2. Gene
  3. HDAC8 - histone deacetylase 8 Gene

HDAC8 - histone deacetylase 8 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组蛋白脱乙酰酶 8

种属: Rattus norvegicus

同用名: HD8; RGD1562895

基因 ID: 363481 | 基因类型: protein coding

关于 HDAC8

Primary_assembly X: 67,385,289-67,592,923 reverse strand.mRatBN7.2:CM026994.1

This gene has 4 transcripts (splice variants), 202 orthologues, 12 paralogues and is associated with 19 phenotypes. Biased expression in Thymus (RPKM 26.7), Brain (RPKM 23.8) and 9 other tissues.

功能概要

该基因编码的蛋白可启动染色质结合活性和脱乙酰酶活性。参与多个过程，包括细胞对有机环状化合物的反应；大分子代谢过程的负调控；成骨细胞分化的负调控。位于核内。苯丙胺滥用的生物标志物；高血压;和肾血管性高血压。该基因的人类直系同源物与 Cornelia de Lange 综合征 5 和 Wilson-Turner 综合征有关。与人类 HDAC8（组蛋白脱乙酰酶 8）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables chromatin binding activity and deacetylase activity. Involved in several processes, including cellular response to organic cyclic compound; negative regulation of macromolecule metabolic process; and negative regulation of osteoblast differentiation. Located in nucleus. Biomarker of amphetamine abuse; hypertension; and renovascular hypertension. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8). [provided by Alliance of Genome Resources, Apr 2022]

HDAC8 基因产物(1)

mRNA Protein Name
NM_001126373.2 NP_001119845.2 histone deacetylase 8
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
28559304 RGD
enables deacetylase activity IDA
IDA: 通过直接分析推断
23868068 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to forskolin IDA
IDA: 通过直接分析推断
28559304 RGD
involved in cellular response to trichostatin A IDA
IDA: 通过直接分析推断
26391271 RGD
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
28559304 RGD
involved in negative regulation of osteoblast differentiation IMP
IMP: 通过突变表型推断
25019367 RGD
involved in negative regulation of protein modification process IMP
IMP: 通过突变表型推断
25019367 RGD
involved in response to 11-deoxycorticosterone IDA
IDA: 通过直接分析推断
23868068 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HDAC8 蛋白结构

HDAC8

HDAC8: cd10000 (15 - 334)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
蛋白主名 其他名称

histone deacetylase 8

protein deacetylase HDAC8

protein decrotonylase HDAC8

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-109015 Tucidinostat Inhibitor 98.60% 否
HY-13322 Pracinostat Inhibitor 99.82% 是
HY-B0494 Bufexamac Inhibitor ≥98.0% 否
Clinical Phase
生物活性分子 (16)
目录号 产品名 作用方式
纯度 Phase
HY-10990 Abexinostat Inhibitor 98.63% Phase 3
HY-14842 Givinostat Inhibitor 98.16% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-138799 KA2507 Inhibitor 99.24% Phase 2
HY-14718A Resminostat hydrochloride Inhibitor 99.68% Phase 2
HY-101780 Tinostamustine Inhibitor 99.42% Phase 2
HY-14718 Resminostat Inhibitor 99.84% Phase 2
HY-10223 CUDC-101 Inhibitor 98.84% Phase 1
HY-15994 Citarinostat Inhibitor 99.30% Phase 1
HY-124295 MPT0E028 Inhibitor 99.63% Phase 1
HY-10226 JNJ-16241199 Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (111)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13271A Tubastatin A Inhibitor 98.37% 否
HY-18361 TMP195 Inhibitor 99.57% 否
HY-18998 LMK-235 Inhibitor 99.61% 否
HY-13428 Tubacin Inhibitor 99.54% 否
HY-15224 PCI-34051 Inhibitor 99.75% 否
HY-18360 TMP269 Inhibitor 98.05% 否
HY-13271 Tubastatin A Hydrochloride Inhibitor 98.19% 否
HY-N6735 Apicidin Inhibitor 99.87% 否
HY-18613 CAY10603 Inhibitor ≥98.0% 否
HY-16699 Nexturastat A Inhibitor 98.28% 否
HY-111818 TH34 Inhibitor 99.52% 否
HY-111342 HDAC8-IN-1 Inhibitor 99.82% 否
HY-119939 CHDI-390576 Inhibitor 98.07% 否
HY-115475 SW-100 Inhibitor 99.59% 否
HY-111400 SR-4370 Inhibitor 99.95% 否
HY-18976 UF010 99.84% 否
HY-144779 HDAC10-IN-1 Inhibitor 99.11% 否
HY-123295 HDAC3-IN-T247 Inhibitor 98.94% 否
HY-100871 WT-161 Inhibitor 98.36% 否
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.54% 否
HY-19747 HPOB Inhibitor 99.80% 否
HY-13267 Droxinostat Inhibitor 98.91% 否
HY-117348 NCC-149 Inhibitor 99.14% 否
HY-130538 1-Naphthohydroxamic acid Inhibitor 99.72% 否
HY-126330 SS-208 Inhibitor 99.00% 否
HY-18700 BRD73954 Inhibitor ≥98.0% 否
HY-100384 NKL 22 Inhibitor 97.27% 否
HY-110280 MC1742 Inhibitor 99.20% 否
HY-146153 HDAC-IN-40 Inhibitor 98.71% 否
HY-114483 AES-135 Inhibitor 98.21% 否
HY-124782 HDAC8-IN-8 Inhibitor 99.01% 否
HY-131708A FNDR-20123 Inhibitor 98.08% 否
HY-117554 BRD9757 Inhibitor 99.75% 否
HY-162616 SelSA Inhibitor 99.83% 否
HY-164233 YX968 Inhibitor / 否
HY-128582 PI3K/HDAC-IN-1 Inhibitor / 否
HY-152147 SZUH280 Degrader / 否
HY-131708 FNDR-20123 free base Inhibitor / 否
HY-150109 Purinostat mesylate Inhibitor / 否
HY-157314 HDAC6-IN-27 Inhibitor / 否
HY-150595 HDAC6-IN-10 Inhibitor / 否
HY-147966 HDAC-IN-43 Inhibitor / 否
HY-149208 HDAC-IN-53 Inhibitor / 否
HY-153583 HDAC8-IN-4 Inhibitor / 否
HY-19754A CRA-026440 hydrochloride Inhibitor 98.14% 否
HY-156027 SIRT6-IN-3 Inhibitor / 否
HY-141701 mTOR/HDAC-IN-1 Inhibitor / 否
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / 否
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / 否
HY-144297 HDAC1-IN-3 Inhibitor / 否
HY-161524 HDAC6-IN-43 Inhibitor / 否
HY-147731 HDAC6-IN-9 Inhibitor / 否
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / 否
HY-152146 HDAC-IN-50 Inhibitor / 否
HY-143877 NN-390 Inhibitor / 否
HY-149372 HDAC6-IN-17 Inhibitor / 否
HY-126829 Coumarin-SAHA / 否
HY-151443 HDAC-IN-47 Inhibitor / 否
HY-163846 HDAC8-IN-10 Inhibitor / 否
HY-151569 SAHA-OH Inhibitor / 否
HY-146351 HDAC-IN-38 Inhibitor / 否
HY-144293 HDAC-IN-31 Inhibitor / 否
HY-151248 HDAC2-IN-1 Inhibitor / 否
HY-159171 sEH/HDAC6-IN-2 Inhibitor / 否
HY-149578 Tubulin/HDAC-IN-3 Inhibitor / 否
HY-15144B (S)-Trichostatin A Inhibitor / 否
HY-151364 HDAC6/8/BRPF1-IN-1 Inhibitor / 否
HY-146539 HDAC-IN-35 Inhibitor / 否
HY-147991 PDE5/HDAC-IN-1 Inhibitor / 否
HY-161778 ZG-126 Inhibitor / 否
HY-151366 HDAC8/BRPF1-IN-1 Inhibitor / 否
HY-158308 HDAC6-IN-41 Inhibitor / 否
HY-144292 HDAC-IN-30 Inhibitor / 否
HY-159172 HDAC3-IN-4 Inhibitor / 否
HY-163803 CM-444 Inhibitor / 否
HY-144654 HDAC/Top-IN-1 Inhibitor / 否
HY-146750 HDAC-IN-37 Inhibitor / 否
HY-146392 HDAC-IN-39 Inhibitor / 否
HY-150694 HDAC6-IN-11 Inhibitor / 否
HY-144395 HDAC6-IN-4 Inhibitor / 否
HY-162658 Leuxinostat Inhibitor / 否
HY-146684 HDAC-IN-36 Inhibitor / 否
HY-144782 HDAC10-IN-2 Inhibitor / 否
HY-145852 Top/HDAC-IN-2 Inhibitor / 否
HY-152225 MC2625 Inhibitor / 否
HY-146159 PI3K/HDAC-IN-2 Inhibitor / 否
HY-168650 ROCK/HDAC-IN-1 Inhibitor / 否
HY-163834 HDAC6-IN-47 Inhibitor / 否
HY-168287 HDAC3/8 ligand-1 / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-152226 MC2590 Inhibitor / 否
HY-149946 HDAC-IN-57 Inhibitor / 否
HY-149029 TH-6 Inhibitor 95.00% 否
HY-150772 Tubulin/HDAC-IN-1 Inhibitor / 否
HY-147934 HDAC8-IN-3 Inhibitor / 否
HY-161350 ALK/HDAC-IN-1 Inhibitor / 否
HY-162955 LSD1/HDAC-IN-1 Inhibitor / 否
HY-146276 CDK/HDAC-IN-2 Inhibitor / 否
HY-149721 HDAC4-IN-1 Inhibitor / 否
HY-115941 HDAC-IN-9 Inhibitor / 否
HY-151263 G4/HDAC-IN-1 Inhibitor / 否
HY-150577 HDAC-IN-45 Inhibitor / 否
HY-144098 HDAC8-IN-2 Inhibitor / 否
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / 否
HY-157740 XSJ-10 Inhibitor / 否
HY-169226 HDAC6-IN-51 Inhibitor / 否
HY-163143 HDAC8-IN-6 Inhibitor / 否
HY-139795 ZYJ-25e Inhibitor / 否
HY-19754 CRA-026440 Inhibitor / 否
HY-119550 J1075 Inhibitor / 否
HY-139815 ZYJ-34c Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens HDAC8 NCBI NCBI:55869
Mus musculus HDAC8 NCBI NCBI:70315
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