2. Gene
  3. Maob - monoamine oxidase B Gene

Maob - monoamine oxidase B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：单胺氧化酶 B

种属: Rattus norvegicus

基因 ID: 25750 | 基因类型: protein coding

关于 Maob

Primary_assembly X: 5,907,266-6,011,003 forward strand.mRatBN7.2:CM026994.1

This gene has 2 transcripts (splice variants), 333 orthologues, 10 paralogues and is associated with 15 phenotypes. Biased expression in Liver (RPKM 548.4), Lung (RPKM 237.7) and 5 other tissues.

功能概要

该基因编码的蛋白可启动黄素腺嘌呤二核苷酸结合活性；相同的蛋白质结合活性；和伯胺氧化酶活性。参与多个过程，包括血清素分泌的负调节；多巴胺代谢过程的正向调节；和对皮质酮的反应。位于线粒体外膜。帕金森病和胆汁淤积的生物标志物。该基因的人类直系同源物与阿尔茨海默病和帕金森病有关。与人 MAOB（单胺氧化酶 B）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables flavin adenine dinucleotide binding activity; identical protein binding activity; and primary amine oxidase activity. Involved in several processes, including negative regulation of serotonin secretion; positive regulation of dopamine metabolic process; and response to corticosterone. Located in mitochondrial outer membrane. Biomarker of Parkinson's disease and cholestasis. Human ortholog(s) of this gene implicated in Alzheimer's disease and Parkinson's disease. Orthologous to human MAOB (Monoamine Oxidase B). [provided by Alliance of Genome Resources, Apr 2022]

Maob 基因产物(1)

mRNA Protein Name
NM_013198.1 NP_037330.1 amine oxidase [flavin-containing] B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables flavin adenine dinucleotide binding IDA
IDA: 通过直接分析推断
18424170 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18198902 RGD
enables monoamine oxidase activity IDA
IDA: 通过直接分析推断
20493079 RGD
enables primary methylamine oxidase activity IDA
IDA: 通过直接分析推断
18424170 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of serotonin secretion IMP
IMP: 通过突变表型推断
12175458 RGD
involved in phenylethylamine catabolic process IDA
IDA: 通过直接分析推断
18539264 RGD
involved in positive regulation of dopamine metabolic process IMP
IMP: 通过突变表型推断
12175458 RGD
involved in response to aluminum ion IEP
IEP: 通过表达模式推断
19526156 RGD
involved in response to corticosterone IEP
IEP: 通过表达模式推断
15919584 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
20022592 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
19779138 RGD
involved in response to selenium ion IEP
IEP: 通过表达模式推断
18304392 RGD
involved in response to steroid hormone IDA
IDA: 通过直接分析推断
18539264 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
16904659 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
18256746 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite IDA
IDA: 通过直接分析推断
12379239 RGD
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
12379239 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
12379239 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Maob 蛋白结构

YobN

YobN: COG1231 (4 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 520 a.a.
蛋白主名 其他名称

amine oxidase [flavin-containing] B

MAO-B

monoamine oxidase type B

相关产品

Approval
生物活性分子 (13)
目录号 产品名 作用方式
纯度 是否罕见病
HY-14280 Entacapone Inhibitor 99.97% 是
HY-N0159 Paeonol 99.98% 否
HY-14199 Selegiline hydrochloride Inhibitor 99.94% 否
HY-A0091A Pargyline Inhibitor 99.92% 否
HY-A0091 Pargyline hydrochloride Inhibitor 99.91% 否
HY-70057 Safinamide Inhibitor 99.89% 是
HY-14855B Tedizolid phosphate Inhibitor 99.65% 是
HY-70057A Safinamide mesylate Inhibitor 99.87% 是
HY-B1558A Bifemelane hydrochloride Inhibitor 99.86% 否
HY-N0159R Paeonol (Standard) / 否
HY-14198 Selegiline Inhibitor / 否
HY-14280R Entacapone (Standard) Inhibitor / 否
HY-14280A Entacapone sodium salt Inhibitor / 否
Clinical Phase
生物活性分子 (7)
目录号 产品名 作用方式
纯度 Phase
HY-103164A 8-(3-Chlorostyryl)caffeine / Phase 4
HY-129388B Pulrodemstat benzenesulfonate Inhibitor 99.64% Phase 2
HY-112623 Vafidemstat Inhibitor 99.53% Phase 2
HY-10400 Ladostigil hemitartrate Inhibitor 98.90% Phase 2
HY-10399A Ladostigil hydrochloride Inhibitor 99.94% Phase 2
HY-10399 Ladostigil Inhibitor / Phase 2
HY-129388 Pulrodemstat Methylbenzenesulfonate Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (137)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0529 Rosmarinic acid 99.73% 否
HY-W008566 Norharmane Inhibitor 99.46% 否
HY-N7204 4-Hydroxyderricin 99.97% 否
HY-N0918 Desmethoxyyangonin Inhibitor 99.47% 否
HY-19333 OG-L002 Inhibitor 99.81% 否
HY-110130 RN-1 dihydrochloride Inhibitor 99.13% 否
HY-16677A Mofegiline hydrochloride Inhibitor 99.57% 否
HY-E70074 Monoamine oxidase, plasma / 否
HY-100588 VU0364770 Agonist 99.94% 否
HY-103164 (E)-8-(3-Chlorostyryl)caffeine 99.00% 否
HY-127109 Tisolagiline Inhibitor 99.97% 否
HY-131036 MAO-IN-M30 dihydrochloride Inhibitor 99.25% 否
HY-14201 Lazabemide Inhibitor 99.95% 否
HY-156255 MAO-B-IN-25 Inhibitor 99.11% 否
HY-N9540 Methyl citrate Inhibitor ≥98.0% 否
HY-W001601 Budipine Antagonist 99.41% 否
HY-129388A Pulrodemstat Inhibitor / 否
HY-N2336 Rosmarinic acid racemate Inhibitor 98.01% 否
HY-119532 Nordeprenyl 95.03% 否
HY-121072 ASS234 Inhibitor 99.6% 否
HY-132907 MAO-B-IN-2 Inhibitor 99.05% 否
HY-14203 (R)-Safinamide Inhibitor 99.88% 否
HY-14280S Entacapone-d10 Inhibitor ≥98.0% 否
HY-146958 MAO-B-IN-8 Inhibitor 98.03% 否
HY-D0004 Azure B Inhibitor 98.13% 否
HY-W010130 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone Inhibitor 99.96% 否
HY-117173 (Rac)-Rasagiline Inhibitor / 否
HY-114915 PSB-1434 Inhibitor 98.05% 否
HY-115986 MAO-B-IN-5 Inhibitor / 否
HY-115987 MAO-B-IN-6 Inhibitor / 否
HY-116097 PSB-1491 Inhibitor / 否
HY-116765 MAO-B-IN-35 / 否
HY-117502 SL-25.1188 Inhibitor / 否
HY-120419 PF9601N Inhibitor 99.85% 否
HY-120826 A2AAR/hMAO-B-IN-1 Inhibitor / 否
HY-127109A Tisolagiline methylsulfate Inhibitor / 否
HY-129479 Almoxatone Inhibitor / 否
HY-130205 Milacemide hydrochloride Inhibitor / 否
HY-14202 Lazabemide hydrochloride Inhibitor / 否
HY-143244 Monoamine Oxidase B inhibitor 1 Inhibitor / 否
HY-143245 Monoamine Oxidase B inhibitor 2 Inhibitor / 否
HY-143329 MAO-B-IN-3 Inhibitor / 否
HY-143330 MAO-B-IN-4 Inhibitor / 否
HY-143438 2-PAT Inhibitor / 否
HY-144673 LSD1-IN-12 Inhibitor / 否
HY-144756 LSD1-IN-15 Inhibitor / 否
HY-144757 LSD1-IN-16 Inhibitor / 否
HY-144758 LSD1-IN-17 Inhibitor / 否
HY-144824 Monoamine oxidase/Aromatase-IN-1 Inhibitor / 否
HY-145695 Dual AChE-MAO B-IN-1 Inhibitor / 否
HY-145845 HDAC1/MAO-B-IN-1 Inhibitor / 否
HY-146149 MAO-B-IN-11 Inhibitor / 否
HY-146150 MAO-B-IN-12 Inhibitor / 否
HY-146312 AChE/BChE/MAO-B-IN-1 Inhibitor 99.57% 否
HY-146314 MAO-B-IN-9 Inhibitor 99.70% 否
HY-146347 MAO-B-IN-10 Inhibitor / 否
HY-146677 5-HT6R/MAO-B modulator 1 / 否
HY-146762 MAO-B-IN-7 Inhibitor / 否
HY-147362 MAO-B-IN-14 Inhibitor / 否
HY-147953 MAO-B-IN-13 Inhibitor / 否
HY-149242 MAO-B-IN-20 Inhibitor / 否
HY-149477 IHC3 Inhibitor / 否
HY-149527 MAO-B-IN-23 Inhibitor / 否
HY-149528 MAO-B-IN-24 Inhibitor / 否
HY-149820 MAO-B-IN-22 Inhibitor / 否
HY-149978 LSD1-IN-26 / 否
HY-149984 MAO-B-IN-21 Inhibitor / 否
HY-150563 Neuroinflammatory-IN-2 Inhibitor / 否
HY-151094 FTEAA Inhibitor / 否
HY-151208 MAO-B-IN-16 Inhibitor / 否
HY-151209 MAO-B-IN-15 Inhibitor / 否
HY-151210 MAO-B-IN-17 Inhibitor ≥99.0% 否
HY-151800 MAO-A/B-IN-2 Inhibitor / 否
HY-152109 AChE/MAO-IN-1 Inhibitor / 否
HY-152110 AChE/MAO-IN-2 Inhibitor / 否
HY-152111 AChE/MAO-B-IN-3 Inhibitor / 否
HY-152112 AChE/BChE/MAO-B-IN-2 Inhibitor / 否
HY-152113 AChE/BChE/MAO-B-IN-3 Inhibitor / 否
HY-152114 AChE/BChE/MAO-B-IN-4 Inhibitor / 否
HY-154977 ETAP Inhibitor / 否
HY-155330 PZ-1922 / 否
HY-155330A PZ-1922 free base / 否
HY-156348 MAO-B-IN-26 Inhibitor / 否
HY-157087 AChE/MAO-B-IN-4 Inhibitor / 否
HY-157089 AChE/MAO-B-IN-5 Inhibitor / 否
HY-157517 MAO-B-IN-29 Inhibitor / 否
HY-157934 MAO-IN-4 Inhibitor / 否
HY-157981 AChE-IN-60 Inhibitor / 否
HY-157982 BChE-IN-28 Inhibitor / 否
HY-158092 ChEs/MAOs-IN-2 Inhibitor / 否
HY-158732 MAO-B-IN-33 Inhibitor / 否
HY-159106 MeSeI / 否
HY-160002 MAO-B-IN-27 Inhibitor / 否
HY-161240 MAO-B-IN-30 Inhibitor 98.53% 否
HY-162061 ChEs/MAOs-IN-1 Inhibitor / 否
HY-162303 C175-0062 Inhibitor / 否
HY-162606 MAO-A/B-IN-3 Inhibitor / 否
HY-162760 COMT-IN-1 Inhibitor / 否
HY-163322 MAO-A inhibitor 2 Inhibitor / 否
HY-163380 CA/MAO-B-IN-1 Inhibitor 98.34% 否
HY-163474 MAO-B-IN-32 Inhibitor / 否
HY-163879 hMAO-B-IN-9 Inhibitor / 否
HY-16731 Sembragiline Inhibitor / 否
HY-168138 MAO-B-IN-34 Inhibitor / 否
HY-168590 MAO-B-IN-36 Inhibitor / 否
HY-168728 MAO-B-IN-37 Inhibitor / 否
HY-169156 HDAC6-IN-49 Inhibitor / 否
HY-170487 MAO-B-IN-38 Inhibitor / 否
HY-170798 Monoamine Oxidase B inhibitor 6 Inhibitor / 否
HY-170887 MAO-B-IN-39 / 否
HY-172101 AChE/MAO-B-IN-7 Inhibitor / 否
HY-70057S1 Safinamide-d4-1 Inhibitor / 否
HY-N12134 Methyl piperate Inhibitor / 否
HY-N1636 1-Methyl-2-nonyl-4(1H)-quinolone Inhibitor / 否
HY-N1638 1-Methyl-2-undecyl-4(1H)-quinolone Inhibitor / 否
HY-RS08022 MAOB Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08023 Maob Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08024 Maob Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W035384 MAO-B ligand-1 Inhibitor / 否
HY-W083026 (E)-CHBO4 Inhibitor 97.04% 否
HY-W205529 RO 16-6491 free base / 否
HY-W269511 NW-1689 / 否
HY-W335927 MAO-B-IN-19 Inhibitor / 否
HY-W845607 Milacemide Inhibitor / 否
HY-10399B (S)-Ladostigil Inhibitor / 否
HY-105041 Tedizolid phosphate sodium Inhibitor / 否
HY-123556 SZV-558 Inhibitor / 否
HY-123665 PSB-1410 Inhibitor 99.22% 否
HY-129444 MD 780236 free base Inhibitor / 否
HY-134664 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate Inhibitor / 否
HY-164649 Atibeprone Inhibitor / 否
HY-19333A OG-L002 hydrochloride Inhibitor / 否
HY-N13041 Acacetin 7-O-(6-O-malonylglucoside) Inhibitor / 否
HY-W029600 6,7-Dimethylisatin Inhibitor / 否
HY-W655727 (-)-2-Phenylpropylamine Inhibitor / 否
HY-W700241 Norharman-d7 Inhibitor / 否
HY-W792513 WAY-620147 Inhibitor ≥98.0% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Maob NCBI NCBI:4129
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