1. Gene
  2. JAK1 - Janus kinase 1 Gene

JAK1 - Janus kinase 1 Gene

中文名称:两面神激酶 1

种属: Homo sapiens

同用名: JTK3; AIIDE; JAK1A; JAK1B

基因 ID: 3716 | 基因类型: protein coding

关于 JAK1

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:64,833,229-65,067,746 (from NCBI)

This gene has 31 transcripts (splice variants), 238 orthologues, 32 paralogues and is associated with 113 phenotypes. Ubiquitous expression in lymph node (RPKM 51.3), fat (RPKM 49.8) and 25 other tissues.

功能概要

该基因编码一种膜蛋白,它是一类蛋白酪氨酸激酶 (PTK) 的成员,其特征是存在紧邻 PTK 结构域 N 端的第二个磷酸转移酶相关结构域。编码的激酶使 STAT 蛋白 (信号转导和转录激活因子) 磷酸化,并在干扰素-α/β、干扰素-γ 和细胞因子信号转导中发挥关键作用。该基因在影响介导炎症、上皮重塑和转移性癌症进展的基因表达方面起着至关重要的作用。该基因是白细胞介素 6 (IL-6) /JAK1/STAT3 免疫和炎症反应的关键组成部分,是缓解细胞因子风暴的治疗靶点。该基因的激酶活性直接被细胞因子信号转导抑制因子 1 (SOCS1) 蛋白抑制。可变剪接导致多个转录本变体。[RefSeq 提供,2020 年 7 月]

This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic Cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020]

JAK1 基因产物(12)

mRNA Protein Name
NM_002227.4 NP_002218.2 tyrosine-protein kinase JAK1 isoform 1
NM_001321853.2 NP_001308782.1 tyrosine-protein kinase JAK1 isoform 1
NM_001321852.2 NP_001308781.1 tyrosine-protein kinase JAK1 isoform 1
NM_001321854.2 NP_001308783.1 tyrosine-protein kinase JAK1 isoform 1
XM_047419674.1 XP_047275630.1 tyrosine-protein kinase JAK1 isoform X1
XM_047419676.1 XP_047275632.1 tyrosine-protein kinase JAK1 isoform X2
XM_047419675.1 XP_047275631.1 tyrosine-protein kinase JAK1 isoform X1
NM_001321856.2 NP_001308785.1 tyrosine-protein kinase JAK1 isoform 1
XM_047419677.1 XP_047275633.1 tyrosine-protein kinase JAK1 isoform X2
NM_001321855.2 NP_001308784.1 tyrosine-protein kinase JAK1 isoform 1
NM_001321857.2 NP_001308786.1 tyrosine-protein kinase JAK1 isoform 2
NM_001320923.2 NP_001307852.1 tyrosine-protein kinase JAK1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
7657660 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7759950 GOA
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
11909529 GOA
enables protein tyrosine kinase activity EXP
EXP: 通过实验结果推断
1386289 GOA
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
7532278 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
24882218 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell surface receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
7657660 GOA
involved in cell surface receptor signaling pathway via JAK-STAT IMP
IMP: 通过突变表型推断
28111307 GOA
involved in interleukin-10-mediated signaling pathway IDA
IDA: 通过直接分析推断
7543512 GOA
involved in interleukin-11-mediated signaling pathway IDA
IDA: 通过直接分析推断
8272872 GOA
involved in interleukin-15-mediated signaling pathway IDA
IDA: 通过直接分析推断
7568001 GOA
involved in interleukin-2-mediated signaling pathway IDA
IDA: 通过直接分析推断
7973659 GOA
involved in interleukin-4-mediated signaling pathway IDA
IDA: 通过直接分析推断
7929391 GOA
involved in interleukin-6-mediated signaling pathway IDA
IDA: 通过直接分析推断
8272873 GOA
involved in interleukin-9-mediated signaling pathway IDA
IDA: 通过直接分析推断
8756628 GOA
involved in positive regulation of homotypic cell-cell adhesion IMP
IMP: 通过突变表型推断
21679692 GOA
involved in positive regulation of protein localization to nucleus IDA
IDA: 通过直接分析推断
26479788 GOA
involved in positive regulation of sprouting angiogenesis IGI
IGI: 通过遗传相互作用推断
20299512 GOA
involved in protein localization to cell-cell junction IMP
IMP: 通过突变表型推断
21679692 GOA
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
28111307 GOA
acts upstream of or within response to antibiotic IDA
IDA: 通过直接分析推断
16280321 GOA
involved in type I interferon-mediated signaling pathway IDA
IDA: 通过直接分析推断
7532278 GOA
involved in type II interferon-mediated signaling pathway IDA
IDA: 通过直接分析推断
8232552 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10502458 GOA
is active in cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
8272873 GOA
is active in extrinsic component of cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
7973659 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10502458 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

JAK1 蛋白结构

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (584 - 844)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (876 - 1147)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1154 a.a.
蛋白主名 其他名称

tyrosine-protein kinase JAK1

JAK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
JAK1 P23458 STAT1 Homo sapiens P42224
Anti Tag CoIP
32953130
种属内
JAK1 P23458 JAK2 Homo sapiens O60674
Confocal
26175413
种属内
JAK1 P23458 JAK2 Homo sapiens O60674
Anti Bait CoIP
26175413
种属内
JAK1 P23458 STAT3 Homo sapiens P40763
Anti Tag CoIP
31462771
种属内
JAK1 P23458 IFNAR2 Homo sapiens P48551
Anti Bait CoIP
16710296
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 JAK1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P78739 JAK1 Protein, Human (sf9, His) P23458 (A561-N852) ≥95%
HY-P700583 JAK1 Protein, Human (P. pastoris, His) P23458 (E850-K1154) ≥95%

关联疾病

疾病名称 别名
Myeloproliferative Neoplasm

Myeloproliferative Disorder

Chronic Myeloproliferative Disease

Myeloproliferative Neoplasms

Chronic Myeloproliferative Disorder

Cmpd

Cmpd, U

Chronic Myeloproliferative Disorders

Mpd

Mpn

Myeloproliferative Disorders

Myeloproliferative Disease

Campomelic Dysplasia

Nasopharyngitis

Chronic Nasopharyngitis

Chronic Rhinopharyngitis

Immunodeficiency 35

Tyrosine Kinase 2 Deficiency

IMD35

Tyk2 Deficiency

Autosomal Recessive Hyper-Ige Syndrome With Atypical Mycobacteriosis

Susceptibility To Infection Due To Tyk2 Deficiency

Hyper-Ige Syndrome With Atypical Mycobacteriosis, Autosomal Recessive

Hies With Atypical Mycobacteriosis, Autosomal Recessive

Autosomal Recessiv Hies With Atypical Mycobacteriosis

Autosomal Recessive Hyper-Ige Syndrome Due To Tyk2 Deficiency

Autosomal Recessive Hies With Atypical Mycobacteriosis

Autoinflammation, Immune Dysregulation, And Eosinophilia

AIIDE

Atopic Dermatitis, Enteritis, Colitis, And Eosinophilia

Mixed Lacrimal Gland Cancer

Carcinoma Ex Pleomorphic Adenoma Of Lacrimal Gland

Carcinoma Ex Pleomorphic Adenoma Of The Lacrimal Gland

Malignant Mixed Neoplasm Of Lacrimal Gland

Autoimmune Disease Of Skin And Connective Tissue
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Central Nervous System Vasculitis

Vasculitis, Central Nervous System

Bone Marrow Cancer

Malignant Neoplasm Of Bone Marrow

Bone Marrow Neoplasm

Bone Marrow Tumor

Malignant Bone Marrow Tumor

Myeloproliferative Disorders

Bone Marrow Neoplasms

Myeloproliferative Disease

Chronic Myeloproliferative Disorder

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Herpes Zoster

Shingles

Zoster

Herpes Zona

Herpes Zoster Disease

Zona Zoster

Herpes Zoster Of Skin And Mucous Membranes

Zoster Nos

Zoster With Nervous System Involvement

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

T-Cell Prolymphocytic Leukemia

T Cell Prolymphocytic Leukemia

Prolymphocytic Leukemia, T-Cell Type

T-Pll

T-Cell Chronic Lymphocytic Leukemia

Lymphocytic Leukemia T-Cell Chronic

Doid:0081042

Leukemia, T-Cell, Chronic

Prolymphocytic Leukaemia Of T-Cell Type Without Mention Of Remission

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Hemophagocytic Lymphohistiocytosis

Lymphohistiocytosis, Hemophagocytic

Haemophagocytic Syndrome

Lymphohistiocytosis Hemophagocytic

Hemophagocytic Syndrome

Familial Hemophagocytic Lymphocytosis

Histiocytoses Of Mononuclear Phagocytes

Haemophagocytic Lymphohistiocytosis Nos

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]

Leukemia, Acute, X-Linked
Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Jak1 Deficiency

Autosomal Recessive Msmd Due To Partial Jak1 Deficiency

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous

Cmc

Candidiasis Chronic Mucocutaneous

Polycythemia

Erythrocythemia

Polycythemia Vera

Polycythaemia Due To High Altitude

Severe Combined Immunodeficiency, X-Linked

X-Linked Severe Combined Immunodeficiency

SCIDX1

XSCID

Scidx

X-Linked Scid

X-Scid

Severe Combined Immunodeficiency, X-Linked, T Cell-Negative, B Cell-Positive, Nk Cell-Negative

Scid, X-Linked

Immunodeficiency 4

Imd4

Gamma Chain Deficiency

Scid-X1

X-Linked Combined Immunodeficiency Diseases

Thymic Epithelial Hypoplasia

Severe Combined Immunodeficiency T- B+ Due To Gamma Chain Deficiency

Severe Combined Immunodeficiency T- B+, X-Linked

Il2rg Scid, T- B+ Nk-

T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency

T-B+ Scid Due To Gamma Chain Deficiency

T-B+ Severe Combined Immunodeficiency, X-Linked

Severe Combined Immunodeficiency X-Linked T-Cell-Negative/B-Cell-Positive/Nk-Cell-Negative

Agammaglobulinemia Swiss Type

Scid X-Linked

Severe Combined Immunodeficiency X-Linked T Cell-Negative/B Cell-Positive/Nk Cell-Negative

Severe Combined Immunodeficiency X-Linked T-Cell Negative/B-Cell Positive/Nk-Cell Negative

Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency

Myeloma, Multiple

Multiple Myeloma

Kahler Disease

Myelomatosis

Plasma Cell Myeloma

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler'S Disease

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]

Acute Megakaryoblastic Leukemia In Down Syndrome

Ds-Amkl

Autoimmune Lymphoproliferative Syndrome

ALPS

Canale-Smith Syndrome

Autoimmune Lymphoproliferative Syndrome, Type Ia

Autoimmune Lymphoproliferative Syndrome, Type Ib

Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

Css

Autoimmune Lymphoproliferative Syndrome, Type 1b

Autoimmune Lymphoproliferative Syndrome, Type 1a

Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

Fas Deficiency

Autoimmune Lymphoproliferative Syndrome 1a

ALPS1A

Autoimmune Lymphoproliferative Syndrome Type Ia

Autoimmune Lymphoproliferative Syndrome 1b

ALPS1B

Autoimmune Lymphoproliferative Syndrome Type Ib

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Hypereosinophilic Syndrome

Eosinophilia

HES

Eosinophilic Leukocytosis

Hypereosinophilic Syndrome, Idiopathic

Idiopathic Hypereosinophilic Syndrome

Disseminated Eosinophilic Collagen Disease

Eosinophilic Disorder

Disorders With Increased Eosinophil Counts

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Encephalopathy With Basal Ganglia Calcification

Aicardi-Goutières Syndrome

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1

Alopecia Universalis Congenita

Alopecia Universalis

ALUNC

Atrichia, Generalized

Au

Alopecia Areata Universalis

Atrichia Generalized

Myelofibrosis

Primary Myelofibrosis

Agnogenic Myeloid Metaplasia

Idiopathic Myelofibrosis

Myeloid Metaplasia

Myelofibrosis With Myeloid Metaplasia

Osteomyelofibrosis

Megakaryocytic Myelosclerosis

Myelosclerosis

Chronic Idiopathic Myelofibrosis

Myelofibrosis, Idiopathic

Myelofibrosis With Myeloid Metaplasia, Somatic

Myelofibrosis, Somatic

Aleukemic Myelosis

Bone Marrow Fibrosis

MYELOF

MMM

Agnogenic Myeloid Metaplasia With Myelofibrosis

Ammm

Myelosclerosis With Myeloid Metaplasia

Myelofibrosis Nos

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Immunodeficiency 27a

IMD27A

Autosomal Recessive Ifngr1 Deficiency

Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis

Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency

Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency

Autosomal Recessive Msmd Due To Partial Ifngammar1 Deficiency

Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency

Immunodeficiency 27a, Mycobacteriosis, Autosomal Recessive

Ifngr1 Deficiency, Autosomal Recessive

Immunodeficiency 27a, Mycobacteriosis, Ar

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar1 Deficiency

Msmd Due To Complete Ifngammar1 Deficiency

Msmd Due To Complete Interferon Gamma Receptor 1 Deficiency

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 1 Deficiency

Familial Disseminated Atypical Mycobacterial Infection

Interferon Gamma, Receptor 1, Deficiency

Immunodeficiency, Type 27a, Mycobacteriosis, Ar

Mycobacterial Disease, Mendelian Susceptibility To

Skin Disease

Skin Diseases

Abnormality Of The Skin

Skin Diseases, Genetic

Genodermatosis

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Sezary'S Disease

Sezary Syndrome

Sézary Syndrome

Sezary'S Lymphoma

Sezary Disease

Sezary Erythroderma

Sezary Lymphoma

Autoimmune Disease Of Musculoskeletal System
Fallopian Tube Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of The Fallopian Tube

Plasmablastic Lymphoma

Pbl

Immunoblastic Large-Cell Lymphoma

Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Disease

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease

Intellectual Developmental Disorder, Autosomal Dominant 4

MRD4

Autosomal Dominant Non-Syndromic Intellectual Disability 4

Mental Retardation, Autosomal Dominant 4

Autosomal Dominant Intellectual Developmental Disorder 4

Lymphoblastic Leukemia, Acute, With Lymphomatous Features

LALL

Lymphomatous All

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia With Lymphomatous Features

Chilblain Lupus 1

Chilblain Lupus

CHBL1

Chilblain Lupus Erythematosus

Chle

Hutchinson Lupus

Chilblain Lupus, Type 1

Fibrosarcoma

Neoplasms, Fibrous Tissue

Fibrocytic Tumor

Fibrosarcoma Of Soft Tissue

Fibrous Tissue Neoplasm

Hyper Ige Syndrome

Hyper-Ige Syndrome

Hyper Immunoglobulin E Syndrome

Hies

Hyper-Ige Recurrent Infection Syndrome

Hyperimmunoglobulin E Syndrome

Hyper Ige

Job Syndrome

Hartnup Disease

Dermatitis

Eczema

Skin Inflammation

Inflammatory Dermatosis

Psoriasis
Measles

Rubeola

Morbilli

Measles Nos

Koplik Spots

Lymphoproliferative Syndrome

Lymphoproliferative Disorder

Lymphoproliferative Disorders

Lymphoproliferative Disorders, Susceptibility To

Essential Thrombocythemia

Essential Thrombocytosis

Familial Thrombocytosis

Hemorrhagic Thrombocythemia

Hereditary Thrombocythemia

Primary Thrombocytosis

Idiopathic Thrombocythemia

Primary Thrombocythemia

Thrombocythemia, Essential

Essential Thrombocythaemia

Et

Familial Thrombocythemia

Thrombocythemia Essential

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia

Blood Platelet Disease

Platelet Disorder

Blood Platelet Disorders

Thrombocytopathy

Platelet Dysfunction

Platelet Disorders

Qualitative Platelet Deficiency

Polycythemia Vera

PV

Polycythemia Rubra Vera

Prv

Osler-Vaquez Disease

Chronic Erythremia

Polycythaemia Rubra Vera

Primary Polycythemia

Vaquez Disease

Polycythemia Vera, Somatic

Osler-Vaquez Syndrome

Proliferative Polycythaemia

Polycythemia Ruba Vera

Acquired Primary Erythrocytosis

Heilmeyer-Schoner Disease

Vaquez Osler Disease

Primary Polycythaemia

Wernicke Encephalopathy

Wernicke'S Encephalopathy

Wernicke'S Disease

Encephalopathy, Wernicke'S

Wernicke-Korsakoff Syndrome

Encephalopathy Due To Vitamin B1 Deficiency

Wernicke Disease

Wernicke Syndrome

Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To

Psoriatic Arthropathy

Arthropathic Psoriasis

Arthritis, Psoriatic

Arthritis Psoriatica

PSORAS

Arthritic Psoriasis

Psoriasis Arthropathica

Arthritis Psoriatic

Arthritis, Psoriatic, Susceptibility To

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Temporal Arteritis

Polymyalgia Rheumatica

Giant Cell Arteritis

Cranial Arteritis

Horton Disease

Gca

Horton'S Disease

Rhizomelic Pseudopolyarthritis

Arteritis Cranialis

Arteritis Temporalis

Horton'S Arteritis

Horton'S Giant Cell Arteritis

Horton'S Temporal Arteritis

Horton'S Syndrome

Gca - [Giant Cell Arteritis]

Senile Arthritis

Polymyalgia Arteritica

Pmr - [Polymyalgia Rheumatica]

Forestier-Certonciny Syndrome

Rheumatic Polymyalgia

Polymyalgia

Breast Implant-Associated Anaplastic Large Cell Lymphoma
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo

Hepatitis C

Chronic Hepatitis C

Hepatitis C Infection

Hepatitis Nona Nonb

Nanbh

Viral Hepatitis C

Hepatitis C Chronic

Hepatitis C, Chronic

Chronic Type C Viral Hepatitis

Chronic Hcv - [Hepatitis C Virus] Infection

Hepatitis C Nos

Hepatitis C Infection Nos

Hepatitis C-Related Cirrhosis

Type C Viral Hepatitis

Hep C Nos

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Sting-Associated Vasculopathy With Onset In Infancy

Savi

Sting-Associated Vasculopathy, Infantile Onset

Sting-Associated Vasculopathy, Infantile-Onset

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus JAK1 VGNC VGNC:67876
Canis familiaris JAK1 VGNC VGNC:42175
Macaca mulatta JAK1 VGNC VGNC:73810
Rattus norvegicus JAK1 RGD RGD:69056
Bos taurus JAK1 VGNC VGNC:30364
Mus musculus JAK1 MGD MGI:96628
Others JAK1 NCBI