2. Gene
  3. Cdk7 - cyclin-dependent kinase 7 Gene

Cdk7 - cyclin-dependent kinase 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 7

种属: Rattus norvegicus

同用名: CAK; P39 Mo15

基因 ID: 171150 | 基因类型: protein coding

关于 Cdk7

Primary_assembly 2: 31,840,558-31,865,383 reverse strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 214 orthologues, 24 paralogues and is associated with 2 phenotypes. Biased expression in Kidney (RPKM 187.4), Adrenal (RPKM 173.5) and 9 other tissues.

功能概要

该基因编码的蛋白可启动细胞周期蛋白依赖性蛋白丝氨酸/苏氨酸激酶活性。通过 RNA 聚合酶 II 参与蛋白质磷酸化和转录。位于多个细胞成分中，包括细胞骨架；胞质溶胶；和核。转录因子 TFIIH 全息复合体的一部分。与人 CDK7（细胞周期蛋白依赖性激酶 7）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cyclin-dependent protein serine/threonine kinase activity. Involved in protein phosphorylation and transcription by RNA polymerase II. Located in several cellular components, including cytoskeleton; cytosol; and nucleus. Part of transcription factor TFIIH holo complex. Orthologous to human CDK7 (cyclin dependent kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

Cdk7 基因产物(2)

mRNA Protein Name
NM_001398656.1 NP_001385585.1 cyclin-dependent kinase 7 isoform 1
NM_001398657.1 NP_001385586.1 cyclin-dependent kinase 7 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cyclin-dependent protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
8906616 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
7885450 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
8906616 RGD
involved in transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
7553866 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of transcription factor TFIIH holo complex IDA
IDA: 通过直接分析推断
7553866 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Cdk7 蛋白结构

STKc_CDK7

STKc_CDK7: cd07841 (10 - 307)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 7

39 protein kinase

CDK-activating kinase 1

TFIIH basal transcription factor complex kinase subunit

cell division protein kinase 7

cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)

cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase)

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-16297A Abemaciclib Inhibitor 99.97% 是
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% 是
Clinical Phase
生物活性分子 (19)
目录号 产品名 作用方式
纯度 Phase
HY-112272 Lerociclib Inhibitor 98.35% Phase 3
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-50940 AT7519 Inhibitor 99.76% Phase 2
HY-13914 Roniciclib Inhibitor 98.09% Phase 2
HY-10424 Milciclib Inhibitor 99.90% Phase 2
HY-112272A Lerociclib dihydrochloride Inhibitor 98.11% Phase 2
HY-103712B Samuraciclib hydrochloride dihydrate Inhibitor 99.08% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.42% Phase 2
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Phase 2
HY-103712 Samuraciclib Inhibitor / Phase 2
HY-138293 SY-5609 Inhibitor 99.66% Phase 1
HY-10008 SNS-032 Inhibitor 99.54% Phase 1
HY-10012 AZD-5438 Inhibitor 99.85% Phase 1
HY-128587 Mevociclib Inhibitor 99.27% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-15504 RGB-286638 Inhibitor 99.70% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.07% Phase 1
HY-139342 CDK7-IN-4 Inhibitor 98.87% Phase 1
HY-50940A AT7519 TFA Inhibitor 98.53% Phase 1
Pre-clinical Phase
生物活性分子 (72)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-80013 THZ1 Inhibitor 99.84% 否
HY-103618 THZ531 Inhibitor 99.86% 否
HY-103248 Toyocamycin Inhibitor 99.78% 否
HY-101257 YKL-5-124 Inhibitor 98.79% 否
HY-18340 (R)​-​CR8 Inhibitor 99.61% 否
HY-123954 BTX-A51 Inhibitor 98.58% 否
HY-11009 CGP60474 Inhibitor 99.23% 否
HY-80013A THZ1 Hydrochloride Inhibitor 99.06% 否
HY-10014 R547 Inhibitor 99.57% 否
HY-12445 Asnuciclib Inhibitor 99.76% 否
HY-18340A (R)-CR8 trihydrochloride Inhibitor 98.95% 否
HY-12280 THZ2 Inhibitor 99.03% 否
HY-13266A BS-181 hydrochloride Inhibitor 99.80% 否
HY-X0150 JSH-150 Inhibitor 98.66% 否
HY-144117 GFB-12811 Inhibitor 98.04% 否
HY-119940 MC180295 Inhibitor 98.89% 否
HY-12293 LY2857785 Inhibitor 99.92% 否
HY-112626 CDK12-IN-2 Inhibitor 99.36% 否
HY-117203A CDK12-IN-E9 Inhibitor 99.97% 否
HY-12653 LDC4297 Inhibitor 98.25% 否
HY-101257B YKL-5-124 TFA Inhibitor 99.44% 否
HY-N6954 Garcinone C Inhibitor 99.66% 否
HY-107419 NU6140 Inhibitor 99.07% 否
HY-123955 Casein Kinase inhibitor A86 Inhibitor 99.26% 否
HY-12653A LDC4297 hydrochloride Inhibitor 98.23% 否
HY-18285 Longdaysin Inhibitor 99.83% 否
HY-15241 NVP-LCQ195 Inhibitor 98.81% 否
HY-139980 CDK9-IN-13 Inhibitor 99.94% 否
HY-100429 CAN508 Inhibitor 99.59% 否
HY-19988 THZ1-R Inhibitor 98.12% 否
HY-122665 HTH-01-091 Inhibitor 98.64% 否
HY-153278 CDK7-IN-21 Degrader 96.82% 否
HY-14372 BS-194 Inhibitor 99.36% 否
HY-116871 YKL-1-116 Inhibitor / 否
HY-101257A CDK7-IN-1 Inhibitor 98.91% 否
HY-13266 BS-181 Inhibitor 98.10% 否
HY-139011 IV-361 Inhibitor 99.60% 否
HY-X0009A JSH-009 dimaleate Inhibitor / 否
HY-136711 CDK7-IN-2 hydrochloride hydrate Inhibitor / 否
HY-145655 CDK7-IN-11 Inhibitor / 否
HY-110368 BS-181 dihydrochloride Inhibitor / 否
HY-164906 TMX-2138 Degrader / 否
HY-123034 CDKI-83 Inhibitor / 否
HY-151878 CDK7-IN-20 Inhibitor / 否
HY-158170 CDK7-IN-28 Inhibitor / 否
HY-145424 CDK7-IN-10 Inhibitor / 否
HY-151069 TMX-2039 Inhibitor / 否
HY-155787 SHR5428 Inhibitor / 否
HY-156444 HDAC1/CDK7-IN-1 Inhibitor / 否
HY-170425 CDK7-IN-32 Inhibitor / 否
HY-145408 CDK7/9-IN-1 Inhibitor / 否
HY-18969 LDC3140 Inhibitor / 否
HY-146276 CDK/HDAC-IN-2 Inhibitor / 否
HY-163721 CDK7-IN-29 Inhibitor / 否
HY-162619 CDK9-IN-33 Inhibitor / 否
HY-147601 CDK7-IN-16 Inhibitor / 否
HY-145402 CDK7-IN-7 Inhibitor / 否
HY-145394 CDK7-IN-6 Inhibitor / 否
HY-162416 CDK7-IN-27 Inhibitor / 否
HY-139986 CDK7-IN-5 Inhibitor / 否
HY-163856 CDK7-IN-30 Inhibitor / 否
HY-151898 CDK4/6-IN-14 Inhibitor / 否
HY-162706 BSJ-5-63 Degrader / 否
HY-161463 CDK2-IN-28 Inhibitor / 否
HY-142696 CDK6/PIM1-IN-1 Inhibitor / 否
HY-169344 CDK7-IN-31 Inhibitor / 否
HY-147409 Ulecaciclib Inhibitor / 否
HY-143586 CDK7-IN-8 Inhibitor / 否
HY-145389 SZ-015268 Inhibitor / 否
HY-112403 (S)-Roscovitine Inhibitor / 否
HY-112450 Olomoucine II Inhibitor / 否
HY-123826 CCT68127 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdk7 NCBI NCBI:1022
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