2. Gene
  3. KPNA2 - karyopherin subunit alpha 2 Gene

KPNA2 - karyopherin subunit alpha 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核转运蛋白亚基 alpha 2

种属: Homo sapiens

同用名: QIP2; RCH1; IPOA1; PTAC58; SRP1alpha; SRP1-alpha

基因 ID: 3838 | 基因类型: protein coding

关于 KPNA2

Cytogenetic location: 17q24.2 Genomic coordinates (GRCh38): 17:68,035,735-68,046,854 (from NCBI)

This gene has 21 transcripts (splice variants), 131 orthologues and 6 paralogues. Broad expression in testis (RPKM 102.8), bone marrow (RPKM 35.5) and 20 other tissues.

功能概要

将蛋白质输入细胞核是一个至少涉及 2 个步骤的过程。第一个是蛋白质与核膜的能量独立对接，第二个是通过核孔复合体的能量依赖性易位。导入的蛋白质需要一个核定位序列 (NLS) ，它通常由一个短的碱性氨基酸区域或 2 个间隔约 10 个氨基酸的区域组成。已在不同系统中鉴定出参与核输入第一步的蛋白质。这些包括非洲爪蟾蛋白输入蛋白及其酵母同系物 SRP1 (酿酒酵母中 RNA 聚合酶 I 的某些温度敏感突变的抑制因子) ，它们与 NLS 结合。 KPNA2 蛋白与 DNA 解旋酶 Q1 和 SV40 T 抗原的 NLS 相互作用，可能参与蛋白质的核转运。 KPNA2 也可能在 V (D) J 重组中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 2 月]

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic Amino acids or 2 such regions spaced about 10 Amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

KPNA2 基因产物(2)

mRNA Protein Name
NM_001320611.2 NP_001307540.1 importin subunit alpha-1
NM_002266.4 NP_002257.1 importin subunit alpha-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
10869435 GOA
enables nuclear import signal receptor activity IDA
IDA: 通过直接分析推断
32290222 GOA
enables nuclear localization sequence binding IDA
IDA: 通过直接分析推断
17324944 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9168958 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in NLS-bearing protein import into nucleus IDA
IDA: 通过直接分析推断
17324944 GOA
acts upstream of or within entry of viral genome into host nucleus through nuclear pore complex via importin IMP
IMP: 通过突变表型推断
28189564 GOA
involved in positive regulation of type I interferon production IDA
IDA: 通过直接分析推断
32130408 GOA
acts upstream of or within positive regulation of viral life cycle IMP
IMP: 通过突变表型推断
28189564 GOA
involved in protein import into nucleus IDA
IDA: 通过直接分析推断
32290222 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NLS-dependent protein nuclear import complex IPI
IPI: 通过物理相互作用推断
10353244 GOA
is active in cytoplasm IDA
IDA: 通过直接分析推断
7604027 GOA
is active in nuclear membrane IDA
IDA: 通过直接分析推断
7635189 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KPNA2 蛋白结构

IBB

IBB: Importin beta binding domain (6 - 99)

Arm

Arm: Armadillo/beta-catenin-like repeat (109 - 149)

Arm

Arm: Armadillo/beta-catenin-like repeat (151 - 190)

Arm

Arm: Armadillo/beta-catenin-like repeat (196 - 238)

Arm

Arm: Armadillo/beta-catenin-like repeat (249 - 280)

Arm

Arm: Armadillo/beta-catenin-like repeat (284 - 321)

Arm

Arm: Armadillo/beta-catenin-like repeat (324 - 364)

Arm

Arm: Armadillo/beta-catenin-like repeat (367 - 405)

Arm

Arm: Armadillo/beta-catenin-like repeat (410 - 447)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 529 a.a.
蛋白主名 其他名称

importin subunit alpha-1

RAG cohort protein 1

重组 KPNA2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70371 Importin alpha-1/KPNA2 Protein, Human (His) P52292 (M1-F529) ≥95%

关联疾病

疾病名称 别名
Venezuelan Equine Encephalitis

Venezuelan Equine Fever

Venezuelan Equine Encephalomyelitis

Encephalitis Venezuelan Equine

Encephalomyelitis, Venezuelan Equine

Venezuelan Encephalitis

Disorder Due To Venezuelan Equine Encephalitis Virus

Venezuelan Equine Encephalitis Virus Infection

Venezuelan Equine Encephalomyelitis Virus Disease
Encephalitis

Mumps Encephalitis

Mumps Meningoencephalitis

Herpes Simplex Neuroinvasion

Herpetic Encephalitis

Herpetic Encephalopathy

Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

Encephalitis Due To Herpesviridae

Encephalitis Due To Herpesvirus

Herpes Encephalitis

Herpesviral Encephalitis

Herpes Simplex Encephalitis

Hsv - [Herpes Simplex Virus] Encephalitis

Herpes Virus Encephalitis

Simian B Disease

Simian B Disorder

Encephalitis Nec

Idiopathic Encephalitis
Nijmegen Breakage Syndrome

Berlin Breakage Syndrome

NBS

Microcephaly, Normal Intelligence And Immunodeficiency

Ataxia-Telangiectasia Variant

Ataxia-Telangiectasia Variant V1

Seemanova Syndrome Ii

Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome

Seemanova Syndrome Type 2

At-V1

Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies

Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence

Immunodeficiency, Microcephaly, And Chromosomal Instability

Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome

Microcephaly Immunodeficiency Lymphoreticuloma

Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies

Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence

Seemanova Syndrome 2

Ataxia-Telangiectasia Variant 1

Seemanova Syndrome

At V1

Ataxia-Telangiectasia, Variant 1

Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome

V-At

Ataxia Telangiectasia Variant V1
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
Ovarian Endodermal Sinus Tumor

Endodermal Sinus Tumor Of Ovary

Ovarian Yolk Sac Tumor

Endodermal Sinus Tumour Of Ovary

Ovarian Endodermal Sinus Tumour

Ovarian Yolk Sac Tumour
Ovarian Primitive Germ Cell Tumor
Ovarian Dysgenesis 2

Premature Ovarian Failure 4

ODG2

Ovarian Dysgenesis, Hypergonadotropic, X-Linked

Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis

Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis

X-Linked Hypergonadotropic Ovarian Dysgenesis

POF4

Dysgenesis, Ovarian, Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07416 KPNA2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus KPNA2 VGNC VGNC:97476
Bos taurus KPNA2 VGNC VGNC:30701
Rattus norvegicus KPNA2 RGD RGD:621419
Mus musculus KPNA2 MGD MGI:103561
Others KPNA2 NCBI
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