2. Membrane Transporter/Ion Channel MAPK/ERK Pathway Stem Cell/Wnt NF-κB Apoptosis
  3. Sodium Channel MEK ERK NF-κB Apoptosis
  4. Lidocaine hydrochloride hydrate

Lidocaine hydrochloride hydrate  (Synonyms: 盐酸利多卡因; Lignocaine hydrochloride hydrate)

目录号: HY-B0185B 纯度: 99.90%
COA 产品使用指南 技术支持

Lidocaine (Lignocaine) hydrochloride hydrate 抑制涉及复杂电压和依赖性的钠通道 (sodium channels)。Lidocaine hydrochloride hydrate 通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长，迁移和侵袭。Lidocaine hydrochloride hydrate 是一种酰胺衍生物，可用于研究室性心律失常。

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Lidocaine hydrochloride hydrate Chemical Structure

Lidocaine hydrochloride hydrate Chemical Structure

CAS No. : 6108-05-0

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规格 价格 是否有货 数量
5 mg ￥100
In-stock
10 mg ￥145
In-stock
25 mg ￥232
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50 mg ￥320
In-stock
100 mg ￥449
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Other Forms of Lidocaine hydrochloride hydrate:

Lidocaine hydrochloride hydrate 相关抗体

Top Publications Citing Use of Products

    Lidocaine hydrochloride hydrate purchased from MCE. Usage Cited in: J Neuroinflammation. 2017 Nov 2;14(1):211.  [Abstract]

    Immunoblot results demonstrate that Lidocaine inhibits Morphine-induced upregulation of phosphorylation of p38 MAPK, but not the p38 total protein.

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    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Lidocaine (Lignocaine) hydrochloride hydrate inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride hydrate decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride hydrate is an amide derivative and has potential for the research of ventricular arrhythmia[1][2].

    IC50 & Target[1][2]

    ERK

     

    NF-κB

     

    MEK

     

    体外研究
    (In Vitro)

    Lidocaine (Lignocaine) (10 nM; 48 hours) decreases significantly cell proliferation[2].
    Lidocaine (1-10 nM; 24-72 hours) inhibits cell viability and achieves the most suppressing effects at the concentration of 10 nM and treatment time 48 hours[2].
    Lidocaine (10 nM; 48 hours) increases significantly the apoptotic cell rate[2].
    Lidocaine (10 nM; 48 hours) down-regulates Cyclin D1 and up-regulates p21 expression significantly[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Lidocaine hydrochloride hydrate 相关抗体:

    Cell Proliferation Assay[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 10 nM
    Incubation Time: 48 hours
    Result: Decreased significantly cell proliferation.

    Cell Viability Assay[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 1, 5 and 10 nM
    Incubation Time: 24, 48, 72 hours
    Result: Inhibited MKN45 cell viability.

    Apoptosis Analysis[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 10 nM
    Incubation Time: 48 hours
    Result: Increased significantly the apoptotic cell rate.

    Western Blot Analysis[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 10 nM
    Incubation Time: 48 hours
    Result: Down-regulated Cyclin D1 and up-regulated p21 expression significantly.
    体内研究
    (In Vivo)

    Lidocaine (Lignocaine) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by lidocaine has slower onset and faster recovery compared with thermal nociception block[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    288.81

    Formula

    C14H25ClN2O2
    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    盐酸利多卡因；盐酸赛罗卡因；盐酸赛洛卡因；盐酸昔罗卡因
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    溶解性数据
    细胞实验： 

    H2O 中的溶解度 : ≥ 100 mg/mL (346.25 mM)

    * "≥" means soluble, but saturation unknown.

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.4625 mL 17.3124 mL 34.6248 mL
    5 mM 0.6925 mL 3.4625 mL 6.9250 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂： Saline

      Solubility: ≥ 100 mg/mL (346.25 mM); 澄清溶液

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: 99.90%

    COA (287 KB) LCMS (87 KB)

    产品使用指南 (1538 KB)
    参考文献

    Lidocaine hydrochloride hydrate 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.4625 mL 17.3124 mL 34.6248 mL 86.5621 mL
    5 mM 0.6925 mL 3.4625 mL 6.9250 mL 17.3124 mL
    10 mM 0.3462 mL 1.7312 mL 3.4625 mL 8.6562 mL
    15 mM 0.2308 mL 1.1542 mL 2.3083 mL 5.7708 mL
    20 mM 0.1731 mL 0.8656 mL 1.7312 mL 4.3281 mL
    25 mM 0.1385 mL 0.6925 mL 1.3850 mL 3.4625 mL
    30 mM 0.1154 mL 0.5771 mL 1.1542 mL 2.8854 mL
    40 mM 0.0866 mL 0.4328 mL 0.8656 mL 2.1641 mL
    50 mM 0.0692 mL 0.3462 mL 0.6925 mL 1.7312 mL
    60 mM 0.0577 mL 0.2885 mL 0.5771 mL 1.4427 mL
    80 mM 0.0433 mL 0.2164 mL 0.4328 mL 1.0820 mL
    100 mM 0.0346 mL 0.1731 mL 0.3462 mL 0.8656 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Lidocaine hydrochloride6108-05-0Lignocaine hydrochloride盐酸利多卡因盐酸赛罗卡因盐酸赛洛卡因盐酸昔罗卡因Sodium ChannelMEKERKNF-κBApoptosisNa channelsNa+ channelsMitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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    目录号：
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