1. Gene
  2. AGO2 - argonaute RISC catalytic component 2 Gene

AGO2 - argonaute RISC catalytic component 2 Gene

中文名称:argonaute RISC 催化组分 2

种属: Homo sapiens

同用名: PPD; Q10; CASC7; EIF2C2; LESKRES; LINC00980

基因 ID: 27161 | 基因类型: protein coding

关于 AGO2

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:140,520,156-140,642,313 (from NCBI)

This gene has 10 transcripts (splice variants), 211 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in skin (RPKM 3.3), ovary (RPKM 3.3) and 25 other tissues.

功能概要

该基因编码在 RNA 干扰中发挥作用的 Argonaute 蛋白家族成员。编码的蛋白质是高度碱性的,包含一个 PAZ 结构域和一个 PIWI 结构域。它可能与 dicer1 相互作用并在短干扰 RNA 介导的基因沉默中发挥作用。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供,2009 年 9 月]

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

AGO2 基因产物(2)

mRNA Protein Name
NM_001164623.3 NP_001158095.1 protein argonaute-2 isoform 2
NM_012154.5 NP_036286.2 protein argonaute-2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA 7-methylguanosine cap binding IDA
IDA: 通过直接分析推断
17524464 GOA
enables RNA endonuclease activity IDA
IDA: 通过直接分析推断
18178619 GOA
enables RNA polymerase II complex binding IDA
IDA: 通过直接分析推断
25336585 GOA
enables core promoter sequence-specific DNA binding IMP
IMP: 通过突变表型推断
25336585 GOA
enables double-stranded RNA binding IDA
IDA: 通过直接分析推断
19966796 GOA
enables endoribonuclease activity, cleaving miRNA-paired mRNA IDA
IDA: 通过直接分析推断
15260970 GOA
enables endoribonuclease activity, cleaving miRNA-paired mRNA IMP
IMP: 通过突变表型推断
22795694 GOA
enables endoribonuclease activity, cleaving siRNA-paired mRNA IDA
IDA: 通过直接分析推断
15260970 GOA
enables mRNA 3'-UTR AU-rich region binding IDA
IDA: 通过直接分析推断
17382880 GOA
enables mRNA cap binding IDA
IDA: 通过直接分析推断
17524464 GOA
enables mRNA cap binding IPI
IPI: 通过物理相互作用推断
23409027 GOA
enables miRNA binding IDA
IDA: 通过直接分析推断
15260970 GOA
enables miRNA binding IPI
IPI: 通过物理相互作用推断
31012336 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14749716 GOA
contributes to siRNA binding IDA
IDA: 通过直接分析推断
15973356 GOA
enables siRNA binding IDA
IDA: 通过直接分析推断
17495927 GOA
enables single-stranded RNA binding IDA
IDA: 通过直接分析推断
19966796 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in P-body assembly IDA
IDA: 通过直接分析推断
31400113 GOA
involved in RISC complex assembly IDA
IDA: 通过直接分析推断
19701182 GOA
involved in RNA secondary structure unwinding IDA
IDA: 通过直接分析推断
19966796 GOA
involved in RNA secondary structure unwinding IMP
IMP: 通过突变表型推断
22795694 GOA
involved in miRNA processing IDA
IDA: 通过直接分析推断
19966796 GOA
involved in miRNA-mediated gene silencing by inhibition of translation IDA
IDA: 通过直接分析推断
17671087 GOA
involved in miRNA-mediated gene silencing by inhibition of translation IMP
IMP: 通过突变表型推断
18771919 GOA
involved in miRNA-mediated gene silencing by mRNA destabilization IDA
IDA: 通过直接分析推断
15260970 GOA
involved in miRNA-mediated gene silencing by mRNA destabilization IMP
IMP: 通过突变表型推断
18771919 GOA
involved in negative regulation of translational initiation IDA
IDA: 通过直接分析推断
17524464 GOA
involved in positive regulation of angiogenesis IDA
IDA: 通过直接分析推断
27208409 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
25336585 GOA
involved in positive regulation of translation IDA
IDA: 通过直接分析推断
17382880 GOA
involved in positive regulation of trophoblast cell migration IMP
IMP: 通过突变表型推断
27208409 GOA
involved in pre-miRNA processing IDA
IDA: 通过直接分析推断
16424907 GOA
involved in regulation of synapse maturation IDA
IDA: 通过直接分析推断
29735530 GOA
involved in regulation of synapse maturation IMP
IMP: 通过突变表型推断
29735530 GOA
involved in siRNA processing IDA
IDA: 通过直接分析推断
23661684 GOA
involved in siRNA-mediated gene silencing by mRNA destabilization IDA
IDA: 通过直接分析推断
15260970 GOA
involved in siRNA-mediated gene silencing by mRNA destabilization IMP
IMP: 通过突变表型推断
22795694 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in P-body IDA
IDA: 通过直接分析推断
20616046 GOA
part of RISC complex IDA
IDA: 通过直接分析推断
15260970 GOA
part of RISC complex IGI
IGI: 通过遗传相互作用推断
31012336 GOA
part of RISC complex IPI
IPI: 通过物理相互作用推断
19826008 GOA
part of RISC-loading complex IDA
IDA: 通过直接分析推断
15973356 GOA
part of RISC-loading complex IPI
IPI: 通过物理相互作用推断
23661684 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
15260970 GOA
located in extracellular exosome IDA
IDA: 通过直接分析推断
28159509 GOA
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
29735530 GOA
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
29735530 GOA
located in nucleus IDA
IDA: 通过直接分析推断
23985560 GOA
is active in postsynapse IDA
IDA: 通过直接分析推断
29735530 GOA
is active in postsynapse IMP
IMP: 通过突变表型推断
29735530 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

AGO2 蛋白结构

ArgoL1

ArgoL1: Argonaute linker 1 domain (175 - 227)

PAZ

PAZ: PAZ domain (235 - 370)

Piwi

Piwi: Piwi domain (518 - 817)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 859 a.a.
蛋白主名 其他名称

protein argonaute-2

PAZ Piwi domain protein

重组 AGO2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72835 AGO2/Argonaute-2 Protein, Human (sf9, His) Q9UKV8 (M1-A859) ≥95%

关联疾病

疾病名称 别名
Lessel-Kreienkamp Syndrome

LESKRES

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Eunuchism
Patau Syndrome

Trisomy 13

Complete Trisomy 13 Syndrome

Trisomy 13 Syndrome

D1 Trisomy

Patau'S Syndrome

Complete Trisomy 13

Chromosome 13, Trisomy 13 Complete

D Trisomy Syndrome

Bartholin-Patau Syndrome

Chromosome 13 Duplication

D1 Trisomy Syndrome

D>1< Trisomy Syndrome

Patau

Chromosome 13 Trisomy

Abnormal Autosomes 13

Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome

Orofaciodigital Syndrome Viii

Edwards Syndrome

Trisomy 18

Complete Trisomy 18 Syndrome

OFD8

Orofaciodigital Syndrome 8

Trisomy 18 Syndrome

Oral-Facial-Digital Syndrome With Hypoplastic Epiglottis

E3 Trisomy

Oral-Facial-Digital Syndrome Type 8

Orofaciodigital Syndrome Type 8

Ofds Viii

Oral-Facial-Digital Syndrome, Type Viii

Ofd Syndrome 8

Ofds 8

Oral Facial Digital Syndrome 8

Oral Facial Digital Syndrome Type 8

18 Trisomy

Chromosome 18 Trisomy

Trisomy 16-18

Trisomy E

Trisomy E Syndrome

Chromosome 18 Duplication

Oral-Facial-Digital Syndrome, Edwards Type

Orofaciodigital Syndrome, Edwards Type

Chromosome 18, Trisomy

Cleft Lip/Palate With Abnormal Thumbs And Microcephaly

Trisomy 18 Chromosome

Abnormal Autosomes 18

Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility

Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria

Cervical Non-Keratinizing Squamous Cell Carcinoma
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus AGO2 RGD RGD:621255
Mus musculus AGO2 MGD MGI:2446632
Felis catus AGO2 VGNC VGNC:81639
Canis familiaris AGO2 VGNC VGNC:37707
Bos taurus AGO2 VGNC VGNC:50167
Macaca mulatta AGO2 VGNC VGNC:81347
Others AGO2 NCBI