Hdac8 - histone deacetylase 8 Gene

中文名称：组蛋白脱乙酰酶 8

种属: Mus musculus

同用名: 2610007D20Rik

关于 Hdac8

功能概要

预测该基因编码的蛋白可启动染色质结合活性；热休克蛋白结合活性；和组蛋白脱乙酰酶活性。预计参与多个过程，包括组蛋白去乙酰化；大分子代谢过程的负调控；和染色体组织的调节。预计位于核质和质膜中。预计是组蛋白脱乙酰酶复合物的一部分。以多种结构表达，包括 2 细胞期胚胎；脑;胚胎外胚层；前肠;和视网膜。该基因的人类直系同源物与 Cornelia de Lange 综合征 5 和 Wilson-Turner 综合征有关。与人类 HDAC8（组蛋白脱乙酰酶 8）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable chromatin binding activity; heat shock protein binding activity; and histone deacetylase activity. Predicted to be involved in several processes, including histone deacetylation; negative regulation of macromolecule metabolic process; and regulation of chromosome organization. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of histone deacetylase complex. Is expressed in several structures, including 2-cell stage embryo; brain; embryo ectoderm; foregut; and retina. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8). [provided by Alliance of Genome Resources, Apr 2022]