2. 一站式药筛
  3. 化合物库
  4. 结构多样性片段化合物库
结构多样性片段化合物库 - Structurally Diverse Fragment Library

Cat. No.: HY-L187

基于片段的药物开发 (FBDD) 是可应用于科学研究和商业化的药物开发方法，可增强对一些 “不可成药物” 靶点的识别。基于片段的药物开发发现了低分子量配体 (<300Da) 能够与相关大分子结合。这些片段分子可以覆盖广阔的化学空间，易于后期进行结构优化。目前，已经有多种基于片段开发发的药物进入临床试验，其中 Vemurafenib 和 Venetoclax 两种药物已经获得批准上市。

MCE 基于 Tanimoto 系数，使用相似性算法，从大规模的片段分子中精心挑选了 2,323 个高结构多样性的符合 ‘RO3’ 片段分子，可应用于基于片段的药物开发。

我们将在明确您的产品用途后，向符合资质的客户通过定制合成服务的方式提供 MCE 结构多样性片段化合物库，我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中，2,323 个产品以 10 mM 浓度提供。

溶液包装中，我们对于溶液状态稳定且溶解度不低于 10 mM 的产品，提供 10 mM 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
- +
联系专家定制

Compound Screening Libraries

Download

Top Publications Citing Use of MCE Products

View More

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 2,323 high diversity fragments for high throughput screening (HTS) and high content screening (HCS).

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some compounds have been approved by FDA.

•   Structurally diverse, bioactive, and cell permeable.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 2,323 fragments as pre-dissolved solutions or solid.
Solution: 2,323 compounds supplied in 10 mM solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

相关服务推荐
定制您专属的化合物库
  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式（固体或溶液）
  •  YES
联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

* Container：

       留言给我们：

    Bulk Inquiry

    Inquiry Information

    产品名称：
    Structurally Diverse Fragment Library
    目录号：
    HY-L187
    需求量：

    Request for SDF File

    Please fill out this form to request the SDF file. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * 客户姓名：

    * Email：

    		 

    * 公司或机构名称：

    * 电话：

    		     

       留言给我们：

    Request for SDF File

    We have received your request and will respond to you as soon as possible.

    嗨！很高兴为您提供帮助！

    尊敬的 MCE 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z