2. Gene
  3. PGP - phosphoglycolate phosphatase Gene

PGP - phosphoglycolate phosphatase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷酸乙醇酸磷酸酶

种属: Homo sapiens

同用名: AUM; G3PP; PGPase

基因 ID: 283871 | 基因类型: protein coding

关于 PGP

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,211,593-2,214,840 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues and 3 paralogues. Broad expression in testis (RPKM 12.7), brain (RPKM 7.6) and 25 other tissues.

功能概要

启用甘油 3 磷酸酶活性和磷酸乙醇酸磷酸酶活性。参与甘油生物合成过程；甘油磷脂代谢过程；和糖异生的负调节。预计在细胞质中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Enables glycerol-3-phosphatase activity and phosphoglycolate Phosphatase activity. Involved in glycerol biosynthetic process; glycerophospholipid metabolic process; and negative regulation of gluconeogenesis. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PGP 基因产物(1)

mRNA Protein Name
NM_001042371.3 NP_001035830.1 glycerol-3-phosphate phosphatase
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glycerol-3-phosphatase activity IDA
IDA: 通过直接分析推断
26755581 GOA
enables phosphoglycolate phosphatase activity IDA
IDA: 通过直接分析推断
26755581 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in glycerol biosynthetic process IDA
IDA: 通过直接分析推断
26755581 GOA
involved in glycerophospholipid metabolic process IDA
IDA: 通过直接分析推断
26755581 GOA
involved in negative regulation of gluconeogenesis IMP
IMP: 通过突变表型推断
26755581 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PGP 蛋白结构

Hydrolase_6

Hydrolase_6: Haloacid dehalogenase-like hydrolase (31 - 138)

Hydrolase_like

Hydrolase_like: HAD-hyrolase-like (233 - 315)

  • 0
  • 100
  • 200
  • 300
  • 321 a.a.
蛋白主名 其他名称

glycerol-3-phosphate phosphatase

aspartate-based ubiquitous Mg(2+)-dependent phosphatase

关联疾病

疾病名称 别名
Sennetsu Fever

Sennetsu Ehrlichiosis

Human Ehrlichial Infection, Sennetsu Type
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (14)
目录号 产品名 作用方式
纯度 是否罕见病
HY-14275 Verapamil 99.96% 是
HY-10440 Vismodegib 99.97% 是
HY-A0064 Verapamil hydrochloride 99.98% 是
HY-N6972 Cepharanthine 99.91% 是
HY-17367A Atazanavir sulfate 99.94% 是
HY-B0777 Moxidectin Inhibitor 99.32% 是
HY-W018791 Bifendate 99.91% 否
HY-17367 Atazanavir 99.86% 是
HY-145574 Iruplinalkib Inhibitor 99.29% 否
HY-N7120 Penicillin G procaine hydrate Inhibitor 99.52% 否
HY-B0501 Danofloxacin mesylate Inhibitor 99.87% 否
HY-16397 Phenformin 99.72% 否
HY-A0064R Verapamil hydrochloride (Standard) / 否
HY-B0777R Moxidectin (Standard) Inhibitor / 否
Clinical Phase
生物活性分子 (15)
目录号 产品名 作用方式
纯度 Phase
HY-10550 Tariquidar Inhibitor 99.45% Phase 3
HY-50671 Zosuquidar trihydrochloride Inhibitor 99.79% Phase 3
HY-15255 Zosuquidar Inhibitor 99.90% Phase 3
HY-10550A Tariquidar methanesulfonate, hydrate Inhibitor 98.52% Phase 3
HY-110377 Tariquidar dihydrochloride Inhibitor / Phase 3
HY-19642A Glesatinib hydrochloride Inhibitor 98.01% Phase 2
HY-106004 Zamicastat Inhibitor ≥98.0% Phase 2
HY-14942 Berubicin Inhibitor 87.76% Phase 2
HY-19642 Glesatinib Inhibitor / Phase 2
HY-132189 Laniquidar Inhibitor / Phase 2
HY-120464 PF-05212377 Inhibitor / Phase 2
HY-16773 Vedroprevir Inhibitor / Phase 2
HY-50879 Elacridar Inhibitor 99.94% Phase 1
HY-17013A Dofequidar fumarate Inhibitor ≥98.0% Phase 1
HY-17013 Dofequidar Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (114)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10010 Ko 143 Inhibitor 99.97% 否
HY-13925 PD0166285 99.46% 否
HY-50880 Elacridar hydrochloride Inhibitor 99.93% 否
HY-N0069 Solamargine 99.97% 否
HY-N6684 Deoxynivalenol 99.39% 否
HY-108694 γ-Tocotrienol Inhibitor 99.73% 否
HY-N3584 Paris saponin VII 99.96% 否
HY-107643 Reversan Inhibitor 99.90% 否
HY-N3308 Medicarpin Inducer 99.70% 否
HY-N1941 Isosinensetin Inhibitor 99.65% 否
HY-N2453 Convallatoxin 98.66% 否
HY-W009141 1-Monopalmitin Inhibitor 99.42% 否
HY-100750 Norverapamil hydrochloride Inhibitor 99.80% 否
HY-108286 Talinolol Antagonist 99.64% 否
HY-161246 uPSEM792 Agonist 99.92% 否
HY-N6932 Voacamine 99.64% 否
HY-113805 MC70 Inhibitor 99.50% 否
HY-119823 PGP-4008 Inhibitor 99.69% 否
HY-19753 KS176 Inhibitor 99.09% 否
HY-N2103 Tenacissoside G 99.64% 否
HY-119101 AZD-5672 95.74% 否
HY-W001601 Budipine Antagonist 99.41% 否
HY-101791 P-gp inhibitor 1 Inhibitor 98.79% 否
HY-19626 NSC23925 Inhibitor 99.43% 否
HY-126940 Furanodiene 99.65% 否
HY-132866 YS-370 Inhibitor 98.50% 否
HY-A0064S Verapamil-d3 hydrochloride 99.57% 否
HY-N0689 Evodine Inhibitor 99.20% 否
HY-N1457 Chrysosplenetin 99.75% 否
HY-N4108 Hypophyllanthin Inhibitor 98.84% 否
HY-N6748 Roquefortine C 98.42% 否
HY-143792 HTT-D3 Inhibitor / 否
HY-162753 ZW-1226 98.13% 否
HY-N2416 Taccalonolide A 99.29% 否
HY-N3028 Taccalonolide B Inhibitor 99.46% 否
HY-16191 ELR510444 ≥98.0% 否
HY-162373 α-Amylase/α-Glucosidase-IN-10 Inhibitor / 否
HY-112912 P-gp modulator 1 / 否
HY-130244 BACE1-IN-5 Inhibitor / 否
HY-10550B Tariquidar dimesylate Inhibitor / 否
HY-128685 FD 12-9 Inhibitor / 否
HY-146096 RMS3 / 否
HY-146097 RMS5 / 否
HY-149053 OY-101 Inhibitor / 否
HY-17367S2 Atazanavir-d9 / 否
HY-17367S3 Atazanavir-d5 / 否
HY-106753 Tolnapersine / 否
HY-108286S (Rac)-Talinolol-d5 Antagonist / 否
HY-121247 Bromotetrandrine / 否
HY-135328 Norverapamil Inhibitor / 否
HY-135328AS Norverapamil-d7 hydrochloride Antagonist 98.77% 否
HY-135328S Norverapamil-d7 Inhibitor / 否
HY-136589 Verapamil EP Impurity C hydrochloride Inhibitor 99.61% 否
HY-13925A PD0166285 dihydrochloride / 否
HY-14275S1 Verapamil-d7 / 否
HY-144366 P-gp inhibitor 3 Inhibitor / 否
HY-144393 P-gp/BCRP-IN-1 Inhibitor / 否
HY-144774 Topoisomerase I inhibitor 5 / 否
HY-146117 P-gp modulator 2 Modulator / 否
HY-146118 P-gp modulator 3 Modulator / 否
HY-146391 P-gp inhibitor 4 Modulator / 否
HY-147758 BACE1/2-IN-1 Inhibitor / 否
HY-149053B (R)-OY-101 / 否
HY-149240 Anticancer agent 108 Inhibitor / 否
HY-149277 FM04 Inhibitor / 否
HY-149360 P-gb-IN-1 Inhibitor / 否
HY-149813 P-gp inhibitor 14 Inhibitor / 否
HY-149981 P-gp inhibitor 13 Inhibitor / 否
HY-150565 P-gp inhibitor 5 Inhibitor / 否
HY-152079 CYP1B1-IN-3 Inhibitor / 否
HY-155032 P-gp inhibitor 15 Inhibitor / 否
HY-155391 hCA/Wnt/β-catenin-IN-1 Inhibitor 99.96% 否
HY-157330 P-gp inhibitor 16 / 否
HY-157483 P-gp inhibitor 18 Inhibitor / 否
HY-157484 P-gp inhibitor 19 Inhibitor / 否
HY-157876 Anticancer agent 191 Inhibitor / 否
HY-158236 ORL1 antagonist 2 Antagonist / 否
HY-158435 P-gp inhibitor 23 Inhibitor / 否
HY-159085 P-gp inhibitor 24 Inhibitor / 否
HY-159614 PG-PS Activator / 否
HY-161260 P-gp inhibitor 20 Inhibitor / 否
HY-161645 P-gp modulator-4 Modulator / 否
HY-161776 P-gp/CDK2-IN-1 Inhibitor / 否
HY-162040 P-gp inhibitor 17 Inhibitor / 否
HY-162369 PID-9 Inhibitor / 否
HY-162396 P-gp inhibitor 21 Inhibitor / 否
HY-162447 P-gp inhibitor 22 / 否
HY-162822 P-gp modulator-5 Modulator / 否
HY-163204 RhQ-DMB Inhibitor / 否
HY-168008 P-gp inhibitor 25 Inhibitor / 否
HY-168186 P-gp inhibitor 26 Inhibitor / 否
HY-168711 P-gp inhibitor 27 Inhibitor / 否
HY-17367S4 Atazanavir-d6 99.28% 否
HY-A0064S1 Verapamil-d6 hydrochloride / 否
HY-N10562 Mutabilol Modulator / 否
HY-N10563 Coleon-U-quinone Inhibitor / 否
HY-N10564 8α,9α-Epoxycoleon-U-quinone Modulator / 否
HY-N144114 P-gp inhibitor 2 Inhibitor / 否
HY-RS10394 PGP Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W140488 1,2-Didecanoyl-sn-glycero-3-phosphoethanolamine / 否
HY-123934 VU6007477 Modulator / 否
HY-129698 MS-073 Inhibitor / 否
HY-17013D Dofequidar sesquifumarate Inhibitor / 否
HY-B0777S Moxidectin-d3 Inhibitor / 否
HY-N13157 11α-O-Benzoyl-12β-O-acetyltenacigenin B Inhibitor / 否
HY-N7305 Jatrophane 5 Inhibitor / 否
HY-N7332 Pepluanin A Inhibitor / 否
HY-W699430 Norverapamil-d6 hydrochloride Inhibitor / 否
HY-W700684 N-Didesmethyl Loperamide / 否
HY-W705354 Vismodegib-d4 / 否
HY-W716916 Vismodegib-d7 / 否
HY-W854295 Phosphatidylinositol-1,2-dioctanoyl sodium Inhibitor / 否
HY-13646B Encequidar hydrochloride Inhibitor / 否
HY-U00247 MCI826 Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PGP VGNC VGNC:32798
Macaca mulatta PGP VGNC VGNC:104745
Mus musculus PGP MGD MGI:1914328
Felis catus PGP VGNC VGNC:80673
Rattus norvegicus PGP RGD RGD:1307773
Macaca fascicularis PGP NCBI NCBI:102115347
Others PGP NCBI
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