(20S)-Protopanaxadiol (Synonyms: 20 (S)-原人参二醇; 20-Epiprotopanaxadiol; 20(S)-APPD)

目录号: HY-N0797 纯度: 99.85%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

20S-protopanaxadiol (aPPD) 是人参皂甙的代谢产物，抑制 Akt 活性并诱导多种肿瘤细胞凋亡。

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(20S)-Protopanaxadiol Chemical Structure

CAS No. : 30636-90-9

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规格	价格	是否有货
5 mg	￥440	In-stock
10 mg	￥679	In-stock
25 mg	￥1424	In-stock
50 mg	￥2278	In-stock
100 mg	￥3484	In-stock
200 mg		询价
500 mg		询价

or 大包装询价

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Customer Review

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(20S)-Protopanaxadiol (Standard) 询价

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生物活性
纯度 & 产品资料
参考文献

生物活性

20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	99.89 μM Compound: PPD	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 22342101]
A549	IC₅₀	99.89 μM Compound: PPD	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 21216145]
COLO 205	IC₅₀	49.16 μM Compound: PPD	Cytotoxicity against human COLO205 cells after 72 hrs by MTT assay Cytotoxicity against human COLO205 cells after 72 hrs by MTT assay	[PMID: 21216145]
DU-145	IC₅₀	60.41 μM Compound: PPD	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 21216145]
Hep 3B2	IC₅₀	14.69 μM Compound: PPD	Cytotoxicity against human Hep3B cells after 72 hrs by MTT assay Cytotoxicity against human Hep3B cells after 72 hrs by MTT assay	[PMID: 22342101]
HepG2	IC₅₀	39.42 μM Compound: PPD	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 21216145]
HepG2	IC₅₀	45.67 μM Compound: 3	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 26420067]
HL-60	IC₅₀	15.53 μM Compound: 3	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 26420067]
HL-60	IC₅₀	27.06 μM Compound: PPD	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 21216145]
HUVEC	EC₅₀	2.16 μg/mL Compound: 1	Antiproliferative activity against HUVEC cells after 72 hrs Antiproliferative activity against HUVEC cells after 72 hrs	[PMID: 18271556]
LLC-PK1	IC₅₀	36.7 μM Compound: PPD	Cytotoxicity against pig LLC-PK1 cells after 4 hrs by MTT assay Cytotoxicity against pig LLC-PK1 cells after 4 hrs by MTT assay	[PMID: 25453798]
MCF7	IC₅₀	6.62 μM Compound: PPD	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 21216145]
MDA-MB-231	IC₅₀	5.9 μM Compound: PPD	Antiproliferative activity against human MDA-MB-231 cells after 4 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 4 hrs by MTT assay	[PMID: 25453798]
SF-188	IC₅₀	24 μM Compound: 1	Cytotoxicity against human SF188 cells after 24 hrs Cytotoxicity against human SF188 cells after 24 hrs	[PMID: 17261067]
U-87MG ATCC	IC₅₀	36.74 μM Compound: PPD	Cytotoxicity against human U87 cells after 72 hrs by MTT assay Cytotoxicity against human U87 cells after 72 hrs by MTT assay	[PMID: 22342101]
U-87MG ATCC	IC₅₀	38 μM Compound: 1	Cytotoxicity against human U87MG cells after 24 hrs Cytotoxicity against human U87MG cells after 24 hrs	[PMID: 17261067]

体外研究
(In Vitro)

20S-protopanaxadiol treatment upregulates the flotillin-1 level in the rafts of N2a cells to 142.91±10.71% of the control. 20S-protopanaxadiol can have an opposite effect on raft resident protein flotillin-1, depending on the cell type^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

460.73

Formula

C₃₀H₅₂O₃

CAS 号

30636-90-9

性状

固体

颜色

White to off-white

中文名称

20 (S)-原人参二醇

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

DMSO 中的溶解度 : 50 mg/mL (108.52 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1705 mL	10.8523 mL	21.7047 mL
5 mM	0.4341 mL	2.1705 mL	4.3409 mL
10 mM	0.2170 mL	1.0852 mL	2.1705 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.43 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.85%

选择批次：

Data Sheet (615 KB) SDS (393 KB)

COA (288 KB) HNMR (278 KB) RP-HPLC (198 KB) MS (69 KB)

产品使用指南 (1538 KB)

参考文献

[1]. iu Y, Yang G, Bu X, et al. Cell-type-specific regulation of raft-associated Akt signaling. Cell Death Dis. 2011;2(4):e145. Published 2011 Apr 14. [Content Brief]

(20S)-Protopanaxadiol 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1705 mL	10.8523 mL	21.7047 mL	54.2617 mL
	5 mM	0.4341 mL	2.1705 mL	4.3409 mL	10.8523 mL
	10 mM	0.2170 mL	1.0852 mL	2.1705 mL	5.4262 mL
	15 mM	0.1447 mL	0.7235 mL	1.4470 mL	3.6174 mL
	20 mM	0.1085 mL	0.5426 mL	1.0852 mL	2.7131 mL
	25 mM	0.0868 mL	0.4341 mL	0.8682 mL	2.1705 mL
	30 mM	0.0723 mL	0.3617 mL	0.7235 mL	1.8087 mL
	40 mM	0.0543 mL	0.2713 mL	0.5426 mL	1.3565 mL
	50 mM	0.0434 mL	0.2170 mL	0.4341 mL	1.0852 mL
	60 mM	0.0362 mL	0.1809 mL	0.3617 mL	0.9044 mL
	80 mM	0.0271 mL	0.1357 mL	0.2713 mL	0.6783 mL
	100 mM	0.0217 mL	0.1085 mL	0.2170 mL	0.5426 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

(20S)-Protopanaxadiol (Synonyms: 20 (S)-原人参二醇; 20-Epiprotopanaxadiol; 20(S)-APPD)

Customer Review

Other Forms of (20S)-Protopanaxadiol: