2. Gene
  3. Pcsk9 - proprotein convertase subtilisin/kexin type 9 Gene

Pcsk9 - proprotein convertase subtilisin/kexin type 9 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: FH3; PC9; Narc1; HCHOLA3

基因 ID: 100102 | 基因类型: protein coding

关于 Pcsk9

功能概要

Enables Apolipoprotein binding activity; lipoprotein particle binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including cellular response to Insulin stimulus; cellular response to starvation; and regulation of neuron apoptotic process. Acts upstream of or within several processes, including low-density lipoprotein receptor particle metabolic process; regulation of low-density lipoprotein particle receptor catabolic process; and triglyceride metabolic process. Located in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; and extracellular space. Is expressed in several structures, including alimentary system; cerebellum; genitourinary system; liver; and telencephalon. Human ortholog(s) of this gene implicated in familial hypercholesterolemia and hypobetalipoproteinemia. Orthologous to human PCSK9 (proprotein convertase subtilisin/kexin type 9). [provided by Alliance of Genome Resources, Apr 2022]

Pcsk9 基因产物(1)

mRNA Protein Name
NM_153565.2 NP_705793.1 proprotein convertase subtilisin/kexin type 9 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables apolipoprotein binding IDA
IDA: 通过直接分析推断
22580899 MGI
enables low-density lipoprotein particle binding IDA
IDA: 通过直接分析推断
22580899 MGI
enables low-density lipoprotein particle receptor binding IDA
IDA: 通过直接分析推断
17080197 MGI
enables very-low-density lipoprotein particle binding IDA
IDA: 通过直接分析推断
22580899 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to insulin stimulus IDA
IDA: 通过直接分析推断
16407292 MGI
involved in cellular response to starvation IDA
IDA: 通过直接分析推断
16407292 MGI
acts upstream of or within cholesterol metabolic process IDA
IDA: 通过直接分析推断
17242417 MGI
involved in kidney development IEP
IEP: 通过表达模式推断
12552133 MGI
acts upstream of or within lipoprotein metabolic process IDA
IDA: 通过直接分析推断
17242417 MGI
involved in liver development IEP
IEP: 通过表达模式推断
12552133 MGI
acts upstream of or within low-density lipoprotein receptor particle metabolic process IDA
IDA: 通过直接分析推断
17242417 MGI
involved in neurogenesis IEP
IEP: 通过表达模式推断
12552133 MGI
involved in neuron differentiation IDA
IDA: 通过直接分析推断
16893422 MGI
involved in neuron differentiation IMP
IMP: 通过突变表型推断
12552133 MGI
acts upstream of or within phospholipid metabolic process IDA
IDA: 通过直接分析推断
17242417 MGI
acts upstream of or within regulation of low-density lipoprotein particle receptor catabolic process IMP
IMP: 通过突变表型推断
15741654 MGI
involved in regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
22481440 MGI
acts upstream of or within triglyceride metabolic process IDA
IDA: 通过直接分析推断
17242417 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in COPII-coated ER to Golgi transport vesicle IDA
IDA: 通过直接分析推断
23580231 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
23580231 MGI
located in extracellular region IDA
IDA: 通过直接分析推断
12552133 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
17080197 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

proprotein convertase subtilisin/kexin type 9

NARC-1

convertase subtilisin

neural apoptosis regulated convertase 1

proprotein convertase 9

proprotein convertase PC9

subtilisin/kexin-like protease PC9

重组 Pcsk9 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71189 PCSK9 Protein, Mouse (HEK293, His, solution) Q80W65 (Q35-Q155&S156-Q694) ≥95%

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-132591 Inclisiran Inhibitor 91.03% 否
HY-132591A Inclisiran sodium Inhibitor 98.10% 否
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P9928 Alirocumab Inhibitor 97.00% 否
Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-12090 Anacetrapib Inhibitor 99.25% Phase 3
HY-112598A PF-06815345 hydrochloride Inhibitor 98.15% Phase 1
HY-148687 SPC5001 Inhibitor 93.97% Phase 1
HY-112598 PF-06815345 Inhibitor / Phase 1
抗体抑制剂 (8)
目录号 产品名 作用方式
纯度 Phase
HY-P9928A Alirocumab (anti-PCSK9) Inhibitor 98.24% Phase 4
HY-P99187 Bococizumab Inhibitor 99.80% Phase 3
HY-P99871 Ebronucimab Inhibitor / Phase 3
HY-P99696 Lerodalcibep / Phase 3
HY-P99773 Ongericimab Inhibitor / Phase 3
HY-P99822 Recaticimab Inhibitor 99.71% Phase 3
HY-P99552 Tafolecimab Inhibitor 95.04% Phase 3
HY-P99626 Frovocimab Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (60)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-120088A PF-06446846 hydrochloride Inhibitor 99.23% 否
HY-12402 SBC-115076 Inhibitor 99.54% 否
HY-P2276 Pep2-8 Inhibitor 99.74% 否
HY-148673 AZD0780 Inhibitor 99.97% 否
HY-143221 AS-Inclisiran sodium Inhibitor 96.58% 否
HY-152221 PCSK9-IN-10 Inhibitor 98.95% 否
HY-143219 SS-Inclisiran sodium Inhibitor 98.88% 否
HY-101354 R-IMPP Inhibitor 98.42% 否
HY-152223 PCSK9-IN-11 Inhibitor 99.66% 否
HY-150223 GalNAc unconjugated/naked Inclisiran Inhibitor 92.95% 否
HY-143220 SS(no Galnac)-Inclisiran sodium Inhibitor 97.78% 否
HY-W510159 5-O-Methylembelin Inhibitor 98.84% 否
HY-130245 PCSK9 degrader 1 Degrader 98.33% 否
HY-101832 SBC-110736 Inhibitor 99.93% 否
HY-141714 SBC-115337 Inhibitor 98.05% 否
HY-148758 PCSK9-IN-13 Inhibitor 98.00% 否
HY-148687A SPC5001 sodium Inhibitor 93.97% 否
HY-P2276A Pep2-8 TFA Inhibitor 99.44% 否
HY-161940 PCSK9-IN-30 Inhibitor / 否
HY-120088 PF-06446846 Inhibitor / 否
HY-158825 Cepadacursen sodium / 否
HY-139998 PCSK9-IN-3 Inhibitor / 否
HY-148626 CVI-LM001 Inhibitor / 否
HY-161434 PCSK9-IN-26 Inhibitor / 否
HY-153454 PCSK9-IN-18 Inhibitor / 否
HY-128334 PCSK9 modulator-2 Modulator / 否
HY-RS10177 PCSK9 Human Pre-designed siRNA Set A Inhibitor / 否
HY-153453 PCSK9-IN-17 Inhibitor / 否
HY-146084 PCSK9 modulator-3 Modulator / 否
HY-148689A SPC4061 sodium Inhibitor / 否
HY-155006 PCSK9-IN-19 Inhibitor / 否
HY-157434 PCSK9-IN-23 Inhibitor / 否
HY-153452 PCSK9-IN-16 Inhibitor / 否
HY-130245A (R,R)-PCSK9 degrader 1 Degrader / 否
HY-153391 PCSK9-IN-14 Inhibitor / 否
HY-153451 PCSK9-IN-15 Inhibitor / 否
HY-132897 PCSK9-IN-2 Inhibitor / 否
HY-146085 PCSK9 modulator-4 Modulator / 否
HY-160036 PCSK9-IN-22 Inhibitor / 否
HY-161942 PCSK9-IN-31 Inhibitor / 否
HY-163141 PCSK9-IN-24 Inhibitor / 否
HY-N10702 PCSK9-IN-9 Inhibitor / 否
HY-161435 PCSK9-IN-27 Inhibitor / 否
HY-163794 DC371739 Inhibitor 95.56% 否
HY-161939 7030B-C5 Inhibitor / 否
HY-147252A Bezeparsen sodium Inhibitor / 否
HY-141724 PCSK9 ligand 1 Inhibitor / 否
HY-134482 PCSK9-IN-1 Inhibitor / 否
HY-147252 Bezeparsen Inhibitor / 否
HY-148689 SPC4061 Inhibitor / 否
HY-161941 MeIm Inhibitor / 否
HY-164344 PCSK9 allosteric binder-1 / 否
HY-168156 PCSK9-IN-32 Inhibitor / 否
HY-161938 BRD8518 Inhibitor / 否
HY-159595 PCSK9-IN-29 Inhibitor / 否
HY-158827 AZD8233 / 否
HY-162562 E28362 Inhibitor / 否
HY-N13083 PCSK9-IN-28 Inhibitor / 否
HY-158827A AZD8233 sodium / 否
HY-155415 PCSK9-IN-20 Inhibitor / 否
抗体抑制剂 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99816 Ralpancizumab Inhibitor / 否
HY-P99251 Lodelcizumab Inhibitor / 否
HY-P99251 Lodelcizumab Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pcsk9 NCBI NCBI:255738
Macaca fascicularis Pcsk9 NCBI NCBI:102142788
Rattus norvegicus Pcsk9 NCBI NCBI:298296
Macaca mulatta Pcsk9 NCBI NCBI:717147
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