A549
|
IC50 |
|
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
|
[PMID: 26638042]
|
A549
|
IC50 |
0.5 mM
Compound: Caffeic acid
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by FMCA assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by FMCA assay
|
[PMID: 27162124]
|
A549
|
IC50 |
0.7 mM
Compound: Caffeic acid
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 27162124]
|
A549
|
IC50 |
0.7 mM
Compound: Caffeic acid
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by luminescence-based ATP assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by luminescence-based ATP assay
|
[PMID: 27162124]
|
AGS
|
IC50 |
|
Cytotoxicity against human AGS cells after 96 hrs by MTT assay
Cytotoxicity against human AGS cells after 96 hrs by MTT assay
|
[PMID: 23746477]
|
B16-F10
|
IC50 |
|
Antiproliferative activity against mouse B16F10 cells after 72 hrs by MTT assay
Antiproliferative activity against mouse B16F10 cells after 72 hrs by MTT assay
|
[PMID: 26638042]
|
BALB/3T3
|
IC50 |
|
Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay
Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay
|
[PMID: 10096863]
|
BMDC
|
IC50 |
|
Inhibition of LPS-induced IL-12 p40 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
Inhibition of LPS-induced IL-12 p40 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
|
[PMID: 25769817]
|
BMDC
|
IC50 |
|
Inhibition of LPS-induced IL-6 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
Inhibition of LPS-induced IL-6 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
|
[PMID: 25769817]
|
BMDC
|
IC50 |
|
Inhibition of LPS-induced TNF-alpha production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
Inhibition of LPS-induced TNF-alpha production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
|
[PMID: 25769817]
|
BMDM
|
IC50 |
41 μM
Compound: Caffeic acid
|
Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-base
Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-base
|
[PMID: 31257875]
|
Caco-2
|
IC50 |
|
Antiproliferative activity against human Caco2 cells after 72 hrs by MTT assay
Antiproliferative activity against human Caco2 cells after 72 hrs by MTT assay
|
[PMID: 26638042]
|
EA.hy 926
|
EC50 |
12.6 μM
Compound: Caffeic acid
|
Cytoprotective activity against H2O2-induced cytotoxicity in human EAhy926 cells pre-incubated for 24 hrs before H2O2 challenge for 12 hrs by MTT assay
Cytoprotective activity against H2O2-induced cytotoxicity in human EAhy926 cells pre-incubated for 24 hrs before H2O2 challenge for 12 hrs by MTT assay
|
10.1039/C4MD00022F
|
Erythrocyte
|
IC50 |
|
Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me
Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me
|
[PMID: 29631958]
|
Erythrocyte
|
IC50 |
|
Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet
Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet
|
[PMID: 29631958]
|
HCT-116
|
IC50 |
|
Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay
|
[PMID: 23746477]
|
HeLa
|
IC50 |
2.54 mM
Compound: 22, 3,4-dihydroxy-cinnamic acid
|
Inhibition of HDAC in human Hela cells nuclear extracts by fluorimetric assay
Inhibition of HDAC in human Hela cells nuclear extracts by fluorimetric assay
|
[PMID: 19520580]
|
HeLa
|
IC50 |
|
Antiallergic activity in Ca(2+)-stimulated differentiated human HeLa cells assessed as inhibition of cys-leukotriene release after 6 days by ELISA
Antiallergic activity in Ca(2+)-stimulated differentiated human HeLa cells assessed as inhibition of cys-leukotriene release after 6 days by ELISA
|
[PMID: 19942440]
|
Hep 3B2
|
IC50 |
|
Inhibition of MMP9 in human Hep3B cells using gelatin as substrate
Inhibition of MMP9 in human Hep3B cells using gelatin as substrate
|
[PMID: 23375794]
|
HT-22
|
EC50 |
|
Neuroprotective activity against glutamate-induced cell death in mouse HT-22 cells assessed as increase in cell viability after 24 hrs by EZ-Cytox assay
Neuroprotective activity against glutamate-induced cell death in mouse HT-22 cells assessed as increase in cell viability after 24 hrs by EZ-Cytox assay
|
[PMID: 32991171]
|
HT-29
|
IC50 |
|
Growth inhibition of human HT-29 cells after 48 hrs by MTT assay
Growth inhibition of human HT-29 cells after 48 hrs by MTT assay
|
[PMID: 27783972]
|
HT-29
|
IC50 |
|
Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay
|
[PMID: 23746477]
|
LNCaP
|
IC50 |
|
Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs by WST-1 assay
Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs by WST-1 assay
|
[PMID: 24080105]
|
MCF7
|
IC50 |
> 550 μM
Compound: Caffeic acid
|
Cytotoxicity against human MCF7 cells assessed as [3H]-hypoxanthine incorporation after 48 hrs
Cytotoxicity against human MCF7 cells assessed as [3H]-hypoxanthine incorporation after 48 hrs
|
[PMID: 20954722]
|
MDA-MB-231
|
IC50 |
|
Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay
Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay
|
[PMID: 27783972]
|
MOLM-13
|
IC50 |
|
Antiproliferative activity against human MOLM13 cells by Cell-Titer Glo assay
Antiproliferative activity against human MOLM13 cells by Cell-Titer Glo assay
|
[PMID: 30370766]
|
MOLM-14
|
IC50 |
|
Antiproliferative activity against human MOLM14 cells by Cell-Titer Glo assay
Antiproliferative activity against human MOLM14 cells by Cell-Titer Glo assay
|
[PMID: 30370766]
|
MT4
|
IC50 |
|
Antiviral activity against wild type HIV1 NL4-3 infected in human MT4 cells by p24 ELISA
Antiviral activity against wild type HIV1 NL4-3 infected in human MT4 cells by p24 ELISA
|
[PMID: 27676157]
|
MV4-11
|
IC50 |
|
Antiproliferative activity against human MV4-11 cells by Cell-Titer Glo assay
Antiproliferative activity against human MV4-11 cells by Cell-Titer Glo assay
|
[PMID: 30370766]
|
Oocyte
|
IC50 |
16.7 μM
Compound: Caf-COOH
|
Antagonist activity at Gloeobacter violaceus ligand-gated ion channel expressed in Xenopus oocytes assessed as inhibition of MES buffer pH 5.5 -induced currents after 30 secs by voltage clamp technique
Antagonist activity at Gloeobacter violaceus ligand-gated ion channel expressed in Xenopus oocytes assessed as inhibition of MES buffer pH 5.5 -induced currents after 30 secs by voltage clamp technique
|
[PMID: 23682762]
|
P388
|
GI50 |
> 25 μg/mL
Compound: caffeic acid
|
Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay
Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay
|
[PMID: 10785435]
|
PC-12
|
IC50 |
75.8 μM
Compound: Caffeic acid
|
Neuroprotection against amyloid beta (25 to 35)-induced cell death in rat PC12 cells preincubated for 3 hrs followed by amyloid beta addition measured after 24 hrs by MTT assay
Neuroprotection against amyloid beta (25 to 35)-induced cell death in rat PC12 cells preincubated for 3 hrs followed by amyloid beta addition measured after 24 hrs by MTT assay
|
[PMID: 29107423]
|
PC-3
|
IC50 |
|
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
|
[PMID: 26638042]
|
Peritoneal macrophage cell
|
IC50 |
> 550 μM
Compound: Caffeic acid
|
Cytotoxicity against mouse peritoneal macrophages assessed as cell viability after 48 hrs by hematocytometer
Cytotoxicity against mouse peritoneal macrophages assessed as cell viability after 48 hrs by hematocytometer
|
[PMID: 20954722]
|
RAW264.7
|
EC50 |
|
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite accumulation administered 1 hr before LPS challenge and measured after 24 hrs by Griess reagent assay
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite accumulation administered 1 hr before LPS challenge and measured after 24 hrs by Griess reagent assay
|
[PMID: 18667320]
|
RAW264.7
|
EC50 |
|
Cytotoxicity against mouse RAW264.7 cells assessed as cell survival after 24 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as cell survival after 24 hrs by MTT assay
|
[PMID: 18667320]
|
SH-SY5Y
|
EC50 |
33.82 μM
Compound: Caffeic acid
|
Neuroprotection against H2O2-induced cell death in human SH-SY5Y cells preincubated for 6 hrs followed by H2O2 addition and measured after 24 hrs by MTT assay
Neuroprotection against H2O2-induced cell death in human SH-SY5Y cells preincubated for 6 hrs followed by H2O2 addition and measured after 24 hrs by MTT assay
|
[PMID: 30470490]
|
T47D
|
IC50 |
2 nM
Compound: Caffeic acid
|
Antiproliferative activity against human T47D cells after 5 days by MTT assay
Antiproliferative activity against human T47D cells after 5 days by MTT assay
|
[PMID: 23228470]
|
U-937
|
CC50 |
> 2000 μM
Compound: 19, CA
|
Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay
Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay
|
[PMID: 22925447]
|
U-937
|
IC50 |
316.5 μM
Compound: 19, CA
|
Antiproliferative activity against human U937 cells assessed as incorporation of [3H]-methyl-thymidine after 12 hrs by scintillation counting
Antiproliferative activity against human U937 cells assessed as incorporation of [3H]-methyl-thymidine after 12 hrs by scintillation counting
|
[PMID: 22925447]
|
U-937
|
EC50 |
|
Cytotoxicity against human U937 cells assessed as reduction in viability incubated for 24 hrs by MTT assay
Cytotoxicity against human U937 cells assessed as reduction in viability incubated for 24 hrs by MTT assay
|
[PMID: 26197161]
|
Vero
|
IC50 |
> 550 μM
Compound: Caffeic acid
|
Cytotoxicity against african green monkey Vero cells assessed as [3H]-hypoxanthine incorporation after 48 hrs
Cytotoxicity against african green monkey Vero cells assessed as [3H]-hypoxanthine incorporation after 48 hrs
|
[PMID: 20954722]
|