL
	20 mM	0.1250 mL	0.6251 mL	1.2501 mL	3.1253 mL
	25 mM	0.1000 mL	0.5001 mL	1.0001 mL	2.5003 mL
	30 mM	0.0833 mL	0.4167 mL	0.8334 mL	2.0835 mL
	40 mM	0.0625 mL	0.3125 mL	0.6251 mL	1.5627 mL
	50 mM	0.0500 mL	0.2500 mL	0.5001 mL	1.2501 mL
	60 mM	0.0417 mL	0.2084 mL	0.4167 mL	1.0418 mL
	80 mM	0.0313 mL	0.1563 mL	0.3125 mL	0.7813 mL
	100 mM	0.0250 mL	0.1250 mL	0.2500 mL	0.6251 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinacrine83-89-6AcriquineParasiteSodium ChannelDNA StainApoptosisNa channelsNa+ channelsAntimalarialinfectionDNA stainRNA stainAKIcancerInhibitorinhibitorinhibit

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Quinacrine (Synonyms: Acriquine)

Customer Review

Other Forms of Quinacrine:

MCE 顾客使用本产品发表的 4 篇科研文献

Quinacrine 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

查看 Parasite 亚型特异性产品:

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生物活性

纯度 & 产品资料

参考文献

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完整储备液配制表

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Quinacrine (Synonyms: Acriquine)

Customer Review

Other Forms of Quinacrine:

Quinacrine 相关抗体

MCE 顾客使用本产品发表的 4 篇科研文献

Quinacrine 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

查看 Parasite 亚型特异性产品:

查看 Sodium Channel 亚型特异性产品:

生物活性

纯度 & 产品资料

参考文献

Quinacrine 相关抗体:

摩尔计算器

稀释计算器

Quinacrine 相关分类

完整储备液配制表

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