2. Apoptosis Neuronal Signaling Anti-infection Epigenetics PI3K/Akt/mTOR
  3. Apoptosis Monoamine Oxidase Bacterial AMPK Caspase
  4. Xanthoangelol

Xanthoangelol 可从Angelica keiskei 中分离得到，可抑制肥胖引起的炎症反应。Xanthoangelol 具有抗菌活性。Xanthoangelol 可抑制单胺氧化酶。Xanthoangelol 诱导神经母细胞瘤和白血病细胞凋亡。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Xanthoangelol Chemical Structure

Xanthoangelol Chemical Structure

CAS No. : 62949-76-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥900
In-stock
5 mg ￥2200
In-stock
10 mg ￥3300
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Xanthoangelol 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

查看 AMPK 亚型特异性产品:

查看所有亚型
NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol possesses antibacterial activity. Xanthoangelol inhibits monoamine oxidases. Xanthoangelol induces apoptosis in neuroblastoma and leukemia cells[1][2][3][4].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BHK-21 CC50
11.8 μM
Compound: 30
Cytotoxicity against hamster BHK-21 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against hamster BHK-21 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 36940609]
HEK293 IC50
21.5 μM
Compound: Xanthoangelol
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay
[PMID: 31648878]
HeLa IC50
1.03 μM
Compound: 11
Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay
Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay
[PMID: 18841906]
HepG2 IC50
13.7 μM
Compound: Xanthoangelol
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay
[PMID: 31648878]
HUVEC IC50
> 100 μM
Compound: 1b
Toxicity against HUVEC incubated for 48 hrs by MTT assay
Toxicity against HUVEC incubated for 48 hrs by MTT assay
[PMID: 25590864]
K562 IC50
3.98 μM
Compound: 1b
Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay
Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay
[PMID: 25590864]
MRC5 IC50
21.7 μM
Compound: Xanthoangelol
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay
[PMID: 31648878]
MRC5 IC50
25 μM
Compound: 23
Cytotoxicity against human MRC5 cells after 48 hrs by resazurin dye-based fluorescence analysis
Cytotoxicity against human MRC5 cells after 48 hrs by resazurin dye-based fluorescence analysis
[PMID: 28075580]
RAW264.7 IC50
1.83 μM
Compound: 11
Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay
Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay
[PMID: 18841906]
THP-1 IC50
23.6 μM
Compound: Xanthoangelol
Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay
Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay
[PMID: 31648878]
THP-1 IC50
25 μM
Compound: 23
Cytotoxicity against human THP1 cells after 48 hrs by resazurin dye-based fluorescence analysis
Cytotoxicity against human THP1 cells after 48 hrs by resazurin dye-based fluorescence analysis
[PMID: 28075580]
体外研究
(In Vitro)

Xanthoangelol (1 和 5 μM，24 小时) 与 4-HD 结合，通过抑制 JNK 通路，抑制完全分化的 3T3-L1 脂肪细胞和 RAW264.7 巨噬细胞的共培养系统中的促炎因子，诸如一氧化氮 (NO)、肿瘤坏死因子-alpha (TNF-a) 和单核细胞趋化蛋白-1 (MCP-1)[1]。
Xanthoangelol (1-100 μM，48 小时)通过细胞毒性降低神经母细胞瘤和白血病细胞的生存率[4]。
Xanthoangelol (1-10 μM，4 小时)在 Jurkat 细胞中通过激活半胱天冬酶-3 诱导浓度依赖性的早期凋亡，随后发生次级细胞死亡[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Xanthoangelol 相关抗体:

Real Time qPCR[1]

Cell Line: LPS-stimulated RAW264.7 macrophages
Concentration: 1 and 5 μM
Incubation Time: 24 h
Result: Decreased NO release, TNF-a and MCP-1 secretion, as well as the mRNA expression in LPS-stimulated RAW264.7 macrophages.

Western Blot Analysis[1]

Cell Line: LPS-stimulated RAW264.7 macrophages
Concentration: 5 μM
Incubation Time: 1 h
Result: Alleviated JNK phosphorylation (by 38% and 49%, respectively), but had no effect on IjB degradation and p38 phosphorylation in LPS-stimulated RAW264.7 macrophages.

Cell Viability Assay[4]

Cell Line: IMR-32 and Jurkat cells
Concentration: 1-100 μM
Incubation Time: 48 h
Result: Markedly reduced IMR-32 and Jurkat cells viability in a concentration-dependent manner.

Apoptosis Analysis[4]

Cell Line: Jurkat cells
Concentration: 1-10 μM
Incubation Time: 4 h
Result: Significantly increased the ratio of apoptotic IMR-32 cells.
体内研究
(In Vivo)

Xanthoangelol (0.1% 或 0.15% w/w，混合于高脂饮食中，每天服用, 持续 14 周) 抑制饮食诱导的肥鼠脂肪组织中的炎性介质[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High-fat diet-induced obese (DIO) mice[1]
Dosage: 0.1% or 0.15% w/w
Administration: mixed in a high-fat diet, daily for 14 weeks
Result: Showed fewer positively stained macrophages, suppressed the gene expression of inflammatory marker MCP-1 and TNF-a, increased oxygen consumption in DIO mice.
分子量

392.49

Formula

C25H28O4
CAS 号
性状

固体

颜色

Light yellow to yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (254.78 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5478 mL 12.7392 mL 25.4784 mL
5 mM 0.5096 mL 2.5478 mL 5.0957 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.88%

COA (285 KB) HNMR (261 KB) LCMS (94 KB)

产品使用指南 (1538 KB)
参考文献

Xanthoangelol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5478 mL 12.7392 mL 25.4784 mL 63.6959 mL
5 mM 0.5096 mL 2.5478 mL 5.0957 mL 12.7392 mL
10 mM 0.2548 mL 1.2739 mL 2.5478 mL 6.3696 mL
15 mM 0.1699 mL 0.8493 mL 1.6986 mL 4.2464 mL
20 mM 0.1274 mL 0.6370 mL 1.2739 mL 3.1848 mL
25 mM 0.1019 mL 0.5096 mL 1.0191 mL 2.5478 mL
30 mM 0.0849 mL 0.4246 mL 0.8493 mL 2.1232 mL
40 mM 0.0637 mL 0.3185 mL 0.6370 mL 1.5924 mL
50 mM 0.0510 mL 0.2548 mL 0.5096 mL 1.2739 mL
60 mM 0.0425 mL 0.2123 mL 0.4246 mL 1.0616 mL
80 mM 0.0318 mL 0.1592 mL 0.3185 mL 0.7962 mL
100 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.6370 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xanthoangelol62949-76-2ApoptosisMonoamine OxidaseBacterialAMPKCaspaseMAOAMP-activated protein kinaseInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Xanthoangelol
目录号：
HY-111588
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z