2. Gene
  3. Nampt - nicotinamide phosphoribosyltransferase Gene

Nampt - nicotinamide phosphoribosyltransferase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：烟酰胺磷酸核糖转移酶

种属: Mus musculus

同用名: Pbef; Pbef1; Visfatin; NAmPRTase; 1110035O14Rik

基因 ID: 59027 | 基因类型: protein coding

关于 Nampt

Chromosome 12: 32,869,544-32,903,348 forward strand.GRCm39:CM001005.3

This gene has 3 transcripts (splice variants), 236 orthologues, 1 paralogue and is associated with 15 phenotypes. Ubiquitous expression in heart adult (RPKM 19.2), bladder adult (RPKM 15.4) and 28 other tissues.

功能概要

实现相同的蛋白质结合活性和烟酰胺磷酸核糖转移酶活性。参与基因表达的昼夜节律调节。在 NAD 生物合成过程和昼夜节律的上游或内部起作用。位于细胞质中。以多种结构表达，包括消化系统；泌尿生殖系统；外皮系统；神经系统;和感觉器官。该基因的人类直系同源物与短暂性脑缺血有关。与人 NAMPT（烟酰胺磷酸核糖基转移酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity and nicotinamide phosphoribosyltransferase activity. Involved in circadian regulation of gene expression. Acts upstream of or within NAD biosynthetic process and circadian rhythm. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human NAMPT (nicotinamide phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Nampt 基因产物(1)

mRNA Protein Name
NM_021524.2 NP_067499.2 nicotinamide phosphoribosyltransferase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16783373 MGI
enables nicotinamide phosphoribosyltransferase activity IDA
IDA: 通过直接分析推断
15381699 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within NAD biosynthetic process IDA
IDA: 通过直接分析推断
15381699 MGI
involved in circadian regulation of gene expression IMP
IMP: 通过突变表型推断
19299583 MGI
involved in circadian rhythm IEP
IEP: 通过表达模式推断
19299583 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15381699 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Nampt 蛋白结构

PBEF_like

PBEF_like: cd01569 (11 - 427)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 491 a.a.
蛋白主名 其他名称

nicotinamide phosphoribosyltransferase

pre-B-cell colony-enhancing factor 1 homolog

相关产品

Clinical Phase
生物活性分子 (5)
目录号 产品名 作用方式
纯度 Phase
HY-50876 Daporinad Inhibitor 99.91% Phase 2
HY-12793 Padnarsertib Inhibitor 99.86% Phase 2
HY-10079 CHS-828 Inhibitor 99.74% Phase 1
HY-136241 OT-82 Inhibitor 99.84% Phase 1
HY-10080 Teglarinad chloride Inhibitor 98.77% Phase 1
Pre-clinical Phase
生物活性分子 (48)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-126255 SBI-797812 Activator 99.74% 否
HY-144776 NAT Activator 99.56% 否
HY-15766 GNE-617 Inhibitor 99.69% 否
HY-12971 Nampt-IN-1 Inhibitor 99.48% 否
HY-12808 STF-118804 Inhibitor 99.72% 否
HY-12628 GNE-618 Inhibitor 99.89% 否
HY-148815 Nampt activator-1 Activator 98.42% 否
HY-148822 Nampt activator-2 Activator 98.80% 否
HY-148948 Nampt activator-3 Activator 99.67% 否
HY-161515 BRD4/NAMPT-IN-1 Inhibitor 99.45% 否
HY-112616 NAMPT inhibitor-linker 2 Inhibitor 98.11% 否
HY-147193 Nampt-IN-10 TFA Inhibitor 98.70% 否
HY-14374 GPP78 Inhibitor ≥99.0% 否
HY-152154 Nampt degrader-2 Inhibitor 99.41% 否
HY-15766A GNE-617 hydrochloride Inhibitor 99.16% 否
HY-14373 CB30865 Inhibitor 98.75% 否
HY-130606 Nampt-IN-5 Inhibitor 98.02% 否
HY-402237 Nampt-IN-15 Inhibitor / 否
HY-108701 Nampt-IN-3 Inhibitor 98.97% 否
HY-101280 LB-60-OF61 Inhibitor 99.25% 否
HY-14375 CB 300919 Inhibitor 98.01% 否
HY-101280A LB-60-OF61 hydrochloride Inhibitor / 否
HY-148572 NAMPT/IDO1-IN-1 Inhibitor / 否
HY-147756 Nampt-IN-7 Inhibitor / 否
HY-162124 HDAC/NAMPT-IN-1 Inhibitor / 否
HY-147795 Nampt-IN-8 Inhibitor / 否
HY-162519 LZFPN-90 Inhibitor / 否
HY-164759 Nampt-IN-13 Inhibitor / 否
HY-162269 Nampt activator-5 Activator / 否
HY-157421 Nampt activator-4 Modulator / 否
HY-147838 Nampt-IN-9 Inhibitor / 否
HY-163499 NAMPT activator-7 Activator / 否
HY-163500 NAMPT activator-8 Activator / 否
HY-163445 NAMPT activator-6 Activator / 否
HY-158319 Mutant IDH1/NAMPT-IN-1 Inhibitor / 否
HY-161051 Anticancer agent 177 Inhibitor / 否
HY-159009 MS7 Inhibitor / 否
HY-110319 (E/Z)-Daporinad hydrochloride Inhibitor / 否
HY-147656 NAMPT degrader-1 Inhibitor / 否
HY-162537 LYP-8 Inhibitor / 否
HY-147193A Nampt-IN-10 trihydrochloride Inhibitor / 否
HY-155506 NAMPT degrader-3 Degrader / 否
HY-163280 JGB-1-155 Activator / 否
HY-163440 PROTAC NAMPT Degrader-1 Degrader / 否
HY-164760 Nampt-IN-14 Inhibitor / 否
HY-125147 A-1293201 Inhibitor / 否
HY-161180 Antitumor agent-136 Inhibitor / 否
HY-10079A CHS-828 (nicotinate) Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nampt NCBI NCBI:10135
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z