Akt1 - thymoma viral proto-oncogene 1 Gene

中文名称：胸腺瘤病毒原癌基因1

种属: Mus musculus

同用名: Akt; PKB; Rac; LTR-akt; PKB/Akt; PKBalpha

关于 Akt1

功能概要

该基因编码 Akt 丝氨酸-苏氨酸蛋白激酶基因家族的创始成员，该家族还包括 Akt2 和 Akt3。这种激酶是磷脂酰肌醇 3 激酶 (PI3K) 通路的主要下游效应因子，可介导各种生长因子的作用，例如血小板衍生生长因子 (PDGF)、表皮生长因子 (EGF)、胰岛素和胰岛素样生长因子我 (IGF-I)。它通过 PI3K 脂质产物募集到细胞膜和通过 3-磷酸肌醇依赖性激酶 1 磷酸化而被激活。然后它进一步磷酸化不同的下游蛋白质以响应各种细胞外信号，从而在介导多种细胞过程中起关键作用，例如葡萄糖代谢，糖原生物合成，蛋白质合成和周转，炎症反应，细胞存活（抗凋亡） ) 和发展。已发现该基因编码不同亚型的可变剪接转录物变体。 [RefSeq 提供，2009 年 9 月]

This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), Insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]