2. Gene
  3. Maoa - monoamine oxidase A Gene

Maoa - monoamine oxidase A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：单胺氧化酶 A

种属: Mus musculus

同用名: 1110061B18Rik

基因 ID: 17161 | 基因类型: protein coding

关于 Maoa

Chromosome X: 16,485,937-16,554,057 forward strand.GRCm39:CM001013.3

This gene has 1 transcript (splice variant), 147 orthologues, 9 paralogues and is associated with 28 phenotypes. Broad expression in large intestine adult (RPKM 27.2), colon adult (RPKM 1.2) and 19 other tissues.

功能概要

该基因编码的蛋白可启动伯胺氧化酶活性。在多巴胺分解代谢过程的上游或内部起作用，并对信号转导进行正向调节。位于线粒体中。以多种结构表达，包括消化系统；中枢神经系统;泌尿生殖系统；周围神经系统神经节；和感觉器官。用于研究 Brunner 综合症。该基因的人类直系同源物与阿尔茨海默病有关；布鲁纳综合症；酒精使用障碍；自闭症谱系障碍；和恐慌症。与人 MAOA（单胺氧化酶 A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables primary amine oxidase activity. Acts upstream of or within dopamine catabolic process and positive regulation of signal transduction. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Used to study Brunner Syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease; Brunner Syndrome; alcohol use disorder; autism spectrum disorder; and panic disorder. Orthologous to human MAOA (Monoamine Oxidase A). [provided by Alliance of Genome Resources, Apr 2022]

Maoa 基因产物(1)

mRNA Protein Name
NM_173740.3 NP_776101.3 amine oxidase [flavin-containing] A
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables primary methylamine oxidase activity IDA
IDA: 通过直接分析推断
23926250 MGI
enables primary methylamine oxidase activity IMP
IMP: 通过突变表型推断
7792602 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
23926250 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within dopamine catabolic process IDA
IDA: 通过直接分析推断
9520487 MGI
acts upstream of or within positive regulation of signal transduction IMP
IMP: 通过突变表型推断
17561096 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Maoa 蛋白结构

YobN

YobN: COG1231 (14 - 462)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 526 a.a.
蛋白主名 其他名称

amine oxidase [flavin-containing] A

MAO-A

monoamine oxidase type A

相关产品

Approval
生物活性分子 (24)
目录号 产品名 作用方式
纯度 是否罕见病
HY-14197A Clorgyline hydrochloride Inhibitor 99.92% 否
HY-14536 Methylene Blue Inhibitor 98.08% 否
HY-N0159 Paeonol 99.98% 否
HY-14280 Entacapone Inhibitor 99.97% 是
HY-14199 Selegiline hydrochloride Inhibitor 99.94% 否
HY-A0091A Pargyline Inhibitor 99.92% 否
HY-A0091 Pargyline hydrochloride Inhibitor 99.91% 否
HY-B0534 Moclobemide Inhibitor 99.90% 是
HY-70057 Safinamide Inhibitor 99.89% 是
HY-14855B Tedizolid phosphate Inhibitor 99.65% 是
HY-B1359 Methylene blue trihydrate Inhibitor ≥98.0% 是
HY-70057A Safinamide mesylate Inhibitor 99.87% 是
HY-B0678 Metaxalone 99.77% 否
HY-D0958 Methylene blue hydrate Inhibitor / 否
HY-14196 Toloxatone Inhibitor 98.11% 否
HY-14197 Clorgyline Inhibitor 99.76% 否
HY-100679 Pirlindole Inhibitor 98.90% 否
HY-B1558A Bifemelane hydrochloride Inhibitor 99.86% 否
HY-B0884 Minaprine Inhibitor / 否
HY-14198 Selegiline Inhibitor / 否
HY-100679A Pirlindole mesylate Inhibitor / 否
HY-14280R Entacapone (Standard) Inhibitor / 否
HY-B0678R Metaxalone (Standard) / 否
HY-14280A Entacapone sodium salt Inhibitor / 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-100178 CX-157 Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (84)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0529 Rosmarinic acid 99.73% 否
HY-W008566 Norharmane Inhibitor 99.46% 否
HY-B1311 Proadifen hydrochloride 99.98% 否
HY-110130 RN-1 dihydrochloride Inhibitor 99.13% 否
HY-19333 OG-L002 Inhibitor 99.81% 否
HY-16677A Mofegiline hydrochloride Inhibitor 99.57% 否
HY-E70074 Monoamine oxidase, plasma / 否
HY-B0884A Minaprine dihydrochloride Inhibitor 99.90% 否
HY-100588 VU0364770 Agonist 99.93% 否
HY-131036 MAO-IN-M30 dihydrochloride Inhibitor 99.25% 否
HY-14201 Lazabemide Inhibitor 99.95% 否
HY-156255 MAO-B-IN-25 Inhibitor 99.11% 否
HY-164099 LSD1/HDAC6-IN-2 Inhibitor 99.66% 否
HY-124591 TC-2153 Inhibitor 98.73% 否
HY-145259 HDAC6-IN-3 Inhibitor ≥98.0% 否
HY-N12485 MAO-A inhibitor 1 Inhibitor 98.55% 否
HY-13339 Brofaromine Inhibitor 99.60% 否
HY-N2336 Rosmarinic acid racemate Inhibitor 98.01% 否
HY-100027A Ro 41-1049 hydrochloride Inhibitor 99.96% 否
HY-121072 ASS234 Inhibitor 99.6% 否
HY-14280S Entacapone-d10 Inhibitor ≥98.0% 否
HY-151466 HIF-1α-IN-5 Inhibitor 99.95% 否
HY-151596 MAO-A/5-HT2AR-IN-1 Inhibitor 99.71% 否
HY-D0004 Azure B Inhibitor 98.13% 否
HY-W010130 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone Inhibitor 99.96% 否
HY-Y1322 Triphenyl phosphate Activator / 否
HY-14260 RS 8359 Inhibitor 97.03% 否
HY-108048 Desoxypeganine Inhibitor / 否
HY-108048A Desoxypeganine hydrochloride Inhibitor / 否
HY-116097 PSB-1491 Inhibitor / 否
HY-119885A (±)-Amiflamine Inhibitor 99.23% 否
HY-120017 Befloxatone Inhibitor / 否
HY-125515 Tetrahydroharmine Inhibitor 98.00% 否
HY-129449 AnnH31 Inhibitor 99.91% 否
HY-135265 Moclobemide N-Oxide Inhibitor / 否
HY-14202 Lazabemide hydrochloride Inhibitor / 否
HY-143438 2-PAT Inhibitor / 否
HY-143721 SSAO inhibitor-2 Inhibitor / 否
HY-144673 LSD1-IN-12 Inhibitor / 否
HY-144756 LSD1-IN-15 Inhibitor / 否
HY-144757 LSD1-IN-16 Inhibitor / 否
HY-144758 LSD1-IN-17 Inhibitor / 否
HY-149408 MAOA-IN-1 Inhibitor / 否
HY-149528 MAO-B-IN-24 Inhibitor / 否
HY-149978 LSD1-IN-26 / 否
HY-151094 FTEAA Inhibitor / 否
HY-151800 MAO-A/B-IN-2 Inhibitor / 否
HY-152109 AChE/MAO-IN-1 Inhibitor / 否
HY-152110 AChE/MAO-IN-2 Inhibitor / 否
HY-15386 Cimoxatone Inhibitor / 否
HY-154977 ETAP Inhibitor / 否
HY-157934 MAO-IN-4 Inhibitor / 否
HY-157981 AChE-IN-60 Inhibitor / 否
HY-157982 BChE-IN-28 Inhibitor / 否
HY-158092 ChEs/MAOs-IN-2 Inhibitor / 否
HY-158732 MAO-B-IN-33 Inhibitor / 否
HY-159106 MeSeI / 否
HY-161240 MAO-B-IN-30 Inhibitor 98.53% 否
HY-162606 MAO-A/B-IN-3 Inhibitor / 否
HY-162760 COMT-IN-1 Inhibitor / 否
HY-163322 MAO-A inhibitor 2 Inhibitor / 否
HY-163618 DHMQ / 否
HY-168021 MAO-A/SERT-IN-1 Inhibitor / 否
HY-170487 MAO-B-IN-38 Inhibitor / 否
HY-70057S1 Safinamide-d4-1 Inhibitor / 否
HY-B0534S Moclobemide-d8 Inhibitor / 否
HY-B0534S1 Moclobemide-d4 Inhibitor ≥99.0% 否
HY-B0678S Metaxalone-d3 ≥98.0% 否
HY-B0678S1 Metaxalone-d6 / 否
HY-N12134 Methyl piperate Inhibitor / 否
HY-N1638 1-Methyl-2-undecyl-4(1H)-quinolone Inhibitor / 否
HY-RS08019 MAOA Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08020 Maoa Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08021 Maoa Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-105041 Tedizolid phosphate sodium Inhibitor / 否
HY-105127 Brofaromine hydrochloride Inhibitor / 否
HY-134664 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate Inhibitor / 否
HY-14536A Methylene blue (purity≥70%) Inhibitor ≥95.0% 否
HY-19333A OG-L002 hydrochloride Inhibitor / 否
HY-N13041 Acacetin 7-O-(6-O-malonylglucoside) Inhibitor / 否
HY-W029600 6,7-Dimethylisatin Inhibitor / 否
HY-W655727 (-)-2-Phenylpropylamine Inhibitor / 否
HY-W700241 Norharman-d7 Inhibitor / 否
HY-W792513 WAY-620147 Inhibitor ≥98.0% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Maoa NCBI NCBI:4128
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