2. Gene
  3. KPNA2 - karyopherin subunit alpha 2 Gene

KPNA2 - karyopherin subunit alpha 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核转运蛋白亚基 alpha 2

种属: Homo sapiens

同用名: QIP2; RCH1; IPOA1; PTAC58; SRP1alpha; SRP1-alpha

基因 ID: 3838 | 基因类型: protein coding

关于 KPNA2

Cytogenetic location: 17q24.2 Genomic coordinates (GRCh38): 17:68,035,735-68,046,854 (from NCBI)

This gene has 21 transcripts (splice variants), 131 orthologues and 6 paralogues. Broad expression in testis (RPKM 102.8), bone marrow (RPKM 35.5) and 20 other tissues.

功能概要

将蛋白质输入细胞核是一个至少涉及 2 个步骤的过程。第一个是蛋白质与核膜的能量独立对接，第二个是通过核孔复合体的能量依赖性易位。导入的蛋白质需要一个核定位序列 (NLS) ，它通常由一个短的碱性氨基酸区域或 2 个间隔约 10 个氨基酸的区域组成。已在不同系统中鉴定出参与核输入第一步的蛋白质。这些包括非洲爪蟾蛋白输入蛋白及其酵母同系物 SRP1 (酿酒酵母中 RNA 聚合酶 I 的某些温度敏感突变的抑制因子) ，它们与 NLS 结合。 KPNA2 蛋白与 DNA 解旋酶 Q1 和 SV40 T 抗原的 NLS 相互作用，可能参与蛋白质的核转运。 KPNA2 也可能在 V (D) J 重组中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 2 月]

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic Amino acids or 2 such regions spaced about 10 Amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

KPNA2 基因产物(2)

mRNA Protein Name
NM_001320611.2 NP_001307540.1 importin subunit alpha-1
NM_002266.4 NP_002257.1 importin subunit alpha-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
10869435 GOA
enables nuclear import signal receptor activity IDA
IDA: 通过直接分析推断
32290222 GOA
enables nuclear localization sequence binding IDA
IDA: 通过直接分析推断
17324944 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9168958 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in NLS-bearing protein import into nucleus IDA
IDA: 通过直接分析推断
17324944 GOA
acts upstream of or within entry of viral genome into host nucleus through nuclear pore complex via importin IMP
IMP: 通过突变表型推断
28189564 GOA
involved in positive regulation of type I interferon production IDA
IDA: 通过直接分析推断
32130408 GOA
acts upstream of or within positive regulation of viral life cycle IMP
IMP: 通过突变表型推断
28189564 GOA
involved in protein import into nucleus IDA
IDA: 通过直接分析推断
32290222 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NLS-dependent protein nuclear import complex IPI
IPI: 通过物理相互作用推断
10353244 GOA
is active in cytoplasm IDA
IDA: 通过直接分析推断
7604027 GOA
is active in nuclear membrane IDA
IDA: 通过直接分析推断
7635189 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KPNA2 蛋白结构

IBB

IBB: Importin beta binding domain (6 - 99)

Arm

Arm: Armadillo/beta-catenin-like repeat (109 - 149)

Arm

Arm: Armadillo/beta-catenin-like repeat (151 - 190)

Arm

Arm: Armadillo/beta-catenin-like repeat (196 - 238)

Arm

Arm: Armadillo/beta-catenin-like repeat (249 - 280)

Arm

Arm: Armadillo/beta-catenin-like repeat (284 - 321)

Arm

Arm: Armadillo/beta-catenin-like repeat (324 - 364)

Arm

Arm: Armadillo/beta-catenin-like repeat (367 - 405)

Arm

Arm: Armadillo/beta-catenin-like repeat (410 - 447)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 529 a.a.
蛋白主名 其他名称

importin subunit alpha-1

RAG cohort protein 1

KPNA2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
KPNA2 P52292 PNMA5 Homo sapiens Q96PV4
Validated Y2H
25416956
种属内
KPNA2 P52292 PNMA5 Homo sapiens Q96PV4
Y2H Array
25416956
种属内
KPNA2 P52292 FLJ13057 Homo sapiens Q53SE7
Y2H Prey Pooling
25416956
种属内
KPNA2 P52292 NECAB2 Homo sapiens Q7Z6G3-2
Validated Y2H
25416956
种属内
KPNA2 P52292 NUTM1 Homo sapiens Q86Y26
Y2H Prey Pooling
25416956
种属内
KPNA2 P52292 NUTM1 Homo sapiens Q86Y26
Validated Y2H
25416956
种属内
KPNA2 P52292 NUTM1 Homo sapiens Q86Y26
Y2H Array
25416956
种属内
KPNA2 P52292 MORF4L1 Homo sapiens Q9UBU8-2
Y2H Prey Pooling
32296183
种属内
KPNA2 P52292 MORF4L1 Homo sapiens Q9UBU8-2
Validated Y2H
32296183
种属间
KPNA2 P52292 E6 Human papillomavirus P03126
SLC
22898364
种属内
KPNA2 P52292 KPNB1 Homo sapiens Q14974-1
GMS
19668212
种属内
KPNA2 P52292 KPNB1 Homo sapiens Q14974-1
SAXS
19668212
种属内
KPNA2 P52292 KPNB1 Homo sapiens Q14974-1
Solution Sedimentation
19668212
种属内
KPNA2 P52292 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
25416956
种属内
KPNA2 P52292 NUP50 Homo sapiens Q9UKX7
Anti Tag CoIP
33961781
种属内
KPNA2 P52292 NUP50 Homo sapiens Q9UKX7
Validated Y2H
32296183
种属内
KPNA2 P52292 NUP50 Homo sapiens Q9UKX7
Y2H Array
25416956
种属内
KPNA2 P52292 NUP50 Homo sapiens Q9UKX7
Anti Tag CoIP
35271311
种属内
KPNA2 P52292 NUP50 Homo sapiens Q9UKX7
Y2H Prey Pooling
25416956
种属间
KPNA2 P52292 ns6_sars2 SARS-CoV-2 P0DTC6
Anti Tag CoIP
32979938
种属间
KPNA2 P52292 a0a3g5biz0_sars SARS coronavirus Urbani A0A3G5BIZ0
IF
17596301
种属间
KPNA2 P52292 a0a3g5biz0_sars SARS coronavirus Urbani A0A3G5BIZ0
Anti Tag CoIP
17596301
种属内
KPNA2 P52292 IRF3 Homo sapiens Q14653
Anti Tag CoIP
34950606
种属内
KPNA2 P52292 RECQL Homo sapiens P46063
Pull Down
9168958
种属内
KPNA2 P52292 RECQL Homo sapiens P46063
Y2H
9168958
种属内
KPNA2 P52292 KPNB1 Homo sapiens Q14974
Anti Tag CoIP
33961781
种属内
KPNA2 P52292 KPNB1 Homo sapiens Q14974
Anti Tag CoIP
28514442
种属内
KPNA2 P52292 KPNB1 Homo sapiens Q14974
Pull Down
11024021
种属内
KPNA2 P52292 KPNB1 Homo sapiens Q14974
Anti Tag CoIP
17596301
种属内
KPNA2 P52292 KPNB1 Homo sapiens Q14974
Anti Tag CoIP
35271311
种属内
KPNA2 P52292 NUP62 Homo sapiens P37198
Validated Y2H
25416956
种属内
KPNA2 P52292 NUP62 Homo sapiens P37198
Y2H Array
25416956
种属内
KPNA2 P52292 BRCA1 Homo sapiens P38398
Y2H
9497340
种属内
KPNA2 P52292 S100A6 Homo sapiens P06703
Pull Down
20965181
种属内
KPNA2 P52292 HNRNPC Homo sapiens P07910
Validated Y2H
25416956
种属内
KPNA2 P52292 HNRNPC Homo sapiens P07910
Y2H
21988832
种属内
KPNA2 P52292 HNRNPC Homo sapiens P07910
Y2H Prey Pooling
25416956
种属内
KPNA2 P52292 DCPS Homo sapiens Q96C86
Validated Y2H
32296183
种属内
KPNA2 P52292 NMNAT1 Homo sapiens Q9HAN9
Y2H Array
31515488
种属内
KPNA2 P52292 NMNAT1 Homo sapiens Q9HAN9
Validated Y2H
25416956
种属内
KPNA2 P52292 NMNAT1 Homo sapiens Q9HAN9
Validated Y2H
32296183
种属间
KPNA2 P52292 lt_sv40 Simian virus 40 P03070
Pull Down
20701745
种属内
KPNA2 P52292 MDFI Homo sapiens Q99750
Y2H Prey Pooling
25416956
种属间
KPNA2 P52292 L2 Human papillomavirus P03107
Pull Down
15507604
种属间
KPNA2 P52292 L1 Human papillomavirus P03101
Pull Down
15507604
种属内
KPNA2 P52292 RBPMS Homo sapiens Q93062
Validated Y2H
25416956
种属内
KPNA2 P52292 RBPMS Homo sapiens Q93062
Y2H Array
25416956
种属内
KPNA2 P52292 HMG20A Homo sapiens Q9NP66
Y2H Prey Pooling
25416956
种属内
KPNA2 P52292 HMG20A Homo sapiens Q9NP66
Validated Y2H
25416956
种属内
KPNA2 P52292 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25416956
种属内
KPNA2 P52292 TADA2A Homo sapiens O75478
Y2H Array
25416956
种属内
KPNA2 P52292 TADA2A Homo sapiens O75478
Validated Y2H
25416956
种属内
KPNA2 P52292 MLH1 Homo sapiens P40692
Y2H Array
31515488
种属内
KPNA2 P52292 MLH1 Homo sapiens P40692
Y2H Prey Pooling
25416956
种属内
KPNA2 P52292 MLH1 Homo sapiens P40692
Y2H Array
29892012
种属内
KPNA2 P52292 SF1 Homo sapiens Q15637
Y2H Fragment Pooling
26420826
种属内
KPNA2 P52292 SERTAD3 Homo sapiens Q9UJW9
Y2H Prey Pooling
25416956
种属内
KPNA2 P52292 SERTAD3 Homo sapiens Q9UJW9
Validated Y2H
25416956
种属内
KPNA2 P52292 SERTAD3 Homo sapiens Q9UJW9
Y2H Array
25416956
种属内
KPNA2 P52292 S100A2 Homo sapiens P29034
Pull Down
20965181
种属内
KPNA2 P52292 INO80E Homo sapiens Q8NBZ0
Y2H Array
25416956
种属内
KPNA2 P52292 INO80E Homo sapiens Q8NBZ0
Y2H Prey Pooling
25416956
种属内
KPNA2 P52292 JUN Homo sapiens P05412
Pull Down
21988832
种属内
KPNA2 P52292 RNMT Homo sapiens O43148
Anti Tag CoIP
35271311
种属间
KPNA2 P52292 npm2.L Crosspus laevis Q6GQG6
Pull Down
20965181
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 KPNA2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70371 Importin alpha-1/KPNA2 Protein, Human (His) P52292 (M1-F529) ≥95%

KPNA2 抗体

目录号 产品名 应用 反应物种
HY-P81670 KPNA2 Antibody (YA1415) WB, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Venezuelan Equine Encephalitis

Venezuelan Equine Fever

Venezuelan Equine Encephalomyelitis

Encephalitis Venezuelan Equine

Encephalomyelitis, Venezuelan Equine

Venezuelan Encephalitis

Disorder Due To Venezuelan Equine Encephalitis Virus

Venezuelan Equine Encephalitis Virus Infection

Venezuelan Equine Encephalomyelitis Virus Disease
Encephalitis

Mumps Encephalitis

Mumps Meningoencephalitis

Herpes Simplex Neuroinvasion

Herpetic Encephalitis

Herpetic Encephalopathy

Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

Encephalitis Due To Herpesviridae

Encephalitis Due To Herpesvirus

Herpes Encephalitis

Herpesviral Encephalitis

Herpes Simplex Encephalitis

Hsv - [Herpes Simplex Virus] Encephalitis

Herpes Virus Encephalitis

Simian B Disease

Simian B Disorder

Encephalitis Nec

Idiopathic Encephalitis
Nijmegen Breakage Syndrome

Berlin Breakage Syndrome

NBS

Microcephaly, Normal Intelligence And Immunodeficiency

Ataxia-Telangiectasia Variant

Ataxia-Telangiectasia Variant V1

Seemanova Syndrome Ii

Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome

Seemanova Syndrome Type 2

At-V1

Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies

Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence

Immunodeficiency, Microcephaly, And Chromosomal Instability

Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome

Microcephaly Immunodeficiency Lymphoreticuloma

Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies

Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence

Seemanova Syndrome 2

Ataxia-Telangiectasia Variant 1

Seemanova Syndrome

At V1

Ataxia-Telangiectasia, Variant 1

Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome

V-At

Ataxia Telangiectasia Variant V1
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
Ovarian Endodermal Sinus Tumor

Endodermal Sinus Tumor Of Ovary

Ovarian Yolk Sac Tumor

Endodermal Sinus Tumour Of Ovary

Ovarian Endodermal Sinus Tumour

Ovarian Yolk Sac Tumour
Ovarian Primitive Germ Cell Tumor
Ovarian Dysgenesis 2

Premature Ovarian Failure 4

ODG2

Ovarian Dysgenesis, Hypergonadotropic, X-Linked

Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis

Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis

X-Linked Hypergonadotropic Ovarian Dysgenesis

POF4

Dysgenesis, Ovarian, Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07416 KPNA2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus KPNA2 VGNC VGNC:97476
Bos taurus KPNA2 VGNC VGNC:30701
Rattus norvegicus KPNA2 RGD RGD:621419
Mus musculus KPNA2 MGD MGI:103561
Others KPNA2 NCBI
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