Terameprocol (Synonyms: EM-1421)

目录号: HY-10447 纯度: 99.76%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Terameprocol 是 Nordihydroguaiaretic acid 的合成衍生物，是一种非选择性的脂氧合酶抑制剂。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Terameprocol Chemical Structure

CAS No. : 24150-24-1

1. 客户无需承担相应的运输费用。

2. 同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

可免费申领三个不同产品的试用装。

3. 试用装只面向终端客户。

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥610	In-stock
5 mg	￥343	In-stock
10 mg	￥550	In-stock
25 mg	￥1000	In-stock
50 mg	￥1600	In-stock
100 mg	￥2600	In-stock
200 mg		询价
500 mg		询价

or 大包装询价

* Please select Quantity before adding items.

Customer Review

Terameprocol 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

查看 Lipoxygenase 亚型特异性产品:

查看所有亚型

5-LOX 12-LOX 15-LOX

生物活性
纯度 & 产品资料
参考文献

生物活性

Terameprocol is a synthetic derivative of Nordihydroguaiaretic acid and a non-selective lipoxygenase inhibitor. Terameprocol has antiviral and antitumor effects^[1]^[2]^[3].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
786-0	GI₅₀	4.54 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human 786-0 cells after 72 hrs by MTT assay Cytotoxicity against human 786-0 cells after 72 hrs by MTT assay	[PMID: 24080463]
A-375	IC₅₀	16.6 μM Compound: 1a, M4N	Cytotoxicity against human A375 cells after 5 days by MTT assay Cytotoxicity against human A375 cells after 5 days by MTT assay	[PMID: 19615898]
BXPC-3	GI₅₀	17.1 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human BxPC3 cells after 72 hrs by MTT assay Cytotoxicity against human BxPC3 cells after 72 hrs by MTT assay	[PMID: 24080463]
C8166	CC₅₀	28.8 μM Compound: 21	Cytotoxicity against human C8166 cells by MTT assay Cytotoxicity against human C8166 cells by MTT assay	[PMID: 19413342]
HeLa	GI₅₀	> 50 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 24080463]
Hep 3B2	IC₅₀	≤ 10 μM Compound: 3, M4N	Cytotoxicity against human Hep3B cells after 3 days by MTT assay Cytotoxicity against human Hep3B cells after 3 days by MTT assay	[PMID: 21123067]
HepG2	IC₅₀	44.5 μM Compound: 1a, M4N	Cytotoxicity against human HepG2 cells after 5 days by MTT assay Cytotoxicity against human HepG2 cells after 5 days by MTT assay	[PMID: 19615898]
HT-29	IC₅₀	≤ 10 μM Compound: 3, M4N	Cytotoxicity against human HT-29 cells after 3 days by MTT assay Cytotoxicity against human HT-29 cells after 3 days by MTT assay	[PMID: 21123067]
HT-29	IC₅₀	61.5 μM Compound: 1a, M4N	Cytotoxicity against human HT-29 cells after 5 days by MTT assay Cytotoxicity against human HT-29 cells after 5 days by MTT assay	[PMID: 19615898]
K562	IC₅₀	5.87 mg/L Compound: 2, EM-1421, M4N, Terameprocol	Inhibition of growth metabolism of human K562 cells at 37 degC by TAM air microcalorimetry Inhibition of growth metabolism of human K562 cells at 37 degC by TAM air microcalorimetry	[PMID: 23434529]
LNCaP	IC₅₀	≤ 10 μM Compound: 3, M4N	Cytotoxicity against human LNCAP cells after 3 days by MTT assay Cytotoxicity against human LNCAP cells after 3 days by MTT assay	[PMID: 21123067]
MCF7	IC₅₀	≤ 10 μM Compound: 3, M4N	Cytotoxicity against human MCF7 cells after 3 days by MTT assay Cytotoxicity against human MCF7 cells after 3 days by MTT assay	[PMID: 21123067]
MCF7	IC₅₀	42.4 μM Compound: 1a, M4N	Cytotoxicity against human MCF7 cells after 5 days by MTT assay Cytotoxicity against human MCF7 cells after 5 days by MTT assay	[PMID: 19615898]
NCI/ADR-RES	IC₅₀	≤ 10 μM Compound: 3, M4N	Cytotoxicity against human NCI/ADR-RES cells after 3 days by MTT assay Cytotoxicity against human NCI/ADR-RES cells after 3 days by MTT assay	[PMID: 21123067]
T47D	GI₅₀	5.36 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human T47D cells after 72 hrs by MTT assay Cytotoxicity against human T47D cells after 72 hrs by MTT assay	[PMID: 24080463]
T98G	GI₅₀	> 50 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human T98G cells after 72 hrs by MTT assay Cytotoxicity against human T98G cells after 72 hrs by MTT assay	[PMID: 24080463]
U-87MG ATCC	GI₅₀	> 50 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human U87 cells after 72 hrs by MTT assay Cytotoxicity against human U87 cells after 72 hrs by MTT assay	[PMID: 24080463]

Clinical Trial

分子量

358.47

Formula

C₂₂H₃₀O₄

CAS 号

24150-24-1

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : 100 mg/mL (278.96 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7896 mL	13.9482 mL	27.8963 mL
5 mM	0.5579 mL	2.7896 mL	5.5793 mL
10 mM	0.2790 mL	1.3948 mL	2.7896 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.76%

选择批次：

Data Sheet (584 KB) SDS (398 KB)

COA (261 KB) HNMR (239 KB) LCMS (87 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Hwu JR, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation. J Med Chem. 1998 Jul 30;41(16):2994-3000. [Content Brief]

[2]. Chen H, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA. J Med Chem. 1998 Jul 30;41(16):3001-7. [Content Brief]

[3]. Park R, et al. Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors. Clin Cancer Res. 2005 Jun 15;11(12):4601-9. [Content Brief]

Terameprocol 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7896 mL	13.9482 mL	27.8963 mL	69.7408 mL
	5 mM	0.5579 mL	2.7896 mL	5.5793 mL	13.9482 mL
	10 mM	0.2790 mL	1.3948 mL	2.7896 mL	6.9741 mL
	15 mM	0.1860 mL	0.9299 mL	1.8598 mL	4.6494 mL
	20 mM	0.1395 mL	0.6974 mL	1.3948 mL	3.4870 mL
	25 mM	0.1116 mL	0.5579 mL	1.1159 mL	2.7896 mL
	30 mM	0.0930 mL	0.4649 mL	0.9299 mL	2.3247 mL
	40 mM	0.0697 mL	0.3487 mL	0.6974 mL	1.7435 mL
	50 mM	0.0558 mL	0.2790 mL	0.5579 mL	1.3948 mL
	60 mM	0.0465 mL	0.2325 mL	0.4649 mL	1.1623 mL
	80 mM	0.0349 mL	0.1744 mL	0.3487 mL	0.8718 mL
	100 mM	0.0279 mL	0.1395 mL	0.2790 mL	0.6974 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Terameprocol24150-24-1EM-1421EM1421EM 1421LipoxygenaseLOXInhibitorinhibitorinhibit

您最近查看的产品:

产品名称：

* 需求量：

* 客户姓名：

* Email：

* 电话：

* 公司或机构名称：

留言给我们：

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Terameprocol (Synonyms: EM-1421)

Customer Review